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Field Evaluation of a Duplex RT-RAA Assay for Rapid Detection of SARS-CoV-2--Hebei Province,China,January 2021

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China CDC weekly 2022年第23期4卷 504-508页

作者： Ruiqing Zhang Shunxiang Qi jiandong li Shiyou liu Guangyue Han Xinxin Shen Qi li Wenbo Xu Xuejun Ma National Institute for Viral Disease Control and Prevention China CDCBeijingChina Hebei Center for Disease Control and Prevention Shijiazhuang CityHebei ProvinceChina Center for Biosafety Mega-Science Chinese Academy of SciencesWuhan CityHubei ProvinceChina

Introduction:Recently,a local cluster epidemic has occurred in Shijiazhuang City,Hebei *** to promptly identify patients with fever in rural areas was the major reason for this ***:We presented the field evaluation of a new real-time reverse transcription recombinase-aided amplification(RT-RAA)kit incorporating an endogenous internal control in a single-tube format,completed at the Hebei CDC from January 17,2021 to January 27,***:We evaluated the diagnostic performance of RT-RAA assay using automatic extracted RNA of 808 clinical *** with reverse transcriptase real-time quantitative PCR(qRT-PCR),RT-RAA kit achieved 92.41%sensitivity,98.78%specificity and a 96.29%coincidence rate,demonstrating an excellent agreement between the RTRAA assay and qRT-PCR ***,58 samples were extracted using a manual extraction method within 5 minutes,but only samples with high nucleic acid concentration(cycle threshold value not higher than 32)could be stably ***:The RT-RAA is more suitable to meet the needs of rapid,sensitive,and accurate detection in community-level medical institutions.

关键词： Duplex Hebei prompt

Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

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Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： Xiangjun li jiandong Zhang Siqi Zhang Shengling Shi Yi’an Lu Ying Leng Chunyan li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple *** the past 20 years,the search for biomarke rs for neuromyelitis optica has been ***,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis *** in this area is consistently increasing,with China and the United States leading the way on the number of studies *** Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this ***,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this *** analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this *** analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple ***,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum *** oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated *** biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric *** latest prospective clinical trials are exploring the potential of these *** results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelit

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

Bayesian integer frequency offset estimator for MIMO-OFDM systems

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Journal of Systems Engineering and Electronics 2008年第6期19卷 1109-1114页

作者： Zhao linjing Lu Zhuo li jiandong Broadband Wireless Communications Lab Information Science Inst. State Key Lab of ISN Xidian Univ. Xi'an 710071 P. R. China

Carrier frequency offset （CFO） in MIMO-OFDM systems can be decoupled into two parts： fraction frequency offset （FFO） and integer frequency offset （IFO）. The problem of IFO estimation is addressed and a new IFO estimator based on the Bayesian philosophy is proposed. Also, it is shown that the Bayesian IFO estimator is optimal among all the IFO estimators. Furthermore, the Bayesian estimator can take advantage of oversampling so that better performance can be obtained. Finally, numerical results show the optimality of the Bayesian estimator and validate the theoretical analysis.

关键词： multiple-input-multiple-oputput orthogonal frequency-division multiplexing integer frequency offset estimation

Selectively T cell phosphorylation activation of azvudine in the thymus tissue with immune protection effect

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3140-3154页

作者： Ning Sheng Rui li Yang li Zhe Wang Lulu Wang Yuhuan li Jinlan Zhang jiandong Jiang State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Thymus is the important immune organ,responsible for T cell development and *** lower circulating T counts have been observed in patients who died from COVID-19 compared with ***,also known as FNC,is a thymus-homing anti-SARS-CoV-2 drug in treating COVID-19 *** this study,single-cell transcriptome,proteomics,and parallel reaction monitoring(PRM)were applied to insight into the activation process of FNC in rat and SARS-CoV-2 rhesus monkey *** results indicated that thymic immune cells possess a robust metabolic capacity for cytidine-analogue drugs such as *** enzymes involved in the FNC phosphorylation process,such as Dck,Cmpk1,and Nme2,were highly expressed in CD4+ T cells,CD8+ T cells,and DP(CD4+ CD8+)***,FNC could upregulate multiple phosphorylated kinases in various cell types while downregulating the phosphatases,phosphoribosyl transferases,and deaminases,*** robust phosphorylation capacity of the thymus for cytidine analogue drug FNC,and the activation effect of FNC on the NAs metabolism system potentially contribute to its enrichment in the thymus and immune protection *** suggests that it is crucial to consider the expression level of phosphorylation kinases when evaluating NA drug properties,as an important factor during antiviral drug design.

