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显微镜外科手术治疗脑胶质瘤的近期效果及对认知功能的影响

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中国临床实用医学 2021年第2期12卷 30-34页

作者：茹小红田志华申剑波李敏段海锋张浩黄可丰山西省晋城市人民医院神经外科 048000

目的探究与分析显微镜外科手术治疗脑胶质瘤的近期效果及对认知功能的影响。方法回顾性分析2018年1月至2020年1月山西省晋城市人民医院神经外科收治的121例脑胶质瘤患者的临床资料,男74例,女47例,年龄(45.85±3.28)岁,年龄范围为32~67... 详细信息

目的探究与分析显微镜外科手术治疗脑胶质瘤的近期效果及对认知功能的影响。方法回顾性分析2018年1月至2020年1月山西省晋城市人民医院神经外科收治的121例脑胶质瘤患者的临床资料,男74例,女47例,年龄(45.85±3.28)岁,年龄范围为32~67岁。根据不同手术治疗方法分为开颅组(n=55)及显微组(n=66),开颅组患者行开颅肿瘤切除术治疗,显微组患者行显微镜外科手术治疗。比较两组患者临床治疗效果、术前及术后3个月的脑脊液精氨酸加压素(AVP)、催产素、β-内啡肽(β-EP)水平、神经功能评分、精神状态评分、术前及术后1年患者日常生活能力评分、复发率及病死率。结果显微组患者临床总有效率92.4%(61/66)高于开颅组80.0%(44/55),差异有统计学意义(P0.05)。显微组患者术后3个月脑脊液AVP[(15.37±1.99)ng/L]、催产素[(6.18±0.85)ng/L]及β-EP水平[(82.55±7.41)ng/L]均高于开颅组[(11.58±2.20)ng/L、(4.17±0.77)ng/L、(64.26±5.40)ng/L],差异有统计学意义(P0.05)。显微组患者术后3个月NIHSS评分[(6.78±1.04)分]低于开颅组[(9.25±1.26)分],MMSE评分[(24.66±4.10)分]高于开颅组[(18.24±3.17)分];显微组患者术后1年ADL[(18.67±6.11)分]低于开颅组[(30.48±5.33)分],差异有统计学意义(P0.05)。结论显微镜外科手术治疗脑胶质瘤的近期效果显著,可更好地促进改善患者的神经功能及精神状态,短期随访认知功能较好,日常生活能力较高。

关键词：显微镜外科手术脑胶质瘤近期治疗效果认知功能

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植物多糖的提取分离及应用研究进展

中国农学通报 2007年第9期23卷 192-195页

作者：史霖宫长荣毋丽丽代丽沈剑波陈长清杨少杰河南农业大学农学院河南郑州450002

植物多糖参与机体各种生理代谢,具有调节机体免疫、抑制肿瘤、延缓衰老、降血糖血脂、抗辐射、抗菌、抗病毒等生物活性,其独特的活性和来源的天然性在保障人体健康应用中具有强大潜力。笔者介绍了植物多糖的提取分离方法,生物活性,开发... 详细信息

植物多糖参与机体各种生理代谢,具有调节机体免疫、抑制肿瘤、延缓衰老、降血糖血脂、抗辐射、抗菌、抗病毒等生物活性,其独特的活性和来源的天然性在保障人体健康应用中具有强大潜力。笔者介绍了植物多糖的提取分离方法,生物活性,开发与利用等近年来的研究成果。

关键词：植物多糖提取分离生物活性

中国农业社会化服务水平评价指标体系构建与发展对策

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农业展望 2023年第10期19卷 60-68页

作者：沈剑波张蕴灵袁俊林刘帮迪冉国伟张云鹤中国公路工程咨询集团有限公司/空间信息应用与防灾减灾技术交通运输行业研发中心北京100097 北京市农林科学院信息技术研究中心北京100097 煤炭工业规划设计研究院有限公司北京100120 农业农村部规划设计研究院北京100125

