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Secondary metabolites of mulberry leaves exert anti-lung cancer activity through regulating the PD-L1/PD-1 signaling pathway

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Journal of Pharmaceutical Analysis 2024年第6期14卷 914-925页

作者： Guiqin Ye Xin Sun Jiuzhou li Yuanyuan Mai Ruilan Gao jianbin Zhang Cancer Center Department of Medical OncologyKey Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang ProvinceZhejiang Provincial People's HospitalAffiliated People's HospitalHangzhou Medical CollegeHangzhou310014China Clinical Laboratory Yuhuan City HospitalTaizhouZhejiang317600China Hangzhou Medical College Hangzhou311300China Department of Neurosurgery Binzhou People's HospitalBinzhouShandong256600China Institute of Hematology Research The First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou310060China

Lung cancer ranks the top of malignancies that cause cancer-related deaths *** leaves of Morus alba L are traditional Chinese medicine widely applied in respiratory *** previous work has demonstrated the anti-lung cancer effect of secondary metabolites of mulberry leaf,but their mechanism of action has still not fully *** synthesized Moracin N(MAN)-Probe conjugated with alkyne to label lung cancer cells and identified protein targets by chemical proteomic *** and its probe exerted similar growth-inhibitory effect on human lung cancer *** proteomic results showed that MAN targeted the programmed death ligand 1(PD-L1)checkpoint pathway and T cell receptor(TCR)signaling pathway,indicating its immune-regulatory ***-free surface plasmon resonance(SPR)results showed the direct interaction of MAN with PD-L1 *** docking analysis demonstrated that MAN bound to E158 residue of PD-L1 *** downregulated the expression levels of PD-L1 in a time-and dose-dependent manner and disrupted the PD-L1/programmed death 1(PD-1)binding,including other secondary metabolites of mulberry leaves Guangsangon E(GSE)and Chalcomoracin(CMR).Human peripheral blood mononuclear cells(PBMCs)co-cultured with MAN-treated A549 cells,resulting in the increase of CD8^(+)GZMB^(+)T cells and the decrease of CD8^(+)PD-1^(+)T *** suggested that MAN exerts anti-cancer effect through blocking the PD-L1/PD-1 *** vivo,MAN combined with anti-PD-1 antibody significantly inhibited lung cancer development and metastasis,indicating their synergistic *** together,secondary metabolites of mulberry leaves target the PD-L1/PD-1 signaling,enhance T cell-mediated immunity and inhibit the tumorigenesis of lung *** modulatory effect on tumor microenvironment makes them able to enhance the therapeutic efficacy of immune checkpoint inhibitors in lung cancer.

关键词： Moracin N Click chemistry PD-L1 T cell Lung cancer

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无理由退货政策下的在线定价及补偿优化策略

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系统工程理论与实践 2016年第11期36卷 2811-2819页

作者：李建斌李赟华中科技大学管理学院武汉430074

在传统零售行业,质量越好退货越少,退货政策的慷慨程度通常被用作消费者识别商家质量水平的一个依据.一般理论认为,无理由退货通常是质量水平高的商家采用的慷慨退货政策.但在如今的在线零售领域,绝大多数的在线零售商都承诺无理由退货... 详细信息

在传统零售行业,质量越好退货越少,退货政策的慷慨程度通常被用作消费者识别商家质量水平的一个依据.一般理论认为,无理由退货通常是质量水平高的商家采用的慷慨退货政策.但在如今的在线零售领域,绝大多数的在线零售商都承诺无理由退货,显然基于传统零售的退货政策理论已不适用于新环境下的在线零售.为了找到在电子商务环境下,无理由退货在哪些情况下能更大程度地增加销售利润和社会福利,文中建立了一个由垄断制造商和异质偏好消费者组成的在线零售模型.通过这一模型,发现无理由退货政策的盈利能力取决于商品质量水平,退货残值大小及消费者退货麻烦成本等因素.通过探讨质量风险与提供无理由退货的在线零售商利润间的关系,得到在特定技术成本和退货损失下,无理由退货是中等质量水平在线零售商的最佳退货处理策略.另外,在承诺无理由退货基础上增加一个策略性补偿,以使消费者接受商品而取消退货,通常是质量水平较低的在线零售商行为.

