检索结果-南通市图书馆

Chinese Journal of Polymer Science 2022年第1期40卷 75-84页

作者： Zi-Yun Shen Qi-Yong Mei yi Liu Liu-Chun Zheng Chun-Cheng Li Jia-jian Liu Yao-Nan Xiao Shao-Hua Wu Bo Zhang Beijing National Laboratory for Molecular Sciences Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Department of Neurosurgery Changzheng Hospitalthe Second Military Medical UniversityShanghai 200003China School of Textile Science and Engineering Tiangong UniversityTianjin 300387China

A series of non-isocyanate linear high molecular weight poly(ester urethane)s(PETUs)were prepared through an environmentallyfriendly route based on dimethyl carbonate,1,6-hexanediol and 1,*** this route,the polyurethane diol was first prepared by the reaction between bis-1,6-hexamethylencarbamate(BHC)and 1,6-hexanediol.A series of polyester soft segments of polyurethane have been synthesized from the polycondensation of adipic acid and different diols,including butanediol,hexanediol,octanediol and *** subsequent polycondensation of polyurethane diol and polyester diol led to linear *** resultant polymers were characterized by GPC,FTIR,^(1)H-NMR,^(13)C-NMR,DSC,WAXD,TGA and tensile *** results indicated that PETUs possess weight-average molecular weights higher than 1×10^(5) and the tensile strength as high as 10 *** thermal properties,crystallization behavior,microphase separation behavior and morphology were studied by DSC and AFM,and the results indicated that the degree of phase separation was affected by two factors,the crystallization and hydrogen bonding interaction between soft segment and hard segment.

关键词： Non-isocyanate Poly(ester urethane) Polyester-diol

在线全文

学校读者我要写书评

暂无评论

麦冬多糖对破骨细胞分化的影响研究

现代医药卫生 2024年第2期40卷 190-195页

作者：易倩张合富李官翔樊丽莎邓加加张伶燕张健贵州中医药大学药学院贵州贵阳520025 贵州中医药大学实验动物研究所贵州贵阳520025

目的探讨麦冬多糖(OPS)对破骨细胞分化的影响。方法从C57BL/6j小鼠股骨中提取骨髓单核巨噬细胞(BMMs),在细胞培养液中分别添加2.5、10.0和40.0μg/mL OPS(A、B、C组),对照组未添加OPS。检测OPS对BMMs细胞活性、破骨细胞骨吸收能力及抗... 详细信息

目的探讨麦冬多糖(OPS)对破骨细胞分化的影响。方法从C57BL/6j小鼠股骨中提取骨髓单核巨噬细胞(BMMs),在细胞培养液中分别添加2.5、10.0和40.0μg/mL OPS(A、B、C组),对照组未添加OPS。检测OPS对BMMs细胞活性、破骨细胞骨吸收能力及抗酒石酸酸性磷酸酶(TRAP)活性的影响,同时分析OPS对碳酸酐酶2(Car2)、组织蛋白酶K(CTSK)、基质金属蛋白酶9(MMP-9)、TRAP、液泡型H^(+)-ATP酶(V-ATPase)mRNA表达的影响。结果A、B、C组48、96 h时吸光度值比较,差异无统计学意义(P>0.05)。与对照组(1.00±0.15)比较,B组成熟破骨细胞数目降低至(0.61±0.06)(P<0.05),而C组成熟破骨细胞数目为(0.31±0.03)(P<0.05)。与对照组相比,B、C组5 d时破骨细胞TRAP活性显著降低(P<0.05)。A、B、C组7 d时破骨细胞TRAP活性显著低于对照组(P<0.05)。A、B、C组骨吸收面积仅为对照组的71%、40%和6%(P<0.05)。与对照组比较,B、C组Car2、CTSK、MMP-9、TRAP、V-ATPase mRNA表达水平显著降低(P<0.01)。结论OPS可显著抑制破骨细胞分化功能,是一种潜在的用于骨质疏松治疗的抗骨吸收药物。

关键词：破骨细胞麦冬多糖分化骨吸收骨质疏松

Atmospheric Sulfur Deposition for a Red Soil Broadleaf Forest in Southern China

在线全文

学校读者我要写书评

暂无评论

Pedosphere 2004年第3期14卷 323-330页

作者： XUCheng-Kai HUZheng-yi CAIZu-Cong WANGTi-jian HEYuan-Qiu CAOZhi-Hong StateKeyLaboratoryofSoilandSustainableAgriculture InstituteofSoilScienceChineseAcademyofSciencesNanjing210008（China） DepartmentofAtmosphericScience NanjingUniversityNanjing210093（China）

