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Molecular Dynamics Simulation of Persistent Slip Bands Formation in Nickel-base Superalloys

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International Journal of Automation and computing 2017年第1期14卷 68-79页

作者： jian-Feng Huang Zhong-Lai Wang Er-Fu Yang don McGlinchey yuan-Xin Luo Yun Li Yi Chen School of Engineering and Built Environment Glasgow Caledonian UniversityGlasgow G4 0BAUK University of Electronic Science and Technology of China Chengdu 611731China Space Mechatronic Systems Technology Laboratory(SMe STech) Department of DesignManufacture and Engineering ManagementJames Weir BuildingUniversity of StrathclydeGlasgow G1 1X JUK College of Mechanical Engineering Chongqing UniversityChongqing 400044China School of Computer Science and Network Security Dongguan University of TechnologyDongguan 523808China

Persistent slip band （PSB） is an important and typical microstructure generated during fatigue crack initiation. Intensive work has been done to investigate the mechanisms of the formation of persistent slip bands since the 1950s when Wadsworth[1] observed the fatigue fracture in copper. Simulations have indicated that PSBs formation during fatigue crack initiation is related to the dislocation driving force and interaction. In this paper, a molecular dynamics （MD） simulation associated with embedded atom model （EAM） is applied to the PSBs formation in nickel-base superalloys with different microstructure and temperature under tensile- tensile loadings. Five MD models with different microstructure （pure 5/ phase and γ/γ＇ phase）, grain orientation （[1 0 0][0 1 0][0 0 1] and [1 1 1][1 0 1][1 2 1]） and simulation temperature （300 K, 600 K, 900 K） were built up in these simulations. Our results indicated that within the γ phase by massive dislocations, pile-up and propagation which can penetrate the grain. Also, it is found that the temperature will affect the material fatigue performance and blur PSBs appearance. The simulation results are in strong agreement with published experimental test result. This simulation is based on the work[2]. The highlights of the article include： 1） investigation of the PSB formation via molecular dynamics simulation with three different parameters, 2） conduct of a new deformation and velocity combination controlled simulation for the PSB formation, 3） high-performance computing of PSB formation, and 4） systematic analysis of the PSB formation at the atomic scale in which the dislocation plays a critical role.

关键词： Persistent slip bands (PSB) molecular dynamics superalloys computational simulation embedded atom model (EAM).

Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine

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Cancer Biology & Medicine 2023年第4期20卷 287-296页

作者： Xue Wang jian Yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang pin Zhang Fei Ma Binghe Xu Peng yuan Department of VIP Medical Services National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Comprehensive Oncology Huanxing Cancer HospitalBeijing 100026China Department of Medical Oncology and Clinical Trial Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in *** study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with hormone receptor positive(HR+)/human epidermal growth factor receptor-2-negative(HER2−)recurrent or metastatic breast ***:Patients were intramuscularly administered fulvestrant 500 mg(day 1 per cycle for 28 days)and oral vinorelbine(60 mg/m2 on days 1,8,and 15 of each cycle).The primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival,objective response rate,disease control rate,duration of response,and ***:A total of 38 patients with HR+/HER2−advanced breast cancer included in the study were followed up for a median time of 25.1 *** overall median PFS was 9.86 months[95%confidence interval(CI)7.2-23.13],and the median PFS of the first-line and the second-line treatment population was 20.73 months(95%CI 9.82 to NR)and 4.27 months(95%CI 3.68 to NR),*** adverse events reported were of grade 1/2,and none were of grade 4/***:This is the first exploratory study of a fulvestrant and oral vinorelbine regimen in the treatment of HR+/HER2−recurrent and metastatic breast *** combination chemo-endocrine therapy was efficacious,safe,and promising for patients with HR+/HER2−advanced breast cancer.

关键词： HR+/HER2−breast cancer recurrence metastasis fulvestrant oral vinorelbine

水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效

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中成药 2024年第5期46卷 1514-1519页

作者：郭建恩张佳华张园纪品川高志旭高占华安丽萍杨佳琦常柏天津中医药大学研究生院天津301617 承德医学院河北承德067000 承德市中医院河北承德067000 天津医科大学朱宪彝纪念医院天津300070

目的探讨水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效。方法83例患者随机分为对照组(42例)和观察组(41例),对照组给予厄贝沙坦片,观察组在对照组基础上加用水陆二仙丹联合抵挡汤加减方,疗程12周。检测临床疗效、中医... 详细信息

