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Oxcarbazepine oral suspension in young pediatric patients with partial seizures and/or generalized tonic-clonic seizures in routine clinical practice in China: a prospective observational study

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World Journal of Pediatrics 2018年第3期14卷 280-289页

作者： Jiong qin yi Wang Xin-Fang Huang Yu-qin Zhang Fang Fang yin-Bo Chen Zhong-Dong Lin Yan-Chun Deng Fei yin Li jiang Ye Wu Xiang-Shu Hu Department of Pediatrics Peking University People’s HospitalNo.11 Xi Zhi Men Nan Da JieXicheng DistrictBeijing 100044China Department ofP ediatrics Peking University First HospitalBeijingChina Department ofN eurology Children’s HospitalFudan UniversityShanghaiChina Department ofP ediatrics Quanzhou Women’s andChildren’s HospitalQuanzhouChina Department of N eurology Tianjin Children’s HospitalTianjinChina Department of N eurology Beijing Children’s HospitalBeijingChina Department of Pediatric Neurology The First Bethune HospitalJilin UniversityChangchunChina Department of Pediatric Neurology The 2nd Affi liated HospitalWenzhou Medical UniversityWenzhouChina Department of N eurology Xijing HospitalXi’anChina Department of P ediatrics Xiangya HospitalCentral South UniversityChangshaChina Department of N eurology Children’s HospitalChongqing Medical UniversityChongqingChina The third Department ofN eurology Guangdong 999 Brain HospitalGuangzhouChina

Background This study aimed to assess efficacy and safety of oxcarbazepine (OXC) oral suspension in pediatric patients aged 2-5 years with partial seizures (PS) and/or generalized tonic-clonic seizures (GTCS) in real-world clinical practice in China. Methods This 26-week, prospective, single-arm, multicenter, observational study recruited pediatric patients aged 2-5 years with PS or GTCS suitable for OXC oral suspension treatment based on physicians' judgments from 11 medical centers in China. Enrolled subjects started OXC oral suspension treatment as monotherapy or in combination with other antiepileptic drugs. Primary efficacy outcome was the percentage of pediatric subjects achieving ≥ 50% seizure frequency reduction at the end of the 26-week treatment. Secondary efficacy-related parameters and safety parameters such as adverse events (AEs) and serious AEs (SAEs) were also monitored during the 26-week treatment period. Results Six hundred and six pediatric patients were enrolled and 531 (87.6%) completed the study. After 26 weeks of treat-ment, 93.3% subjects achieved ≥ 50% seizure frequency reduction, and 81.8% achieved 100% seizure frequency reduction compared to baseline. Among diff erent seizure types, OXC was eff ective in all subjects with simple PS and in > 90% of subject with other type of seizure present in the study. AEs were observed in 49 (8.1%) subjects. Only three subjects expe-rienced SAE. Rash (n = 18, 2.97%) was the most common AE. Only 17 subjects discontinued due to AEs. Conclusion This study, reporting the real-world data, further confi rms the efficacy and good safety profi le of OXC oral suspension in Chinese pediatric patients aged 2-5 years with PS and/or GTCS.

关键词： Antiepileptic drugs Generalized tonic-clonic seizures Oxcarbazepine oral suspension Partial seizures Pediatric patients

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县域科技创新-乡村产业-经济发展耦合协调研究——以广西14个县(区)为例

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江西农业学报 2024年第7期36卷 89-98页

作者：屈婷婷容建波钟翠孔令孜崔勇周保吉覃颖广西壮族自治区农业科学院农业科技信息研究所广西南宁530007 广西艺术学院智慧人居环境产业学院广西南宁530007 广西西大县域经济发展研究院广西南宁530004

以广西14个县(区)为研究对象,采用层次分析法、熵权评价法和组合赋权法,对2020—2022年案例县(区)的科技创新、乡村产业、经济发展水平进行了评价,采用耦合协调度模型测算了案例县(区)两系统和三系统的耦合协调度及相对发展度,结果表明:... 详细信息