构建符合中国国情的农业社会化服务水平评价指标体系,对于规范农业社会化服务的服务内容、提升中国农业社会化服务供给水平以及服务质量具有重要的作用。在梳理总结已有研究的基础上,基于农业社会化服务的内涵,建立了一套符合中国国情... 详细信息

构建符合中国国情的农业社会化服务水平评价指标体系,对于规范农业社会化服务的服务内容、提升中国农业社会化服务供给水平以及服务质量具有重要的作用。在梳理总结已有研究的基础上,基于农业社会化服务的内涵,建立了一套符合中国国情的农业社会化服务水平评价指标体系,同时采用层次分析法对各评价指标的权重进行计算。农业社会化服务水平评价指标权重从大到小依次为:耕种防收四环节托管服务面积、年服务营业收入、农资供应服务量、服务基地“三品一标”面积、服务户数、净利润率、固定资产净值、新技术应用项目(个数或面积)、投入产出比率、农机数量、承担服务项目数量、农业劳动生产率、农民参加培训次数、从业人员数、是否有专业信息管理软件、服务合同签订率、经营时长、好评率、服务人员从业资格持证率、是否具有服务规程、服务人员受培训次数。最后,在评价指标体系研究的基础上,提出了中国农业社会化服务的发展对策。研究结果为提升中国农业社会化服务的服务能力提供了重要的参考与借鉴,对于促进乡村振兴及农业农村现代化的早日实现具有重要的理论价值和实践意义。

关键词：农业社会化服务评价指标体系层次分析法

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Feasibility and utility of intraoperative optical coherence tomography during vitreoretinal surgery:A 4-year report in Chinese population

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Journal of Innovative Optical Health Sciences 2021年第1期4卷 46-55页

作者： Jiwei Tao Huan Chen Jiafeng Yu Dan Cheng Yiqi Chen jianbo Mao Jia Fang Lijun shen Department of Retina Center Affiliated Eye Hospital of Wenzhou Medical University HangzhouZhejiang ProvinceP.R.China

The objective is to introduce the application of intraoperative optical coherence tomography(iOCT)in pars plana vitrectomy(PPV)for various vitreoretinal diseases,and to report the 4-year assessment of feasibility and utility in Chinese *** reported a retrospective case series of patients who underwent PPV and iOCT scan at Eye Hospital of Wenzhou Medical University from January 2016 to January *** characteristics were documented before operation,and we intraoperatively recorded the time and results of iOCT scanning,specific surgical maneuvers performed,the consistency with the planned strategies before surgery,the type of OCT images obtained,and adverse events(AEs).The surgeon feedback was collected to evaluate the utility of iOCT during *** total 339 eyes successfully completed iOCT scan,with an average scanning time of 3.54±2.3 min,including 59 cases of idiopathic macular hole(iMH),134 cases of idiopathic epiretinal membrane(iERM),33 cases of lamellar macular hole(LMH),40 cases of high myopic maculopathy,13 cases of vitreous macular traction(VMT),60 cases of dense vitreous hemorrhage(VH).The iOCT findings were not consistent with exami-nation under the operating microscope in 49 cases(14.5%),including 29 cases(8.6%)which changed the operation strategies during *** Hole-door phenomenon arose in 20 cases(33.9%)of iMH and 3 cases(25%)of high myopic MH after ILMs ***,the residue ERM was observed in nine cases(6.7%)of iERM and two cases(14.3%)in high myopic ERM after ILMs *** new surgical methods could also be confirmed using *** ap-plication of iOCT has a significant clinical functionality in vitreoretinal surgery,providing the surgeon with a new surgical understanding,guiding the selection of a more reasonable operative procedure during surgery,predicting postoperative recovery and improving postoperative outcomes.

