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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

Neural Regeneration Research 2025年第3期20卷 887-899页

作者： jianan wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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Experimental analyses on phase transitions in compiling satisfiability problems

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Science China(Information Sciences) 2015年第3期58卷 80-90页

作者： GAO Jian wang jianan YIN MingHao College of Information Science and Technology Dalian Maritime University College of Computer Science Northeast Normal University

In the past decade,a kind of well-known phenomena in many complex combinatorial problems such as satisfiability problem,called phase transition,have been widely *** this paper,the phase transition phenomena are investigated during compiling k-satisfiability problems into tractable languages with empirical *** binary decision diagram and deterministic-decomposable negation normal form are selected as the tractable target languages for the *** intensive experiments,it can be concluded that an easy–hard–easy pattern exists during the compilations,which is only related to the ratio of the number of clauses to that of variables if we set k to a fixed value,rather than to the target ***,it can be concluded that the space exhausted during the compilations grows exponentially with the number of variables growing,whereas there is also a phase transition separating the polynomial-increment region from the exponential-increment ***,it can be observed that there is a phase transition of prime implicants around peak points of the easy–hard–easy pattern and the ratios of random instances whose average lengths of prime implicants are larger than the threshold 0.5 change *** these analyses,it can be concluded that prime implicant length and solution interchangeability are crucial impacts on sizes of compilation results.

关键词： phase transition knowledge compilation random k-SAT prime implicants easy–hard–easy pattern

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Multiple-stage spatial-temporal cooperative guidance without time-to-go estimation

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Chinese Journal of Aeronautics 2024年第9期37卷 399-416页

作者： Chunyan wang Weilin wang Wei DONG jianan wang Fang DENG School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China National Key Lab of Autonomous Intelligent Unmanned Systems Beiing Institute of TechnologyBeijing 100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120China

This paper investigates the spatial-temporal cooperative guidance problem for multiple flight vehicles without relying on time-to-go ***,a two-stage cooperative guidance strategy,namely the cooperative guidance and the Proportional Navigation Guidance(PNG)stage strategy,is developed to realize the spatial-temporal constraints in two *** the former stage,two controllers are designed and superimposed to satisfy both impact time consensus and impact angle *** the convergent conditions are satisfied,the flight vehicles will switch to the PNG stage to ensure zero miss *** further extend the results to three dimensions,a planar pursuit guidance stage is additionally imposed at the beginning of *** to the inde-pendence of time-to-go estimation,the proposed guidance strategy possesses great performance in satisfying complex spatial-temporal constraints even under flight speed ***,several numerical simulations are implemented to verify the effectiveness and advantages of the proposed results under different scenarios.

关键词： Cooperative guidance Guided missiles Impact time consensus Impact angle constraint Spatial-temporal cooperative guidance

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Interaction between reactive oxygen species and hormones during the breaking of embryo dormancy in Sorbus pohuashanensis by exogenous nitric oxide

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Journal of Forestry Research 2022年第2期33卷 435-444页

作者： Hao wang Shuoran Tang jianan wang Hailong Shen Ling Yang State Key Laboratory of Tree Genetics and Breeding School of ForestryNortheast Forestry UniversityHarbin 150040People’s Republic of China

The breaking of dormancy mediated by reac-tive nitrogen species(RNS)is related to the accumulation of reactive oxygen species(ROS)in germinating embryos but the underlying mechanism is *** objectives of this study were:(1)to explore the relationship between RNS-mediated dormancy release and ROS accumulation in germinating embryos of Sorbus pohuashanensis;and,(2)to investigate the relationships among germination time,ROS metabolism,and endogenous hormone *** studied the effects of exogenous nitric oxide(NO)donor sodium nitroprusside(SNP),the NO scavenger(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide(PTIO),abscisic acid(ABA),the exogenous ethylene donor ethrel,and the ethylene receptor inhibitor 2,5-norbornadien(NBD)on embryo germination and seedling *** were released from dormancy by pretreatment with NO or ethylene, which was related to increased ethylene biosyn-thesis and decreased ABA levels. Breaking of dormancy by SNP was related to increased levels of ethylene, hydrogen peroxide, and glutathione, increased activities of superoxide dismutase and glutathione peroxidase, and decreased levels of ABA, superoxide anions, and malondialdehyde. These effects of nitric oxide were especially significant in seedling hypocotyls and radicles. These results demonstrate that NO can break S. pohuashanensis embryo dormancy by induc-ing ethylene biosynthesis, and that this signalling pathway is closely related to ROS accumulation and the antioxidant defence response.