目的探讨水陆二仙丹联合抵挡汤加减方对早中期糖尿病肾病患者的临床疗效。方法83例患者随机分为对照组(42例)和观察组(41例),对照组给予厄贝沙坦片,观察组在对照组基础上加用水陆二仙丹联合抵挡汤加减方,疗程12周。检测临床疗效、中医证候评分、血糖指标(FBG、HbA1c)、血脂指标(TC、TG)、肾功能指标(BUN、Scr、24 h UTP、eGFR)、炎症因子(IL-1β、hs-CRP、IL-6、TNF-α、IL-18、TGF-β1)、免疫功能指标(淋巴细胞、中性粒细胞、CD8^(+)、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、不良反应发生率变化。结果观察组总有效率高于对照组(P0.05)。结论水陆二仙丹联合抵挡汤加减方可安全有效地改善早中期糖尿病肾病患者临床症状,其机制可能与降低炎症水平、改善机体免疫功能有关。

关键词：水陆二仙丹抵挡汤加减方厄贝沙坦片早中期糖尿病肾病

Prevalence of fatty liver disease and its risk factors in the population of South China

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World Journal of Gastroenterology 2007年第47期13卷 6419-6424页

作者： Yong-jian Zhou Yu-yuan Li Yu-Qiang Nie Jin-Xiang Ma Lun-Gen Lu Sheng-Li Shi Min-Hu Chen pin-Jin Hu Department of Gastroenterology The First Affiliated Hospital Sun Yat-Sen University of Medical Sciences Guangzhou 510080 Guangdong Province China Department of Gastroenterology and Hepatology First Municipal People's Hospital of Guangzhou Guangzhou Medical College Guangzhou 510180 Guangdong Province China Department of Prevention Medicine Guangzhou Medical College Guangzhou 510182 Guangdong Province China Department of Gastroenterology Renji Hospital Shanghai Institute of Digestive Disease Shanghai Jiaotong University School of Medicine Shanghai 200001 China

AIM: To investigate the population-based prevalence of fatty liver disease (FLD) and its risk factors in Guangdong Province,China. METHODS: A cross-sectional survey with multiple-stage stratified cluster and random sampling of inhabitants over 7-year-old was performed in 6 urban and rural areas of Guangdong Province,China. Questionnaires,designed by co-working of epidemiologists and hepatologists,included demographic characteristics,current medication use,medical history and health-relevant behaviors,i.e. alcohol consumption,smoking habits,dietary habits and physical activities. Anthropometric measurements,biochemical tests and abdominal ultrasonography were carried out. RESULTS: Among the 3543 subjects,609 (17.2%) were diagnosed having FLD (18.0% males,16.7% females,P > 0.05). Among them,the prevalence of confirmed alcoholic liver disease (ALD),suspected ALD and nonalcoholic fatty liver disease (NAFLD) were 0.4%,1.8%,and 15.0%,respectively. The prevalence rate (23.0%) was significantly higher in urban areas than (12.9%) in rural areas. After adjustment for age,gender and residency,the standardized prevalence of FLD in adults was 14.5%. Among them,confirmed ALD,suspected ALD and NAFLD were 0.5%,2.3%,and 11.7%,respectively,in adults and 1.3% (all NAFLD) in children at the age of 7-18 years. The overall prevalence of FLD increased with age in both genders to the peak of 27.4% in the group of subjects at the age of 60-70 years. The prevalence rate was significantly higher in men than in women under the age of 50 years (22.4% vs 7.1%,P < 0.001). However,the opposite phenomenon was found over the age of 50 years (20.6% vs 27.6%,P < 0.05). Multivariate and logistic regression analysis indicated that male gender,urban residency,low education,high blood pressure,body mass index,waist circumference,waist to hip ratio,serum triglyceride and glucose levels were the risk factors for FLD. CONCLUSION: FLD,especially NAFLD,is prevalent in South China. There are many risk factors f

关键词： Fatty liver disease Prevalence Epidemiology Risk factors

LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy

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Chinese Journal of Cancer 2012年第5期31卷 223-232页

作者： Ji-Liang Qiu pin-Zhu Huang Jing-Hong You Ru-Hai Zou Li Wang jian Hong Bin-Kui Li Kai Zhou Yun-Fei yuan State Key Laboratory of Oncology in South China GuangzhouGuangdong 510060P.R.China Department of Hepatobiliary Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China epartment of General Surgery the People's Hospital of Jiangxi ProvinceNanchangJiangxi 330006.P.R.China

