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Eco-friendly aqueous foam stabilized by cellulose microfibers with great salt tolerance and high temperature resistance

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Petroleum Science 2023年第4期20卷 2499-2511页

作者： Li-Li Yang Xian-Bo He yi-Xiu Cheng Guan-Cheng jiang Ze-Yu Liu Shi-Bo Wang Shi-Xin Qiu jian-Hua Wang Wei-Guo Tian MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and EngineeringChina University of Petroleum(Beijing)Changping DistrictBeijing102249China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of Chemistry Chinese Academy of Sciences(CAS)Haidian DistrictBeijing100190China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

A low-cost eco-friendly aqueous foam,especially the robust foam with great tolerance to high salinity and high temperature,is in great demand in the oil industry,e.g.,oil and gas well or geothermal well ***,an ultra-stable aqueous foam was developed using the biodegradable cellulose microfiber(CMF)as a foam *** foam stabilized by CMF shows excellent tolerance to the high concentration of NaCl(6.0 wt%)and CaCl_(2)(0.25 wt%)and the related drainage half-life times(T_(0.5))reach 1750 and 2340 s *** contrast,the foams without CMF are completely drained(T_(0.5)=0 s)when NaCl concentration is greater than 6.0 wt%or CaCl_(2) concentration is greater than 0.20 wt%.Notably,T0.5 of the foams stabilized by CMF at these saline concentrations still can maintain above 1000 s even after aging at 120℃ for 16 h,exhibiting an outstanding foam-stabilizing performance at high *** results suggest that the salt and high-temperature tolerance of CMF in foam stabilization is attributed to the electrically uncharged surfaces,the formation of a gel-like structure and the excellent thermal *** work not only provides a promising candidate of aqueous foam stabilizer to deal with high temperature and high salinity but also presents a natural-based solution for an environmentally friendly drilling industry in the future.

关键词： Aqueous foam Foam stabilizer Cellulose microfiber Salt tolerance Sustainable

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基于应变片法的低温条件下热膨胀特征参数的测量方法与装置（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第5期15卷 323-330页

作者： Ke TANG Long SHA yi-jian LI Tao JIN Shu-juan LIU Institute of Refrigeration and Cryogenics Zhejiang University

研究目的:为了满足低温系统的材料选择和结构设计对于材料热膨胀特征参数的需求,研发低温条件下精确、快速、方便操作、低成本的热膨胀特征参数测量方法和系统装置。创新要点:完成了卡玛合金箔应变片在77–293 K低温温区敏感系数的修正... 详细信息

研究目的:为了满足低温系统的材料选择和结构设计对于材料热膨胀特征参数的需求,研发低温条件下精确、快速、方便操作、低成本的热膨胀特征参数测量方法和系统装置。创新要点:完成了卡玛合金箔应变片在77–293 K低温温区敏感系数的修正,保证了基于应变片技术的低温条件材料热膨胀特征参数测量的精度;所研制装置合理的热设计和等速率式温度控制模式使得材料热膨胀特征参数在77–293 K温区的测量可在14小时内快速完成。研究方法:针对77–293 K温区,基于应变片测量方法,研制了采用比例-积分-微分(PID)温控系统的固体材料热膨胀特征参数测量装置(见图2和3)。通过将304不锈钢的测量数据与美国国家标准与技术研究院(NIST)公布数据进行比较,完成了卡玛合金箔应变片在77–293 K低温温区的敏感系数修正(见图7和8)。采用修正后的敏感系数进行无氧铜线性收缩率测量,并与NIST公布数据比较(见图9和表2),验证了该装置在77–293 K低温温区的测量精度。重要结论:获得了77–293 K低温温区卡玛合金箔应变片敏感系数的修正结果;基于修正敏感系数的应变片法测量装置,采用0.3 K/min的等速率式温度控制模式,可实现77–293 K低温温区固体材料热膨胀特征参数的精确、快速测量。

关键词：热膨胀线性收缩率应变片低温

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不同钾素供应和光强对油菜叶片光合能力的影响

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中国油料作物学报 2024年第4期46卷 843-854页

作者：何紫瑶陈其睿胡文诗谷贺贺宋毅叶晓磊张洋洋陆志峰任涛鲁剑巍华中农业大学资源与环境学院/华中农业大学微量元素研究中心湖北武汉430070

为明确钾素供应和光强对油菜叶片生长和光合特性的影响,本研究采用钾素供应和光强两因素的试验设计,其中钾素供应设计3个水平,分别为严重缺钾(0.03 mmol·L^(-1)KCl)、轻度缺钾(0.09 mmol·L^(-1)KCl)和充足钾供应(2.00 mmol·L^(-1)KC... 详细信息

