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Nano Research 2024年第8期17卷 7136-7143页

作者： Lijie Ma Xiaolin Wang Xiang Chen jianbin gao Yiwen Wang Yuehai Song Yaran Zhao Shizhe gao Lin Li Jianchao Sun School of Environment and Material Engineering Yantai UniversityYantai 264005China College of Textile Science and Engineering(International Institute of Silk) Zhejiang Sci-Tech UniversityHangzhou 310018China BNU-HKUST Laboratory of Green Innovation Advanced Institute of Natural SciencesBeijing Normal UniversityZhuhai 519087China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Vanadium dioxide(VO_(2)) with the advantages of high theoretical capacity and tunnel structure has attracted considerable promising candidates for aqueous zinc-ion ***,the intrinsic low electronic conductivity of VO_(2) results in an unsatisfactory electrochemical ***,a flower-like VO_(2)/carbon nanotubes(CNTs)composite was obtained by a facile hydrothermal *** unique flower-like morphology shortens the ion transport length and facilitates electrolyte ***,the CNT conductive networks is in favor of fast electron transfer.A highly reversible zinc storage mechanism was revealed by ex-situ X-ray diffraction and X-ray photoelectron *** a result,the VO_(2)/CNTs cathode exhibits a high reversible capacity(410 mAh·g^(−1)),superior rate performance(305 mAh·g^(−1)at 5 A·g^(−1)),and excellent cycling stability(a reversible capacity of 221 mAh·g^(−1)was maintained even after 2000 cycles).This work provides a guide for the design of high-performance cathode materials for aqueous zinc metal batteries.

关键词： VO_(2)/carbon nanotubes morphology engineering zinc metal batteries cathode materials conductive networks

基于区块链的外包安全多方统计计算可验证隐私保护方案

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无线电工程 2024年第4期54卷 835-847页

作者：夏虎田雯高建彬张天义高然夏琦电子科技大学计算机科学与工程学院四川成都611731

安全多方求和/乘积是安全多方计算(Secure Multi-Party Computation, MPC)的一种典型问题,近年来在智能电网、电子投票和联合征信等场景中有诸多应用。如何实现数据隐私保护是安全多方求和/乘积计算应用领域的一个关键性问题。针对此问... 详细信息

安全多方求和/乘积是安全多方计算(Secure Multi-Party Computation, MPC)的一种典型问题,近年来在智能电网、电子投票和联合征信等场景中有诸多应用。如何实现数据隐私保护是安全多方求和/乘积计算应用领域的一个关键性问题。针对此问题,引入了区块链构建可信数据共享环境,以此为基础结合可验证秘密共享协议设计了简单可行的基于区块链的外包安全多方统计计算可验证隐私保护方案。应用实例证明了方案的安全性和可行性,理论分析和实验测试表明该方案可实现安全多方统计计算过程中数据的可验证隐私保护,且较Feldman方案在数据验证过程中有更小的计算开销。

关键词：区块链安全多方计算智能合约隐私保护秘密共享

重型柴油机匹配双喷SCR系统实现超低排放的研究

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车用发动机 2024年第4期 9-16页

作者：朱敏霖王辉高建宾赵令猛李明星王晓辉广西玉柴机器股份有限公司广西玉林537000

以一款满足国六b排放标准的重型柴油机为研究对象,探索匹配双喷铜基SCR系统实现超低排放的潜力。研究表明:匹配双喷SCR系统的柴油机通过排气热管理优化、氨存储和当量喷射策略的协同优化,具有满足欧七排放草案限值的能力。同时发现,尿... 详细信息

以一款满足国六b排放标准的重型柴油机为研究对象,探索匹配双喷铜基SCR系统实现超低排放的潜力。研究表明:匹配双喷SCR系统的柴油机通过排气热管理优化、氨存储和当量喷射策略的协同优化,具有满足欧七排放草案限值的能力。同时发现,尿素喷射会大幅度增加PN排放,对PN_(10)的影响远大于对PN_(23)的影响,其中ufSCR的尿素喷射对PN_(10)排放影响较大,可通过优化SCR混合器降低PN_(10)排放。发动机本体的N_(2)O排放较低,N_(2)O主要在催化器产生,特别是SCR和ASC单元;在不同温度区间NO_(2)的生成机理和速率有较大区别,与尿素喷射量有较大关联性。

关键词：柴油机选择性催化还原喷射策略排放控制

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基于信誉分类的拜占庭容错共识算法

无线电工程 2024年第4期54卷 804-816页

作者：高建彬刘洋洋夏虎程捷夏琦电子科技大学计算机科学与工程学院四川成都611731

针对许可区块链场景下实用拜占庭容错(Practical Byzantine Fault Tolerance,PBFT)共识算法通信开销大、主节点选取随意以及吞吐量低等问题,通过引入并优化信誉评分模型(Reputation Scoring Model,RSM)。提出了一种基于信誉分类的拜占... 详细信息