以广西14个县(区)为研究对象,采用层次分析法、熵权评价法和组合赋权法,对2020—2022年案例县(区)的科技创新、乡村产业、经济发展水平进行了评价,采用耦合协调度模型测算了案例县(区)两系统和三系统的耦合协调度及相对发展度,结果表明:(1)各县(区)科技创新、乡村产业和经济发展指数总体呈现低分集聚、波动上升、区域差异明显等特征。(2)各县(区)两系统呈现耦合协调度均值逐年递增的磨合发展阶段,三系统的耦合协调度均值高于两系统,处于耦合发展阶段;大多数县(区)存在明显的科技发展滞后现象。(3)提出要加快实施县域科技创新能力提升行动,加大对县域特色产业创新的政策支持,大力实施乡村特色产业振兴科技专项,加快构建多部门联动的创新协同机制等对策建议。

关键词：县域科技创新乡村产业经济发展耦合协调

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Exploration of Zhangs' Rockery Gardening: A Case Study of Qi Biaojia's Yu Garden

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Journal of Landscape Research 2018年第6期10卷 31-35,38页

作者： qin Ke LIAO yi School of Architecture and Arts North China University of Technology

Zhang yifan is the son of gardening Master Zhang Nanyuan, and his story can only be found in Qi Biaojia's Diary. Qi recorded his communications with Zhang yifan and Zhang's transformation over Yu Garden in detail, thus the diary shows high documentation value. Zhang's transformation over Yu Garden was important for others exploring and understanding the contents, style, and construction period of Zhangs' rockery gardening, and also for spreading Zhangs' style in Yuezhong(the present Shaoxing City, and Xiaoshan District of Hangzhou, including 8 counties of the former Shaoxing Prefecture). This paper summarized and verified the characteristics, contents and construction period of Zhangs' rockery gardening by analyzing the study case, and elaborated the spreading and development of Zhangs' gardening style in Yuezhong.

关键词： Zhang Nanyuan Zhang yifan Yu Garden Rockery

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Aspiration therapy for acute embolic occlusion of the superior mesenteric artery

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World Journal of Gastroenterology 2019年第7期25卷 848-858页

作者： yi-Ren Liu Zhu Tong Cheng-Bei Hou Shi-Jun Cui Lian-Rui Guo yi-Xia Qi Li-Xing Qi jian-Ming Guo Yong-Quan Gu Department of Vascular Surgery Xuanwu Hospital Capital Medical University Center of Evidence-Based Medicine Xuanwu Hospital Capital Medical University

BACKGROUND Embolic superior mesenteric artery(SMA) occlusion is associated with high mortality rates. Delayed treatment often leads to serious consequences, including intestinal necrosis, resection, and even patient death. Endovascular repair is being introduced, which can improve clinical symptoms and prognosis and decrease the incidence of exploratory laparotomy. Many reports have described successful endovascular revascularization of embolic SMA occlusion. However,most of those reports are case reports, and there are few reports on Chinese patients. In this paper, we describe the technical and clinical outcomes of aspiration therapy using a guiding catheter and long sheath technique which facilitates the endovascular repair *** To evaluate the complications, feasibility, effectiveness, and safety of endovascular treatment for the acute embolic occlusion of the *** This retrospective study reviewed eight patients(six males and two females)from August 2013 to October 2018 at Xuanwu Hospital, Capital Medical University. The patients presented with acute embolic occlusion of the SMA on admission and were initially diagnosed by computed tomography angiography(CTA). The patients who underwent endovascular treatment with a guiding catheter had no obvious evidence of bowel infarct. No intestinal necrosis was identified by gastrointestinal surgeons through peritoneal puncture or CTA. The complications, feasibility, effectiveness, safety, and mortality were *** Six(75%) patients were male, and the mean patient age was 70.00 ± 8.43 years(range, 60-84 years). The acute embolic occlusion of the SMA was initially diagnosed by CTA. All patients had undertaken anticoagulation primarily, and percutaneous aspiration using a guiding catheter was then undertaken because the emboli had large amounts of thrombus residue. No death occurred among the patients. Complete patency of the suffering artery trunk was achieved in six patients, and defect filling w