关键词： NO-dependent dormancy Hydrogen peroxide Ethylene Embryo germination Mountain ash(Sorbus pohuashanensis)

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Nonlinear Filtering With Sample-Based Approximation Under Constrained Communication:Progress, Insights and Trends

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1539-1556页

作者： Weihao Song Zidong wang Zhongkui Li jianan wang Qing-Long Han IEEE the State Key Laboratory for Turbulence and Complex Systems Department of Mechanics and Engineering ScienceCollege of Engineering Peking University the Department of Computer Science Brunel University London the School of Aerospace Engineering Beijing Institute of Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

The nonlinear filtering problem has enduringly been an active research topic in both academia and industry due to its ever-growing theoretical importance and practical *** main objective of nonlinear filtering is to infer the states of a nonlinear dynamical system of interest based on the available noisy measurements. In recent years, the advance of network communication technology has not only popularized the networked systems with apparent advantages in terms of installation,cost and maintenance, but also brought about a series of challenges to the design of nonlinear filtering algorithms, among which the communication constraint has been recognized as a dominating concern. In this context, a great number of investigations have been launched towards the networked nonlinear filtering problem with communication constraints, and many samplebased nonlinear filters have been developed to deal with the highly nonlinear and/or non-Gaussian scenarios. The aim of this paper is to provide a timely survey about the recent advances on the sample-based networked nonlinear filtering problem from the perspective of communication constraints. More specifically, we first review three important families of sample-based filtering methods known as the unscented Kalman filter, particle filter,and maximum correntropy filter. Then, the latest developments are surveyed with stress on the topics regarding incomplete/imperfect information, limited resources and cyber ***, several challenges and open problems are highlighted to shed some lights on the possible trends of future research in this realm.

关键词： Communication constraints maximum correntropy filter networked nonlinear filtering particle filter sample-based approximation unscented Kalman filter

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Slag Characteristics of Biomass Pellet Fuels with Different Additives to Tobacco-Stalk for Tobacco Curing Heating

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Energy Engineering 2024年第11期121卷 3401-3415页

作者： jianan wang Yikuan Fan Weidong Duan Zhaopeng Song College of Tobacco Science Henan Agricultural UniversityZhengzhou450000China China National Tobacco Corporation Henan Provincial Company Zhengzhou450046China Tobacco Production Department China Tobacco Henan Industrial Co.Ltd.Zhengzhou450000China

Since pure tobacco stalk(TS)biomass pellet fuels tend to slag,five anti-slagging agents were added to the crushed TS to obtain a pellet fuel that could be used in biomass burners to provide heat for tobacco *** obtained results revealed that the main component of TS pellet fuel was K_(2)Si_(2)O_(5).During fuel combustion process,additives generated higher melting point silicate compounds by Al–K,Ca–K,and Ca–K elemental structures to replace single K elemental structure of TS,enhancing the anti-slagging efficiency of the pellet fuel from 21.63%to 78.29%and promoting the precipitation of K,Mg,and Na elements in the slag *** investigating the anti-slagging mechanism pathways of the additives in TS biomass pellet fuels,altering of the structure of silicate ion group pathway was found to improve anti-slagging effects that met the requirements of production formula.

关键词： Pellet fuel additives flue-cured tobacco heating potassium precipitation silicate

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Prediction of large vessel occlusion for ischaemic stroke by using the machine learning model random forests

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Stroke & Vascular Neurology 2022年第2期7卷 94-100页

作者： jianan wang Jungen Zhang Xiaoxian Gong Wenhua Zhang Ying Zhou Min Lou Department of Neurology Zhejiang University School of Medicine Second Affiliated Hospital Department of NeurologyHangzhouZhejiangChina

Backgrounds The timely identification of large vessel occlusion(LVO)in the prehospital stage is extremely important given the disease morbidity and narrow time window for *** current evaluation strategies still remain *** goal of this study was to develop a machine learning(ML)model to predict LVO using prehospital accessible *** Consecutive acute ischaemic stroke patients who underwent CT or MR angiography and received reperfusion therapy within 8 hours from symptom onset in the Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation-II dataset from January 2016 to August 2021 were *** developed eight ML models to integrate National Institutes of Health Stroke Scale(NIHSS)items with demographics,medical history and vascular risk factors to identify LVO and validate its *** Finally,15365 patients were included in the training set and 4215 patients were included in the test *** the test set,random forests(RF),gradient boosting machine and extreme gradient boosting presented area under the curve(AUC)of 0.831(95%CI 0.819 to 0.843),which were higher than other models,and RF presented the highest specificity(0.827).In addition,the AUC of RF was higher than other scales,and the accuracy of the model was improved by 6.4%compared with *** also found the top five items of identifying LVO were total NIHSS score,gaze deviation,level of consciousness(LOC),LOC commands and motor left *** Our proposed model could be a useful screening tool to predict LVO based on the prehospital accessible medical data.

