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Optically active micelles from self-assembly of MPEG-b-PMALM copolymer in water

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Chinese Chemical Letters 2009年第2期20卷 231-234页

作者： Fa Bao Zhao Zhi Lei Liu jian ping Sun liang Feng Ji Wen Hu Guangzhou Institute of Chemistry Chinese Academy of Sciences Guangzhou 510650 China

Reported here is fabrication of optically active micelles with broad range of morphologies in water, such as spheres, cylinders, and vesicles, from self-assembly of poly（ethylene glycol） monomethyl ether-b-poly- （methacryloyl-L-leucine methyl ester）（MPEG-b-PMALM） copolymer, which was prepared via atom transfer radical polymerization （ATRP） from vinyl monomer bearing chiral amino acid moieties, N-methacryloyl L-leucine methyl ester （MALM）, using bromine （Br） end-capped poly（ethylene golycol） monomethylether （MPEG-Br） as macroinitiator in the presence of CuBr/Me6TREN as catalytic system.

关键词： Block copolymers Chiroptical properties Micelles Circular dichroism (CD)

High birth weight and its interaction with physical activity influence the risk of obesity in early school-aged children

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World Journal of Pediatrics 2020年第4期16卷 385-392页

作者： Jia-Ru Deng Wei-Qing Tan Shu-Yi Yang Li-ping Ao jian-ping liang Li-Xia Li Yan-Hui Gao Yi Yang Li Liu Department of Epidemiology and Biostatistics School of Public HealthGuangdong Pharmaceutical University283 Jianghai RoadGuangzhou510310China Guangzhou Health Care Promotion Center for Primary and Middle Schools Guangzhou510180China Futian Hospital for Prevention and Treatment of Chronic Disease Shenzhen518048China

Background High birth weight(HBW)is associated with childhood obesity,but with inconsistent *** study investigated the relationship between HBW and childhood obesity,and further explored the interaction of HBW with behavioral and socio-economic determinants of *** This cross-sectional study enrolled 1906 grade-two children of Guangzhou,China,from June to November,***/obesity corresponded to a body mass index higher than the sex–age-specific *** obesity was assessed using the sex-specific waist–height ratio *** association of HBW with obesity was evaluated in multivariable logistic regression *** relative excess risk due to interaction(RERI)and the attributable proportion of interaction(AP)indices were used to measure additive interaction,while applying the interaction of OR index for multiplicative interaction *** Children with HBW had an increased risk of overweight/obesity[odds ratio(OR)=2.42,95%confidence interval(CI)=1.56–3.76]compared with those without *** additive interaction of HBW with physical activity was found for overweight/obesity[relative excess risk due to interaction(RERI)=2.69,95%CI=0.62–4.75;attributable proportion of interaction(AP)=0.72,95%CI=0.42–1.02].The HBW children with insufficient activity had higher odds of overweight/obesity compared to the non-HBW children with sufficient activity(OR=3.75,95%CI=2.06–6.83).In addition,we identified a significant interaction of HBW with household income for abdominal obesity(RERI=1.20,95%CI=0.02–2.37;AP=0.76,95%CI=0.16–1.36).Conclusions HBW confers an increased risk for childhood overweight/*** activity attenuates the effect of HBW on overweight/obesity,and HBW possibly synergistically interacts with high household income to promote abdominal obesity in childhood.

关键词： Childhood High birth weight Interaction Obesity Physical activity

Fine structure characterization of an explosively-welded GH3535/316H bimetallic plate interface

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1811-1820页

作者： Jia Xiao Ming Li jian-ping liang Li jiang De-jun Wang Xiang-xi Ye Ze-zhong Chen Na-xiu Wang Zhi-jun Li School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Dalian National Laboratory for Clean Energy Dalian 116023China Ministry of Ecology and Environment Beijing 100135China Institute of Zhejiang University-Quzhou Quzhou 324004China

An explosion-welded technology was induced to manufacture the GH3535/316H bimetallic plates to provide a more cost-effective structural material for ultrahigh temperature,molten salt thermal storage *** microstructure of the bonding interfaces were extensively investigated by scanning electron microscopy,energy dispersive spectrometry,and an electron probe *** bonding interface possessed a periodic,wavy morphology and was adorned by peninsula-or island-like transition *** higher magnification,a matrix recrystallization region,fine grain region,columnar grain region,equiaxed grain region,and shrinkage porosity were observed in the transition zones and surrounding *** backscattered diffraction demonstrated that the strain in the recrystallization region of the GH3535 matrix and transition zone was less than the *** concentration occurred at the interface and the solidification defects in the transition *** dislocation substructure in 316H near the interface was characterized by electron channeling contrast imaging.A dislocation network was formed in the grains of *** microhardness decreased as the distance from the welding interface increased and the lowest hardness was inside the transition zone.