为明确钾素供应和光强对油菜叶片生长和光合特性的影响,本研究采用钾素供应和光强两因素的试验设计,其中钾素供应设计3个水平,分别为严重缺钾(0.03 mmol·L^(-1)KCl)、轻度缺钾(0.09 mmol·L^(-1)KCl)和充足钾供应(2.00 mmol·L^(-1)KCl),光强设置2个水平,分别为低光强(LL,~200μmol·m^(-2)·s^(-1))和高光强(HL,~400μmol·m^(-2)·s^(-1)),在水培条件下研究了不同钾素供应和光强处理油菜叶片的生长、气体交换参数、叶绿素荧光特征以及叶肉细胞超微结构特征,以期为多变环境条件下钾肥的合理施用提供理论依据。结果表明,钾素供应和光强显著影响油菜叶片的生长。相同的钾素供应下,高光强处理油菜叶片厚度和比叶重较低光强分别增加了19.6%~24.3%和57.1%~73.6%,而在严重缺钾胁迫时,净光合速率较低光强条件降低了63.8%。严重缺钾胁迫叶片在高光强条件下受到光抑制,实际光化学效率、最大羧化速率和最大电子传递速率等光合关键参数明显降低,叶绿体发育不良,同时缺钾导致叶肉细胞间空隙比例减小,叶肉导度降低,进而使得叶片光合能力显著下降。综上所述,钾素供应和光强共同调节叶片形态结构,影响光合能力,高光强下钾素供应不足会严重影响油菜的生长,合理施用钾肥有利于提高油菜对光强变化的适应性,保持光合能力的稳定。

关键词：油菜钾光照强度光合作用叶绿体超微结构叶绿素荧光

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Expression profiles and function of Toll-like receptors in human corneal epithelia

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Chinese Medical Journal 2007年第10期120卷 893-897页

作者： WU Xin-yi GAO jian-lu REN Mei-yu Department of Ophthalmology Qilu Hospital Shandong University Jinan 250012 China

Background Toll-like receptors play an important role in the human immune system. This study was conducted to investigate the expression profiles and function of Toll-like receptor （TLR）1-9 in human corneal epithelium. Methods The expression of TLR1-9 mRNA in 20 human donor corneal epithelia samples abraded during photorefractive keratotomy （PRK） and cultivated telomerase-immortalized human corneal epithelial cells （THCEs） was examined by semi-quantitative reverse-transcriptase polymerase chain reaction （RT-PCR） analysis. Human peripheral blood mononuclear cells （PBMCs） were used as positive controls. The expression of the TLR2 and TLR4 proteins was detected by Western analysis. ELISA was used to detect IL-8 secretion from THCEs challenged with ligands for TLR3 and TLR4 with and without antibody blockade. Results The expression of TLR1-9 at the mRNA level was detected in the epithelia of 20 patients and in THCE. Significant differences among individuals were observed. One patient was found to lack of the expression of TLR3, 4, 6 and 8, whereas another did not express TLRS. The expression of TLR2 and TLR4 protein was detected in human corneal epithelial cells. As THCE cells express TLR1-9, cells were challenged with lipopolysaccharides （LPS） and poly I：C to determine whether TLR4 and TLR3 were functional. The results showed that secretion of IL-8 by cells stimulated with LPS and Poly I：C was 7 to 10 fold greater than secretion by unchallenged cells. Blocking TLR4 with an anti-TLR4 antibody significantly inhibited the LPS-induced IL-8 production by THCE （P〈0.05）. Conclusion Human corneal epithelial cells express multiple TLRs and are able to recognize LPS and poly I：C. Different expression profiles among individuals suggest that differences in the susceptibilities and sensitivities to bacterial and viral infection in human populations relate to different patterns of TLR expression.

关键词： Toll-like receptors corneal epithelium, human gene expression ligand

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Effect of Mono-2-ethyhexyl Phthalate on DNA Methylation in Human Prostate Cancer LNCaP Cells

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Biomedical and Environmental Sciences 2017年第9期30卷 641-648页

作者： WU jian Hui CHEN Jiao WANG Yong XIA Bin WANG Rong ZHAO Yan WANG qin Xia SONG Qi YAO Shun Heng ZHANG Yun Hui SUN Zu Yue National Evaluation Centre for the Toxicology of Fertility Regulating Drug Department of Pharmacology and ToxicologyShanghai Institute of Planned Parenthood ResearchShanghai 200032China Key Laboratory of Reproduction Regulation of NPFPC Shanghai 200032China Reproductive and Developmental Research Institute of Fudan University ShanghaiShanghai 200032China Division of Health Risk Factors Surveillance and Control Shanghai Municipal Center for Disease Control and PreventionShanghai 200336China Key Laboratory of Public Health Safety Ministry of EducationSchool of Public HealthFudan UniversityShanghai 200032China

