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Characteristics and long-term prognosis of patients with rectal neuroendocrine tumors

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World Journal of Gastroenterology 2014年第43期20卷 16252-16257页

作者： Yihebali Chi Feng Du Hong Zhao Jin-Wan Wang jian-qiang cai Cancer Institute and Hospital Chinese Academy of Medical Sciences

AIM: To analyze the clinicopathologic characteristics and prognostic factors of rectal neuroendocrine tumors.

关键词： Rectal neuroendocrine tumors Clinical characteristics Prognostic factors

Prognostic factors for 5-year survival after local excision of rectal cancer

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World Journal of Gastroenterology 2009年第10期15卷 1242-1245页

作者： Dong-Bing Zhao Yong-Kai Wu Yong-Fu Shao Cheng-Feng Wang jian-qiang cai Cancer Institute (Hospital) Chinese Academy of Medical Sciences and Peking UnionMedical College Beijing 100021 China

AIM:To evaluate the prognostic factors for 5-year survival after local excision of rectal cancer,and to examine the therapeutic efficacy and surgical indications for this procedure. METHODS:Clinical data,obtained from 106 local rectal cancer excisions performed between January 1980 and December 2005,were retrospectively *** analysis was performed using the Kaplan-Meier method,statistical comparisons were performed using the log-rank test,and multivariate analysis was performed using the Cox proportional hazards model. RESULTS:Transanal,transsacral,and transvaginal excisions were performed in 92,12,and 2 cases, *** rate of complication,local recurrence, and 5-year survival was 6.6%,17.0%,and 86.7%, *** analysis showed that T stage, vascular invasion,and local recurrence were related to the prognosis of the cases(P<0.05).Multivariate analysis showed that T stage[P=0.011,95% confidence interval(CI)=1.194-3.878]and local recurrence(P=0.022,95%CI=1.194-10.160)were the major prognostic factors for 5-year survival of cases after local excision of rectal cancer. CONCLUSION:Local rectal cancer excision is associated with few complications,and suitable for stages Tis and T1 rectal *** of local recurrence,active postoperative follow-up,and administration of salvage therapy are the effective methods to increase the efficacy of local excision of rectal cancer.

关键词： Rectal cancer Surgery Local excision Recurrence Prognosis

Aberrant expression of peroxiredoxin 1 and its clinical implications in liver cancer

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World Journal of Gastroenterology 2015年第38期21卷 10840-10852页

作者： Yu-Lin Sun jian-qiang cai Fang Liu Xin-Yu Bi Lan-Ping Zhou Xiao-Hang Zhao State Key Laboratory of Molecular Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Abdominal Surgery Cancer HospitalChinese Academy of Medical Science and Peking Union Medical College

AIM: To investigate the expression characteristics of peroxiredoxin 1(PRDX1) m RNA and protein in liver cancer cell lines and ***: The RNA sequencing data from 374 patients with liver cancer were obtained from The Cancer Genome Atlas. The expression and clinical characteristics of PRDX1 m RNA were analyzed in this dataset. The Kaplan-Meier and Cox regression survival analysis was performed to determine the relationship between PRDX1 levels and patient survival. Subcellular fractionation and Western blotting were used to demonstrate the expression of PRDX1 protein in six liver cancer cell lines and 29 paired fresh tissue specimens. After bioinformatics prediction,a putative posttranslational modification form of PRDX1 was observed using immunofluorescence under confocal microscopy and immunoprecipitation analysis in liver cancer ***: The m RNA of PRDX1 gene was upregulated about 1.3-fold in tumor tissue compared with the adjacent non-tumor control(P = 0.005). Its abundance was significantly higher in men than women(P < 0.001). High levels of PRDX1 m RNA were associated with a shorter overall survival time(P =0.04) but not with recurrence-free survival. The Cox regression analysis demonstrated that patients with high PRDX1 m RNA showed about 1.9-fold increase of risk for death(P = 0.03). In liver cancer cells,PRDX1 protein was strongly expressed with multiple different bands. PRDX1 in the cytosol fraction existed near the theoretical molecular weight,whereas two higher molecular weight bands were present in the membrane/organelle and nuclear fractions. Importantly,the theoretical PRDX1 band was increased,whereas the high molecular weight form was decreased in tumor tissues. Subsequent experiments revealed that the high molecular weight bands of PRDX1 might result from the post-translational modification by small ubiquitin-like modifier-1(SUMO1).CONCLUSION: PRDX1 was overexpressed in the tumor tissues of liver cancer and served as an independent p

关键词： Peroxiredoxin 1 Liver cancer Prognostic factor Pos

Radiofrequency Ablation versus Liver Resection for Colorectal Cancer Liver Metastasis： An Updated Systematic Review and Meta-analysis

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Chinese Medical Journal 2016年第24期129卷 2983-2990页