关键词： GH3535/316H bimetallic plate ultrahigh temperature molten salt explosive welding interface structure dislocation substructure

Detection of trace heavy metals using atmospheric pressure glow discharge by optical emission spectra

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High Voltage 2019年第3期4卷 228-233页

作者： Xiao Li De-Zheng Yang Hao Yuan jian-ping liang Tao Xu Zi-Lu Zhao Xiong-Feng Zhou LiZhang Wen-Chun Wang Key Laboratory of Materials Modification Dalian University of TechnologyMinistry of EducationDalian 116024People's Republic of China School of Science Shihezi UniversityShihezi 832003People's Republic of China Research group PLASMANT Department of ChemistryUniversity of AntwerpUniversiteitsplein 1BE-2610 Wilrijk-AntwerpBelgium

In this Letter,atmospheric pressure glow discharge based on a small discharge gap is excited by sine AC voltage in air on purpose of detecting trace heavy metal elements in solid samples,which makes the detection limits of trace heavy metal elements reach tensμg/*** waveforms of voltage and discharge current,discharge images,plasma gas temperature,and optical emission spectra are obtained to discuss the feasibility of atmospheric pressure glow discharge on detection of trace heavy *** formation mechanism of optical emission spectra and the strong emission intensity of heavy metal elements show that energetic electrons and excited metal atoms are easily generated by atmospheric pressure glow *** effects of applied voltage and discharge gap on atmospheric pressure glow discharge are discussed to acquire the optimal experimental *** a smaller discharge gap and applied voltage can restrain the transition from glow discharge to arc ***,the limits of detections of Cu and Cd are about 0.0241 and 0.0318μg/g,respectively,by using atmospheric pressure glow discharge with an applied voltage of 3.8 kV,discharge gap of 3.5 mm,and driving frequency of 10 kHz.

关键词： spectra excited restrain

Anti-Influenza A Virus Effect of Hypericum perforatum L. Extract

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Virologica Sinica 2009年第1期24卷 19-27页

作者： Xiu-ying PU jian-ping liang Xue-hong WANG Tao XU Lan-ying HUA Ruo-feng SHANG Yu LIU Yan-mei XING College of Veterinary Medicine Gansu Agricultural University Lanzhou 730070 China Lanzhou Institute of Animal and Veterinary Pharmaceutics Sciences Chinese Academy of Agricultural Sciences Lanzhou 730050 China Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China

To study the antiviral effect of Hypericum perforatum L. extract （HPE） on influenza A virus （IAV）（H1N1） in vitro and in vivo. Cytopathic effect （CPE） and neutral red （NR） dye uptake were used to examine the antiviral effect of HPE on Madin Darby Canine Kidney （MDCK） cells which were infected with IAV in vitro HPE was effective against influenza A virus （IAV） in vitro, with a 50% effective concentration （EC50） of 40 ug/mL, The mean 50% cytotoxic concentration （CC50） in the MDCK used in these experiments was 1.5 mg/mL. Ribavirin was run in parallel with EC50 values of 5.0 ug/mL; the mean CC50 for ribavirin was 520 ug/mL. Oral gavage administrations of HPE or ribavirin to mice infected with the IAV were highly effective in preventing death, slowing the decline of arterial oxygen saturation, inhibiting lung consolidation and reducing lung virus titers. The minimum effective dose of HPE in these studies was 31.25 mg/kg/day, which was administered twice daily for 5 d beginning 4 h prior to virus exposure. Below a dosage of 2000 mg/kg/day, almost all treated mice survived, which suggests that HPE is of low toxicity. Ribavirin＇s minimum effective dose was 40 mg/kg/day with the LDso determined to be 200 mg/kg/day. Delay of the initiation of either HPE or ribavirin therapy, using approximately 1/3 LD50 dose each time, could still be protective as late as 48 h after exposure to the IAV. While both agents appeared to have similar efficacy against IAV infections, HPE was considered to be less toxic and may warrant further evaluation as a possible therapy for influenza.

关键词： Influenza A virus (IAV) Hypericum perforatum L. extract (HPE) Ribavirin

In vivo Inhibition of NAS Preparation on H9N2 Subtype AIV

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Virologica Sinica 2010年第2期25卷 145-150页

作者： Ruo-feng SHANG jian-ping liang Zhong-yuan NA Hong-jun YANG YU LU Lan-ying HUA Wen-zhu GUO Ying CUI Ling WANG Key Laboratory of New Animal Medicine Project Chinese Academy of Agricultural Sciences Lanzhou Insititute of Animal Husbandry ＆ Veterinary Pharamaceutics Science Chinese Academy of Agricultural Sciences Lanzhou 730050 China Yunnan Eco-agricultural Research Institute Kunming 650106 China

NAS preparation, a kind of Chinese herbal medicine found by the Yunnan Eco-agricultural Research Institute, has potential antiviral activity. In this paper, the inhibiting effect of NAS preparation on H9N2 subtype Avian influenza virus (AIV) was investigated in vivo. Chickens infected with H9N2 virus were treated with NAS preparation for 4 days. The virus was then detected by hemoagglutination (HA) test and reverse transcription polymerase chain reaction (RT-PCR). The results showed that no H9N2 virus could be detected at the 7th day when the chickens were treated with 0.2g/kg/d or 0.1g/kg/d of NAS preparation. However the virus could be detected in other chickens without NAS preparation treatment. This result suggested that NAS preparation may be a potential drug candidate to control infection of H9N2 subtype AIV in chickens.

