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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian shen Robert J.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Synergistic effect Intermetallics Single atomic sites Oxygen reduction reaction Hydrogen evolution reaction

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无人机倾斜摄影在大比例尺测图中的应用研究

山西建筑 2018年第35期44卷 193-194页

作者：沈建波黄薏吕晓芳上海中房测绘有限公司上海200434 北京新武测信息技术有限公司北京100083

利用低空无人机倾斜摄影技术,获取地面实景三维模型转换成大比例尺数字地形图,并通过与传统实测地形图进行对比试验,验证了无人机倾斜摄影在大比例尺测图中的可靠性与精度。

关键词：无人机倾斜摄影大比例尺地形图精度分析

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深埋煤层运输巷变形特征及支护优化研究

中国矿山工程 2022年第5期51卷 48-53页

作者：李振武何建新沈建波济宁能源发展集团有限公司山东济宁272000 山东济矿鲁能煤电有限公司阳城煤矿山东济宁272502

为解决矩形巷道顶板因应力集中易产生冒顶破坏问题,以安居煤矿C2316工作面运输巷为研究背景,采用理论计算、数值模拟等得出了巷道失稳破坏的原因,并通过支护优化进行改善。结果表明,通过理论计算得出巷道顶板松动圈的高度为L_(s)=3 m,... 详细信息

为解决矩形巷道顶板因应力集中易产生冒顶破坏问题,以安居煤矿C2316工作面运输巷为研究背景,采用理论计算、数值模拟等得出了巷道失稳破坏的原因,并通过支护优化进行改善。结果表明,通过理论计算得出巷道顶板松动圈的高度为L_(s)=3 m,两帮的松动圈宽度为L_(e)=2.5 m,原支护方案锚杆长度未穿过巷道松动圈。因此,提出了将巷道顶板锚杆支护改为全锚索支护,帮部锚杆长度由1 800 mm换成3 000 mm方案后。经现场实践,巷道顶板移近量、两帮收敛量分别达到30 mm, 28 mm,巷道围岩变形量得到有效控制,满足安全生产要求。

关键词：矩形巷道松动圈数值模拟理论计算

烟草N-TSNAs及其前体物在烟叶烘烤过程中含量的变化

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中国农学通报 2007年第6期23卷 179-182页

作者：宫长荣沈剑波司辉王娜河南农业大学农学院河南郑州450002 武汉烟草集团技术中心湖北武汉430051

研究表明,烟叶在烘烤过程中,硝酸盐、亚硝酸盐和烟草特有亚硝胺(N-TSNAs)含量在变黄阶段上升,定色阶段含量下降,干筋阶段基本保持平稳变化;烤后烟叶硝酸盐、亚硝酸盐和N-TSNAs含量高于鲜烟叶。膜脂过氧化产物丙二醛(MDA)的含量、相对电... 详细信息

研究表明,烟叶在烘烤过程中,硝酸盐、亚硝酸盐和烟草特有亚硝胺(N-TSNAs)含量在变黄阶段上升,定色阶段含量下降,干筋阶段基本保持平稳变化;烤后烟叶硝酸盐、亚硝酸盐和N-TSNAs含量高于鲜烟叶。膜脂过氧化产物丙二醛(MDA)的含量、相对电导度和伤害度在变黄阶段急剧增加,定色阶段和干筋阶段缓慢增加,直至烘烤结束。

关键词：烤烟烘烤烟草特有亚硝胺(N-TSNAs)

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天然气过江隧道充排水方案研究

上海煤气 2019年第5期 8-10,11-13页

作者：宋玉银李斌蒋袁曦申建波中国市政工程西南设计研究总院有限公司

研究了天然气过江隧道充排水模式,得出了充水时间、排水泵的配置及可行的排水时间,为工程运行维护提供了技术支持。

关键词：天然气过江隧道充排水排水泵

From waste to wealth:Coal tar residue derived carbon materials as low-cost anodes for potassium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 464-475页

作者： Zhonghua Lu Jun shen Xin Zhang Lingcong Chao Liang Chen Ding Zhang Tao Wei Shoudong Xu College of Chemical Engineering and Technology Taiyuan University of TechnologyTaiyuan 030024China College of Chemistry Taiyuan University of TechnologyTaiyuan 030024China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan 430205China School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China