关键词： Intraoperative optical coherence tomography vitreoretinal diseases pars plana vit-rectomy surgical guidance

Binder-free carbon fiber/TiNb2O7 composite electrode as superior high-rate anode for lithium ions batteries

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Chinese Chemical Letters 2017年第12期28卷 2219-2222页

作者： shenghui shen shengjue Deng Yu Zhong jianbo Wu Xiuli Wang Xinhui Xia Jiangping Tu State Key Laboratory of Silicon Materials Key Laboratory of Advanced Materials and Applications for Batteries of Zhejiang Provinceand School of MaterialsScience and Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory for Cutting Tools Toizhou UniversityTaizhou 318000Chino

Construction of advanced high-rate anodes is critical for the development of high-power lithium ion batteries （LIBs）. In this work, we report a binder-free carbon fiber/CF）]titanium niobium oxide （TiNb2O7 （TNO）） composite electrode via a simple solvothermal method combined with heat treatment. Continuous TNO film consisting of cross-linked TNO nanoparticles of 30-50 nm is strongly anchored on the carbon fiber forming integrated CF/TNO composite electrode. Owing to the intimate three- dimensional structure, the as-prepared CF]TNO electrode presents exceptional high-rate performance （245 mAh/g at 1 C, and 138 mAh/g at 80 C） and enhanced cyclability with a capacity of 150 mAh]g at the current density of 10 C after 1000 cycles. Our results demonstrate the CF/TNO electrode as efficient anode for application in high-power lithium ion batteries.

关键词： Titanium niobium oxideIntegrated electrodeAnodeLithium ion batteriesHigh power

雷公藤内酯醇调控GDNF、ZO-1表达对DSS诱导的小鼠结肠炎肠黏膜稳定性的影响

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交通医学 2022年第4期36卷 331-335页

作者：秦春峰尤国莉阮云沈剑波朱笑林周国雄南通市通州区中医院内科江苏226300 建湖县人民医院消化内科南通大学附属医院消化内科南通大学药学院

目的:探究葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎(UC)模型中胶质细胞源性神经营养因子(GDNF)、闭锁小带蛋白1(ZO-1)的表达以及雷公藤内酯醇(TL)对肠黏膜稳定性的影响。方法:将80只BALB/c雄性小鼠随机分成8组,其中10只为空白对照组(N... 详细信息

目的:探究葡聚糖硫酸钠(DSS)诱导的小鼠溃疡性结肠炎(UC)模型中胶质细胞源性神经营养因子(GDNF)、闭锁小带蛋白1(ZO-1)的表达以及雷公藤内酯醇(TL)对肠黏膜稳定性的影响。方法:将80只BALB/c雄性小鼠随机分成8组,其中10只为空白对照组(NC),其余70只饮用5%DSS溶液建立UC模型。建模第3天将70只小鼠随机分为模型组(M),丙二醇组(PG),雷公藤内酯醇低浓度组(TLL)、中浓度组(TLM)和高浓度组(TLH),地塞米松组(D),美沙拉嗪组(MS),分别给予相应药物治疗。7天后处死动物,取结肠组织进行病理学检查,采用实时定量PCR法及Western Blot法检测GDNF、ZO-1 mRNA及蛋白的表达。结果:与NC组比较,TL低中高剂量组从第4天至第7天体质量下降,但明显高于M组,差异有统计学意义(P<0.05)。病理检查显示M组小鼠肠黏膜明显受损,杯状细胞减少,出现大量炎性肉芽组织。TLM、TLH组结肠黏膜相对完整,大部分上皮细胞及腺体结构完整,极少量炎症细胞浸润,黏膜下层未见水肿。与NC组比较,模型组肠黏膜中GDNF、ZO-1 mRNA表达水平明显降低,而TLL组、TLM组、TLH组中GDNF、ZO-1 mRNA表达水平均升高,呈剂量依赖性,其中TLH组表达升高最为显著(P<0.01)。与NC组比较,模型组肠黏膜中GDNF、ZO-1蛋白表达水平明显降低,且呈剂量依赖性(P<0.05),TLL组、TLM组、TLH组中GDNF、ZO-1蛋白表达水平均升高,其中TLH组表达升高最为显著(P<0.01)。结论:雷公藤内酯醇治疗能显著减轻DSS诱导的结肠炎,可能通过增加GDNF、ZO-1的表达而保护肠黏膜结构稳定性,有望成为治疗UC的新方法。

