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Chinese Chemical Letters 2013年第10期24卷 893-896页

作者： Feng-Tian Wu Ping Liu Xiao-wei Ma jian-wei xie Bin Dai School of Chemistry and Chemical Engineering/the Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan Shihezi University

Tetrazole-l-acetic acid was found to serve as a superior ligand for Cul-catalyzed N-arylation of imidazoles with aryl iodides under a low catalyst loading （5 mol% of Cul）. A variety of aryl iodides could he aminated... 详细信息

关键词： Tetrazole-l-acetic acid N-Arylation Imidazoles Copper Aryl iodides

Prognostic impact of dissected lymph node count on patients with node-negative gastric cancer

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World Journal of Gastroenterology 2009年第31期15卷 3926-3930页

作者： Chang-Ming Huang jian-Xian Lin Chao-Hui Zheng Ping Li jian-wei xie Bi-Juan Lin Hui-Shan Lu Department of Ontology Affiliated Union Hospital Fujian Medical University No. 29 Xinquan Road Fuzhou 350001 Fujian Province China

AIM:To investigate the long-term effect of the number of resected lymph nodes (LNs) on the prognosis of patients with node-negative gastric ***: Clinical data of 211 patients with gastric cancer, without nodal involvement, were analyzed retrospectively after D2 radical operation. We analyzed the relationship between the number of resected LNs with the 5-year survival, the recurrence rate and the post-operative complication ***: The 5-year survival of the entire cohort was 82.2%. The total number of dissected LNs was one of the independent prognostic factors. Among patients with comparable depth of invasion, the larger the number of resected LNs, the better the survival (P0.01). The post-operative complication rate was 10.9% and was not signif icantly correlated with the number of dissected LNs (P>0.05).CONCLUSION: For node-negative gastric cancer, sufficient number of dissected LNs is recommended during D2 lymphadenectomy, to improve the long-term survival and reduce the recurrence. Suitable increments of the dissected LN count would not increase the post-operative complication rate.

关键词： Stomach neoplasms Lymph nodes Gastrectomy Lymphadenectomy Prognosis

Role of 3DCT in laparoscopic total gastrectomy with spleen-preserving splenic lymph node dissection

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World Journal of Gastroenterology 2014年第16期20卷 4797-4805页

作者： Jia-Bin Wang Chang-Ming Huang Chao-Hui Zheng Ping Li jian-wei xie jian-Xian Lin Jun Lu Department of Gastric Surgery Fujian Medical University Union Hospital

AIM: To investigate whether computed tomography with 3D imaging (3DCT) can reduce the risks associated with laparoscopic surgery.

关键词： Stomach neoplasms Spleen preservation Laparoscopy Lymph node dissection Computed tomography angiography with three-dimensional imaging

The roles of carboxylesterase and CYP isozymes on the in vitro metabolism of T-2 toxin

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Journal of Medical Colleges of PLA(China) 2015年第1期30卷 21-27页

作者： Ni-ni Lin Jia Chen Bin Xu Xia wei Lei Guo jian-wei xie State Key Laboratory of Toxicology and Medical Countermeasures and Laboratory of Toxicant Analysis Institute of Pharmacology and ToxicologyAcademy of Military Medical Sciences

Background: T-2 toxin poses a great threat to human health because it has the highest toxicity of the currently known trichothecene mycotoxins. To understand the in vivo toxicity and transformation mechanism of T-2 toxin, we investigated the role of two principal phase Ⅰ drug-metabolizing enzymes(cytochrome P450 [CYP450] enzymes) on the metabolism of T-2 toxin, which are crucial to the metabolism of endogenous substances and xenobiotics. We also investigated carboxylesterase, which also plays an important role in the metabolism of toxic ***: A chemical inhibition method and a recombinant method were employed to investigate the metabolism of the T-2 toxin by the CYP450 enzymes, and a chemical inhibition method was used to study carboxylesterase metabolism. Samples incubated with human liver microsomes were analyzed by high performance liquid chromatography-triple quadrupole mass spectrometry(HPLC- Qq Q MS) after a simple ***: In the presence of a carboxylesterase inhibitor, only 20% T-2 toxin was metabolized. When CYP enzyme inhibitors and a carboxylesterase inhibitor were both present, only 3% of the T-2 toxin was metabolized. The contributions of the CYP450 enzyme family to T-2 toxin metabolism followed the descending order CYP3A4, CYP2E1, CYP1A2, CYP2B6 or CYP2D6 or ***: Carboxylesterase and CYP450 enzymes are of great importance in T-2 toxin metabolism, in which carboxylesterase is predominant and CYP450 has a subordinate role. CYP3A4 is the principal member of the CYP450 enzyme family responsible for T-2 toxin metabolism. The metabolite produced by carboxylesterase is HT-2, and the metabolite produced by CYP 3A4 is 3'-OH T-2. The different metabolites show different toxicities. Our results will provide useful data concerning the toxic mechanism, the safety evaluation, and the health risk assessment of T-2 toxin.

