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Engineering 2024年第6期37卷 96-104页

作者： Yinglu Liu Dan Wang Changlin Liu Qianqian Hao jian Li Jie-xin Wang Xiuyun Chen Peng Zhong Xibin Shao jian-Feng Chen State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China BOE Technology Group Co. Ltd.Beijing 100176China

Transparent photoresists with a high refractive index(RI)and high transmittance in visible wavelengths have promising functionalities in optical *** work reports a kind of tunable optical material composed of titanium dioxide nanoparticles embedded in acrylic resin with a high RI for ultraviolet(UV)-imprint *** hybrid film exhibits a tunable RI of up to 1.67(589 nm)after being cured by UV light,while maintaining both a high transparency of over 98%in the visible light range and a low haze of less than 0.05%.The precision machining of optical microstructures can be imprinted easily and efficiently using the hybrid resin,which acts as a light guide plate(LGP)to guide the light from the side to the top in order to conserve the energy of the display *** preliminary studies based on both laboratory and commercial experiments pave the way for exploiting the unparalleled optical properties of nanocomposite resins and promoting their industrial application.

关键词： Photoresist Tunable refractive index Hanson solubility Ultraviolet imprint Organic-inorganic composites

Clinical efficacy of Gamma Knife® combined with transarterial chemoembolization and immunotherapy in the treatment of primary liver cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1601-1608页

作者： Guo-Feng Wang Chang-xin Shu Xiao-Dong Cai Hong-Bo Wang jian-Hong Xu yu-Qing Jia Department of General Surgery Yangzhou Friendship Hospital Affiliated to Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND This study was designed to investigate the clinical efficacy and safety of Gamma Knife®combined with transarterial chemoembolization(TACE)and immunotherapy in the treatment of primary liver *** To investigate the clinical efficacy and safety of Gamma Knife®combined with TACE and immune-targeted therapy in the treatment of primary liver *** Clinical data from 51 patients with primary liver cancer admitted to our hospital between May 2018 and October 2022 were retrospectively *** patients underwent Gamma Knife®treatment combined with TACE and *** clinical efficacy,changes in liver function,overall survival(OS),and progression-free survival(PFS)of patients with different treatment responses were evaluated,and adverse reactions were *** The last follow-up for this study was conducted on October 31,*** evaluation of the 51 patients with primary liver cancer revealed a partial response(PR)in 27 patients,accounting for 52.94%(27/51);stable disease(SD)in 16 patients,accounting for 31.37%(16/51);and progressive disease(PD)in 8 patients,accounting for 15.69%(8/51).The objective response rate was 52.94%,and the disease control rate was 84.31%.Alanine aminotransferase,aspartate aminotransferase,lactate dehydrogenase,and alpha-fetoprotein isoform levels decreased after treatment compared with pretreatment(all P=0.000).The median OS was 26 months[95%confidence interval(95%CI):19.946-32.054]in the PR group and 19 months(95%CI:14.156-23.125)in the SD+PD group,with a statistically significant difference(P=0.015).The median PFS was 20 months(95%CI:18.441-34.559)in the PR group and 12 months(95%CI:8.745-13.425)in the SD+PD group,with a statistically significant difference(P=0.002).Common adverse reactions during treatment included nausea and vomiting(39.22%),thrombocytopenia(27.45%),and leukopenia(25.49%),with no treatment-related deaths *** Gamma Knife®combined with TACE and immune-targeted th

关键词： Gamma Knife® Transarterial chemoembolization Immunotherapy Primary liver cancer Liver function

Reliability of transparent conductive oxide in ambient acid and implications for silicon solar cells

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eScience 2024年第3期4卷 142-151页

作者： jian yu yu Bai Qingqing Qiu Zehua Sun Lei Ye Cheng Qian Zhu Ma xin Song Tao Chen Junsheng yu Wenzhu Liu School of New Energy and Materials Southwest Petroleum UniversityChengdu 610500China Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences(CAS)Shanghai 201800China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054China State Key Laboratory of Silicon Materials Zhejiang UniversityHangzhou 310027China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164China