关键词：雷公藤内酯醇溃疡性结肠炎胶质细胞源性神经营养因子闭锁小带蛋白1

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Speed Measurement Feasibility by Eddy Current Effect in the High-Speed MFL Testing

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Structural Durability & Health Monitoring 2023年第4期17卷 299-314页

作者： Zhaoting Liu jianbo Wu Sha He Xin Rao Shiqiang Wang shen Wang Wei Wei School of Mechanical Engineering Sichuan UniversityChengdu610065China Safety Environment Quality Surveillance and Inspection Research Institute of CNPC Chuanqing Drilling&Exploration Guanghan618300China Chengdu Xionggu Oil&Gas Technology Co. Ltd.Chengdu610000China Chengdu Institute of Special Equipment Inspection and Testing Chengdu610036China

It is known that eddy current effect has a great influence on magnetic flux leakage testing(MFL).Usually,contacttype encoder wheels are used to measure MFL testing speed to evaluate the effect and further compensate testing *** speed measurement method is complicated,and inevitable abrasion and occasional slippage will reduce the measurement *** order to solve this problem,based on eddy current effect due to the relative movement,a speed measurement method is proposed,which is contactless and *** the high-speed MFL testing,eddy current induced in the specimen will cause an obvious modification to the applied *** modified field,which is measured by Hall sensor,can be utilized to reflect the moving ***,the measurement principle is illustrated based on Faraday’s ***,dynamic finite element simulations are conducted to investigate the modified magnetic field ***,laboratory experiments are performed to validate the feasibility of the proposed *** results show that Bmz(r1)and Bmx(r2)have a linear relation with moving speed,which could be used as an alternative measurement parameter.

关键词： Magnetic flux leakage testing(MFL) speed measurement eddy current effect modified magnetic field

Source-network Frequency Cooperative Control and Parameter Optimization Method for High Proportion Renewable Energy UHVDC Feeder Grid

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Dianwang Jishu/Power System Technology 2025年第1期49卷 263-271页

作者： Xie, Yan Tang, Xiaojun Dong, Yu Ma, Shiying shen, Jiakai Yan, Jianfeng Haidian District Beijing 100192 China State Grid Corporation of China Xicheng District Beijing 100031 China

How to balance the frequency regulation performance and the economic cost to reduce or prevent the system’s generator-tripping and load-shedding is a crucial challenge in enhancing the reliability of high-ratio renewable energy power systems. To explore the power system source-network frequency cooperative control methods, this paper takes renewable energy generators and LCC-HVDC systems as examples, analyzes the frequency regulation principle and control strategy of the main potential resources, and constructs a multi-dimensional evaluation index system for different frequency regulation measures. Further, combining the ideas of global optimization of parameters based on typical scenarios, disturbances and secondary optimization based on actual disturbances, a source-network frequency cooperative control and parameter optimization method based on the comprehensive effectiveness assessment of frequency regulation measures is proposed. Finally, based on the 2023 data of a UHVDC feeder grid and the frequency test data of a typical renewable energy power station, the PSASP software platform is used to construct a simulation model of the region's power grid after calibration. The validation and analysis of the proposed method is carried out for the typical daytime and nighttime operation modes. The results show that the source-network frequency cooperative control and parameter optimization method based on the comprehensive effectiveness assessment of frequency regulation measures proposed in the paper can significantly improve the frequency support capability of the system while considering the economic cost. © 2025 Power System Technology Press. All rights reserved.

关键词： HVDC power transmission