Stem cell marker LIN28,related closely with SOX2 and OCT4,has been studied as a biomarker for the maintainance of pluripotent cells in several *** previous study showed that SOX2 and OCT4 were negative predictors for hepatocellular carcinoma(HCC).However,the predictive value of LIN28 in HCC outcome is still *** hypothesized that LIN28 may also play a role as a biomarker for *** test this hypothesis,we examined the expression of LIN28 in 129 radically resected HCC tissues using reverse transcription-polymerase chain reaction and analyzed the association of LIN28 expression with clinicopathologic features and *** study showed that LIN28 was expressed at a higher frequency in tumor tissues than in non-HCC tissues(45.0% vs.21.7%,P = 0.020).Moreover,LIN28 expression was significantly increased in cases with large tumor size(P = 0.010).Univariate analysis did not reveal a significant correlation between LIN28 expression and overall survival or recurrence-free *** HCC patients who met the Milan criteria,stratified analysis revealed shorter overall survival(P = 0.007) and recurrence-free survival(P < 0.001) in those with detectable LIN28 expression compared to those with no detectable LIN28 ***,multivariate analysis revealed that LIN28 was a negative independent predictor for both overall survival(hazard ratio= 7.093,P = 0.017) and recurrence-free survival(hazard ratio=5.518,P = 0.004) in patients who met the Milan *** together,our results suggest that LIN28 identifies low-risk and high-risk subsets of HCC patients meeting the Milan criteria who undergo hepatectomy.

关键词：切除术肝癌标准米兰患者预后生物标志物价值

基于PPARγ对糖转运及代谢的影响探讨罗格列酮对糖尿病小鼠胰腺癌模型的作用机制

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中国药理学通报 2024年第7期40卷 1325-1334页

作者：胡瑞萍尚利峰王和静车红霞王明亮杨欢靳媛媛张菲菲张建岭甘肃省第三人民医院甘肃兰州730000 青岛市第八人民医院山东青岛266121 兰州大学第一医院甘肃兰州730000

目的基于PPARγ对糖转运及代谢的影响探讨罗格列酮(rosiglitazone,Rsg)对糖尿病小鼠胰腺癌模型的作用机制。方法采用高脂高糖饮食+STZ建造T2DM模型;选择造模成功的T2DM小鼠和正常小鼠,建造PANC02细胞移植瘤模型。T2DM移植瘤小鼠和正常... 详细信息

目的基于PPARγ对糖转运及代谢的影响探讨罗格列酮(rosiglitazone,Rsg)对糖尿病小鼠胰腺癌模型的作用机制。方法采用高脂高糖饮食+STZ建造T2DM模型;选择造模成功的T2DM小鼠和正常小鼠,建造PANC02细胞移植瘤模型。T2DM移植瘤小鼠和正常移植瘤小鼠分组均为:Rsg;PPARγ抑制剂(pin-2);Rsg+PPARγ抑制剂(Rsg+pin-2),并分别以正常移植瘤小鼠(NDM)和T2DM移植瘤小鼠(DM)作为对照组。干预后取材;HE染色观察组织病理变化;免疫组化检测组织中Ki67和PCNA的表达;TUNEL检测细胞凋亡情况;免疫荧光检测PPARγ的表达;RT-PCR法测定Glucokinase、GLUT2、Nkx6.1、PDX-1 mRNA的表达;Western blot检测Glucokinase、GLUT2、Nkx6.1、PDX-1蛋白的表达。结果Rsg可使NDM和DM小鼠移植瘤质量、病理变化、Ki67和PCNA的表达均明显降低(Ppin-2均可逆转Rsg导致的NDM和DM小鼠指标变化;与NDM小鼠比,DM组小鼠上述相关指标对Rsg和pin-2更加敏感。结论相比于非糖尿病胰腺癌,Rsg可更加敏感地通过激活PPARγ抑制糖尿病胰腺癌的增殖,诱导其凋亡,并通过改变糖脂代谢基因,重编程胰腺癌代谢,进而达到抑癌的作用。

关键词：罗格列酮 PPARγ 2型糖尿病胰腺癌糖转运抑癌

基于高光谱成像技术的全麦粉中don含量预测方法研究

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中国粮油学报 2024年第8期39卷 82-88页

作者：邢常瑞赵双玲孙钰莹张洁李光磊赵小旭袁建鞠兴荣南京财经大学食品科学与工程学院江苏省现代粮食流通与安全协同创新中心江苏省粮油品质控制及深加工技术重点实验室南京210023 河南省农业农村科技教育中心郑州450008 山东美正生物科技有限公司日照102100