关键词： Azvudine T cell Thymus Phosphorylation activation Nucleoside analogue

Opportunistic Vector Perturbation with Superposition Signalling

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China Communications 2015年第12期12卷 160-165页

作者： CHEN Rui li Changle li jiandong State Key Laboratory of Integrated Service Networks Xidian University

In this letter,we first put forward a new basic problem to the famous vector perturbation(VP) precoding that whether the extended constellation of VP could transmit more information ***,we propose an opportunistic vector perturbation(OVP) precoding with superposition signalling scheme,which is aimed at getting the performance of VP closer to capacity *** main idea is using subsequent recoverable data symbol vector to perturb currently transmitting data symbol vector *** and simulation results show that the proposed OVP can transmit more valid information bits than conventional VP at the same transmit power,modulation order and number of antennas.

关键词：扰动矢量信号叠加传输数据仿真结果预编码信息位

Immunogenicity and protective efficacy of an inactivated SFTS vaccine candidate in mice

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Biosafety and Health 2022年第1期4卷 45-52页

作者： Aqian li Xinxian Dai Lei Chen lin liu Chuan li Yang liu Wei Wu Xiaoxia Huang jiandong li Shiwen Wang Mifang liang Xiuling li Dexin li Department of Viral Hemorrhagic Fever National Institute for Viral Disease Control and PreventionChina CDCBeijing 102206China b National Vaccine and Serum Institute Beijing 102206China Suzhou Institute of Systems Medicine Suzhou 215123China China CDC-WIV Joint Research Center for Emerging Diseases and Biosafety Center for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China

Severe fever with thrombocytopenia syndrome(SFTS),caused by a novel identified bunyavirus SFTS virus(SFTSV),was an emerging viral infectious disease that was firstly reported in *** are no licensed vaccines and therapeutics against SFTSV currently.B‐Propiolactone(BPL)inactivated whole virions of SFTSV strain AH12 were prepared as experimental vaccine in different antigen dose with or without Al(OH)3 *** experimental SFTS vaccine was a satisfying immunogen,which could efficiently trigger the development of high levels of SFTSV NP‐specific IgG antibodies and neutralizing antibodies against SFTSV Strain HB29 in BALB/c and C57/BL6 mice,and could induce SFTS virus‐specific cellular immune responses to a certain extent.A single dose of vaccine was immunogenically insufficient in BALB/c mice;the second and third dose resulted in significant boost in antibody *** use of Al(OH)3 adjuvant resulted in higher antibody *** mediate‐dose of vaccine could induce as high and equivalent level of antibody titer as that of high‐*** experimental SFTS vaccine in mediate‐and high antigen dose with adjuvant resulted in solid protection of C57/BL6 mice against wild‐type SFTSV challenge with markedly accelerated virus clearance from blood and spleen compared with *** experimental SFTS vaccine prepared in this study could efficiently elicit virus specific humoral and cellular immune responses in both BALB/c and C57/BL6 mice,and could protect C57/BL6 mice against SFTS virus *** results supplied evidence that inactivated vaccine was a promising vaccine candidate for the prevention of SFTSV infection.

关键词： SFTS virus Inactivated vaccine Immunogenicity Protective efficacy

Research progress in failure mechanisms and electrolyte modification of high-voltage nickel-rich layered oxide-based lithium metal batteries

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InfoMat 2024年第2期6卷 57-75页

作者： jiandong liu Xinhong Hu Shihan Qi Yurong Ren Yong li Jianmin Ma School of Chemistry Tiangong UniversityTianjinthe People's Republic of China School of Physics and Electronics Hunan UniversityChangshathe People's Republic of China School of Materials Science and Engineering Jiangsu Collaborative Innovation Center of Photovoltaic Science and EngineeringChangzhou UniversityChangzhouthe People's Republic of China State Key Laboratory of Space Power-Sources Technology Shanghai Institute of Space Power SourcesShanghaithe People's Republic of China

