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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi Yang Xuerui pang Yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Research progress in metal-organic frameworks and their derivatives in electrochemistry

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Science China Chemistry 2025年

作者： Lingling Chen Yuxin Liu Yichun Su Wenchen Zhu Guangyu Du Huan pang School of Chemistry and Chemical Engineering Yangzhou University Department of Applied Physics The Hong Kong Polytechnic University Interdisciplinary Materials Research Center Institute for Advanced Study Chengdu University State Key Laboratory of Coordination Chemistry Nanjing University

Metal-organic frameworks (MOFs) are distinguished by their unique porosity and meticulously ordered framework structures,setting them apart from conventional complexes. These materials are defined by their highly organized crystalline and pore structures, extensive surface areas, robust porosity, and superior adsorption capabilities. Owing to their exceptional structural and functional attributes, MOFs and their derivatives are leveraged across a broad spectrum of applications, demonstrating significant potential across diverse sectors. In recent times, the scientific community has increasingly focused on MOFs, underscoring their growing importance in research. Despite the promising array of applications for MOFs and their derivatives,challenges persist in practical deployments, and the pathway to research advancement remains daunting. This document delves into the synthesis and various applications of MOFs and their derivatives, particularly in the domains of energy storage, catalysis,sensing, and water treatment. It also highlights the ongoing research progress in the field of electrochemistry, including developments in lithium ion batteries (LIBs), lithium-sulfur batteries (LSBs), zinc-ion batteries (ZIBs), aqueous nickel-zinc batteries (NZBs), and supercapacitors. Finally, it provides an outlook on the future prospects and potential hurdles facing the development of MOF materials.

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Collaborative City Digital Twin for the COVID-19 Pandemic:A Federated Learning Solution

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Tsinghua Science and Technology 2021年第5期26卷 759-771页

作者： Junjie pang Yan Huang Zhenzhen Xie jianbo Li Zhipeng Cai the College of Computer Science and Technology Qingdao UniversityQingdao 266000China the Business School Qingdao UniversityQingdao 266000China the College of Computing and Software Engineering Kennesaw State UniversityAtlantaGA 30060USA the College of Computer Science and Technology Jilin UniversityChangchun 130012China the Department of Computer Science Georgia State UniversityAtlantaGA 30303USA

The novel coronavirus,COVID-19,has caused a crisis that affects all segments of the *** the knowledge and understanding of COVID-19 evolve,an appropriate response plan for this pandemic is considered one of the most effective methods for controlling the spread of the *** studies indicate that a city Digital Twin(DT)is beneficial for tackling this health crisis,because it can construct a virtual replica to simulate factors,such as climate conditions,response policies,and people's trajectories,to help plan efficient and inclusive ***,a city DTsystem relies on long-term and high-quality data collection to make appropriate decisions,limiting its advantages when facing urgent crises,such as the COVID-19 *** Learning(FL),in which all clients can learn a shared model while retaining all training data locally,emerges as a promising solution for accumulating the insights from multiple data sources ***,the enhanced privacy protection settings removing the privacy barriers lie in this *** this work,we propose a framework that fused city DT with FL to achieve a novel collaborative paradigm that allows multiple city DTs to share the local strategy and status *** particular,an FL central server manages the local updates of multiple collaborators(city DTs),providing a global model that is trained in multiple iterations at different city DT systems until the model gains the correlations between various response plans and infection *** approach means a collaborative city DT paradigm fused with FL techniques can obtain knowledge and patterns from multiple DTs and eventually establish a"global view"of city crisis ***,it also helps improve each city's DT by consolidating other DT's data without violating privacy *** this paper,we use the COVID-19 pandemic as the use case of the proposed *** experimental results on a real dataset with various response plans val

关键词： COVID-19 Digital Twin(DT) Federated Learning(FL) deep learning

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矿山生态修复市场化政策评估与优化研究

中国国土资源经济 2024年第4期37卷 11-19页

作者：庞剑波刘向敏余振国杨婧杜越天自然资源部国土空间生态修复司北京100812 中国自然资源经济研究院北京101149

以市场化方式推进矿山生态修复,是解决修复资金短缺、促进矿山生态产品价值实现与提升的重要途径。文章采用文献资料分析、案例分析、归纳演绎等方法,对以市场化方式推进矿山生态修复政策实施效果进行评估,结果表明:各地积极推动政策落... 详细信息

