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Effect of Cu（Ⅱ） on Degradation and Decolorization of Rhodamine B in Subcritical Water

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Chemical Research in Chinese Universities 2017年第4期33卷 643-647页

作者： CHENG Kai YANG Wei WANG Hui ZHOU Jie WU Shengji YU Tianming pan jianbo College of Materials and Environmental Engineering Hangzhou Dianzi University Hangzhou 310018 P. R. China Eanlu Environment Technology Co. Ltd. Quzhou 324000 P R. China

In this paper, subcritical water, an environmentally friendly solvent, was employed to degrade rhodamine B, which served as a model dye in textile industrial effluents. The effect of Cu（Ⅱ） on the degradation of rhodamine B was evaluated. Further, the degradation kinetics of rhodamine B in subcritical water was evaluated via a Weibull model. The results show that subcritical water could efficiently degrade and decolorize rhodamine B. The addition of Cu（Ⅱ） into subcritical water could accelerate the degradation of rhodamine B and lower the temperature for its com- plete degradation. The Weibull equation could well express the degradation kinetics of rhodamine B. The calculated rate constants showed Arrhenius behavior and presented high correlation coefficients. The activation energy was 109.4 kJ/mol for subcritical water degradation of rhodamine B, whereas it became lower（93.4 kJ/mol） when Cu（Ⅱ） was added to the subcritical water. The frequency factors for the degradation of rhodamine B by subcritical water without and with Cu（Ⅱ） were calculated to be 1.0×10n and 3.2×109 min-1, respectively. The above results indicate that subcritical water treatment is a promising process for degrading and decolorizing textile dyes. The results will provide a theoretic support for the industrial application of subcritical water treatment.

关键词： Subcritical water Degradation kinetics Rhodamine B Weibull equation Copper ion

Aging Behavior of As-Extruded Ti Particles Reinforced VW94 Composites

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 401-406页

作者： Dongmei Pu Xianhua Chen Jingfeng Wang Jun Tan jianbo Li Hong Yang Bo Feng Kaihong Zheng Fusheng pan College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400045China Institute of New Materials Guangdong Academy of SciencesGuangzhou 510650China

The ageing behavior of as-extruded Ti_(P)/VW94 composites was *** peak hardness of the composites increases compared to the matrix alloy and the 5%Ti_(P)/VW94 composite presents the highest peak hardness of 148.7 HV after aging for about 50 ***,the hardness increments first decrease and then slightly increase with increasing Ti particle content due to the introduction of high-density dislocations by Ti particles.

关键词： Magnesium matrix composites Ti particles Ageing behavior Hardness

A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells

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Genes & Diseases 2023年第6期10卷 2586-2596页

作者： Jiaqi Wang Jiying Zhu Junchi Hu Ziruoyu Wang Xiaobo Wang jianbo pan Yiwei Chu Zengxia Li Wei Jiang Chunmin Liang Jun Hou Jianming Guo Yongjun Dang Shuai Jiang Key Laboratory of Metabolism and Molecular Medicine Ministry of Education and Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Immunology School of Basic Medical SciencesFudan UniversityShanghai 200032China Laboratory of Tumor Immunology Department of AnatomyHistologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Center for Novel Target and Therapeutic Intervention Chongqing Medical UniversityChongqing 400016China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Urology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Urology Zhongshan Hospital Wusong BranchFudan UniversityShanghai 200940China

Bladder cancer(BLCA)remains a difficult malignancy to manage because of its high recurrence,intense follow-up,and invasive diagnostic and treatment *** checkpoint inhibitors(ICIs)have forged a new direction for the treatment of BLCA,but it is currently challenging to predict whether an individual patient will be sensitive to *** collected 43 urine/tumor samples from BLCA patients for primary bladder cancer cells(BCCs)culturing using our previously reported BCC culture *** used flow cytometry(FCM)to measure the expression levels of Programmed Death-Ligand 1(PD-L1)on BCCs before and after interferon-gamma(IFN-γ)treatment and found that PD-L1 expression and the sensitivities to IFN-γvaried among ***-sequencing,western blotting,and programmed death-1(PD-1)binding assays confirmed that the BCC FCM-based PD-L1 detection platform(BC-PD-L1)was reliable and was not hindered by the glycosylation of *** the subsequent retrospective study,we found that IFN-γ-stimulated PD-L1(sPD-L1)expression on BCCs detected by BC-PD-L1 could predict the prognosis of BLCA ***,the prognostic value was similar or even better in urine-derived BC-PD-L1(UBC-PD-L1).Transcriptome analysis showed that BCCs with high sPD-L1 tended to enrich genes associated with the collagen-containing extracellular matrix,cell–cell adhesion,and positive regulation of the immune *** addition,the UBC-PD-L1 also exhibited predictive value for ICI response in BLCA *** conclusion,as a novel personalized urine-detection method,UBC-PD-L1 may provide a rapid,accurate,and non-invasive tool for monitoring tumor progression,predicting therapeutic responses,and helping improve BLCA clinical treatment in future.