关键词： Superior mesenteric artery Acute embolic occlusion Aspiration embolectomy Transcatheter thrombolysis Endovascular repair

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淫羊藿素调控巨噬细胞极化治疗肝内胆管癌的药效作用及机制初探

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药学学报 2024年第8期59卷 2227-2236页

作者：王婧雯李珍黄秀勤徐子婧耿嘉豪许燕瑜梁天祎湛小燕康利平王伽伯宋鑫华南方医科大学中医药学院广东广州510000 首都医科大学中医药学院北京100071 解放军总医院第五医学中心北京100071 道地药材品质保障与资源持续利用全国重点实验室北京100070

肝内胆管癌(intrahepatic cholangiocarcinoma, ICC)发病率持续攀升,目前尚无有效治疗药物。免疫微环境在ICC发展中扮演重要角色,是当前研究热点。淫羊藿素(icaritin, ICA)是治疗晚期肝细胞癌的创新中药,被认为有潜在的免疫调控抗肿瘤作... 详细信息

肝内胆管癌(intrahepatic cholangiocarcinoma, ICC)发病率持续攀升,目前尚无有效治疗药物。免疫微环境在ICC发展中扮演重要角色,是当前研究热点。淫羊藿素(icaritin, ICA)是治疗晚期肝细胞癌的创新中药,被认为有潜在的免疫调控抗肿瘤作用,与中医“扶正”治疗肿瘤的认识潜在相合。然而, ICA是否可用于ICC治疗尚未见研究报道。为此,本研究选取免疫系统完整的原位ICC小鼠模型sgp19/kRas,首次在体内评估了ICA治疗ICC的药效,并通过流式细胞术分析ICA对ICC小鼠肿瘤免疫微环境的影响[本实验所有动物实验均获得首都医科大学动物伦理委员会(中国北京)批准,批准号:AEEI-2023-138]。本研究应用100 mg·kg^(-1)ICA灌胃治疗sgp19/kRas ICC原位小鼠模型,结果显示, ICA治疗3周后能够显著抑制sgp19/kRas ICC小鼠模型的肿瘤生长及肿瘤细胞增殖。通过流式细胞术分析ICA对ICC小鼠肿瘤免疫微环境的影响,结果表明, ICA治疗后能够显著降低M2型巨噬细胞占比,并且显著增加CD3^(+)CD4^(+)T细胞的数量。体外实验阐明ICA能促进巨噬细胞向M1型巨噬细胞极化,抑制其向M2型巨噬细胞极化。此外,转录组学分析结果提示, ICA能够增强Toll样受体9 (TLR9)的表达,影响巨噬细胞一氧化氮代谢合成途径及膜受体相关活性,发挥其巨噬细胞极化调节功能。综上,本研究发现ICA治疗能显著延缓sgp19/kRas ICC小鼠肿瘤进展。机制上, ICA可能通过上调TLR9受体表达水平,促进巨噬细胞向M1细胞的极化,改变肿瘤免疫微环境,进而达到抗ICC的作用。

关键词：肝内胆管癌淫羊藿素免疫微环境巨噬细胞极化 Toll样受体9

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A Facile Strategy for Intrinsic Low-Dk and Low-Df Polyimides Enabled by Spirobifluorene Groups

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高分子科学：英文版 2023年第2期41卷 288-296页

作者： Wan-yi Tan Ling-Feng jian Wei-Peng Chen Yong-Wen Zhang Xiao-Chuang Lu Wan-Jun Huang Ji-Sheng Zhang Jing-Wu Wu Jun-Li Feng yi-Dong Liu Ting-Ting Cui Yong-Gang Min Guangdong University of Technology(GDUT) Guangzhou510006China Huimai Materials Technology(Guangdong)Co. Ltd.Foshan528200China Shenzhen Customs Industrial Product Inspection Technology Center Shenzhen518026China