以市场化方式推进矿山生态修复,是解决修复资金短缺、促进矿山生态产品价值实现与提升的重要途径。文章采用文献资料分析、案例分析、归纳演绎等方法,对以市场化方式推进矿山生态修复政策实施效果进行评估,结果表明:各地积极推动政策落实与细化,实施机制不断完善创新,形成了可推广的“矿山生态修复+”典型模式。“十四五”以来,矿山生态修复项目吸引的社会资金总体规模小、比例低、地区差异大。矿山生态修复市场化政策实施过程中存在社会资本参与动力不足、规划引领作用有待提升、指标激励新机制效果尚未显现、废弃土石料利用存在违法违规风险等问题。因此,应加强规划引领与管理,打通指标激励实施路径,规范矿山生态修复土石料利用政策边界和监督管理,优化项目管理周期和多部门协调合作机制,加大政策宣传解读力度并持续跟踪政策实施进展,进一步完善矿山生态修复市场化激励政策。

关键词：矿山生态修复市场化方式激励政策效果评估

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渤海沉积物中Fe,Al,Mn的分布及某些地球化学特征的研究

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海洋科学 1983年第4期 22-25页

作者：郭津年李健博吴景阳庞学忠中国科学院海洋研究所中国科学院海洋研究所中国科学院海洋研究所现在中国科学院物质结构研究所工作

本文对渤海沉积物样品中Fe,Al,Mn元素的地球化学特征进行了初步研究。各元素的测定方法是:重铬酸钾容量法测定Fe;EDTA容量法测定Al;过碘酸钾比色法测定Mn。兹将研究结果分述如下。一、渤海沉积物中Fe,Al,Mn的含量及分布

关键词：渤海沉积物粒级 Fe,Al,Mn 沉积物类型 Mn Al 地球化学特征

An efficient and balanced feature pyramid network: shared-FPN

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Optoelectronics Letters 2025年

作者： Tian Sulong Qin Longfei pang Wenchao Gao Ying Zhao Dexin School of Computer Science and Engineering， Tianjin University of Technology Tianjin Key Laboratory of Intelligence Computing and Novel Software Technology， Tianjin University of Technology

In the field of object detection， it is challenging to achieve a balance between neck complexity and accuracy. To address this issue， we propose an efficient and decoupled neck module called Shared-FPN(Shared Feature Pyramid Network). Our design aims to effectively address the trade-off between these two factors. Neck modules are crucial for effectively fusing multi-scale information in neural network models. However， traditional neck designs， with their single structure， have struggled to significantly improve detection performance. In recent years， the incorporation of neural architecture search techniques in neck design has led to an increase in model complexity. This trade-off between model complexity and detection performance highlights the need for more efficient neck design approaches. Not only does Shared-FPN not increase the number of model parameters and FLOPs， but it also can be easily ported to any of the detection models. It improves on PAFPN by using transposed convolution with a large convolution kernel as the upsampling module， designing spatial pyramidal pooling-fast downsampling(SPPFD) based on shared pooling， and designing shared convolution as the right part module. To evaluate the performance of Shared-FPN in object detection tasks， we conducted experiments on object detection datasets. The results show that Shared-FPN achieved excellent performance across all sizes. In particular， on the VOC 2012 dataset， which contains mostly large objects， Shared-FPN's mAP was improved by 11.2% compared to FPN with YOLOX-s as the detector. On the COCO dataset， which contains mostly small objects， Shared-FPN's mAP was improved by 7.8% compared to FPN and 7.1% compared to PAFPN with Faster RCNN as the detector. Shared-FPN can be easily inserted into any of the detectors for better performance in various scenarios， such as small， medium or large objects.