Transparent conductive oxide(TCO)films,known for their role as carrier transport layers in solar cells,can be adversely affected by hydrolysis products from *** this study,we explored the morphology,optical-electrical properties,and deterioration mechanisms of In2O3-based TCO films under acetic acid stress.A reduction in film thickness and carrier concentration due to acid-induced corrosion was observed.X-ray photoelectron spectroscopy and inductively coupled plasma emission spectrometry analyses revealed that TCOs doped with less-reactive metals exhibited enhanced corrosion *** efficiency of silicon heterojunction(SHJ)solar cells with tin-doped indium oxide,titanium-doped indium oxide,and zinc-doped indium oxide films decreased by 10%,26%,and 100%,respectively,after 200h of *** also found that tungsten-doped indium oxide could effectively safeguard SHJ solar cells against acetic acid corrosion,which offers a potential option for achieving long-term stability and lower levelized cost of solar cell *** research provides essential insights into selecting TCO films for solar cells and highlights the implications of ethylene-vinyl acetate hydrolysis for photovoltaic modules.

关键词： Surface morphology Deterioration mechanism Acid-induced-corrosion Transparent conductive oxide EVA hydrolysis

Calcium-chelating peptides from rabbit bone collagen:characterization,identification and mechanism elucidation

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Food Science and Human Wellness 2024年第3期13卷 1485-1493页

作者： Fuhuan yuan yu Fu Liang Ma Hankun Zhu Yong yu.xin Feng Yi Sun Hongjie Dai xin Liu Zhengfang Liu yuhao Zhang College of Food Science Southwest UniversityChongqing 400715China Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing Chongqing 400715China Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationChongqing 400715China Angel Yeast Co. Ltd.Yichang 443003China

This study aimed to characterize and identify calcium-chelating peptides from rabbit bone collagen and explore the underlying chelating *** peptides and calcium were extracted from rabbit bone by instant ejection steam explosion(ICSE)combined with enzymatic hydrolysis,followed by chelation reaction to prepare rabbit bone peptide-calcium chelate(RBCP-Ca).The chelating sites were further analyzed by liquid chromatography-tandem mass(LC-MS/MS)spectrometry while the chelating mechanism and binding modes were *** structural characterization revealed that RBCP successfully chelated with calcium ***,LC-MS/MS analysis indicated that the binding sites included both acidic amino acids(Asp and Glu)and basic amino acids(Lys and Arg),Interestingly,three binding modes,namely Inter-Linking,Loop-Linking and Mono-Linking were for the first time found,while Inter-Linking mode accounted for the highest proportion(75.1%),suggesting that chelation of calcium ions frequently occurred between two ***,this study provides a theoretical basis for the elucidation of chelation mechanism of calcium-chelating peptides.

关键词： Rabbit bone Collagen peptide Peptide-calcium chelate Chelation mechanism Liquid chromatography-tandem mass(LC-MS/MS)

Physics of cavitation near particles

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Journal of Hydrodynamics 2024年第1期36卷 102-118页

作者： Jia-xin yu Xiao-yu Wang Jun-wei Shen Jin-sen Hu Xiang-qing Zhang Da-qing He yu-ning Zhang Key Laboratory of Power Station Energy Transfer Conversion and System(Ministry of Education) School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBeijing102206China

The combined effect of cavitation and silt abrasion presents a great challenge and threat to secure the operation and the efficiency of hydraulic machineries working in sediment-laden *** present paper critically reviews the current research progress on the interaction mechanisms of the bubbles and the ***,the analytical models including boundary treatment methods for predicting the jet dynamics of the bubble collapse near particles are ***,the bubble collapsing dynamics,jet dynamics and shock wave characteristics near particles are revealed both experimentally and ***,the bubble-particle-wall system is investigated with a focus on microjets.

关键词： Cavitation bubble particle jet shock wave

Drinking water quality & health risk assessment of secondary water supply systems in residential neighborhoods