A two-year study in a typical red soil region of Southern China was conductedto determine 1) the dry deposition velocity (V_d) for SO_2 and particulate SO_4^(2-) above abroadleaf forest, and 2) atmospheric sulfur fluxes so as to estimate the contribution of variousfractions in the total. Using a resistance model based on continuous hourly meteorological data,atmospheric dry sulfur deposition in a forest was estimated according to V_d and concentrations ofboth atmospheric SO_2 and particulate SO_4^(2-). Meanwhile, wet S deposition was estimated based onrainfall and sulfate concentrations in the rainwater. Results showed that about 99% of the drysulfur deposition flux in the forest resulted from SO_2 dry deposition. In addition, the observeddry S deposition was greater in 2002 than in 2000 because of a higher average concentration of SO_2in 2002 than in 2000 and not because of the average dry deposition velocity which was lower for SO_2in 2002. Also, dry SO_2 deposition was the dominant fraction of deposited atmospheric sulfur inforests, contributing over 69% of the total annual sulfur deposition. Thus, dry SO_2 depositionshould be considered when estimating sulfur balance in forest ecological systems.

关键词： atmospheric sulfur deposition dry deposition velocity particulateSO_4^(2-) red soil, SO_2

不同雌雄成虫密度及性比对红彩瑞猎蝽繁殖力和寿命的影响

在线全文

学校读者我要写书评

暂无评论

湖北农业科学 2024年第6期63卷 75-80页

作者：游梓翊夏长剑蒲小明孙郑邓海滨广东省烟草科学研究所广东韶关512029 中国烟草总公司海南省公司海口雪茄研究所海口571100 广东省农业科学院植物保护研究所广州510640

在室内条件[温度(28±1)℃,相对湿度70%±7%,光照周期16 h(L)∶8 h(D)]下,测定不同雌雄成虫密度(雌∶雄=1∶1、2∶2、3∶3和4∶4)和不同性比(头/盒)(雌∶雄=1∶0、1∶2、1∶3、1∶4、2∶1、3∶1、3∶2和4∶1)对捕食性天敌红彩瑞猎蝽(Rhy... 详细信息

在室内条件[温度(28±1)℃,相对湿度70%±7%,光照周期16 h(L)∶8 h(D)]下,测定不同雌雄成虫密度(雌∶雄=1∶1、2∶2、3∶3和4∶4)和不同性比(头/盒)(雌∶雄=1∶0、1∶2、1∶3、1∶4、2∶1、3∶1、3∶2和4∶1)对捕食性天敌红彩瑞猎蝽(Rhynocoris fuscipes Fabricius)产卵前期、产卵期、产卵量、孵化率、寿命和子代雌雄性比的影响。结果表明,红彩瑞猎蝽成虫繁殖存在孤雌生殖现象,可产下有效卵。不同雌雄成虫密度和雌雄性比对红彩瑞猎蝽产卵前期和卵孵化率的影响不明显,对产卵期、产卵量、子代雌雄性比和雌雄成虫寿命有显著影响,总产卵量随着配比中雌成虫密度的增加而增加,但是每雌产卵量和孵出若虫数量逐渐减少;雌成虫、雄成虫平均寿命均随着雌雄成虫密度的增加而减小。其中雌雄性比为2∶1的处理平均产卵期最长(39.5 d),平均每雌产卵量最高(136.40粒),每雌孵出若虫数最多(130.30头)。在交配过程中,红彩瑞猎蝽成虫密度过大会出现种内互残现象,基于研究结果中各项繁殖力和寿命参数结果,雌雄性比2∶1是人工饲养红彩瑞猎蝽成虫繁殖的较佳密度和性比。

关键词：红彩瑞猎蝽(Rhynocoris fuscipes Fabricius) 性比雌雄成虫密度繁殖能力寿命

Characteristics and Correlation Analysis of Negative Emotions, Quality of Life, and Chinese Medicine Syndromes in Patients with Lung Cancer after Surgery: A Cross-sectional Study

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2023年第3期9卷 307-313页

作者： Cong-Meng Zhang yi-Feng Gu Sheng-Ping Shen yi-Chao Wang Ao Qi Ling-Zi Su Jia-Lin Yao Jia-Qi Li Wen-Xiao Yang qin Wang Li-Jing Jiao Xiong qin Ya-Bin Gong Ling Xu Department of Oncology Shanghai Yueyang Integrated Traditional Chinese Medicine and Western Medicine HospitalShanghaiChina Department of Oncology Shanghai Chest HospitalAffiliated Chest Hospital of Shanghai Jiao Tong UniversityShanghaiChina Department of Thoracic Surgery Shanghai Pulmonary HospitalShanghaiChina