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Interannual variability of boreal summer intraseasonal oscillation over the northwestern Pacific influenced by the Pacific Meridional Mode

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 6-11页

作者： Haoyu Zhou pang-Chi Hsu Lin Chen Yitian Qian Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental Change/Collaborative Innovation Center on Forecast and Evaluation of Meteorological DisastersNanjing University of Information Science and TechnologyNanjingChina

During the boreal summer,intraseasonal oscillations exhibit significant interannual variations in intensity over two key regions:the central-western equatorial Pacific(5°S-5°N,150°E-150°W)and the subtropical Northwestern Pacific(10°-20°N,130°E-175°W).The former is well-documented and considered to be influenced by the ENSO,while the latter has received comparatively less attention and is likely influenced by the Pacific Meridional Mode(PMM),as suggested by partial correlation analysis *** elucidate the physical processes responsible for the enhanced(weakened)intraseasonal convection over the subtropical northwestern Pacific during warm(cold)PMM years,the authors employed a moisture budget *** findings reveal that during warm PMM years,there is an increase in summer-mean moisture over the subtropical northwestern *** increase interacts with intensified vertical motion perturbations in the region,leading to greater vertical moisture advection in the lower troposphere and consequently resulting in convective *** a process is pivotal in amplifying intraseasonal convection *** observational findings were further verified by model experiments forced by PMM-like sea surface temperature patterns.

关键词： Boreal summer intraseasonal oscillation Interannual variability Pacific Meridional Mode Moisture budget analysis

Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages

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Science China Life Sciences 2025年

作者： Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han Zekun Yang Yehui Duan Weijun pang Yulong Yin Fengna Li Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences University of Chinese Academy of Sciences Laboratory of Animal Fat Deposition and Muscle Development College of Animal Science and Technology Northwest A&F University College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity, aging and metabolic disease. Since obese and lean pigs are ideal models for metabolic research. Here, we compared metabolome and transcriptome of Longissimus dorsi(LD) muscle between Taoyuan black(TB, obese) and Duroc(lean) pigs at different ages. We defined the “window phase” of intramuscular fat(IMF) deposition in TB pig, which has significantly higher IMF than Duroc pig. Our results displayed discrepant lipid composition and different expression genes(DEGs) enriched in lipid metabolism, and both metabolome and transcriptome analyses revealed stronger energy expenditure and more active amino acid and protein metabolism in Duroc pig. 10 up-and 51 down-regulated biomarker metabolites with age-and breed-specificity were identified. Potential secretory metabolites, including organic acid(fumaric acid, succinate,malic acid, and gamma-aminobutyric acid), amino acid(L-lysine, and L-glutamic acid), lipid(2-hydroxyisovaleric acid, and L-carnitine) were demonstrated a significant correlation with IMF deposition. Our research highlights the huge difference of metabolic spectrum in skeletal muscle between obese and lean model and muscle-derived secretory metabolites might act as an ambassador of intercellular communication to regulate systematic metabolism.

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Boosting aqueous nickel-zinc battery stability with bimetallic ion-integrated 1D metal-organic nanowires

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Science China Chemistry 2025年

作者： Yihao Chen Jin Liang Yichun Su Guoyin Zhu Hengyue Xu Hongye Ding Guangxun Zhang Dianheng Yu Zizhou Shen Yizhou Zhang Wei Huang Huan pang School of Chemistry and Chemical Engineering Yangzhou University Key Laboratory of Flexible Electronics (KLoFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University (NanjingTech) Institute of Advanced Materials and Flexible Electronics (IAMFE) School of Chemistry and Materials Science Nanjing University of Information Science & Technology Department of Chemistry Tsinghua University State Key Laboratory of Coordination Chemistry Nanjing University

Limited by low conductivity,designing cathode materials with excellent electron transfer efficiency for high-performance nickel-zinc batteries （NZBs） remains *** this study,a series of bimetallic metal-organic nanowires were fabricated by doping M ions in NiNTA,resulting in NiMNTA (M=Mg2+,Mn2+,Co2+,Zn2+,Ag+),and NixCo6-xNTA （x=1,2,3,4,5）.The proportions and types of metal ions can be modified without altering the initial coordination structure.X-ray absorption fine structure spectroscopy （XAFS） revealed that only M–O bonds,not metal bonds,were present in the *** performance of Ni2Co4NTA as the cathode for aqueous NZBs was significantly improved,achieving the maximum energy density of 279.17Wh kg-1with the high cycle stability （retention rate of 72.0%after 1,000 cycles）.The flexible Ni2Co4NTA//Zn@carbon cloth battery employing gel electrolyte also exhibits the excellent Coulombic efficiency of 96%after 350 *** approach shows considerable potential for designing one-dimensional materials with bimetallic modifications,providing new strategies for developing cathode materials for NZBs with high specific capacity and cycle stability.

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