关键词： boosting random narrow

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Effects of a nitric oxide donor and nitric oxide scavengers on Sorbus pohuashanensis embryo germination

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Journal of Forestry Research 2018年第3期29卷 628-635页

作者： Ling Yang Dongyan Zhang Hongnan Liu Cheng Wei jianan wang Hailong Shen State Key Laboratory of Forest Genetics and Breeding School of Forestry Northeast Forestry University

The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination of Sorbus pohuashanensis were studied in a petri dish test. SNP at 0.5–5 mmol L-1 increased germination percentage, mean time to germination, germination index and germination energy compared with the control to different degrees. Treatment with 2 mmol L-1 SNP improved germination most significantly; embryo germination percentage for mother tree 1(91.11%) and mother tree 2(64.44%) were much higher than the control. In addition,excessive SNP levels did not enhance embryo *** treatment with SNP and an NO scavenger delayed embryo germination. Treatment with c PTIO inhibited embryo germination; germination percentage was 42.22% and was lower than that of the control. These results show that low concentrations of exogenous NO can enhance the embryo germination of S. pohuashanensis,providing a simple, effective way for promoting germination of S. pohuashanensis.

关键词： Mountain ash Embryo germination Nitric oxide Sodium nitroprusside Nitric oxide scavenger

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Solving diversified top-k weight clique search problem

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Science China(Information Sciences) 2021年第5期64卷 47-48页

作者： Junping ZHOU Chumin LI Yupeng ZHOU Mingyang LI Lili LIANG jianan wang School of Information Science and Technology Northeast Normal University Modélisation Information & Systèmes Université de Picardie Jules Verne

Dear editor,Diversified top-k weight clique search （DTKWCS） is a problem that computes k cliques to maximize the sum of weights of all vertices contained in the cliques;that is,∑;∈{c;∪c;∪…∪c;}w（v） is maximiz... 详细信息

关键词： Information Systems and Communication Service

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Different physiopsychological changes between AMS-susceptible and AMS-resistant pre-selected Antarctic expeditioners in Tibet

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Advances in Polar Science 2021年第3期32卷 239-247页

作者： WU Xiaopei LIU Shiying wang Xi wang jianan QIN Pengrui XU Chengli Institute of Basic Medical Sciences Chinese Academy of Medical Sciences School of Basic Medicine Peking Union Medical CollegeBeijing 100005China Center of Environmental and Health Sciences Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100005China

Through dynamically monitoring changes of acute mountain sickness(AMS)occurrences,cardiopulmonary function and mood states from Shanghai(4 m)to Lhasa(3650 m)and Yambajan(4300 m),Tibet,we obtained physiopsychological data of the 37th Chinese Antarctic pre-selected expeditioners for Kunlun *** analyzing different physiopsychological changes between AMS-susceptible(AMS-S)and AMS-resistant(AMS-R)expeditioners,we would explore indicators to screen hypoxia-susceptible *** to AMS occurrences evaluated by Lake Louise Score(LLS)in Yambajan,we divided the expeditioners(n=24,31.92±5.76 a)into AMS-S and AMS-R *** a series of medical instrumentsand questionnaires,we monitored their cardiopulmonary function and mood states,and analyzed the differences of physiopsychological parameters between AMS-S and AMS-R *** with Shanghai,when expeditioners arrived in Yambajan,in both AMS-S and AMS-R groups,oxygen saturation(SpO2)significantly decreased,and blood pressure significantly increased(P<0.05).As for electrocardiogram(ECG),interval from the beginning to the end of QRS complex wave(QRS),interval from the beginning of QRS complex wave to the end of T wave(QT),interval between 2 adjacent P waves(PP)and interval between 2 adjacent R waves(RR)significantly decreased,heart rate(HR)and HR-corrected QT interval(QTc)significantly increased(P<0.05).Cardiac contractility and pumping function significantly decreased,systemic vascular resistance significantly increased(P<0.05).Pulmonary airway patency significantly increased(P<0.05).Compared with AMS-R group,AMS-S group showed significantly lower SpO2 and higher stroke volume variation(SVV)in Shanghai,however,significantly lower maximal expiratory flow at 75%of forced vital capacity(MEF75),higher levels of anxiety,fatigue and confusion in Yambajan(P<0.05).In conclusion,when expeditioners arrived at 4300 m,their cardiopulmonary function and mood states changed ***2,SVV,MEF75,anxie

关键词： Antarctic preselected expeditioner hypoxia Tibet acute mountain sickness cardiovascular function pulmonary function mood

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