作者： Yue Han Dong Yan Fei Xu Xiao Li jian-qiang cai Department of Interventional Therapies National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Abdominal Surgical Oncology National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background： Controversial results about the therapeutic value of radiofrequency ablation （RFA） and liver resection （LR） in the treatment of colorectal cancer liver metastasis （CRCLM） have been reported. Thus, we performed the present meta-analysis to summarize the related clinical evidences. Methods： A systematic literature search was conducted using PubMed （Medline）, EMBASE, Cochrane Library, and Web of Science, for all years up to April 2016. Pooled analyses of the overall survival （OS）, progression-free survival （PFS）, and morbidity rates were performed. Results： A total of 14 studies were finally enrolled in the meta-analysis. Patients treated by LR gained a longer OS and PFS than those of patients treated by RFA. Patients in the RFA group had lower morbidity rates than those of patients in the LR group. Publication bias analysis revealed that there was no significant publication bias in the meta-analysis. Conclusions： Patients with CRCLM gained much more survival benefits from LR than that from RFA. RFA rendered lower rates of morbidities. More well-designed randomized controlled trails comparing the therapeutic value of LR and RFA are warranted.

关键词： Colorectal Liver Metastasis Liver Resection, Meta-analysis Radiofrequency Ablation

Prognostic Factors of Gastrointestinal Stromal Tumors： A Single Institutional Retrospective Experience with Surgical Management over 20 Years

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Clinical oncology and cancer researeh 2010年第3期7卷 175-180页

作者： Yong-kai WU Dong-bing ZHAO Cheng-feng WANG jian-qiang cai Yong-fu SHAO Ping ZHAO Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China.

OBJECTIVE To analyze the pathological features and prognosis factors of gastrointestinal stromal tumor （GIST） after primary resection. METHODS Medical records of the diagnosis, surgery, and follow-up of 327 patients with GISTs who underwent surgery between 1988 and 2007 were retrospectively reviewed. The predic-tive factors for the survival of these patients were identi. ed using multivariate analysis. RESULTS In the 327 tumors, 152 （46.5%） were located in the stomach, 89 （27.2%） in the small intestine, 33 （10.1%） in the colon and rectum, and 43 （13.1%） in other sites including the omentum and mesentery. The 3-year and 5-year overall survival rates of the 327 GIST patients were 74.4% and 62.7%, respectively, and univariate survival analysis demonstrated that factors, such as tumor size, mitotic index, NIH categories, Ki-67 index, tumor location, surgical margins, tumor bleeding, and tumor necrosis have significant effect on survival of the patients （P 〈 0.05）. Multivariate analysis demonstrated that the NIH categories, surgical margins, and Ki-67 index were independent prognostic factors for the survival rate. In the group of patients with postoperative recurrence or metastasis, the median survival time of patients who did not receive imatinib treatment was 30 months and that of patients who received imatinib treatment was 59 months. Their 5-year survival rates were 16.4% and 39.4%, respectively, and the difference was statistically significant （P = 0.017）. CONCLUSION Complete resection is the .rst choice of treat-ment for GISTs. It is reasonable to evaluate the prognosis of resect-able GISTs and guide the adjunctive therapy with NIH categories and Ki-67 index. Imatinib treatment can *** increase the survival rate of patients with recurrent and metastatic GISTs.

关键词： gastrointestinal stromal tumors prognostic factors surgical management survival adjuvant therapy

Prognositic factors and clinicopathologic characteristics of small gastrointestinal stromal tumor of the stomach:a retrospective analysis of 31 cases in one center

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Cancer Biology & Medicine 2013年第3期10卷 165-168页

作者： Zhen Huang Yuan Li Hong Zhao jian-Jun Zhao jian-qiang cai Department of Abdominal Surgery Cancer Institute and HospitalChinese Academy of Medical Science and Peking Union Medical College

Objective： To analyze the clinicopathologic characteristics and prognostic factors of small gastrointestinal stromal tumor （GIST） of the stomach. Methods： A total of 31 small gastric GIST patients, including 10 males and 21 females, with a median age of 58 years （37- 81 years）, who underwent surgery at any time from 1999 to 2012 were included in this study. The clinical records of the patients were analyzed retrospectively. Results： Abdominal discomfort and pain （10 cases, 32.3%, respectively） were the two most common complaints among the patients. All patients received surgery, 11 received gastric wedge resection, 11 received subtotal gastrectom）5 5 received laparoscopic gastric wedge resection, and 4 received endoscopic submucosal dissection. No severe adverse complication was observed. A total of 29 patients （93.5%） were followed up. During the follow-up, 2 patients were found to exhibit tumor recurrence, and 1 patient had liver metastases. One patient died of tumor progressionwhile another died of another malignant tumor. Median progression free survival （PFS） time was 120.3 months, and median overall survival （OS） time was 130.4 months. Conclusion： Small gastric GIST has better prognosis. Surgery is the best choice for therapy. Micro-invasive procedures are safe and effective for elective patients. Tumor necrosis, tumor bleeding, and muscle invasion are potential prognostic factors of small gastric GIST.