关键词： NAS preparation H9N2 subtype AIV HA RT-PCR

Efficacy and Safety of Domestic Leuprorelin in Girls with Idiopathic Central Precocious Puberty： A Multicenter,Randomized, Parallel, Controlled Trial

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Chinese Medical Journal 2015年第10期128卷 1314-1320页

作者： Wen-Jing Li Chun-Xiu Gong Mei-Jie Guo Jie Xing Tang Li Wen-Hui Song Xiao-ping Luo Di Wu jian-ping liang Bing-Yan Cao Yi Gu Chang Su Xue-Jun liang Min Liu Rui Wang Feng-Ting Li Department of Endocrine and Genetic Metabolic Beijing Children&#39 s Hospital Capital Medical UniversityBeijing 100045China Department of Adolescent Medicine Harbin Children&#39 s Hospital HarbinHeilongjiang 150010China Department of Developmental Pediatrics The Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Pediatrics The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266003China Department of Endocrinology Shanxi Children&#39 s Hospital TaiyuanShanxi 030013China Department of Pediatrics Tongji HospitalTongJi Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China

Background：In central precocious puberty （CPP）,the pulse secretion and release ofgonadotropin-releasing hormone （GnRH） are increased due to early activation of the hypothalamic-pituitary-gonadal axis,resulting in developmental abnormalities with gonadal development and appearance of secondary sexual *** CPP without organic disease is known as idiopathic CPP （ICPP）.The objective of the study was to evaluate the clinical efficacy and safety of domestic leuprorelin （GnRH analog） in girls with ***：A total of 236 girls with ICPP diagnosed from April 2012 to January 2014 were selected and were randomized into two *** hundred fifty-seven girls in the test group were treated with domestic leuprorelin acetate,79 girls in the control group were treated with imported leuprorelin *** all were treated and observed for 6 *** 6-month treatment,the percentage of children with peak luteinizing hormone （LH） ≤3.3 U/L,the percentage of children with peak LH/peak follicle stimulating hormone （FSH） ratio 〈0.6,the improvements of secondary sexual characteristics,gonadal development and sex hormone levels,the change of growth rate of bone age （BA） and growth velocity,and drug adverse effects between two groups were ***：After the treatment,the percentage of children with a suppressed LH response to GnRH,defined as a peak LH ≤3.3 U/L,at 6 months in test and control groups were 96.80% and 96.20%,respectively,and the percentage of children with peak LH/FSH ratio ≤0.6 at 6 months in test and control groups were 93.60% and 93.70%,*** sizes of breast,uterus and ovary of children and the levels of estradiol （E2） were significantly reduced,and the growth rate of BA was also *** the differences between pre-and post-treatment in each group were statistically significant （P 〈 0.05）,but the differences of the parameters between two groups were not significant （P 〉 0.05）.Conclusions：Domestic leuprorelin is effective and

关键词： Central Precocious Puberty Gonadotropin-releasing Hormone Analog Idiopathic Central Precocious Puberty Leuprorelin

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

“One stone, two birds”: Salt template enabling porosity engineering and single metal atom coordinating toward high-performance zinc-ion capacitors

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Journal of Energy Chemistry 2025年第1期100卷 637-645页

作者： Chunliu Zhu Huanyu liang ping Li Chenglong Qiu Jingyi Wu Jingwei Chen Weiqian Tian Yue Zhu Zhi Li Huanlei Wang School of Materials Science and Engineering Ocean University of China Department of Chemical and Materials Engineering University of Alberta

Zinc-ion hybrid capacitors （ZIHCs） have received increasing attention as energy storage devices owing to their low cost,high safety,and environmental ***,their progress has been hampered by low energy and power density,as well as unsatisfactory long-cycle stability,mainly due to the lack of suitable electrode *** this context,we have developed manganese single atoms implanted in nitrogen-doped porous carbon nanosheets （MnSAs/NCNs） using a metal salt template method as cathodes for *** metal salt serves a dual purpose in the synthesis process:It facilitates the uniform dispersion of Mn atoms within the carbon matrix and acts as an activating agent to create the porous *** applied in ZIHCs,the MnSAs/NCNs electrode demonstrates exceptional performance,including a high capacity of 203 m Ah g-1,an energy density of 138 Wh kg-1at 68 W kg-1,and excellent cycle stability with 91%retention over 10,000 *** calculations indicate that the introduced Mn atoms modulate the local charge distribution of carbon materials,thereby improving the electrochemical *** work demonstrates the significant potential of carbon materials with metal atoms in zinc-ion hybrid capacitors,not only in enhancing electrochemical performance but also in providing new insights and methods for developing high-performance energy storage devices.

关键词： Zinc ion hybrid capacitors Cathodes Carbon materials Heteroatoms Single atoms