关键词： T-2 toxin Cytochrome P450 Carboxylesterase Metabolism Human liver microsomes

Comparision of modified and conventional delta-shaped gastroduodenostomy in totally laparoscopic surgery

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World Journal of Gastroenterology 2014年第30期20卷 10478-10485页

作者： Chang-Ming Huang Mi Lin jian-Xian Lin Chao-Hui Zheng Ping Li jian-wei xie Jia-Bin Wang Jun Lu Department of Gastric Surgery Fujian Medical University Union Hospital

AIM: To evaluate the safety and feasibility of a modified delta-shaped gastroduodenostomy (DSG) in totally laparoscopic distal gastrectomy (TLDG).

关键词： Stomach neoplasms Totally laparoscopic surgery Digestive tract reconstruction Modified anastomosis Treatment outcome

Laparoscopic spleen-preserving splenic hilar lymphadenectomy in 108 consecutive patients with upper gastric cancer

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World Journal of Gastroenterology 2014年第32期20卷 11376-11383页

作者： Ping Li Chang-Ming Huang Chao-Hui Zheng jian-wei xie Jia-Bin Wang jian-Xian Lin Jun Lu Yi Wang Qi-Yue Chen Department of Gastric Surgery Fujian Medical University Union Hospital

AIM: To evaluate the feasibility and short-term efficacy of laparoscopic spleen-preserving splenic hilar (No. 10) lymphadenectomy to treat advanced upper gastric cancer (AUGC).

关键词： Stomach neoplasms Spleen-preservation laparoscopy Gastrectomy Lymphadenectomy

Small-volume chylous ascites after laparoscopic radical gastrectomy for gastric cancer:Results from a large population-based sample

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World Journal of Gastroenterology 2015年第8期21卷 2425-2432页

作者： Jun Lu Zhen-Quan wei Chang-Ming Huang Chao-Hui Zheng Ping Li jian-wei xie Jia-Bin Wang jian-Xian Lin Qi-Yue Chen Long-Long Cao Mi Lin Department of Gastric Surgery Fujian Medical University Union Hospital Department of General Surgery Sanming No. 2 Hospital

AIM:To report the incidence and potential risk factors of small-volume chylous ascites(SVCA)following laparoscopic radical gastrectomy(LAG).METHODS:A total of 1366 consecutive gastric cancer patients who underwent LAG from January 2008 to June 2011 were enrolled in this *** analyzed the patients based on the presence or absence of ***:SVCA was detected in 57(4.17%)patients,as determined by the small-volume drainage(range,30-100 m L/24 h)of triglyceride-rich *** univariate and multivariate analyses revealed that the total number of resected lymph nodes(LNs),No.8 or No.9 LN metastasis and N stage were independent risk factors for SVCA following LAG(P0.05).CONCLUSION:SVCA following LAG developed significantly more frequently in the patients with≥32harvested LNs,≥3 metastatic LNs,or No.8 or No.9LN ***,which was successfully treated with conservative management,was associated with a prolonged hospital stay but was not associated with the prognosis.

关键词： Gastric cancer Laparoscopic gastrectomy Small volu

Expression of CRM1 and CDK5 shows high prognostic accuracy for gastric cancer

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World Journal of Gastroenterology 2017年第11期23卷 2012-2022页

作者： Yu-Qin Sun jian-wei xie Hong-Teng xie Peng-Chen Chen Xiu-Li Zhang Chao-Hui Zheng Ping Li Jia-Bin Wang jian-Xian Lin Long-Long Cao Chang-Ming Huang Yao Lin College of Life Sciences Fujian Normal University Department of Gastric Surgery Fujian Medical University Union Hospital