High-voltage nickel(Ni)-rich layered oxide-based lithium metal batteries(LMBs)exhibit a great potential in advanced batteries due to the ultra-high energy ***,it is still necessary to deal with the challenges in poor cyclic and thermal stability before realizing practical application where cycling life is *** many improved strategies,mechanical and chemical stability for the electrode electrolyte interface plays a key role in addressing these ***,extensive effort has been made to address the challenges of electrode-electrolyte *** this progress,the failure mechanism of Ni-rich cathode,lithium metal anode and electrolytes are reviewed,and the latest breakthrough in stabilizing electrode-electrolyte interface is also ***,the challenges and future research directions of Ni-rich LMBs are put forward.

关键词： electrode-electrolyte interface electrolyte modification failure mechanisms high voltage lithium metal anode nickel-rich layered oxide cathode

2024年7月中国需关注的突发公共卫生事件风险评估

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疾病监测 2024年第7期39卷 817-819页

作者：杨康秦颖牟笛李建东魏建春王锐任婧寰王霄晔施国庆孟玲向妮娟亳州市疾病预防控制中心安徽亳州236800 中国疾病预防控制中心应急中心传染病溯源预警与智能决策全国重点实验室北京102206 中国疾病预防控制中心传染病处传染病溯源预警与智能决策全国重点实验室北京102206 中国疾病预防控制中心传染病预防控制所传染病溯源预警与智能决策全国重点实验室北京102206 中国疾病预防控制中心病毒病预防控制所传染病溯源预警与智能决策全国重点实验室北京102206

目的评估2024年7月在我国(不含香港地区、澳门特别行政区和台湾省,下同)发生或者可能由境外输入的突发公共卫生事件风险。方法根据国内外突发公共卫生事件报告及重点传染病监测等各种资料和部门通报信息,采用专家会商法,并通过视频会议... 详细信息

目的评估2024年7月在我国(不含香港地区、澳门特别行政区和台湾省,下同)发生或者可能由境外输入的突发公共卫生事件风险。方法根据国内外突发公共卫生事件报告及重点传染病监测等各种资料和部门通报信息,采用专家会商法,并通过视频会议形式邀请各省(自治区、直辖市)疾病预防控制中心专家参与评估。结果近期境内新型冠状病毒感染疫情低位回升,可能继续在低水平波动,登革热本地传播疫情风险逐渐增加,可能发生聚集性疫情,炭疽病例仍可能发生,高温中暑、洪涝灾区水源性、食源性和媒介传染病风险增加。结论对新型冠状病毒感染、登革热、炭疽、高温中暑、洪涝灾害予以关注。

关键词：突发公共卫生事件传染病疫情风险评估

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我国肾综合征出血热流行现状与预防控制

热带病与寄生虫学 2024年第3期22卷 129-132,139页

作者：郑张琦林启晗杜珊珊黄晓霞李建东传染病溯源预警与智能决策全国重点实验室国家卫生健康委员会生物安全重点实验室国家卫生健康委员会医学病毒和病毒病重点实验室中国疾病预防控制中心病毒病预防控制所北京102206

肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)是我国重点防治的乙类传染病,曾在我国广泛流行,给人民群众健康带来严重威胁。多年来,在政府主导多部门通力协作全面落实综合防控措施的背景下,HFRS得到有效控制,发病总体... 详细信息

肾综合征出血热(hemorrhagic fever with renal syndrome,HFRS)是我国重点防治的乙类传染病,曾在我国广泛流行,给人民群众健康带来严重威胁。多年来,在政府主导多部门通力协作全面落实综合防控措施的背景下,HFRS得到有效控制,发病总体上进入低水平波动期,但累及地区却在扩大,新的疫源地仍在出现,部分疫源地疫情时有反复,防控工作面临新的形势。进一步巩固防控成果,降低发病率和病死率,仍是当前公共卫生系统亟待解决的挑战之一。为此,本文介绍了HFRS的病原学特征,结合既往疫情资料分析了我国当前HFRS的流行特点,总结了我国HFRS的防控策略与措施,以期为新形势下我国HFRS的防控工作提供有益参考。

关键词：肾综合征出血热汉坦病毒病原学特征流行特征防控策略