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 47-62页

作者： Yating Wei Dong Hu Chengsong Ye Heng Zhang Haoran Li xin yu College of the Environment&Ecology Xiamen UniversityXiamen 361102China School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Secondary water supply systems(SWSSs)are important components of the water supply infrastructure that ensure residents’drinking water *** are characterized by long detention time,warm temperature,and unreasonable management,which may trigger the deterioration of water quality and increase *** this study,drinking water quality index(DWQI)and health risk assessment(HRA)were selected and modified to quantitatively assess the water quality and health risks of SWSSs in residential *** total,121 seasonal water samples were *** was observed that the water quality was excellent with the DWQI of 0.14±0.04,excluding one sample,which was extremely poor owing to its excessive total bacterial *** HRA results revealed that the health risks were low:negligible non-carcinogenic risk for any population;negligible and acceptable carcinogenic risk for children aged 6–17 and ***,samples revealed higher carcinogenic risk(7.63×10−5±3.29×10−6)for children aged 0–5,and arsenic was the major *** samples had poor water quality and higher health risks,which called for *** further investigate the water quality and health risks of SWSSs,monthly sampling was conducted during *** 24 water samples were qualified in Chinese standard(GB 5749-2022)and characterized as excellent *** HRA results were consistent with the seasonal samples’and the health risks were mainly concentrated in ***,our study provides a suitable framework for water quality security,advice for managers,and references for administrators in other cities.

关键词： Drinking water quality Water quality index Health risk assessment Secondary water supply systems Heavy metals

A performance-based hybrid deep learning model for predicting TBM advance rate using Attention-ResNet-LSTM

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 65-80页

作者： Sihao yu Zixin Zhang Shuaifeng Wang xin Huang Qinghua Lei Department of Geotechnical Engineering College of Civil EngineeringTongji UniversityShanghaiChina Key Laboratory of Geotechnical and Underground Engineering Ministry of EducationTongji UniversityShanghaiChina Department of Earth Sciences ETH ZürichZürichSwitzerland Department of Earth Sciences Uppsala UniversityUppsalaSweden

The technology of tunnel boring machine(TBM)has been widely applied for underground construction worldwide;however,how to ensure the TBM tunneling process safe and efficient remains a major *** rate is a key parameter of TBM operation and reflects the TBM-ground interaction,for which a reliable prediction helps optimize the TBM ***,we develop a hybrid neural network model,called Attention-ResNet-LSTM,for accurate prediction of the TBM advance rate.A database including geological properties and TBM operational parameters from the Yangtze River Natural Gas Pipeline Project is used to train and test this deep learning *** evolutionary polynomial regression method is adopted to aid the selection of input *** results of numerical exper-iments show that our Attention-ResNet-LSTM model outperforms other commonly-used intelligent models with a lower root mean square error and a lower mean absolute percentage ***,parametric analyses are conducted to explore the effects of the sequence length of historical data and the model architecture on the prediction accuracy.A correlation analysis between the input and output parameters is also implemented to provide guidance for adjusting relevant TBM operational *** performance of our hybrid intelligent model is demonstrated in a case study of TBM tunneling through a complex ground with variable ***,data collected from the Baimang River Tunnel Project in Shenzhen of China are used to further test the generalization of our *** results indicate that,compared to the conventional ResNet-LSTM model,our model has a better predictive capability for scenarios with unknown datasets due to its self-adaptive characteristic.

关键词： Tunnel boring machine(TBM) Advance rate Deep learning Attention-ResNet-LSTM Evolutionary polynomial regression

A dephosphorylation-dependentmolecular switch for FT repression mediates flowering in Arabidopsis

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Plant Communications 2024年第3期5卷 167-178页

作者： yu Zhang Changmei Hua jian Xuan Kiang Lisha Shen Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Singapore Department of Biological Sciences Faculty of ScienceNational University of SingaporeSingapore 117543Singapore

The reproductive success offlowering plants relies greatly on precise timing of thefloral transition,which isnely modulated by a complex network offloral *** a mainfloral integrator,FLOWERING LOCUS T(FT)is also an essential constituent of theflorigen that is transported from leaves to shoot apices to *** is specically transcribed in leaf vascular tissues,where its production is suppressed by manyflowering repressors,including the MYB transcription factor EARLY FLOWERING MYB PROTEIN(EFM).Here,we show that a plant CTD phosphatase,C-TERMINAL DOMAIN PHOSPHATASE-LIKE 2(CPL2),suppresses FT expression in leaf vascular tissues by modulating the binding activity of ***2 interacts with and dephosphorylates EFM to facilitate the binding of dephosphorylated EFM to FT chromatin,thereby *** results suggest that CPL2-mediated dephosphorylation of thefloral repressor EFM serves as a molecular switch,adding another layer of regulation tone-tune FT transcription and ensure thatflowering occurs at an appropriate time.

