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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Motivating Students to Improve Effectiveness in Teaching

Motivating Students to Improve Effectiveness in Teaching

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教育部中南地区高等学校电子电气基础课教学研究会第二十届学术年会

作者： Tang Wen-hui~1,Gui jian-xiong~2,liu Shi-ping~1 (1.Department of Circuits and Systems,Air Force Radar Academy,P.R.of China 2.Department of laboratory,the eighth hospital,Wuhan,Hubei Province,P.R.of China)

This article proposed the practical methods for teachers to motivate students and achieve the ideal teaching effect in electronic circuit curriculum based on research results of Jean Piaget,Feather and other education... 详细信息

关键词： motivation attribution achievement requirement cognition assessment

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-Xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang Fan Yang jian-Qin liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Anti-breast cancer effect of quercetin nanoparticles based on MOFs for chemo-phototherapy and heat shock proteins inhibition

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Nano Research 2025年第1期18卷 545-558页

作者： Rongyue Zhu Shilang Liao Mengru Cai Dongge Yin Tingting Fu Jing liu Yuji Du Jiahui Kong Rongrong Chang jian Ni Xingbin Yin Beijing University of Chinese Medicine Fangshan DistrictBeijing 102488China

Phototherapy, including photodynamic therapy(PDT) and photothermal therapy (PTT), is a promisingmethod of tumor treatment, which has the advantages ofstrong specificity and small side effects. However, PDT willaggravate the hypoxic environment in tumor cells, and PTTwill lead to heat-resistant reaction, both of which will make theorganism quickly produce heat shock proteins (HSPs) toprotect itself, thus seriously hindering the therapeuticefficiency of phototherapy. As a natural HSPs inhibitor,quercetin (QR) provides a feasible way to solve this ***, a kind of metal organic framework (MOF), Fe-TCPP(FT), was used as a delivery material and photosensitizer tobuild a chemo-phototherapy platform, and QR was used as achemotherapy drug and HSPs inhibitor. On this basis, the nanoparticles (NPs) were modified with PEG-CPP30 (a cellpenetratingpeptide that specifically recognizes human breast cancer MCF-7 cells), which showed excellent targetingcapacity and biocompatibility. The combination of chemotherapy and phototherapy significantly improved the anti-cancereffect. At the same time, NPs also showed prominent anti-HSPs effect. The effective connection of the two played acomplementary role in the process of tumor treatment, which provided a new strategy for the accurate and efficienttreatment of tumors in the future.

关键词： quercetin Fe-metal organic frameworks(MOFs) phototherapy anti-cancer heat shock proteins inhibition

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Multi-color space threshold segmentation and self-learning k-NN algorithm for surge test EUT status identification

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Frontiers of Mechanical Engineering 2016年第3期11卷 311-315页

作者： jian HUANG Gui-xiong liu School of Mechanical & Automotive Engineering South China University of Technology Guangzhou 510641 China

The identification of targets varies in different surge tests. A multi-color space threshold segmentation and self-learning k-nearest neighbor algorithm （k-NN） for equipment under test status identification was proposed after using feature matching to identify equipment status had to train new patterns every time before testing. First, color space （L＊a＊b＊, hue saturation lightness （HSL）, hue saturation value （HSV）） to segment was selected according to the high luminance points ratio and white luminance points ratio of the image. Second, the unknown class sample Sr was classified by the k-NN algorithm with training set T~ according to the feature vector, which was formed from number ofpixels, eccentricity ratio, compact- ness ratio, and Euler＇s numbers. Last, while the classification confidence coefficient equaled k, made Sr as one sample ofpre-training set Tz＇. The training set Tz increased to Tz＋1 by Tz＇ if Tz＇ was saturated. In nine series of illuminant, indicator light, screen, and disturbances samples （a total of 21600 frames）, the algorithm had a 98.65% identification accuracy, also selected five groups of samples to enlarge the training set from To to T5 by itself. Keywords multi-color space, k-nearest neighbor algorithm （k-NN）, self-learning, surge test

关键词： multi-color space k-nearest neighbor algorithm (k-NN) self-learning surge test

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun liu Chong Gao Yong Du Zhe Sun Weilin Xu jian Fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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基于多功能树木养护装置结构设计与应用

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农机化研究 2025年第3期47卷 116-120页

作者：周启兴熊俊康张俭南昌交通学院南昌330100

以进一步提升绿化树木的养护效率为目标,选取多功能设计理念为切入点,针对树木养护作业的机械化装置展开研究。考虑养护树木环境作业特点及养护目标机理,基于机械设计方法与电机控制技术,搭建多功能树木养护装置的架构布局,针对定位功... 详细信息

