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Clinical study of neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1647-1659页

作者： Mu-sen Xu Jia-Le Xu Xin Gao Shao-jian Mo Jia-Yu Xing Jia-Hang Liu Yan-Zhang Tian Xi-Feng Fu The Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various *** categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and *** A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were *** patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 *** collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital *** The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP *** the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥***,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥***,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP *** NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.

关键词： Acute pancreatitis Gallstone Hypertriglyceridemia Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Persistent organ failure

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一种新的混合谱共轭梯度法

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数学的实践与认识 2024年第7期54卷 150-157页

作者：王森森韩信郑宗剑新疆和田学院数学与信息学院新疆和田848000 四川文理学院数学学院四川达州635000 西南大学电子信息工程学院重庆400715

基于修正的共轭参数和谱共轭梯度法,提出了一种用于求解无约束优化问题的新混合谱共轭梯度法.提出的新算法在迭代过程中始终满足充分下降性.此外,新算法在标准Wolfe线搜索准则下是全局收敛的.与现存WYL共轭梯度法的改进版本进行数值仿... 详细信息

基于修正的共轭参数和谱共轭梯度法,提出了一种用于求解无约束优化问题的新混合谱共轭梯度法.提出的新算法在迭代过程中始终满足充分下降性.此外,新算法在标准Wolfe线搜索准则下是全局收敛的.与现存WYL共轭梯度法的改进版本进行数值仿真比较,结果表明所提方法具有更优异的计算性能.

关键词：无约束优化混合谱共轭梯度法标准Wolfe线搜索全局收敛性

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Epidemiological Surveillance: Genetic Diversity of Rotavirus Group A in the Pearl River Delta, Guangdong, China in 2019

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Biomedical and Environmental Sciences 2024年第3期37卷 278-293页

作者： jianG Jie Ying LIANG Dan wang Li XIAO Yun LIANG Yu Feng KE Bi Xia SU Juan XIAO Hong wang Tao ZOU Min LI Hong jian KE Chang Wen School of Public Health Shantou UniversityShantou 515063GuangdongChina Guangdong Provincial Center for Disease Control and Prevention Guangdong Workstation for Emerging Infectious Disease Control and PreventionGuangzhou 511430GuangdongChina Guangdong Provincial Key Laboratory of Virology Institute of Medical MicrobiologyJinan UniversityGuangzhou 510632GuangdongChina School of Public Health Sun Yat-sen UniversityGuangzhou 510275GuangdongChina School of Public Health Southern Medical UniversityGuangzhou 510515GuangdongChina Shantou University Medical College Shantou 515041GuangdongChina

Objective This study aimed to understand the epidemic status and phylogenetic relationships of rotavirus group A(RVA)in the Pearl River Delta region of Guangdong Province,*** This study included individuals aged 28 days–85 years.A total of 706 stool samples from patients with acute gastroenteritis collected between January 2019 and January 2020 were analyzed for 17 causative pathogens,including RVA,using a Gastrointestinal Pathogen Panel,followed by genotyping,virus isolation,and complete sequencing to assess the genetic diversity of *** The overall RVA infection rate was 14.59%(103/706),with an irregular epidemiological *** proportion of co-infection with RVA and other pathogens was 39.81%(41/103).Acute gastroenteritis is highly prevalent in young children aged 0–1 year,and RVA is the key pathogen circulating in patients 6–10 months of age with diarrhea.G9P[8](58.25%,60/103)was found to be the predominant genotype in the RVA strains,and the 41 RVA-positive strains that were successfully sequenced belonged to three different RVA genotypes in the phylogenetic *** analysis showed that gene reassortment events,selection pressure,codon usage bias,gene polymorphism,and post-translational modifications(PTMs)occurred in the G9P[8]and G3P[8]*** This study provides molecular evidence of RVA prevalence in the Pearl River Delta region of China,further enriching the existing information on its genetics and evolutionary characteristics and suggesting the emergence of genetic *** the surveillance of genotypic changes and gene reassortment in RVA strains is essential for further research and a better understanding of strain variations for further vaccine development.