Modified polyimides(MPIs)show great potential towards 5G communication applications,due to its excellent thermal stability,mechanical property and chemical stability as compared to most of *** fluoride groups or porous structure is favorable to ultra-low dielectric constant(D_(k))and dielectric loss(D_(f)).However,the cost of the fluorinated MPIs is high and their synthetic processes are complicated,and porous MPIs suffer poor mechanical ***,increasing the fraction of free volume is a very effective way to lower D_(k)through introducing more ultra-low-D_(k)air ***,most of this kind of MPIs lag far behind the fluorinated MPIs and the porous MPIs in terms of ultra-low D_(f),hindering the application of MPIs in high-speed communication ***,it is highly desirable to develop intrinsic ultra-low-D_(k)/D_(f)MPIs at high frequency with less fluoric groups and nonporous ***,we introduce a facile and effective strategy to lower D_(k)and D_(f)through introducing rigid and large sterically hindered aromatic groups into *** the one hand,their large steric hindrance effect leads to low D_(k)by increasing intrinsic free *** the other hand,the resulting highly stiff polymer chain and strong intermolecular interaction are favorable to reduce D_(f)by inhibiting dipole *** on this strategy,the spirobifluorene groups are *** as-prepared MPIs show excellent dielectric performance with low D_(k)of 2.74–2.76 and low D_(f)of 0.00599 at 10 GHz,to some extent,exceeding the multiple fluorinated MPI with D_(k)/D_(f)of 2.67/0.00663 at 10 GHz.

关键词： Polyimide High speed communication Low dielectric constant Low dielectric loss

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Giant enhancement of photoluminescence emission in monolayer WS_(2)by femtosecond laser irradiation

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Frontiers of physics 2021年第1期16卷 143-150页

作者： Cheng-Bing qin Xi-Long Liang Shuang-Ping Han Guo-Feng Zhang Rui-Yun Chen jian-Yong Hu Lian-Tuan Xiao Suo-Tang Jia State Key Laboratory of Quantum Optics and Quantum Optics Devices Institute of Laser SpectroscopyShanxi UniversityTaiyuan 030006China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China

Monolayer transition metal dichalcogenides have emerged as promising mat erials for opt oelectTonic and nanophotonic ***,the low photoluminescence(PL)quantum yield(QY)hinders their various potential *** we engineer and enhance the PL intensity of monolayer WS_(2)by femtosecond laser *** than two orders of magnitude enhancement of PL intensity as compared to the as-prepared sample is ***,the engineering time is shortened by three orders of magnitude as compared to the improvement of PL intensity by continuous-wave laser *** on the evolution of PL spectra,we attribute the giant PL enhancement to the conversion from trion emission to exciton,as well as the improvement of the QY when exciton and trion are localized to the new-formed *** have created microstructures on the monolayer WS_(2)based on the enhancement of PL intensity,where the engineered structures can be stably stored for more than three *** flexible approach with the feature of excellent long-term storage stability is promising for applications in information storage,display technology,and opto electronic devices.

关键词： monolayers WS_(2) giant enhancement photoluminescence femtosecond laser irradiation micropatterning exciton trion quantum yield

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体育治理结构的域外经验与中国镜鉴

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体育学刊 2017年第5期24卷 41-47页

作者：张琴易剑东安徽工程大学体育学院安徽芜湖241000 江西财经大学江西南昌330013

通过分析英国、美国、芬兰、日本体育治理结构,得出域外体育治理结构的经验:厘清结构归属、明确责权利边界、遵循市场优先原则、强化非政府体育组织的公益服务职能、充分发挥多元主体治理优势、形成协商共治的局面。我国体育管理结构呈... 详细信息

通过分析英国、美国、芬兰、日本体育治理结构,得出域外体育治理结构的经验:厘清结构归属、明确责权利边界、遵循市场优先原则、强化非政府体育组织的公益服务职能、充分发挥多元主体治理优势、形成协商共治的局面。我国体育管理结构呈现"中心-边缘"特征。"中心-边缘"结构在组织机构设置、权力划分和资源流动上,呈现体制管理缺位等问题,体育治理结构正是在应对传统体育管理结构存在问题的意义上产生的。要想实现体育治理结构由"中心-边缘"的单一刚性结构,转变为"多中心"的网络式柔性结构,政府必须成为退居幕后的指挥者,即退出微观领域、把控宏观领域;介入公共领域、退出经营领域;强化行政服务、弱化行政管理;强化立法监督、弱化行政干预,构建一种多元化主体协商共治的治理结构。