AIM To evaluate the predictive value of the expression of chromosomal maintenance(CRM)1 and cyclindependent kinase(CDK)5 in gastric cancer(GC) patients after *** A total of 240 GC patients who received standard gastrectomy were enrolled in the study. The expression level of CRM1 and CDK5 was detected by immunohistochemistry. The correlations between CRM1 and CDK5 expression and clinicopathological factors were explored. Univariate and multivariate survival analyses were used to identify prognostic factors for GC. Receiver operating characteristic analysis was used to compare the accuracy of the prediction of clinical outcome by the parameters. RESULTS The expression of CRM1 was significantly related to size of primary tumor(P = 0.005), Borrmann type(P = 0.006), degree of differentiation(P = 0.004), depth of invasion(P = 0.008), lymph node metastasis(P = 0.013), TNM stage(P = 0.002) and distant metastasis(P = 0.015). The expression of CDK5 was significantly related to sex(P = 0.048) and Lauren's classification(P = 0.011). Multivariate Cox regression analysis identified that CRM1 and CDK5 co-expression status was an independent prognostic factor for overall survival(OS) of patients with GC. Integration of CRM1 and CDK5 expression could provide additional prognostic value for OS compared with CRM1 or CDK5 expression alone(P = 0.001).CONCLUSION CRM1 and CDK5 co-expression was an independent prognostic factors for GC. Combined CRM1 and CDK5 expression could provide a prognostic model for OS of GC.

关键词： Gastric cancer CRM1 CDK5 Prognosis

A Fingerprint Minutiae Matching Method Based on Line Segment Vector

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Journal of Electronic Science and Technology of China 2007年第3期5卷 260-263页

作者： jian-wei Zhong Mei xie with School of Electronic Engineering University of Electronic Science and Technology of China （UESTC） Chengdu 610054 China

Minutiae-based fingerprint matching is the most commonly used in an automatic fingerprint identification system. In this paper, we propose a minutia matching method based on line segment vector. This method uses all the detected minutiae （the ridge ending and the ridge bifurcation） in a fingerprint image to create a set of new vectors （line segment vector）. Using these vectors, we can determine a truer reference point more efficiently. In addition, this new minutiae vector can also increase the accuracy of the minutiae matching. By experiment on the public domain collections of fingerprint images fvc2004 DID set A and DB4 set A, the result shows that our algorithm can obtain an improved verification performance.

关键词： Fingerprint line segment vector matching minutiae.

Low expression of CDK5RAP3 and DDRGK1 indicates a poor prognosis in patients with gastric cancer

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World Journal of Gastroenterology 2018年第34期24卷 3898-3907页

作者： jian-Xian Lin Xin-Sheng xie Xiong-Feng Weng Chao-Hui Zheng jian-wei xie Jia-Bin Wang Jun Lu Qi-Yue Chen Long-Long Cao Mi Lin Ru-Hong Tu Ping Li Chang-Ming Huang Department of Gastric Surgery Fujian Medical University Union Hospital Key Laboratory of Ministry of Education of Gastrointestinal Cancer Fujian Medical University Fujian Key Laboratory of Tumor Microbiology Fujian Medical University

AIM To investigate the effects of different levels of expression of CDK5RAP3 and DDRGK1 on long-term survival of patients undergoing radical *** The expression of CDK5RAP3 and DDRGK1 was detected by immunohistochemistry in 135 patients who received standard gastrectomy were enrolled in the study. Western Blot was used to detect the expression of CDK5RAP3 and DDRGK1 in gastric cancer and its adjacent tissues and cell lines. The correlations between the expression of CDK5RAP3 and DDRGK1 and clinicopathological factors were analyzed, and the value of each parameter to the prognosis of the patients was compared. Receiver operating characteristic analysis was used to compare the accuracy of the prediction of clinical outcome by the *** CDK5RAP3 and DDRGK1 expression was downregulated in the gastric cancer compared to its respective adjacent non-tumor tissues. The expression of CDK5RAP3 was closely related to the age of the patients(P = 0.035) and the T stage of the tumor(P = 0.017). The expression of DDRGK1 was correlated with the sex of the patients(P = 0.080), the degree of tumor differentiation(P = 0.036), the histological type(P = 0.036) and the N stage of the tumor(P = 0.014). Low expression CDK5RAP3 or DDRGK1 is a poor prognostic factor for gastric cancer patients. Prognostic analysis showed that the co-expression of CDK5RAP3 and DDRGK1 was an independent prognostic factor correlating with the overall survival of gastric cancer patients. Combined expression analysis of CDK5RAP3 and DDRGK1 may provide a more accurate prognostic value for overall survival.

关键词： Gastric cancer CDK5RAP3 DDRGK1 Prognosis