Objective:The objective of the study was to observe and analyze the characteristics of negative emotions and quality of life(QoL)in patients with nonsmall cell lung cancer(NSCLC)from 1 to 3 months after surgery,and summarize their population characteristics after *** and Methods:The consolidation rehabilitation period was defined as 1 to 3 months after *** main observation indicators were the general Hospital Anxiety and Depression Scale,the European Organization for the Research and Treatment of Cancer Core QoL Questionnaire(EORTC QLQ-C30),and EORTC QLQ-Lung *** secondary observation indicators were peripheral blood cytokines and immune function *** methods such as one-way analysis of variance and logistic regression were used to analyze the characteristics of this part of the ***:Among patients who underwent lung surgery,the overall incidence of anxiety during consolidation recovery was 13.66%,and that of depression was 10.38%.The scores of fatigue,pain,dyspnea,insomnia,and loss of appetite were significantly higher than those of other symptoms(P=0.000).The presence of anxiety was associated with the site of surgery(P<0.05)and the presence of depression was associated with emotional functioning and dyspnea(P<0.05).Conclusions:The occurrence of negative emotions in the postoperative NSCLC population is related to gender,and the degree of emotions is negatively correlated with QoL and positively correlated with the degree of *** main relevant syndromes are the pulmonary and meridian categories.

关键词： Chinese medicine syndromes lung cancer negative emotions postoperative quality of life rehabilitation

靶向抗TIGIT和PVRIG双特异抗体的制备及体外生物性活性的研究

在线全文

学校读者我要写书评

暂无评论

新疆医科大学学报 2024年第8期47卷 1153-1160页

作者：叶银松米梓毓雷毅康金森郝锋宁金鹰杨建新疆医科大学药学院乌鲁木齐830017 新疆天然药物活性组分与释药技术重点实验室乌鲁木齐830000 康源博创生物科技(北京)有限公司北京100010

目的制备靶向抗T细胞免疫球蛋白-ITIM结构域蛋白(T cell immune receptor with Ig and ITIM domains,TIGIT)和脊髓灰质炎病毒受体相关免疫球蛋白结构域蛋白(Poliovirus receptor-related immunoglobin domain-containing protein,PVRIG)双特异抗体,探究其体外生物学活性。方法用PVRIG人源化抗体hP1和TIGIT人源化抗体hT1构建KY-TIGIT-hlgG4M-PVRIG-SCFV双特异性抗体,将纯化得到KY-TIGIT-hlgG4M-PVRIG-SCFV抗体进行SDS-PAGE凝胶电泳、热稳定性检测和稳定性分析;采用流式细胞术(Fluorescence activated cell sorting,FACS)检测双特异性抗体的结合活性;采用生物干涉膜技术(Bio-layer interferometry,BLI)检测双特异性抗体亲和力;用Jurkat-NFAT-Luc2-PD1-TIGIT-PVRIG细胞和293T-OS8-PVRL2-PDL1细胞中检测双特异性抗体KY-TIGIT-hlgG4M-PVRIG-SCFV对于TIGIT/PVRIG靶点的阻断作用;采用CMV recall assay法检测IFN-r在上清液中的浓度。结果SDS-PAGE凝胶电泳结果显示KY-TIGIT-hlgG4M-PVRIG-SCFV双特异性抗体纯度>95%;Tm结果为Tm1:66.34,Tm2:80.95。采用SEC-HPLC对双特异性抗体KY-TIGIT-hlgG4M-PVRIG-SCFV进行稳定性分析,其纯度均>90%。KY-TIGIT-hlgG4M-PVRIG-SCFV抗体和PVRIG的人源化抗体hP1与293T-PVRIG cell line的EC 50分别为0.16870μg/mL和0.03865μg/mL,与293T-cyno-PVRIG cell line的EC 50分别为0.03714μg/mL和0.03198μg/mL,与Human PVRIG Protein,His Tag的亲和力为1.74E-10M和1.69E-10M。KY-TIGIT-hlgG4M-PVRIG-SCFV抗体和TIGIT的人源化抗体hT1与293T-PVRIG cell line的EC 50分别为0.07027μg/mL和0.03121μg/mL;与293T-cyno-TIGIT cell line的EC 50分别为0.02028μg/mL和0.02822μg/mL;与Human TIGIT Protein,His Tag的亲和力为8.50E-10M和8.47E-10M。KY-TIGIT-hlgG4M-PVRIG-SCFV抗体具有阻断PD1/PDL1/TIGIT/PVRIG相互作用活性,且KY-TIGIT-hlgG4M-PVRIG-SCFV的EC 50为0.007μg/mL,优于单独人源化抗体hT1(EC 50为0.013μg/mL)和hP1(EC 50为0.048μg/mL)的作用。在含pp65 peptide条件下KY-TIGIT-hlgG4M-PVRIG-SCFV抗体分泌IFN-r为349.72 pg/mL,明显高于其他抗体。结论KY-TIGIT-hlgG4M-PVRIG-SCFV抗体具有高亲和力和良好的生物学活性,有望开发成为肿瘤免疫治疗的抗体药物。