以进一步提升绿化树木的养护效率为目标,选取多功能设计理念为切入点,针对树木养护作业的机械化装置展开研究。考虑养护树木环境作业特点及养护目标机理,基于机械设计方法与电机控制技术,搭建多功能树木养护装置的架构布局,针对定位功能、涂白功能和缠绕功能进行相应的装置结构设计。同时,展开树木养护作业试验,结果表明:基于多功能树木养护装置的结构设计方案正确可行,整机的涂白作业效率与缠绕作业效率分别可达95.85%和94.20%,树木涂白与保温缠绕均能满足较好的均匀性,作业过程定位转向精准,具有很好的普适性,可有效降低树木冻害损失,对于树木的养护方式和装置开发有一定参考价值。

关键词：绿化树木多功能设计养护装置涂白作业效率普适性

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Clinical significance and prognostic value of tumor necrosis factor-α and dickkopf related protein-1 in ankylosing spondylitis

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World Journal of Clinical Cases 2020年第7期8卷 1213-1222页

作者： Jun-Hui xiong jian liu jian Chen Department of Rheumatology Lishui People’s HospitalLishui 323000Zhejiang ProvinceChina

BACKGROUND Ankylosing spondylitis(AS)frequently occurs in people aged 30-45 years,and its prevalence is generally believed to be between 0.1%and 1.4%*** present,the“gold standard”for diagnosis of AS requires the provision of pelvic X-rays,which makes it more difficult to perform in population-based epidemiological ***,the identification of serological indicators related to the diagnosis,treatment,and prognosis of AS patients is of great *** To analyze the therapeutic,diagnostic significance and prognostic value of dickkopf-related protein-1(DKK-1)and tumor necrosis factor-α(TNF-α)in *** A total of 113 patients with active AS were selected as the research group,and 100 healthy subjects who underwent physical examination were selected as the control *** levels of DKK-1 and TNF-α in peripheral blood in the two groups were *** diagnostic and predictive values of DKK-1 and TNF-α for AS were analyzed with ROC curves,and the factors influencing AS recurrence were analyzed with COX *** Before treatment,the research group showed lower DKK-1 levels but higher TNF-αlevels than the control group(both aP<0.05).In the research group,DKK-1 was up-regulated and TNF-αwas down-regulated after 12 wk of treatment(aP<0.05).The area under the curve,sensitivity and specificity of DKK-1 combined with TNF-αfor diagnosing AS were 0.934,82.30%and 97.00%,*** treatment,the area under the curve,cutoff value,sensitivity and specificity of DKK-1 for predicting the curative effect were 0.825,68.42 pg/mL,73.68%and 80.00%,respectively,and those of TNF-αwere 0.863,32.79 ng/L,92.11%and 77.33%,***-1 and TNF-αlevels after treatment were closely related to the curative effect(aP<0.05).C-reactive protein,the Bath Ankylosing Spondylitis Disease Activity Index,DKK-1,and TNF-αwere risk factors for AS recurrence(aP<0.05).CONCLUSION DKK-1 and TNF-αare effective in the diagnosis and treatment of AS and are risk f

关键词： Dickkopf-related protein-1 Tumor necrosis factor-α Ankylosing spondylitis Diagnosis Prognosis Peripheral blood

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Low complexity reconfigurable architecture for the 5/3 and 9/7 discrete wavelet transform

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Journal of Systems Engineering and Electronics 2006年第2期17卷 303-308页

作者： xiong Cheng yi Tian Jinwen liu jian Coll. of Electronic Information Engineering South Center Univ. for Nationalities Wuhan 430074 P.R. China Inst. of Pattern Recognition & Artificial Intelligence Key Lab. of Education Ministry for Image Processing and Intelligent Control Huazhong Univ. of Science & Technology Wuhan 430074 P.R. China

Efficient reconfigurable VLSI architecture for 1-D 5/3 and 9/7 wavelet transforms adopted in JPEG2000 proposal, based on lifting scheme is proposed. The embedded decimation technique based on fold and time multiplexing, as well as embedded boundary data extension technique, is adopted to optimize the design of the architecture. These reduce significantly the required numbers of the multipliers, adders and registers, as well as the amount of accessing external memory, and lead to decrease efficiently the hardware cost and power consumption of the design. The architecture is designed to generate an output per clock cycle, and the detailed component and the approximation of the input signal are available alternately. Experimental simulation and comparison results are presented, which demonstrate that the proposed architecture has lower hardware complexity, thus it is adapted for embedded applications. The presented architecture is simple, regular and scalable, and well suited for VLSI implementation.

关键词： VLSI discrete wavelet transform lifting scheme embedded decimation reeonfigurable.

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