don是小麦中检出率较高、危害较严重的真菌毒素之一,是小麦减产和品质劣变的主要威胁。本研究首先采集全麦粉中don含量的短波红外高光谱信息,建立全麦粉中don含量的预测模型,并采用连续投影算法(SPA)进行特征波长的选取,比较了全波长范... 详细信息

don是小麦中检出率较高、危害较严重的真菌毒素之一,是小麦减产和品质劣变的主要威胁。本研究首先采集全麦粉中don含量的短波红外高光谱信息,建立全麦粉中don含量的预测模型,并采用连续投影算法(SPA)进行特征波长的选取,比较了全波长范围和特征波长下建立的偏最小二乘法(PLS)和支持向量机(SVM)模型。结果表明,基于全波长数据建立的全麦粉中don含量的最优预测模型为SVM模型,对应的预测集决定系数R^(2) P为0.640,预测集均方根误差(RMSEP)为1904.43μg/kg,剩余预测残差(RPD)为2.00。基于特征波长建立的最优预测模型为Autoscale-SVM模型(SPA-Autoscale-SVM),模型对应的R^(2) P、RMSEP和RPD分别为0.716、1640.41μg/kg和2.06。预测值与测量值的回归系数R^(2)为0.7449,说明基于特征波长的Autoscale-SVM模型能够预测全麦粉中don含量的变化。为验证所建模型的稳定性,重新挑选小麦样品进行高光谱图像采集,将独立验证集带入所建模型中,验证集的拟合回归系数为0.7178,说明该模型能对全麦粉中don含量进行预测。

关键词：高光谱成像呕吐毒素小麦 PLS SVM

Betavoltaic Battery Conversion Efficiency Improvement Based on Interlayer Structures

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Chinese Physics Letters 2012年第7期29卷 268-271页

作者： LI Da-Rang jianG Lan YIN jian-Hua TAN yuan-yuan LIN Nai Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081 National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083

Significant differences among the doping densities of PN junctions in semiconductors cause lattice mismatch and lattice defects that increase the recombination current of betavoltaic *** extensively decreases the open circuit voltage and the short current,which results in low conversion *** study proposes P+pinN+-structure based betavoltaic batteries by adding an interlayer to typical pin structures to improve conversion *** simulations are conducted for the energy deposition of beta particles along the thickness direction in *** on this,63 Ni-radiation GaAs batteries with pin and P+pinN+ structures are designed and fabricated to experimentally verify the proposed *** turns out that the conversion efficiency of the betavoltaic battery with the proposed P+ pinN+ structure is about 1.45 times higher than that with the traditional pin structure.

关键词： Battery battery semiconductors

股骨远端90°锁定钢板与克氏针治疗大龄儿童股骨髁上骨折的疗效比较

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临床骨科杂志 2024年第3期27卷 424-428页

作者：张远鉴王意菊尹同珍刘阳河北省沧州中西医结合医院小儿骨科、骨肿瘤科河北沧州061013 沧州市中心医院骨科河北沧州061017

目的比较股骨远端90°锁定钢板与克氏针治疗大龄儿童股骨髁上骨折的疗效。方法采用随机数字表法将61例大龄儿童股骨髁上不稳定型骨折患儿分为观察组(31例,采用股骨远端90°锁定钢板治疗)和对照组(30例,采用闭合或切开复位克氏针治疗)。... 详细信息

目的比较股骨远端90°锁定钢板与克氏针治疗大龄儿童股骨髁上骨折的疗效。方法采用随机数字表法将61例大龄儿童股骨髁上不稳定型骨折患儿分为观察组(31例,采用股骨远端90°锁定钢板治疗)和对照组(30例,采用闭合或切开复位克氏针治疗)。记录两组手术情况、疼痛VAS评分、骨折愈合情况以及骨折再移位率,采用Johner-Wruhs标准评价疗效。结果患儿均获得随访,时间6~24个月。手术时间、术中透视次数观察组短(少)于对照组(P<0.05)。术后1个月疼痛VAS评分观察组低于对照组(P<0.05)。两组骨折均愈合,时间3~5个月。末次随访时采用Johner-Wruhs标准评价的疗效优良率观察组高于对照组(P<0.05)。随访期间观察组1例(3.2%)骨折再移位,对照组8例(26.7%)骨折再移位,骨折再移位率观察组小于对照组(P<0.05)。结论股骨远端90°锁定钢板治疗大龄儿童股骨髁上骨折,无需塑形、固定牢固、符合生物力学特点,效果良好;与克氏针治疗相比,手术时间更短,术中透视次数更少,患儿可以更早功能锻炼,骨折再移位率更低。

关键词：股骨髁上骨折股骨远端90°锁定钢板克氏针儿童