关键词： CTD phosphatase MYB protein florigen FT flowering Arabidopsis

Berberine Inhibits Ferroptosis and Stabilizes Atherosclerotic Plaque through NRF2/SLC7A11/GPX4 Pathway

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Chinese Journal of Integrative Medicine 2024年第10期30卷 906-916页

作者： WANG Ting-ting yu Li-li ZHENG Jun-meng HAN xin-yi JIN Bo-yuan HUA Cheng-jun CHEN yu-shan SHANG Sha-sha LIANG Ya-zhou WANG jian-ru Heart Center the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

Objective:To investigate potential mechanisms of anti-atherosclerosis by berberine(BBR)using ApoE-/-***:Eight 8-week-old C57BL/6J mice were used as a blank control group(normal),and 568-week-old AopE-/-mice were fed a high-fat diet for 12 weeks,according to a completely random method,and were divided into the model group,BBR low-dose group(50 mg/kg,BBRL),BBR medium-dose group(100 mg/kg,BBRM),BBR high-dose group(150 mg/kg,BBRH),BBR+nuclear factor erythroid 2-related factor 2(NRF2)inhibitor group(100 mg/kg BBR+30 mg/kg ML385,BBRM+ML385),NRF2 inhibitor group(30 mg/kg,ML385),and positive control group(2.5 mg/kg,atorvastatin),8 in each *** 4 weeks of intragastric administration,samples were collected and serum,aorta,heart and liver tissues were *** kits were used to detect serum lipid content and the expression levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in all experimental *** pathological changes of atherosclerosis(AS)were observed by aorta gross Oil Red O,aortic sinus hematoxylin-eosin(HE)and Masson *** lipopathy was observed in mice by HE *** morphology of mitochondria in aorta cells was observed under transmission electron *** cytometry was used to detect reactive oxygen species(ROS)expression in aorta of mice in each *** content of ferrous ion Fe^(2+)in serum of mice was detected by biochemical *** mRNA and protein relative expression levels of NRF2,glutathione peroxidase 4(GPX4)and recombinant solute carrier family 7 member 11(SLC7A11)were detected by quantitative real time polymerase chain reaction(RT-q PCR)and Western blot,***:BBRM and BBRH groups delayed the progression of AS and reduced the plaque area(P<0.01).The characteristic morphological changes of ferroptosis were rarely observed in BBR-treated AS mice,and the content of Fe^(2+)in BBR group was significantly lower than that in the model group(P<0.01).BBR decreased ROS and MDA levels in mouse

关键词： berberine ApoE−/− ferroptosis atherosclerosis oxidative stress NRF2/SLC7A11/GPX4 pathway

Rational modulation of electronic structure in PtAuCuNi alloys boosts efficient electrocatalytic ethanol oxidation assisted with energy-saving hydrogen evolution

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Journal of Energy Chemistry 2024年第6期93卷 557-567,I0014页

作者： Hu Yao Yinan Zheng xin yu Songjie Hu Baolian Su Xiaohui Guo Key Lab of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education The College of Chemistry and Materials ScienceNorthwest UniversityXi’an 710069ShaanxiChina Department of Inorganic Chemistry University of NamurBruxellesB-5000 NamurBelgium

Compared to conventional electrocatalytic water splitting,electrocatalytic ethanol oxidation reaction(EOR)along with hydrogen production is considered a more energy-efficient ***,we prepared a type of novel quaternary alloy catalyst(PtAuCuNi@NF)that exhibits excellent activity for EOR(0.215 V at 10 mA cm^(-2))and hydrogen evolution reaction(HER)(7 mV at 10 mA cm^(-2)).Experimental results demonstrated that both Cu and Ni modulated the electronic environment around Pt and *** electron-rich active center facilitates the rapid adsorption and dissociation of reactants and intermediates for both EOR and ***,in the ethanol-assisted overall water splitting(E-OWS),a current density of 10 mA cm^(-2)was achieved at 0.28 ***,an advanced acid-base self-powered system(A-Bsps)that can achieve a self-powered voltage of 0.59 V was ***,the self-driven hydrogen production with zero external power supply was realized by integrating A-Bsps with the E-OWS *** interesting results can provide a feasible strategy for designing and developing advanced nanoalloy-based materials for clean energy integration and use in various fields.

关键词： Pt-based alloy Electronic structure Ethanol oxidation Self-powered system Overall water splitting