关键词： Gastrointestinal stromal tumors endoscopy prognosis

Excision Repair Cross-complementation Group 1 is a Prognostic Biomarker in Patients with Colorectal Cancer Receiving Chemotherapy

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Chinese Medical Journal 2016年第5期129卷 586-593页

作者： Mu-Xing Li Xin-Yu Bi Hong Zhao Zhen Huang Yue Han Dong-Bin Zhao jian-Jun Zhao jian-qiang cai Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Interventional Therapies Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background：Conflicting results about the association between expression level of excision repair cross-complementation group 1 （ERCC1） and clinical outcome in patients with colorectal cancer （CRC） receiving chemotherapy have been ***,we searched the available articles and performed the meta-analysis to elucidate the prognostic role of ERCC1 expression in patients with ***：A thorough literature search using PubMed （Medline）,Embase,Cochrane Library,Web of Science databases,and Chinese Science Citation Database was conducted to obtain the relevant *** hazard ratios （HRs） or odds ratios （ORs） with 95% confidence intervals （CIs） were calculated to estimate the ***：A total of 11 studies were finally enrolled in this *** with patients with lower ERCC1 expression,patients with higher ERCC1 expression tended to have unfavorable overall survival （OS）（HR =2.325,95% CI：1.720-3.143,P 〈 0.001）,progression-free survival （PFS）（HR =1.917,95% CI：1.366-2.691,P 〈 0.001） and poor response to chemotherapy （OR =0.491,95% CI：0.243-0.990,P =0.047）.Subgroup analyses by treatment setting,ethnicity,HR extraction,detection methods,survival analysis,and study design demonstrated that our results were ***：ERCC1 expression may be taken as an effective prognostic factor predicting the response to chemotherapy,OS,and *** studies with better study design and longer follow-up are warranted in order to gain a deeper understanding of ERCC 1＇s prognostic value.

关键词： Colorectal Cancer: Excision Repair Cross-complementation Group I Prognosis

Identification of biomarkers for hepatocellular carcinoma by semiquantitative immunocytochemistry

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World Journal of Gastroenterology 2014年第19期20卷 5826-5838页

作者： Hong Mu Kai-Xuan Lin Hong Zhao Shu Xing Cong Li Fang Liu Hai-Zhen Lu Ze Zhang Yu-Lin Sun Xi-Yun Yan jian-qiang cai Xiao-Hang Zhao State Key Laboratory of Molecular Oncology Cancer Institute HospitalChinese Academy of Medical Sciences and Peking Union Medical College Center of Basic Medical Sciences Navy General Hospital of Chinese PLA Department of Abdominal Surgery Cancer Institute HospitalChinese Academy of Medical Science and Peking Union Medical College Key Laboratory of Protein and Peptide Pharmaceutical National Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academy of Sciences Department of Pathology Cancer Institute HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM: To investigate the expression of key biomarkers in hepatoma cell lines, tumor cells from patients’ blood samples, and tumor tissues.

关键词： Hepatocellular carcinoma Biomarker Immunocytochemistry Semiquantitative analysis Three-dimensional reconstruction

Evaluation of Eight Different Clinical Staging Systems Associated with Overall Survival of Chinese Patients with Hepatocellular Carcinoma

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Chinese Medical Journal 2015年第3期128卷 316-321页

作者： jian-Jun Zhao Tao Yan Hong Zhao jian-Guo Zhou Zhen Huang Ye-Fan Zhang Yuan Li Zhi-Yu Li Xin-Yu Bi jian-qiang cai Department of Abdominal Surgery Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China Department of Anesthesiology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China

Background： Hepatocellular carcinoma （HCC） is a common cancer in China, an area of high hepatitis B virus （HBV） infection. Although several staging systems are available, there is no consensus on the best classification to use because multiple factors, such as etiology, clinical treatment and populations could affect the survival of HCC patients. Methods： This study analyzed 743 HBV-related Chinese HCC patients who received surgery first and evaluated the predictive values of eight different commonly used staging systems in the clinic. Results： The overall 1-, 3-, 5-year survival rates and a median survival were 91.5%, 70.3%, 55.3% and 72 months respectively. Barcelona Clinic Liver Cancer （BCLC） staging systems had the best stratification ability and showed the lowest Akaike information criterion （AIC） values （2896.577）, followed by tumor-node-metastasis Th （TNM 7^th）（AIC = 2899.980）, TNM 6th （AIC = 2902.17）, Japan integrated staging score （A1C = 2918.085）, Tokyo （AIC = 2938.822）, Cancer of the Liver Italian Program score （AIC = 2941.950）, Chinese University Prognostic Index grade （AIC = 2962.027）, and Okuda （AIC = 2979.389）. Conclusions： BCLC staging system is a better staging model for HBV infection patients with HCC in Chinese population among the eight currently used staging systems. These identifications afford a large group of Chinese HCC patients with HBV infection and could be helpful to design a new staging system for a certain population.

关键词： Chinese Population Clinical Staging Ssystem Hepatocellular Carcinoma Survival