Objective To evaluate whether mono（2‐ethylhexyl） phthalate（MEHP） affects genomic DNA methylation and the methylation status of some specific genes such as patched gene（PTCH） and smoothened gene（SMO） in LNCaP cells. Methods LNCaP cells were treated with MEHP（0, 1, 5, 10, and 25 μmol/L） for 3 days. An ELISA assay was preformed to detect genomic methylation, including 5‐methylcytosine（5‐mC） and 5‐hydroxymethylcytosine（5‐hmC） content. A pyrosequencing assay was applied to assess DNA methylation in PTCH and SMO gene promoters. The correlation between DNA methylation and gene expression was assessed. Results The proportion of cytosines with 5‐mC methylation in LNCaP cells was significantly decreased by MEHP（1, 5, 10, and 25 μmol/L） in a dose‐dependent manner（P 〈 0.01）. For genes in the Hedgehog pathway, there was no significant MEHP concentration‐dependent difference in the DNA methylation of PTCH and SMO. Conclusion MEHP might affect the progression of prostate cancer through its effect on global DNA methylation.

关键词： Mono(2‐ethyhexyl) phthalate LNCaP Genomic Methylation PTCH SMO

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激光粒度仪测定Y型分子筛粉体粒度的影响因素

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石化技术与应用 2024年第1期42卷 71-74页

作者：曹庚振王辰晨黄剑锋杨一青中国石油石油化工研究院、兰州化工研究中心甘肃兰州730060

采用带有湿法分散单元的马尔文激光粒度仪,对Y型分子筛粉体粒度进行测试,考察了加样方式、超声时间、折射率、吸收率、转速、遮光度等因素对粉体粒度的影响。结果表明:Y型分子筛粉体粒度的最佳测试条件为:预分散加样法,超声功率为40 W,... 详细信息

采用带有湿法分散单元的马尔文激光粒度仪,对Y型分子筛粉体粒度进行测试,考察了加样方式、超声时间、折射率、吸收率、转速、遮光度等因素对粉体粒度的影响。结果表明:Y型分子筛粉体粒度的最佳测试条件为:预分散加样法,超声功率为40 W,超声处理时间为60 s,进样器转速为2500 r/min,样品遮光度为8%~15%,折射率为1.46,吸收率为0.001;经5次重复测定,D10,D50,D90(样品累计粒径分布百分数为10%,50%,90%时相对应的粒径)的相对标准偏差最高为6.275%,加权残差值最高为0.429。

关键词：激光粒度仪 Y型分子筛粒径分布粒度加权残差相对标准偏差

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Analysis of Distributed and Adaptive Genetic Algorithm for Mining Interesting Classification Rules

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现代电子技术 2008年第10期31卷 132-135,138页

作者： yi Yunfei LIN Fang qin Jun Hechi University H echi 546300 China College of Computer Science South Central University for Nationalities Wuhan430074China

Distributed genetic algorithm can be combined with the adaptive genetic algorithm for mining the interesting and comprehensible classification *** paper gives the method to encode for the rules,the fitness function,th... 详细信息

关键词：分析方法分类规则计算方法编码智能系统

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Chinese Tuina Downregulates the Elevated Levels of Tissue Plasminogen Activator in Sciatic Nerve Injured Sprague-Dawley Rats

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Chinese Journal of Integrative Medicine 2017年第8期23卷 617-624页

作者： PAN Fan YU Tian-yuan Steven Wong XIAN Si-tong LU Meng-qian WU jian-cong GAO Yu-feng LI Xiao-qin GENG Nan YAO Bin-bin Collage of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine The 2nd Massage Department Beijing Massage Hospital Department of Encephalopathy of Mogol Medicine Affiliated Hospital of Inner Mongolia University for the Nationalities Department of Acupuncture and Moxibustion Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine Department of Massage Physiotherapy Beijing University of Chinese Medicine Dongfang Hospital

Objective：To elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury,and to detect the levels of tissue plasminogen activator（t PA）and plasminogen activator inhibitor-1（PAI-1）,which is thought to play an important role in nerve ***：Thirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats（sham-operated group）went through a sham *** group was given no treatment while tuina group received tuina therapy since day 7 *** treatment was performed once a day and lasted for 20 *** sciatic functional index was examined every 5days during the treatment *** rats＇gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tP A and ***：Tuina therapy improved the motor function of sciatic nerve injured rats（P〈0.05）,however,it did not increase muscle volume（P〈0.05）.Tuina downregulated the levels of t PA and PAI-1（P〈0.05）.Conclusions：The present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury.