关键词： Infectious diarrheal disease Rotavirus Phylogenetic analysis Gene rearrangement Codon usage bias Genetic diversity

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The recirculation flow after different cross-section shaped high-rise buildings with applications to ventilation assessment and drag parameterization

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Building Simulation 2024年第4期17卷 509-524页

作者： Keyi Chen Ziwei Mo jian Hang School of Atmospheric Sciences Sun Yat-sen University&Southern Marine Science and Engineering Guangdong LaboratoryZhuhai519082China Key Laboratory of Tropical Atmosphere-Ocean System Ministry of EducationZhuhai519000China

The building cross-section shape significantly affects the flow characteristics around buildings,especially the recirculation region behind the high-rise *** generic building shapes including square,triangle,octagon,T-shaped,cross-shaped,#-shaped,H-shaped and L-shaped are examined to elucidate their effects on the flow patterns,recirculation length L and areas A using computational fluid dynamics(CFD)simulations with Reynolds-averaged Navier-Stokes(RANS)*** sizes and positions of the vortexes behind the buildings are found to be substantially affected by the building shapes and subsequently changing the recirculation *** recirculation length L is in the range of 1.6b-2.6b with an average of *** maximum L is found for L-shaped building(2.6b)while the shortest behind octagon building(1.6b).The vertical recirculation area Av is in the range of 1.5b^(2)-3.2b^(2)and horizontal area Ah in 0.9b^(2)-2.2b^(2).The L,Av and Ah generally increase with increasing approaching frontal area when the wind direction changes but subject to the dent structures of the#-shaped and cross-shaped *** area-averaged wind velocity ratio(AVR),which is proposed to assess the ventilation performance,is in the range of 0.05 and 0.14,which is around a three-fold difference among the different building *** drag coefficient parameterized by Ah varies significantly,suggesting that previous models without accounting for building shape effect could result in large uncertainty in the drag *** findings provide important reference for improving pedestrian wind environment and shed some light on refining the urban canopy parameterization by considering the building shape effect.

关键词： recirculation region cross-section shape ventilation assessment drag parameterization computational fluid dynamics

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BioTreasury:a community-based repository enabling indexing and rating of bioinformatics tools

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Science China(Life Sciences) 2024年第2期67卷 221-229页

作者： Qi Zhao Xin Zhou Jingxing Wu Jieyi Cai Xiaoqiong Bao Lin Tang Chaoye wang Chunlei Liu Yukai wang Yuyan Teng Mohan Zheng Weiping Mu Zhixiang Zuo Yubin Xie Xiaotong Luo jian Ren School of Life Sciences State Key Laboratory of Oncology in South ChinaCancer CenterGuangdong Provincial Clinical Research Center for CancerSun Yat-sen UniversityGuangzhou 510060China Institute of Precision Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Institute of Gastroenterology Department of General SurgeryGuangdong Provincial Key Laboratory of Colorectal and Pelvic Floor DiseasesThe Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510275China

The exponential growth of bioinformatics tools in recent years has posed challenges for scientists in selecting the most suitable one for their data analysis ***,to aid scientists in making informed choices,a community-based platform that indexes and rates bioinformatics tools is urgently *** this study,we introduce Bio Treasury(http://***),an integrated communitybased repository that provides an interactive platform for users and developers to share their experiences in various bioinformatics *** Treasury offers a comprehensive collection of well-indexed bioinformatics software,tools,and databases,totaling over 10,000 *** the past two years,we have continuously improved and maintained Bio Treasury,adding several exciting features,including creating structured homepages for every tool and user,a hierarchical category of bioinformatics tools and classifying tools using large language model(LLM).Bio Treasury streamlines the tool submission process with intelligent ***,Bio Treasury provides a wide range of social features,for example,enabling users to participate in interactive discussions,rate tools,build and share tool collections for the *** believe Bio Treasury can be a valuable resource and knowledge-sharing platform for the biomedical *** empowers researchers to effectively discover and evaluate bioinformatics tools,fostering collaboration and advancing bioinformatics research.