关键词： T细胞免疫球蛋白和ITIM结构域蛋白脊髓灰质炎病毒受体相关免疫球蛋白结构域蛋白人源化抗体双特异性抗体生物学活性

The Significant Role of Radiosonde-measured Cloud-base Height in the Estimation of Cloud Radiative Forcing

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2021年第9期38卷 1552-1565页

作者： Hui XU jianping GUO jian LI Lin LIU Tianmeng CHEN Xiaoran GUO Yanmin LYU Ding WANG yi HAN Qi CHEN Yong ZHANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China College of Earth Sciences University of Chinese Academy of SciencesBeijing 100049China Meteorological Observation Center China Meteorological AdministrationBeijing 100081China

The satellite-based quantification of cloud radiative forcing remains poorly understood,due largely to the limitation or uncertainties in characterizing cloud-base height(CBH).Here,we use the CBH data from radiosonde measurements over China in combination with the collocated cloud-top height(CTH) and cloud properties from MODIS/Aqua to quantify the impact of CBH on shortwave cloud radiative forcing(SWCRF).The climatological mean SWCRF at the surface(SWCRFSUR),at the top of the atmosphere(SWCRFTOA),and in the atmosphere(SWCRFATM) are estimated to be-97.14,-84.35,and 12.79 W m^(-2),respectively for the summers spanning 2010 to 2018 over *** illustrate the role of the cloud base,we assume four scenarios according to vertical profile patterns of cloud optical depth(COD).Using the CTH and cloud properties from MODIS alone results in large uncertainties for the estimation of SWCRFATM,compared with those under scenarios that consider the ***,the biases of the CERES estimation of SWCRFATM tend to increase in the presence of thick clouds with low ***,the discrepancy of SWCRFATM relative to that calculated without consideration of CBH varies according to the vertical profile of *** a uniform COD vertical profile is assumed,the largest SWCRF discrepancies occur during the early morning or late *** comparison,the two-point COD vertical distribution assumption has the largest uncertainties occurring at noon when the solar irradiation *** findings justify the urgent need to consider the cloud vertical structures when calculating the SWCRF which is otherwise neglected.

关键词： cloud base height radiosonde radiative forcing China climatology

Baculoviral inhibitor of apoptosis protein repeatcontaining protein 3 delays early Wallerian degeneration after sciatic nerve injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第4期17卷 845-853页

作者： Min Cai jian Shao Bryant Yung yi Wang Nan-Nan Gao Xi Xu Huan-Huan Zhang Yu-Mei Feng Deng-Bing Yao Nantong University Medical School NantongJiangsu ProvinceChina School of Life Sciences Jiangsu Key Laboratory of NeuroregenerationCo-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Wallerian degeneration is a complex biological process that occurs after nerve injury,and involves nerve degeneration and *** cells play a crucial role in the cellular and molecular events of Wallerian degeneration of the peripheral nervous ***,Wallerian degeneration regulating nerve injury and repair remains largely unknown,especially the early *** have previously reported some key regulators of Wallerian degeneration after sciatic nerve *** inhibitor of apoptosis protein repeat-containing protein 3(BIRC3)is an important factor that regulates apoptosis-inhibiting *** this study,we established rat models of right sciatic nerve *** vitro Schwann cell models were also established and subjected to gene transfection to inhibit and overexpress *** data indicated that BIRC3 expression was significantly up-regulated after sciatic nerve *** BIRC3 upregulation and downregulation affected the migration,proliferation and apoptosis of Schwan cells and affected the expression of related factors through activating c-fos and ERK signal *** of BIRC3 delayed early Wallerian degeneration through inhibiting the apoptosis of Schwann cells after sciatic nerve *** findings suggest that BIRC3 plays an important role in peripheral nerve injury repair and *** study was approved by the Institutional Animal Care and Use Committee of Nantong University,China(approval No.2019-nsfc004)on March 1,2019.