针对许可区块链场景下实用拜占庭容错(Practical Byzantine Fault Tolerance,PBFT)共识算法通信开销大、主节点选取随意以及吞吐量低等问题,通过引入并优化信誉评分模型(Reputation Scoring Model,RSM)。提出了一种基于信誉分类的拜占庭容错(Byzantine Fault Tolerance Based on Reputation Classification,RCBFT)共识算法。定义RSM,依据节点的历史共识行为所获得的信誉评分排序对参与节点进行动态分类以及分级管理,提出基于信誉分类的多层次节点架构;在可信节点层中随机选取节点来担任主节点,优化主节点选取机制;设计了缓冲节点层类型转换策略(Type Conversion Strategy for Nodes,TCSN),兼顾了环境等非主观因素导致低信誉评分的诚实节点不能参与共识的问题,使得诚实节点尽可能多地参与共识,而拜占庭节点快速下降到最差类型中限制共识权限;RCBFT共识算法还对传统三阶段共识协议进行优化,减少通信开销,在确保容错性的同时能够提高算法性能。实验分析表明,相较于PBFT共识算法,RCBFT共识算法能够提升交易吞吐量,降低通信开销与共识时延。

关键词：区块链共识算法信誉分类拜占庭节点性能提升

Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

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Journal of Pharmaceutical Analysis 2024年第6期14卷 914-925页

作者： Guiqin Ye Xin Sun Jiuzhou Li Yuanyuan Mai Ruilan gao jianbin Zhang Cancer Center Department of Medical OncologyKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou310014China Clinical Laboratory Yuhuan City HospitalTaizhouZhejiang317600China Hangzhou Medical College Hangzhou311300China Department of Neurosurgery Binzhou People's HospitalBinzhouShandong256600China Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China

Lung cancer ranks the top of malignancies that cause cancer-related deaths *** leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory *** previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully *** synthesized Moracin N(MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic *** and its probe exerted similar growth-inhibitory effect on human lung cancer *** proteomic results showed that MAN targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCR)signaling pathway,indicating its immune-regulatory ***-free surface plasmon resonance(SPR)results showed the direct interaction of MAN with PD-L1 *** docking analysis demonstrated that MAN bound to E158 residue of PD-L1 *** downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMR).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAN-treated A549 cells,resulting in the increase of CD8^(+)GZMB^(+)T cells and the decrease of CD8^(+)PD-1^(+)T *** suggested that MAN exerts anti-cancer effect through blocking the PD-L1/PD-1 *** vivo,MAN combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic *** together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung *** modulatory effect on tumor microenvironment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.

关键词： Moracin N Click chemistry PD-L1 T cell Lung cancer

干旱胁迫下胡麻种子萌发动力学分析及抗旱性鉴定

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广东石油化工学院学报 2024年第3期34卷 116-120页

作者：陆光远高健彬胡伟杰李雪芹赵永国广东石油化工学院生物与食品工程学院广东茂名525000

胡麻是我国重要的经济作物。为了鉴定胡麻种子萌发期的抗旱性,以5个胡麻品种为研究材料,设置5个水分胁迫水平(0,-0.2,-0.4,-0.6,-0.8 MPa)进行发芽实验。研究结果表明:轻度干旱胁迫(-0.2 MPa)对胡麻种子发芽影响较小,甚至提高了个别品... 详细信息

胡麻是我国重要的经济作物。为了鉴定胡麻种子萌发期的抗旱性,以5个胡麻品种为研究材料,设置5个水分胁迫水平(0,-0.2,-0.4,-0.6,-0.8 MPa)进行发芽实验。研究结果表明:轻度干旱胁迫(-0.2 MPa)对胡麻种子发芽影响较小,甚至提高了个别品种的发芽率或促进根系生长;在中度干旱胁迫(-0.6 MPa)下,种子萌发率明显下降,从最低24.70%(SL297)到最高75.70%(DG241),平均发芽时间(MGT)也延长到36.80~56.60 h,根长降低到正常条件测定值的24.6%~57.8%。5个胡麻品种对干旱胁迫的响应存在基因型差异,其中在-0.8 MPa条件下仅有JN221还能萌发。综合分析多个指标,认为DG241和JN221的抗旱性较好,MG231次之,而SL297的抗旱性最差。

关键词：胡麻种子萌发干旱胁迫

Laparoscopic sacrocolpopexy for treatment of pelvic organ prolapse,a prospective observation cohort with follow-up time over 7 years

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Chinese Medical Journal 2024年第12期137卷 1477-1479页

作者： jianbin Guo Xiaochen Song Shuo Liang Yuan Wang Yang Ye Qianqian gao Juan Chen Lan Zhu Department of Obstetrics and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeNational Clinical Research Center for Obstetric&Gynecologic DiseasesBeijing 100730China

To the Editor:Pelvic organ prolapse(POP)is a common pelvic floor disorder in older women and is responsible for a significant decrease in health-related quality of *** the increased longevity of women,POP is becoming a major health concern.[1]Laparoscopic sacrocolpopexy(LSC)is a common mesh-based surgical approach for severe prolapse,and a high cure rate and few complications have been reported.[2]To our knowledge,the long-term durability,complications,and pelvic floor symptoms after LSC have not been fully evaluated in detail.A few studies assessed the 5-year outcome after LSC,but these reports were limited by their retrospective design,uneven follow-up time,or inconsistent outcome assessment.