Carbon materials are widely recognized as highly promising electrode materials for various energy storage system *** tar residues(CTR),as a type of carbon-rich solid waste with high value-added utilization,are crucially important for the development of a more sustainable *** this study,we employed a straightforward direct carbonization method within the temperature range of 700-1000℃to convert the worthless solid waste CTR into economically valuable carbon materials as anodes for potassium-ion batteries(PIBs).The effect of carbonization temperature on the microstructure and the potassium ions storage properties of CTR-derived carbons(CTRCs)were systematically explored by structural and morphological characterization,alongside electrochemical performances *** on the co-regulation between the turbine layers,crystal structure,pore structure,functional groups,and electrical conductivity of CTR-derived carbon carbonized at 900℃(CTRC-900H),the electrode material with high reversible capacity of 265.6m Ah·g^(-1)at 50 m A·g^(-1),a desirable cycling stability with 93.8%capacity retention even after 100 cycles,and the remarkable rate performance for PIBs were ***,cyclic voltammetry(CV)at different scan rates and galvanostatic intermittent titration technique(GITT)have been employed to explore the potassium ions storage mechanism and electrochemical kinetics of *** indicate that the electrode behavior is predominantly governed by surface-induced capacitive processes,particularly under high current densities,with the potassium storage mechanism characterized by an“adsorption-weak intercalation”*** work highlights the potential of CTR-based carbon as a promising electrode material category suitable for high-performance PIBs electrodes,while also provides valuable insights into the new avenues for the high value-added utilization of CTR.

关键词： coal tar residue carbon materials anode potassium-ion batteries high value-added

华北地区集约化玉米体系减磷增效的根际调控原理与技术规程

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磷肥与复肥 2021年第2期36卷 8-10页

作者：王利阳李海港申建波中国农业大学资源与环境学院资源环境与粮食安全研究中心国家农业绿色发展研究院内蒙古农业大学草原与资源环境学院

局部磷加铵调控(根际调控)可以通过刺激玉米侧根增生并酸化根际来提高磷利用率。对磷加铵局部调控技术进行了规范,包括施肥量选择、肥料种类选择、调控位置的精确确定以及调控次数等关键技术要素,旨在优化调整集约化玉米生产体系磷肥施... 详细信息

局部磷加铵调控(根际调控)可以通过刺激玉米侧根增生并酸化根际来提高磷利用率。对磷加铵局部调控技术进行了规范,包括施肥量选择、肥料种类选择、调控位置的精确确定以及调控次数等关键技术要素,旨在优化调整集约化玉米生产体系磷肥施用制度,提高磷肥利用效率,实现减磷增效,助力农业绿色发展。

关键词：玉米减磷增效启动磷肥根际调控根际酸化

Optimizing electronic structure through point defect engineering for enhanced electrocatalytic energy conversion

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Green Energy & Environment 2025年第1期10卷 109-131页

作者： Wei Ma Jiahao Yao Fang Xie Xinqi Wang Hao Wan Xiangjian shen Lili Zhang Menggai Jiao Zhen Zhou Interdisciplinary Research Center for Sustainable Energy Science and Engineering(IRC4SE2) School of Chemical EngineeringZhengzhou UniversityHenan450001China

Point defect engineering endows catalysts with novel physical and chemical properties,elevating their electrocatalytic *** introduction of defects emerges as a promising strategy,effectively modifying the electronic structure of active *** optimization influences the adsorption energy of intermediates,thereby mitigating reaction energy barriers,altering paths,enhancing selectivity,and ultimately improving the catalytic efficiency of *** elucidate the impact of defects on the electrocatalytic process,we comprehensively outline the roles of various point defects,their synthetic methodologies,and characterization ***,we consolidate insights into the relationship between point defects and catalytic activity for hydrogen/oxygen evolution and CO_(2)/O_(2)/N_(2) reduction reactions by integrating mechanisms from diverse *** underscores the pivotal role of point defects in enhancing catalytic *** last,the principal challenges and prospects associated with point defects in current electrocatalysts are proposed,emphasizing their role in advancing the efficiency of electrochemical energy storage and conversion materials.

关键词： Point defect engineering Doping Vacancy Electrocatalysis Electronic structure