关键词： Chinese medicine physical therapy peripheral neuropathy massage

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High Reliability LM-2F Launch Vehicle for Space Station Mission

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Aerospace China 2022年第1期23卷 12-18页

作者： qin Tong RONG yi HU Yanchen LI Wenqing Beijing Institute of Astronautical Systems Engineering Beijing 100076 China Academy of Launch Vehicle Technology Beijing 100076

As China’s only manned launch vehicle,the LM-2 F Launch vehicle successfully launched the Shenzhou 12 manned spacecraft into its predetermined orbit on June 12,2021,signifying the successful completion of the first manned launch mission in the construction and key technology test stage of China Space Station(CSS).From the launch of the Shenzhou 11 manned spacecraft on October 12,2016 to the launch of Shenzhou 12 in 2021,over the past five years,the LM-2 F launch vehicle has been continuously improved in terms of product reliability through technological innovation and design improvement,and its flight reliability index has increased from 0.97 to *** on the new launch mission requirements for the construction stage of CSS,this paper introduces the technological innovation and reliability improvement methods of the LM-2 F from the aspects of design improvement,research methods and process *** LM-2 F launch vehicle will make greater contributions in supporting the construction of CSS with higher reliability and perfect launch success rate.

关键词： space station mission high reliability technological innovation design improvement

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树豆酮酸A可减轻db/db小鼠非酒精性脂肪肝损伤

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中国生物化学与分子生物学报 2024年第3期40卷 373-382页

作者：王一凡吕厚星李志阳代云莉冯昭卫陈佳佳陈圣杰王建塔肖瑛贵州省常见慢性疾病发病机制及药物研究重点实验室贵州医科大学病理生理学教研室贵阳550025 贵州省化学合成药物研发利用工程技术研究中心贵阳550004

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是指肝中储存过多的脂肪,与肥胖、胰岛素抵抗、2型糖尿病(type-2 diabetes mellitus,T2DM)、血脂异常等代谢综合征密切相关。肝纤维化是NAFLD进一步发展为肝细胞癌(hepatoce... 详细信息

非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)是指肝中储存过多的脂肪,与肥胖、胰岛素抵抗、2型糖尿病(type-2 diabetes mellitus,T2DM)、血脂异常等代谢综合征密切相关。肝纤维化是NAFLD进一步发展为肝细胞癌(hepatocellular carcinoma,HCC)的关键过程,减少肝内的脂肪积累,从而延缓或阻止NAFLD向纤维化的进展是治疗的关键。树豆酮酸A(cajanonic acid A,CAA)在2型糖尿病中能够有效改善胰岛素抵抗,发挥降糖减脂作用。本研究旨在探究CAA对NAFLD肝损伤的保护作用。通过采用db/db自发性NAFLD小鼠模型,将db/db小鼠分为NAFLD组和CAA给药组,CAA组予50 mg/(kg·d)灌胃给药,同期C57BL小鼠作为正常对照组(NC组),每组6只。小鼠生化指标检测和组织病理染色发现,CAA干预可有效缓解db/db小鼠的糖脂代谢紊乱、肝功能损伤(P<0.05)及肝脂肪变性和减少脂质沉积(P<0.05)。ELISA法结果显示,经过CAA治疗后肝组织上清液中白细胞介素1β(Interlecukin-1β,IL-1β)的水平显著降低(P<0.05),提示CAA具有明显抗炎作用,并且CAA干预显著减轻小鼠肝的纤维化程度,天狼星红染色发现,CAA组胶原沉积显著减少(P<0.05),进一步Western印迹结果表明,CAA组纤维化相关基因纤连蛋白(fibronectin,FN)、α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)蛋白质水平表达降低,E-钙黏着蛋白(E-cadherin,E-ca)的表达升高(P<0.05)。E2F转录因子1(E2F transcription factor 1,E2F1)被证实在肝中是葡萄糖和脂质代谢的主要因子,在肥胖小鼠中表达增加,并且可通过PPARγ的转录调节参与脂肪组织代谢,我们猜测,E2F1是CAA改善NAFLD肝脂质沉积和纤维化的中间作用靶标。通过免疫组织化学染色观察E2F1和其同家族拮抗转录因子E2F转录因子7(E2F transcription factor 7,E2F7)在小鼠经CAA处理后在肝组织核质中均表达,通过Western印迹法和实时荧光定量PCR进一步检测蛋白质和mRNA的表达发现,在CAA组中E2F1较NAFLD组基因表达降低(P<0.05),E2F7基因表达增加(P<0.05),并且spearman秩相关分析提示,E2F1和E2F7呈显著负相关(P<0.05)。以上结果表明,树豆酮酸A可有效减轻db/db小鼠非酒精性脂肪性肝损伤,改善糖脂代谢紊乱,抑制脂质过度沉积,减轻肝纤维化以缓解NAFLD进一步发展,同时E2F1和E2F7可能参与了CAA改善脂质代谢和纤维化的过程。

关键词：非酒精性脂肪性肝病 E2F转录因子1 E2F转录因子7 树豆酮酸A 肝纤维化上皮-间充质转化

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