关键词： bioinformatics tools index tool database rating system large language model tool collections shari

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Cosmological Constraints on Neutrino Masses in Light of JWST Red and Massive Candidate Galaxies

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Research in Astronomy and Astrophysics 2024年第4期24卷 7-12页

作者： jian-Qi Liu Zhi-Qi Huang Yan Su School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China CSST Science Center for the Guangdong-Hong Kong-Macao Greater Bay Area Zhuhai 519082China

The overabundance of the red and massive candidate galaxies observed by the James Webb Space Telescope(JWST)implies efficient structure formation or large star formation efficiency at high redshift z~*** the scenario of a low or moderate star formation efficiency,because massive neutrinos tend to suppress the growth of structure of the universe,the JWST observation tightens the upper bound of the neutrino *** A cold dark matter cosmology and a star formation efficiency∈[0.05,0.3](flat prior),we perform joint analyses of Planck+JWST and Planck+BAO+JWST,and obtain improved constraints∑m_(ν)<0.196 eV and ∑m_(ν)+<0.111 eV at 95% confidence level,*** on the above assumptions,the inverted mass ordering,which implies ∑m_(ν)≥0.1 eV,is excluded by Planck+BAO+JWST at 92.7% confidence level.

关键词： (cosmology:)cosmological parameters galaxies:abundances galaxies:formation neutrinos

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基于近红外光谱法的精米品种判别优化研究

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光谱学与光谱分析 2024年第7期44卷 1988-1992页

作者：杨森王振民宋文龙邢键戴景民东北林业大学计算机与控制工程学院黑龙江哈尔滨150040 哈尔滨工业大学仪器科学与工程学院黑龙江哈尔滨150001

由于地理标志性大米巨大的市场价值,导致掺假行为时有发生。因此,为保证地理标志性大米品牌效益和消费者权益,实现准确的精米品种判别具有重要意义。近红外光谱法是精米品种判别的常用方法,通过提取不同品种近红外光谱中的差异性特征实... 详细信息

由于地理标志性大米巨大的市场价值,导致掺假行为时有发生。因此,为保证地理标志性大米品牌效益和消费者权益,实现准确的精米品种判别具有重要意义。近红外光谱法是精米品种判别的常用方法,通过提取不同品种近红外光谱中的差异性特征实现品种分类。然而,现有研究中存在特征波长选取性能不足和针对指定品种判别准确度不足的问题,限制了基于近红外光谱法的精米品种判别准确度的提升。针对上述问题,面向东北地区五常、响水、越光、银水四种大米,从特征波长选取和品种判别策略两个方面,研究基于近红外光谱法的精米品种判别优化。首先,为提高特征波长选取性能,将排列熵和自适应滑动窗口分割相结合,提出了基于自适应滑动排列熵的精米光谱特征波长选取方法,并开展与传统特征波长选取算法的对比实验。其次,为提高面向不同指定品种的判别准确度,提出基于判别目标的精米品种判别策略,通过研究光谱预处理算法与分类建模算法匹配优化,建立“指定品种-选定模型-选定算法的”的判别流程。实验结果表明,采用所提出的自适应滑动排列熵算法进行特征波长选取,相比于传统算法精米品种判别误差至少可降低50%;采用所提出的基于判别目标的精米品种判别策略,相比于传统的基于固定模型的判别策略的判别准确度至少可提高2.5%。

关键词：精米近红外光谱特征波长选取品种判别策略

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The spectrum of rare monogenic diseases in patients with premature coronary artery disease

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Chinese Medical Journal 2024年第10期137卷 1246-1248页

作者： Yaqun Teng Tian Du Siqin Feng Ran Tian Yaping Liu jian Guo Lei wang Zhiyu Zhang Xiaodong Luan Shan He Shengsheng Zhuang Yifei wang Shuyuan Zhang Shi Chen Zhenyu Liu Shuyang Zhang Department of Cardiology State Key Laboratory of Complex Severe and Rare diseasePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Internal Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Basic Medical Sciences Tsinghua University School of MedicineBeijing 100084China Department of Breast Oncology Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060China McKusick-Zhang Center for Genetic Medicine State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Tsinghua University-Peking University Joint Center for Life Sciences Beijing 100084China Department of Cardiology Beijing Tsinghua Changgung HospitalTsinghua UniversityBeijing 102218China Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Research Center for Behavior Medicine in Growth and DevelopmentBeijing 100730China

To the Editor:The global burden of premature coronary artery disease(CAD)is increasing among the young *** CAD generally refers to the occurrence of obstructive coronary atherothrombotic lesions in men and women aged<55 years and<65 years,respectively,and particularly in those aged<45 years.[1]The incidence of CAD in the younger population has remained stable or has increased,despite the declining incidence in older *** with premature CAD have a poor long-term prognosis,experiencing a high rate of recurrent ischemic events,rapid progression to multivessel disease,and frequent premature death.[1]Thus,it is crucial to identify the underlying causes of premature CAD that are distinct from those of age-related CAD and improve patient outcomes through precise diagnosis and treatment.

关键词： premature younger precise

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球状风化花岗岩类土质边坡土-岩界面优势流潜蚀特性研究

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岩土力学 2024年第4期45卷 950-960页

作者：豆红强谢森华简文彬王浩郭朝旭福州大学紫金地质与矿业学院福建福州350108 福建省地质工程勘察院福建省地质灾害重点实验室福建福州350002 福建省地质工程勘察院自然资源部丘陵山地地质灾害防治重点实验室福建福州350002

受降雨作用,球状风化花岗岩类土质边坡的土-岩差异风化界面极易演化为优势渗流通道而发生渗流潜蚀,进而加速该类边坡的变形失稳,然而当前有关其渗流潜蚀作用特征、细颗粒迁移规律等的研究仍鲜见开展。基于多孔介质非饱和渗流理论,综合... 详细信息

受降雨作用,球状风化花岗岩类土质边坡的土-岩差异风化界面极易演化为优势渗流通道而发生渗流潜蚀,进而加速该类边坡的变形失稳,然而当前有关其渗流潜蚀作用特征、细颗粒迁移规律等的研究仍鲜见开展。基于多孔介质非饱和渗流理论,综合考虑细颗粒运移、潜蚀启动响应与非饱和渗流的耦合关系,提出一种可准确描述土-岩界面渗流潜蚀过程的数值计算框架。采用有限元方法,构建优势流作用下非饱和花岗岩残积土的渗流潜蚀模型,并以均质土柱的渗流潜蚀过程为参考,系统研究3种典型土-岩界面埋藏状态下的优势流潜蚀特性。结果表明:球状风化花岗岩类土质边坡的土-岩界面与基质渗透性存在高度差异性,湿润锋形成向下凹陷的渗透漏斗,且随着降雨的持续,湿润锋的凹陷程度愈发明显;细颗粒流失程度与土-岩界面的埋藏状态相关,其中下填土体工况的优势流潜蚀最为显著,其界面处甚至出现超孔隙水压力,最不利于该类边坡的稳定性。研究成果可为降雨条件下球状风化花岗岩类土质边坡稳定性的准确评价提供科学依据。

关键词：优势流潜蚀有限元土-岩界面细颗粒运移多场耦合

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微震非线性优化定位方法研究与应用

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Applied Geophysics 2024年第2期21卷 331-342,420,421页

作者：刘伟建肖扬王浩楠侯梦杰田光辉董森森中原工学院建筑工程学院河南郑州451100 郑州安岩智能科技有限公司河南郑州451100

针对在实际工程应用中,考虑到震动波传播以及各项异性介质等因素的影响,传统线性定位求解过程极易出现发散问题,于是采用数学算法结合微震定位原理,推导得到一种微震非线性优化定位算法;新算法通过引入下山因子,增强了算法的稳定性和收... 详细信息

针对在实际工程应用中,考虑到震动波传播以及各项异性介质等因素的影响,传统线性定位求解过程极易出现发散问题,于是采用数学算法结合微震定位原理,推导得到一种微震非线性优化定位算法;新算法通过引入下山因子,增强了算法的稳定性和收敛性,达到全局收敛的目的;并提出一种多方向迭代的思路,可以使定位结果更加科学和精确,能够有效地降低定位结果中各个方向上的误差;通过长方体煤块声发射震源试验和传统线性定位算法进行比较,使算法的稳定性和震源结果的准确性得到了验证;工程现场应用也证明了它能够有效地降低微震台网布设带来的影响。

关键词：微震定位线性非线性优化定位

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