关键词： Bladder cancer Immune checkpoint inhibitors Predictive model Primary cells Urine

Unidirectional electromagnetic windmill scattering in a magnetized gyromagnetic cylinder

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Chinese Optics Letters 2022年第5期20卷 58-64页

作者： Jianfeng Chen jianbo pan Yidong Zheng Wenyao Liang Zhi-Yuan Li School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China State Key Laboratory of Luminescent Materials and Devices South China University of TechnologyGuangzhou 510640China

We present a discovery of an unusual unidirectionally rotating windmill scattering of electromagnetic waves by a magnetized gyromagnetic cylinder via an analytical theory for rigorous solution to fields and charges and an understanding of the underlying mathematical and physical mechanisms. Mathematically, the generation of nonzero off-diagonal components can break the symmetry of forward and backward scattering coefficients, producing unidirectional windmill scattering. Physically, this windmill scattering originates from the nonreciprocal unidirectional rotation of polarized magnetic charges on the surface of a magnetized gyromagnetic cylinder, which drives the scattering field to radiate outward in the radial direction and unidirectionally emit in the tangential direction. Interestingly, the unidirectional electromagnetic windmill scattering is insensitive to the excitation direction. Moreover, we also discuss the size dependence of unidirectional windmill scattering by calculating the scattering spectra of the gyromagnetic cylinder. These results are helpful for exploring and understanding novel interactions between electromagnetic waves and gyromagnetic materials or structures and offer deep insights for comprehending topological photonic states in gyromagnetic systems from the aspect of fundamental classical electrodynamics and electromagnetics.

关键词： unidirectional electromagnetic windmill scattering magnetized gyromagnetic cylinder topological photonics

ADMETNet：The knowledge base of pharmacokinetics and toxicology network

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Journal of Genetics and Genomics 2017年第5期44卷 273-276页

作者： Quan Xu Ke Liu Xingming Lin Yangmei Qin Linshan Chen Jiao Cheng Mindong Zhong Qiushun He Yinbo Li Tingwu Wang jianbo pan Menglu Peng Lixia Yao Zhiliang Ji State Key Laboratory of Stress Cell Biology School of Life SciencesXiamen UniversityXiamen 361102China Department of Health Sciences Research Mayo ClinicRochesterMN 55905USA The Key Laboratory 0r Chemical Biology of Fujian ProvinceXiamen UniversityXiamen 361005China

A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper *** processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion（ADME）,

关键词： interact eliminated getting Absorption absorbed manner candidate toxicity Browse Pathway

Integrative multi-omics and drug-response characterization of patient-derived prostate cancer primary cells

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3013-3028页

作者： Ziruoyu Wang Yanan Li Wensi Zhao Shuai Jiang Yuqi Huang Jun Hou Xuelu Zhang Zhaoyu Zhai Chen Yang Jiaqi Wang Jiying Zhu jianbo pan Wei Jiang Zengxia Li Mingliang Ye Minjia Tan Haowen Jiang Yongjun Dang Key Laboratory of Metabolism and Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologySchool of Basic Medical SciencesShanghai Medical CollegeFudan University200032ShanghaiChina CAS Key Lab of Separation Sciences for Analytical Chemistry National Chromatographic Research and Analysis CenterDalian Institute of Chemical PhysicsChinese Academy of Sciences116023DalianChina The Chemical Proteomics Center and State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of Sciences201203ShanghaiChina University of Chinese Academy of Sciences 100049BeijingChina Department of Urology Zhongshan HospitalFudan University200032ShanghaiChina Department of Urology Zhongshan Hospital Wusong BranchFudan University200032ShanghaiChina Center for Novel Target and Therapeutic Intervention Chongqing Medical University400016ChongqingChina Department of Urology Huashan HospitalFudan University200040ShanghaiChina