关键词：电子商务无理由退货质量风险定价策略性补偿

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Vocabulary Teaching Strategies Focusing on Language Learner

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Sino-US English Teaching 2004年第6期1卷 27-30,63页

作者： Jia li jianbin Huang Zhejiang University

As we enter the 21st century, acquisition of vocabulary has assumed a more important role, and as some would argue, it has assumed the central role in learning a second language. On one hand, students have a strong desire to improve their English level in order to make them more adaptable when they step into this competitive society after graduation. On the other hand, most students are facing a great difficulty in learning a large number of vocabularies though they do spend a lot of time and energy on it. Also, recent researches show that students don＇t like the classroom that is still teacher-centered and lecture-based. They want to be more involved in class and more responsible for their own studies. Hence, it is important to equip students with necessary strategies for dealing with vocabulary learning activities. In this paper, three strategies are recommended： extensive listening ＆ reading and contextual guesswork, communicative activities and group-work and the use of dictionary.

关键词： vocabulary learner-centered strategy extensive listening & reading guesswork communicative activities dictionary

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食用型向日葵栽培技术与产量提升方法研究

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黑龙江农业科学 2024年第9期 124-128页

作者：赵长延李建斌单维东邓庭和段维柳延涛塔里木大学农学院新疆阿拉尔843300 新疆生产建设兵团第六师种子管理站新疆五家渠831300 新疆生产建设兵团第九师农业技术推广站新疆额敏834600 新疆农垦科学院作物研究所新疆石河子832000

食用型向日葵作为一种重要的农作物,其经济效益十分显著,在农业生产中得到了广泛的种植。目前,一些地区的栽培技术较为粗放,导致经济效益与应有水平有较大的差距。为了提高食用型向日葵产量,转变当前生产模式、提升产品品质、增强经济... 详细信息

食用型向日葵作为一种重要的农作物,其经济效益十分显著,在农业生产中得到了广泛的种植。目前,一些地区的栽培技术较为粗放,导致经济效益与应有水平有较大的差距。为了提高食用型向日葵产量,转变当前生产模式、提升产品品质、增强经济效益以及实现优良品种的配套栽培技术,进而促进农村和农业经济的发展。本文通过对食用型向日葵的生长发育特点、栽培环境、适宜栽培条件等方面进行分析,探讨了食用型向日葵高产栽培技术,并对前人研究进行总结,探索了适合食用型向日葵高产栽培的技术措施。

关键词：食用型向日葵栽培技术产量提升

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lightweight Dual‑Functional Segregated Nanocomposite Foams for Integrated Infrared Stealth and Absorption‑Dominant Electromagnetic Interference Shielding

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Nano-Micro Letters 2024年第11期16卷 38-55页

作者： Zhonglei Ma Ruochu Jiang Jiayao Jing Songlei Kang li Ma Kefan Zhang Junxian li Yu Zhang jianbin Qin Shuhuan Yun Guangcheng Zhang MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary Conditions Shaanxi Key Laboratory of Macromolecular Science and TechnologySchool of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China College of Chemistry and Chemical Engineering Key Laboratory of Auxiliary Chemistry and Technology for Chemical IndustryMinistry of EducationShaanxi University of Science and TechnologyXi’an 710072People’s Republic of China Department of Mechanical and Industrial Engineering University of Toronto5 King’s College RoadTorontoON M5S 3G8Canada Chongqing Innovation Center Northwestern Polytechnical UniversityChongqing 401135People’s Republic of China

lightweight infrared stealth and absorption-dominant electromagnetic interference(EMI)shielding materials are highly desirable in areas of aerospace,weapons,military and wearable ***,lightweight and high-efficiency dual-functional segregated nanocomposite foams with microcellular structures are developed for integrated infrared stealth and absorption-dominant EMI shielding via the efficient and scalable supercritical CO_(2)(SC-CO_(2))foaming combined with hydrogen bonding assembly and compression molding *** obtained lightweight segregated nanocomposite foams exhibit superior infrared stealth performances benefitting from the synergistic effect of highly effective thermal insulation and low infrared emissivity,and outstanding absorption-dominant EMI shielding performances attributed to the synchronous construction of microcellular structures and segregated ***,the segregated nanocomposite foams present a large radiation temperature reduction of 70.2℃ at the object temperature of 100℃,and a significantly improved EM wave absorptivity/reflectivity(A/R)ratio of 2.15 at an ultralow Ti_(3)C_(2)T_(x) content of 1.7 vol%.Moreover,the segregated nanocomposite foams exhibit outstanding working reliability and stability upon dynamic compression *** results demonstrate that the lightweight and high-efficiency dual-functional segregated nanocomposite foams have excellent potentials for infrared stealth and absorption-dominant EMI shielding applications in aerospace,weapons,military and wearable electronics.

关键词： Segregated nanocomposite foams Microcellular structures Infrared stealth EMI shielding Low infrared emissivity

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4℃保存全血制备的去白细胞混合浓缩血小板体外质量评价

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中国输血杂志 2024年第7期37卷 820-826页

作者：安慧娟单泓刘铮张姣姣王姣杰别立莉李建斌金新莉河南省红十字血液中心河南郑州450012

目的探讨全血4℃冷藏条件下保存制备去白细胞混合浓缩血小板的可行性,为成分制备提供理论依据。方法将采集的400 mL ACD-B抗凝全血随机分两组,分别进行4℃和室温保存,在保存后6 h内分离制备出白膜层,于22℃静置过夜保存,次日将白膜层... 详细信息

目的探讨全血4℃冷藏条件下保存制备去白细胞混合浓缩血小板的可行性,为成分制备提供理论依据。方法将采集的400 mL ACD-B抗凝全血随机分两组,分别进行4℃和室温保存,在保存后6 h内分离制备出白膜层,于22℃静置过夜保存,次日将白膜层汇集制备去白细胞混合浓缩血小板,于制备后d1、d3、d5、d7取样,进行血细胞计数及相关参数检测,测定pH、葡萄糖、乳酸含量反映代谢情况,检测血栓弹力图、血小板聚集率及PAC-1、CD62P反映血小板体外功能及活化情况,比较两组血小板差异。结果随着保存时间的延长,两组去白细胞混合浓缩血小板计数逐渐下降,血小板分布宽度(PDW)、平均血小板体积(MPV)、大型血小板比例(P-LCR)均逐渐上升,差异无统计学意义(P>0.05)。两组去白细胞混合浓缩血小板pH、葡萄糖含量均逐渐降低,乳酸含量逐渐增高,无显著性差异(P>0.05)。血栓弹力图结果显示,反应血小板功能的MA值保存期内无显著性变化,且两组间无显著性差异(P>0.05)。血小板聚集率随着保存时间的延长而逐渐降低,两组无统计学差异。血小板PAC-1及CD62P表达率随着保存时间的延长而逐渐升高,两组无统计学差异(P>0.05)。结论全血4℃冷藏保存与室温保存6 h内制备的去白细胞混合浓缩血小板在体外计数、功能、活化方面无统计学差异,4℃冷藏6 h内的全血可考虑作为制备去白细胞混合浓缩血小板的起始血液。

关键词：去白细胞混合浓缩血小板全血冷藏保存血小板质量血小板功能

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Relationship Between Soil Microbial Biomass C and N and Mineralizable Nitrogen in Some Arable Soils on Loess Plateau

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Pedosphere 1998年第4期8卷 349-354页

作者： ZHOUjianbin liSHENGXIU DepartmentofSoilScienceandAgrochemistry NorthwestAgriculturalUniversityYangling712100（CHina） Departm

The chloroform fumigation-incubation method was used to measure the soil microbial biomass C (SMBC)and N (SMBN) in 16 loessial soils sampled from Ausai, Yongshou and Yangling in Shaanxi Province. The SMBC contents in the soils ranged from 75.9 to 301.0 μg Cg-1 with an average of 206.1 μg C g-1, accounting for 1.36%～6.24% of the total soil organic C with an average of 3.07%, and the SMBN contents from 0.51 to 68.40 μg N g-1 with an average of 29.4 μg N g-1, accounting for 0.20%～5.65% of the total N in the soils with an average of 3.36%. A close relationship was found between SMBC and SMBN, and they both were positively correlated with total organic C, total N, NaOH hydrolizable N and mineralizable N. These results confirmed that soil microbial biomass had a comparative role in nutrient cycles of soils.

关键词： carbon mineralizable N nitrogen soil microbial biomass

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油葵耐盐碱种质鉴定与品种选育研究进展

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中国农学通报 2024年第15期40卷 53-58页

作者：李建斌柳延涛赵长延贾秀苹段维刘胜利朱志锋塔里木大学农学院新疆阿拉尔843300 新疆农垦科学院作物研究所新疆石河子832000 甘肃省农业科学院作物研究所兰州730070 中国种子集团有限公司海南三亚572024

油葵是北方地区重要的油料作物之一,目前盐碱危害范围逐步扩大,已成为制约油葵发展的重要瓶颈,为了在盐碱地区开展耐盐碱种质资源鉴定与利用研究,选育优质耐盐碱向日葵品种是提高盐碱地作物种植产量和农业可持续发展的重要措施之一。本... 详细信息

油葵是北方地区重要的油料作物之一,目前盐碱危害范围逐步扩大,已成为制约油葵发展的重要瓶颈,为了在盐碱地区开展耐盐碱种质资源鉴定与利用研究,选育优质耐盐碱向日葵品种是提高盐碱地作物种植产量和农业可持续发展的重要措施之一。本文从归纳油葵响应盐碱胁迫生理机制,总结油葵响应盐碱胁迫分子机制以及分析油葵耐盐碱种质资源的鉴定和优异资源的筛选等方面详细综述国内外进展,概述了目前油葵耐盐碱品种选育及种质资源创新的最新研究状况,并对未来耐盐碱种质资源创新利用和新品种选育提出新的研究思路和方法:一是通过鉴定种质材料,确定其耐盐碱性等级;二是对已收集和筛选到的种质材料进一步研究其抗逆性机制。同时也为开展油葵耐盐碱品种选育提供理论依据奠定基础。

关键词：油葵耐盐碱种质资源鉴定选育

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软岩大变形隧道马蹄形掘进机研发设想与展望

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隧道建设（中英文） 2023年第2期43卷 191-198页

作者：李建斌中国中铁股份有限公司北京100039

基于国内外大量高地应力软岩隧道工程案例和理论研究,分析掘进机在软岩地层施工的难点,对掘进机进行有针对性的研发设计,提出基于“应力释放”设计理念的“软马”掘进机和“半马”掘进机,以及基于“及时支护”理念的“外马”掘进机。结... 详细信息

基于国内外大量高地应力软岩隧道工程案例和理论研究,分析掘进机在软岩地层施工的难点,对掘进机进行有针对性的研发设计,提出基于“应力释放”设计理念的“软马”掘进机和“半马”掘进机,以及基于“及时支护”理念的“外马”掘进机。结合掘进机开挖、支护、衬砌同步施工的特点,探索马蹄形掘进机关键技术及施工方案,吸收国内外软岩大变形地质隧道的施工经验,将先导螺旋开挖装置、拱架外置、盾体变径等技术应用于马蹄形掘进机的设计,预期可解决软岩大变形隧道施工中的问题。最后对全域软岩地质施工装备进行研发展望,概述基于“多地质适应性”理念的多功能、多模式马蹄形隧道掘进机等,以期对软岩大变形地质条件下掘进机工法建造隧道提供新的解决方案和思路。

关键词：软岩大变形隧道马蹄形掘进机多功能多模式掘进机先导螺旋开挖装置拱架外置盾体变径

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Boosting the zinc storage performance of vanadium dioxide by integrated morphology engineering and carbon nanotube conductive networks

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Nano Research 2024年第8期17卷 7136-7143页

作者： lijie Ma Xiaolin Wang Xiang Chen jianbin Gao Yiwen Wang Yuehai Song Yaran Zhao Shizhe Gao lin li Jianchao Sun School of Environment and Material Engineering Yantai UniversityYantai 264005China College of Textile Science and Engineering(International Institute of Silk) Zhejiang Sci-Tech UniversityHangzhou 310018China BNU-HKUST Laboratory of Green Innovation Advanced Institute of Natural SciencesBeijing Normal UniversityZhuhai 519087China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Vanadium dioxide(VO_(2)) with the advantages of high theoretical capacity and tunnel structure has attracted considerable promising candidates for aqueous zinc-ion ***,the intrinsic low electronic conductivity of VO_(2) results in an unsatisfactory electrochemical ***,a flower-like VO_(2)/carbon nanotubes(CNTs)composite was obtained by a facile hydrothermal *** unique flower-like morphology shortens the ion transport length and facilitates electrolyte ***,the CNT conductive networks is in favor of fast electron transfer.A highly reversible zinc storage mechanism was revealed by ex-situ X-ray diffraction and X-ray photoelectron *** a result,the VO_(2)/CNTs cathode exhibits a high reversible capacity(410 mAh·g^(−1)),superior rate performance(305 mAh·g^(−1)at 5 A·g^(−1)),and excellent cycling stability(a reversible capacity of 221 mAh·g^(−1)was maintained even after 2000 cycles).This work provides a guide for the design of high-performance cathode materials for aqueous zinc metal batteries.

关键词： VO_(2)/carbon nanotubes morphology engineering zinc metal batteries cathode materials conductive networks

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