关键词： apoptosis baculoviral inhibitor of apoptosis protein repeat-containing protein 3 nerve degeneration rat Schwann cell sciatic nerve injury signal pathway Wallerian degeneration

The AGH score is a predictor of disease-free survival and targeted therapy efficacy after liver transplantation in patients with hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 245-252页

作者： jian-Hua Li Tuo Chen Hao Xing Rui-Dong Li Cong-Huan Shen Quan-Bao Zhang yi-Feng Tao Zheng-Xin Wang Department of General Surgery Huashan HospitalFudan University12 Urumqi Road(M)Shanghai 200040China Department of Intensive Care Unit Huashan HospitalFudan University12 Urumqi Road(M)Shanghai 200040China

Background:Liver transplantation(LT)is the“cure”therapy for patients with hepatocellular carcinoma(HCC).However,some patients encounter HCC recurrence after ***,there is no effective methods to identify the LT patients who have high risk of HCC recurrence and would benefit from adjuvant targeted *** present study aimed to establish a scoring system to predict HCC recurrence of HCC patients after LT among the Chinese population,and to evaluate whether these patients are suitable for adjuvant targeted ***:Clinical data of HCC patients who underwent LT from March 2015 to June 2019 were retrospectively collected and ***:A total of 201 patients were included in the *** multivariate Cox analysis suggested that preoperative alpha-fetoprotein(AFP)>200μg/L(HR=2.666,95%CI:1.515-4.690;P=0.001),glutamyl transferase(GGT)>96 U/L(HR=1.807,95%CI:1.012-3.224;P=0.045),and exceeding the Hangzhou criteria(HR=2.129,95%CI:1.158-3.914;P=0.015)were independent risk factors for poor disease-free survival(DFS)in patients with HCC who underwent *** established an AFP-GGT-Hangzhou(AGH)scoring system based on these factors,and divided cases into high-,moderate-,and low-risk *** differences in overall survival(OS)and disease-free survival(DFS)rates among the three groups were significant(P<0.05).The efficacy of the AGH scoring system to predict DFS was better than that of the Hangzhou criteria,UCSF criteria,Milan criteria,and TNM *** in the high-risk group,we found that lenvatinib significantly improved prognosis compared with that of the control group(P<0.05).Conclusions:The AGH scoring system provides a convenient and effective way to predict HCC recurrence after LT in HCC patients in *** with a high-risk AGH score may benefit from lenvatinib adjuvant therapy after LT.

关键词： Liver transplantation Hepatocellular carcinoma Prognosis Adjuvant targeted therapy Predicting

Intra-continental deformation and tectonic evolution of the West Junggar Orogenic Belt,Central Asia:Evidence from remote sensing and structural geological analyses

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2020年第2期11卷 651-663页

作者： Wei-Cui Ding Ting-Dong Li Xuan-Hua Chen jian-Ping Chen Sheng-Lin Xu yi-Ping Zhang Bing Li Qiang Yang School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China SinoProbe Center Chinese Academy of Geological Sciences and China Geological SurveyBeijing 100037China Center for Hydrogeology and Environmental Geology CGSBaodingHebei 071051China

The West Junggar Orogenic Belt(WJOB)in northwestern Xinjiang,China,is located in the core of the western part of the Central Asian Orogenic Belt(CAOB).It has suffered two stage tectonic evolutions in Phanerozoic,before and after the ocean–continental conversion in Late *** later on intracontinental deformation,characterized by the development of the NE-trending West Junggar sinistral strike-slip fault system(WJFS)since Late Carboniferous and Early Permian,and the NW-trending Chingiz-Junggar dextral strike-slip fault(CJF)in Mesozoic and Cenozoic,has an important significance for the tectonic evolution of the WJOB and the *** this paper,we conduct geometric and kinematic analyses of the WJOB,based on field geological survey and structural interpretation of remote sensing image *** some piercing points such as truncated plutons and anticlines,an average magnitude of^73 km for the left-lateral strike-slip is calculated for the Darabut Fault,a major fault of the *** partial of the displacement should be accommodated by strike-slip fault-related folds developed during the strike-slip *** and curved faults,asymmetrical folds,and irregular contribution of ultramafic bodies,implies potential opposite vertical rotation of the Miao’ergou and the Akebasitao batholiths,resulted from the sinistral strike-slipping along the Darabut *** to conjugate shearing set of the sinistral WJFS and the dextral CJF since Early Mesozoic,superimposed folds formed with N–S convergence in southwestern part of the WJOB.

关键词： Remote sensing Structural analysis Strike-slip fault system Darabut fault West Junggar Central Asian orogenic belt