关键词： prolapse pelvic Laparoscopic

Catalyst-free electrochemical dearomatization of pyridine derivatives

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Green Synthesis and Catalysis

Green Synthesis and Catalysis 2024年第2期5卷 136-139页

作者： Kui Wang Yingjun Tian Baoying Li Ling Wang Wei gao Xiaofei Jia Ruiming Wang Yanping Zhu jianbin Chen Chen Shandong Provincial Key Laboratory of Molecular Engineering State Key Laboratory of Biobased Material and Green PapermakingSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266042China State Key Laboratory of Biobased Material and Green Papermaking School of BioengineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China

We demonstrated herein an electrochemical dearomatizative alkylation of Katritzky salts,wherein Katritzky salts were harnessed as both radical acceptors and donors.A wide range of privileged dihydropyridine scaffolds was constructed with good to excellent *** voltammetry(CV)and electron paramagnetic resonance(EPR)results confirmed the key intermediates-dihydropyridine radicals and gram-scale reaction highlighted the practical and sustainable feature of the newly developed protocol.

关键词： Dearomatization Electrosynthesis Katritzky salts Dihydropyridine

Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up

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Science China(Life Sciences) 2024年第5期67卷 1061-1068页

作者： Zhibo Zhang jianbin Guo Weijie Tian Ye Zhang Yuelun Zhang Tianshu Sun Jiali Duan Xinmiao Bao Yuan Wang Yang Ye Qianqian gao Honghui Shi Abraham Nick Morse Juan Chen Lan Zhu Departmentof Obstetrics and Gynecology Peking Union MedicalCollege HospitalChinese Academyof Medical Sciences&Peking Union MedicalCollegeNational Clinical Research Center for Obstetricand Gynecologic DiseasesBeijing 100730China Department of Gynecology Guizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002China Department of Obstetrics and Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalBeijing 100730China Tufts University School of Medicine Boston MA 02111USA

Although transvaginal mesh(TVM)repair is no longer used in some countries,long-term outcomes after TVM surgery are of great importance ***,reports with follow-up>10 years are ***,this study aimed to report outcomes in a prospective cohort with at least 10 years of *** with stageⅢ–Ⅳsymptomatic prolapse were approached consecutively from 2008 to 2013 at one tertiary *** main outcome measure was symptomatic *** outcomes included anatomic failure,recurrence,patient satisfaction,complications,and *** Kaplan-Meier curve was used to estimate the cumulative failure *** the 121 patients enrolled in the study,103(85.1%)completed a median follow-up of 11 *** estimated probability rates of symptomatic and anatomic failure were 17.6%and 8.8%in 11 years,*** estimated incidence of symptomatic failure increased by 8.2%between 5 and 11 years;however,the corresponding rate for anatomic failure was 3.7%.The most common complication was vaginal mesh exposure,and its estimated probability increased from 19.3%to 28.4%from 5 to 11 years,*** trimming resolved 80.0%of vaginal *** patients did not report decreased overall *** with vaginal mesh exposure requiring>3 office procedures or mesh removal in the operating room(5.8%by 11 years)had lower satisfaction rates(P<0.01)and were defined as having severe mesh *** rates of postoperative pain,reoperation,and Patient Global Impression of Improvement≥2 were 2.5%,3.3%,and 94.2%,*** results of this study implied that TVM treatment gradually increased the symptomatic failure rate but provided durable anatomical support of the vaginal *** mesh exposure was common in women who were largely not sexually active;however,80%of the cases could be managed in the outpatient clinic,which did not affect patient satisfaction.

关键词： complication efficacy long-term follow-up pelvic organ prolapse safety transvaginal mesh

传统“三位一体”经济体制的形成及市场化取向改革突破口的选择

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中国民航学院学报 1998年第2期16卷 34-38页

作者： gao jianbin (Department of Social Sciences CAIC, Tianjin 300300) 中国民航学院社科部

中国传统经济体制的逻辑起点是重工业优先发展战略。由于重工业资本密集的特征与当时中国资本稀缺的资源禀赋状况形成矛盾，不可能依靠市场机制配置资源而推动重工业优先发展，因此就需要由政府出面，人为压低利率、汇率、能源和原材料... 详细信息

中国传统经济体制的逻辑起点是重工业优先发展战略。由于重工业资本密集的特征与当时中国资本稀缺的资源禀赋状况形成矛盾，不可能依靠市场机制配置资源而推动重工业优先发展，因此就需要由政府出面，人为压低利率、汇率、能源和原材料价格及工资和生活必需品价格，以便降低重工业发展的成本，从而形成“三位一体”的经济体制：扭曲的宏观政策环境、高度集中的资源计划配置和毫无自主权的微观经营机制。本文对传统经济体制形成过程进行分析，以便对我国改革开放以来市场化取向突破口选择有更加深刻的认识。

关键词：经济体制市场化体制改革中国经济发展战略