关键词：体育管理体育治理体育善治治理结构

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Coral-shaped and Core-Shell Structure Copolyethylene Nanocomposites Particles Prepared by in situ Coordination Polymerization

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Chinese Journal of Polymer Science 2015年第12期33卷 1650-1660页

作者： Jing Wang Hong-ming Li jiang-ping Guo 黄启谷 jian-jun yi Yun-fang Liu Ke-jing Gao Wan-tai Yang State Key Laboratory of Chemical Resource Engineering Key Laboratory of Carbon Fiber and Functional PolymersMinistry of Education Beijing University of Chemical Technology Lab for Synthetic Resin Research Institution of Petrochemical Technology China National Petroleum Corporation

The example of the preparation ofnano- and micro-scaled, coral-shaped and core-shell topological morphology of copolyethylene particles promoted by the novel heterogeneous non-metallocene catalyst （m-CH3PhO）TiC13/carbon nanotubes （CNTs） was reported. Mass fraction of titanium component of the catalyst was 4.0 wt% determined by ICP analysis. The catalyst system can effectively catalyze polymerization of ethylene and eopolymerization of ethylene with 1-hexene. Morphological examination of the obtained polymer particles was carried out by scanning electron microscope （SEM） and high resolution transmission electron microscope （HR-TEM） technique. The results revealed that the morphology of the nascent copolyethylene particles looked like coral shape with size in micro-scaled and featured the core-shell structure consisting of CNTs as the core and copolyethylene as the shell.

关键词： Catalysts Composites Copolymers.

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Comparation of the predictive value between ultrasonography and urodynamics for the efficacy of transurethral resection of prostate in benign prostatic hyperplasia patients

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Chinese Medical Journal 2012年第9期125卷 1536-1541页

作者： QI Jun YU Yong-jiang HUANG Tao XU Ding JIAO Yank KANG jian CHEN Ya-qin ZHU Yun-kai HUANG yi-ran Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Ultrasonography Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Urology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background Transurethral resection of prostate （TURP） has been widely used as a golden standard therapy of benign prostatic hyperplasia for over 40 years. However, not all patients achieved favorable outcome postoperatively. Since the level of bladder outlet obstruction and the dysfunction of detrusor （overactive and underactive） were both found to affect surgical efficacy, urodynamics was recommended as routine preoperative examination in selecting proper surgical candidates by International Continence Society in spite of its invasiveness and high cost. The aim of this research was to compare the predictive value between ultrasonography and urodynamics for TURP efficacy and determine if preoperative urodynamic test could be replaced by ultrasonography.Methods Two hundred and seventy-one patients took part in the retrospective analysis. All the subjects had preoperative evaluation of symptoms, life quality, and combined examination of ultrasonography and urodynamics. Surgical efficacy was measured according to the recovery of international prostate symptom score, quality of life score, and maximal flow rate 6 months after TURP. Fisher’s linear discriminant analysis was applied to establish the predictive models of surgical efficacy by choosing parameters from ultrasonography or urodynamics as independent factors. Receiver’s operating characteristic curve was then plotted to compare the values between the models.Results Sensitivity, specificity, positive and negative predictive value of models consisting of parameters from both ultrasonography and urodynamics were favorable. Corresponding models of ultrasonography and urodynamics were found to have non-significant difference in area under curve （P〉0.05）.Conclusions Preoperative ultrasonography has as strong value as urodynamics does in predicting surgical outcome of patients undergone TURP and might take the place of urodynamics in selecting surgical candidates. Further prospective analysis with larger popu

关键词： benign prostatic hyperplasia transurethral resection of prostate treatment efficacy ultrasonography urodynamics

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