Prostate cancer(PCa)is the second most prevalent malignancy in males across the world.A greater knowledge of the relationship between protein abundance and drug responses would benefit precision treatment for ***,we establish 35 Chinese PCa primary cell models to capture specific characteristics among PCa patients,including gene mutations,mRNA/protein/surface protein distributions,and pharmaceutical *** multi-omics analyses identify Anterior Gradient 2(AGR2)as a pre-operative prognostic biomarker in *** the drug library screening,we describe crizotinib as a selective compound for malignant PCa primary *** further perform the pharmacoproteome analysis and identify 14,372 significant protein-drug ***,the diminished AGR2 enhances the inhibition activity of crizotinib via ALK/c-MET-AKT axis activation which is validated by PC3 and xenograft *** integrated multi-omics approach yields a comprehensive understanding of PCa biomarkers and pharmacological responses,allowing for more precise diagnosis and therapies.

关键词： drug PC3 diagnosis operative

A module based modeling framework for estimating lunar dust deposition due to human activities

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Chinese Journal of Aeronautics 2024年第2期37卷 501-510页

作者： Chunjian pan College of Automation Engineering Shanghai University of Electric PowerShanghai 200090China

Lunar dust is considered to be one of the top challenges for enabling humans to have extended stays on the *** activities such as module landings and launches,walking,rover operation and construction activities will inevitably produce a significant amount of ***,it is important to estimate the potential range and intensity of dust deposition caused by these activities to minimize dust accumulation over time and for maintenance planning and execution.A modular model that correlates the dust deposition distribution with initial mean dust particle velocity,its mean ejected angle and the total amount of ejected mass is developed for an elementary mechanical *** modular model is further employed to form a modeling framework to estimate dust deposition of a trajectory based activity of similar repeated movements such as the landing process of a lander,walking and rover *** model forms a unified modeling framework for different trajectory-based activities and is shown to predict consistent and physically meaningful ranges and intensities of dust deposition provided reliable data to calibrate the model parameters.

关键词： Lunar dust Dust deposition Lunar lander Lunar construction Model calibration

Genome-wide association with transcriptomics reveals a shade-tolerance gene network in soybean

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The Crop Journal 2024年第1期12卷 232-243页

作者： Yanzhu Su Xiaoshuai Hao Weiying Zeng Zhenguang Lai Yongpeng pan Can Wang Pengfei Guo Zhipeng Zhang jianbo He Guangnan Xing Wubin Wang Jiaoping Zhang Zudong Sun Junyi Gai Soybean Research Institute/MARA National Center for Soybean Improvement MARA Key Laboratory of Biology and Genetic Improvement of Soybean/State Key Laboratory for Crop Genetics and Germplasm Enhancement/State Innovation Platform for Integrated Production and Education in Soybean Bio-breeding/Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural UniversityNanjing 210095JiangsuChina Guangxi Academy of Agricultural Sciences Nanning 530007GuangxiChina

Shade tolerance is essential for soybeans in inter/relay cropping systems.A genome-wide association study(GWAS)integrated with transcriptome sequencing was performed to identify genes and construct a genetic network governing the trait in a set of recombinant inbred lines derived from two soybean parents with contrasting shade *** improved GWAS procedure,restricted two-stage multi-locus genome-wide association study based on gene/allele sequence markers(GASM-RTM-GWAS),identified 140 genes and their alleles associated with shade-tolerance index(STI),146 with relative pith cell length(RCL),and nine with *** of these genes by biological categories allowed the construction of a protein–protein interaction network by 187 genes,of which half were differentially expressed under shading and non-shading conditions as well as at different growth *** the identified genes,three ones jointly identified for both traits by both GWAS and transcriptome and two genes with maximum links were chosen as beginners for entrance into the ***,both STI and RCL gene systems worked for shade-tolerance with genes interacted each other,this confirmed that shadetolerance is regulated by more than single group of interacted genes,involving multiple biological functions as a gene network.

关键词： Soybean(Glycine max(L.)Merr.) Shade-tolerance Restricted two-stage multi-locus genomewide association study based on gene/allele sequence markers(GASM-RTM-GWAS) Shade-tolerance index(STI) Relative cell length(RCL) Transcriptome

Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： Xia-Hui pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions