检索结果-南通市图书馆

Clinicopathological significance and immunotherapeutic outcome of claudin 18.2 expression in advanced gastric cancer:A retrospective study

引用

Chinese Journal of Cancer Research 2024年第1期36卷 78-89页

作者： Changsong Qi Xiaoyi Chong Ting Zhou Mingyang Ma Jifang Gong Miao Zhang jian Li Jun Xiao Xiaohui Peng zhen Liu Zonghai Li Lin s.en Xiaotian Zhang state Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China CARs.en Therapeutics Co. LtdShanghai 200231China CARs.en Life sciences Co. LtdShanghai 200131China

Objective: Immunotherapeutic outcomes and clinical characteristics of claudin 18 isoform 2 positive(CLDN18.2-positive) gastric cancer(GC) vary in different clinical studies, making it difficult to optimize antiCLDN18.2 therapy. We conducted a retrospective analysis to explore the association of CLDN18.2 expression with clinicopathological characteristics and immunotherapeutic outcomes in ***: A total of 536 advanced GC patients from 2019 to 2021 in the CT041-CG4006 and CT041-sT-01clinical trials were included in the analysis. CLDN18.2 expression on ≥40% of tumor cells(2+, 40%) and CLDN18.2 expression on ≥70% of tumor cells(2+, 70%) were considered the two levels of positively expressed GC. The clinicopathological characteristics and immunotherapy outcomes of GC patients were analyzed according to CLDN18.2 expression ***: CLDN18.2 was expressed in 57.6%(cut-off: 2+, 40%) and 48.9%(cut-off: 2+, 70%) of *** death-ligand 1(PD-L1) and CLDN18.2 were co-expressed in 19.8% [combined positive score(CPs)≥1, CLDN18.2(cut-off: 2+, 40%)] and 17.2% [CPs≥5, CLDN18.2(cut-off: 2+, 70%)] of ***18.2 expression positively correlated with younger age, female sex, non-gastroesophageal junction(nonGEJ), and diffuse phenotype(Pssion were significantly lower in CLDN18.2-positive GC(both Pstasis(Ps more frequent and liver metastasis(Ps less common in CLDN18.2-positive GC. Overall survival and immunotherapy-related progression-free survival(ir PFs) were inferior in the CLDN18.2-positive ***: CLDN18.2-positive GC is associated with poor prognosis and worse immunotherapeutic outcomes. The combination of anti-CLDN18.2 therapy, anti-PD-L1/PD-1 therapy, and chemotherapy for GC requires further investigation.

关键词： Gastric cancer claudin18.2 CT041 PD-L1 immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications

引用

Light(science & Applications) 2024年第2期13卷 254-266页

作者： Hao Hao Qing-Yuan Zhao Yang-Hui Huang Jie Deng Fan Yang sai-Ying Ru zhen Liu Chao Wan Hao Liu Zhi-jian Li Hua-Bing Wang Xue-Cou Tu La-Bao Zhang Xiao-Qing Jia Xing-Long Wu jian Chen Lin Kang Pei-Heng Wu Research Institute of superconductor Electronics(RIsE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Purple Mountain Laboratories NanjingJiangsu 211111China Hefei National Laboratory HefeiAnhui 230088China National Laboratory of solid state Microstructures and Department of Physics Nanjing UniversityNanjing 210023China

Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits to deep space *** achieve gigabit data rates while mitigating strong background noise photons and beam drift in a highly attenuated free-space channel,a comprehensive design of a multi-functional detector is *** this study,we present an innovative compact multi-pixel superconducting nanowire single-photon detector array that integrates near-unity detection efficiency(91.6%),high photon counting rate(1.61 Gcps),large dynamic range for resolving different photon numbers(1-24),and four-quadrant position sensing function all within one ***,we have constructed a communication testbed to validate the advantages offered by such an *** 8-PPM(pulse position modulation)format communication experiments,we have achieved an impressive maximum data rate of 1.5 Gbps,demonstrating sensitivities surpassing previous benchmarks at respective *** incorporating photon number information into error correction codes,the receiver can tolerate maximum background noise levels equivalent to 0.8 photons/slot at a data rate of 120 Mbps—showcasing a great potential for daylight operation ***,preliminary beam tracking tests were conducted through open-loop scanning techniques,which revealed clear quantitative dependence indicating sensitivity variations based on beam *** on the device characterizations and communication results,we anticipate that this device architecture,along with its corresponding signal processing and coding techniques,will be applicable in future space-to-ground communication tasks.

关键词： photon supporting correction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

乙烯与1-己烯共聚合及其共聚物研究

引用

合成树脂及塑料 2024年第3期41卷 21-25,38页

作者：甄建北京燕山石化高科技术有限责任公司北京102500

在1 L聚合釜中进行乙烯与1-己烯共聚合,研究了乙烯与1-己烯共聚合的动力学、竞聚率及所制共聚物的结构与性能,并模拟了串联和并联工艺。结果表明:1-己烯的共聚合能力较好,且具有较好的氢调敏感性,共聚合过程平稳,共聚物颗粒形态较好;乙... 详细信息

在1 L聚合釜中进行乙烯与1-己烯共聚合,研究了乙烯与1-己烯共聚合的动力学、竞聚率及所制共聚物的结构与性能,并模拟了串联和并联工艺。结果表明:1-己烯的共聚合能力较好,且具有较好的氢调敏感性,共聚合过程平稳,共聚物颗粒形态较好;乙烯-1-己烯共聚物与参比试样物性基本相当,熔融焓、结晶焓和1-己烯含量略高。

关键词：乙烯 1-己烯共聚合氢调敏感性颗粒形态

来源：

维普期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Review on recent advances of inorganic electrode materials for potassium-ion batteries

引用

Tungs.en 2024年第1期6卷 174-195页

作者： jian-zhen Xiong Ze-Cheng Yang Xin-Liang Guo Xi-Ying Wang Chao Geng Zong-Fu sun An-Yong Xiao Quan-Chao Zhuang Ya-Xin Chen Zhi-Cheng Ju school of Materials science and Physics China University of Mining and TechnologyXuzhou 221116China

Rechargeable potassium-ion batteries(PIBs)have great potential in the application of electrochemical energy storage devices due to the low cost,the abundant resources and the low standard reduction potential of *** electrode materials are the key factors to determine the electrochemical performance of devices,relevant research is being carried out to build high-performance *** recent years,significant progress has been made in the study of the design of inorganic electrode ***,we review the cathode materials(Prussian blue and its analogues,layered oxides and poly anionic compounds)and the anode materials(antimony-based,selenium-based and bismuth-based compounds).On the basis of previous work,the structural design principles for improving the performance of electrode materials are reasonably *** the same time,the problems that need to be solved in the preparation of electrode materials and the direction of future research and improvement are pointed out.

关键词： Inorganic electrode materials Potassium-ion batteries Cathode materials Anode materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

引用

World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu s.en Yong Zhang Fang Wu Mei-zhen s.en Jun-Lin Liang Xiao-Long Zhang Xiao-jian Liu Xin-shu Li Ren-s.eng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential Evolution Hemivariational Inequalities with Anti-periodic Conditions

引用

Acta Mathematica sinica,english series 2024年第4期40卷 1143-1160页

作者： Jing ZHAO Chun Mei GAN zhen Hai LIU school of Mathematics and Quantitative Economics Guangxi University of Finance and EconomicsNanning 530003P.R.China Guangxi Colleges and Universities Key Laboratory of Optimization Control and engineering Calculation Guangxi Minzu UniversityNanning 530006P.R.China

The goal of this paper is to deal with a new dynamic system called a differential evolution hemivariational inequality(DEHVI)which couples an abstract parabolic evolution hemivariational inequality and a nonlinear differential equation in a Banach ***,by apply ing surjectivity result for pseudomonotone multivalued mappins and the properties of Clarke's subgradient,we show the nonempty of the solution set for the parabolic hemivariational ***,some topological properties of the solution set are established such as boundedness,closedness and ***,we explore the upper semicontinuity of the solution ***,we prove the solution set of the system(DEHVI)is nonempty and the set of all trajectories of(DEHVI)is weakly compact in C(I,X).

关键词： Differential parabolic hemivariational inequality Clarke subdifferential hyperbolicparabolic system parabolic-parabolic system exis.ence result

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

性别刻板印象的变与不变?来自内容、方法与影响的证据

引用

心理科学进展 2024年第6期32卷 939-950页

作者：王祯管健南开大学社会学院社会心理学系天津300071

性别刻板印象作为一种社会认知,是人们对男性和女性的特征、属性和行为的普遍信念。在社会变迁的宏大背景下,研究者通过传统方法(过去-现在-未来评价范式、横断序列设计、横断历史元分析)和新近技术(词嵌入)探讨了性别刻板印象变迁。虽... 详细信息

性别刻板印象作为一种社会认知,是人们对男性和女性的特征、属性和行为的普遍信念。在社会变迁的宏大背景下,研究者通过传统方法(过去-现在-未来评价范式、横断序列设计、横断历史元分析)和新近技术(词嵌入)探讨了性别刻板印象变迁。虽然有少许研究声称性别刻板印象未随时间发生变化,但大部分研究基于社会角色理论,都支持性别刻板印象已随时间发生变迁。变迁模式主要表现为:认为女性在男性化特征(如能动性)上不断增长,而男性在女性化特征上(如共生性)可能有所增长。这些变迁对缩小经济上的性别差异具有积极作用,但也可能会给家庭和健康带来消极后果。未来研究应在多学科交叉、多方法融合的基础上,以细化方式、网络视角去考察性别刻板印象变迁,尤其要重视在中国文化背景下对该主题的探究。

关键词：社会变迁性别刻板印象变迁社会角色理论能动性共生性

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Epileptic brain network mechanisms and neuroimaging techniques for the brain network

引用

Neural Regeneration Research 2024年第12期19卷 2637-2648页

作者： Yi Guo Zhonghua Lin zhen Fan Xin Tian Department of Neurology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina sichuan Provincial Center for Mental Health Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Geriatrics Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurology Chongqing Key Laboratory of NeurologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Epilepsy can be defined as a dysfunction of the brain network,and each type of epilepsy involves different brain-network changes that are implicated diffe rently in the control and propagation of interictal or ictal *** more detailed information on brain network alterations can help us to further understand the mechanisms of epilepsy and pave the way for brain network-based precise therapeutic approaches in clinical *** increasing number of advanced neuroimaging techniques and electrophysiological techniques such as diffusion tensor imaging-based fiber tra ctography,diffusion kurtosis imaging-based fiber tractography,fiber ball imagingbased tra ctography,electroencephalography,functional magnetic resonance imaging,magnetoencephalography,positron emission tomography,molecular imaging,and functional ultrasound imaging have been extensively used to delineate epileptic *** this review,we summarize the relevant neuroimaging and neuroelectrophysiological techniques for assessing structural and functional brain networks in patients with epilepsy,and extensively analyze the imaging mechanisms,advantages,limitations,and clinical application ranges of each technique.A greater focus on emerging advanced technologies,new data analysis software,a combination of multiple techniques,and the construction of personalized virtual epilepsy models can provide a theoretical basis to better understand the brain network mechanisms of epilepsy and make surgical decisions.

关键词： electrophysiological techniques epilepsy functional brain network functional magnetic resonance imaging functional near-infrared spectroscopy machine leaning molecular imaging neuroimaging techniques structural brain network virtual epileptic models

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Examining the spatiotemporal Dynamics and Determinants of Land Urbanization in Prefecture-level Cities,China

引用

Chinese Geographical science 2024年第1期34卷 19-33页

作者： YANG zhen ZHU Huxiao ZHANG Xinlin OU Xiangjun school of Geography Geomatics and Planning&Urban-rural Integration Development Research InstituteJiangsu Normal UniversityXuzhou221116China

Examining the spatiotemporal dynamics and determinants of land urbanization is critical for promoting healthy urban development and the rational use of land *** on the dataset consisting of land use change data and selected factors in 2010 and2020,this study used visual analysis to reveal the spatiotemporal dynamics of land urbanization across prefecture-level cities in ***,the driving forces underlying land urbanization were examined by using geographical detector *** are the findings:1)we find that there exist notable spatial variances in land urbanization across prefecture-level ***,the differentiation in land urbanization between the northern and southern cities is more pronounced than that between the coastal and inland cities,or between the eastern and western ***-level cities located in central and western China have experienced the most rapid growth in land ***,the growth rate in northeastern China is the lowest,while the velocity in eastern China remains relatively *** using spatial autocorrelation analysis,this study reveals that the land urbanization level in prefecture-level cities has significant spatial agglomeration.2)We further find that land urbanization in China is influenced by factors related to urban land supply and demand,and urban population growth,economic growth,land financial and political incentive have greater impact on land urbanization than other factors.3)We also find that the impacts of determinants on China’s land urbanization vary over time,the explanatory power of economic development increased,while the explanatory power of state forces *** argue that integrating the supply and demand factors of land urbanization can provide a more comprehensive understanding of the driving mechanisms underlying land urbanization in China and other transitional countries,and help decision-makers in these countries formulate more detailed and specif

关键词： land urbanization spatial pattern influencing factor geographical detector China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effective time, correction speed and termination time of hemiepiphysiodesis in children

引用

World Journal of Orthopedics 2024年第1期15卷 1-10页

作者： jian-Fa Zeng Yu-Yin Xie Can Liu zhen-Qi song zheng Xu Zhong-Wen Tang Jie Wen s.eng Xiao Department of Pediatric Orthopedics Hunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410013Hunan ProvinceChina Department of Anatomy Hunan Normal University school of MedicineChangsha 410003Hunan ProvinceChina

In children with asymmetric growth on the medial and lateral side of limbs,if there still remains growth potential,the guided growth technique of hemiepiphysiodesis on one side of the epiphysis is recognized as a safe and effective ***,when the hemi-epiphysiodesis start to correct the deformities,how many degrees could hemi-epiphysiodesis bring every month and when to remove the hemi-epiphysiodesis implant without rebound phenomenon are still on *** article reviews the current studies focus on the effective time,correction speed and termination time of hemi-epiphysiodesis.

关键词： Hemi-epiphysiodesis Percutaneous epiphysiodesis Transphyseal screws Eight plate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：