检索结果-南通市图书馆

Regulatory Mechanism of Xiaozheng Tongluo Method on hepatic Lipid Metabolism in ApoE-/- Mice: Insights from the Sterol Regulatory Element-binding Protein-2/3-hydroxy-3-methylglutaryl Coenzyme A Reductase/Low-density Lipoprotein Receptor Signaling Pathwa

在线全文

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第3期10卷 363-369页

作者： Xin Zhang jian-Li Ge Kun Su jian-ming he Min-Mei Zhang Jing Zhang Yun-Long Ma Yun-Chao Sun Xin-Qiang Chu Vascular Surgery Hebei Province Hospital of Chinese Medicine Vascular Surgery Shijiazhuang Hospital of Traditional Chinese Medicine Vascular Surgery Dongzhimen Hospital Beijing University of Chinese Medicine

Objective: The objective of the study was to explore the regulatory mechanism of the Xiaozheng Tongluo method on lipid metabolism in liver tissue based on the sterol regulatory element-binding protein-2/（SREBP2）/3-hydroxy-3-methylglutaryl coenzyme A reductase（HMGCR）/low-density lipoprotein receptor（LDLR） signaling pathway. Materials and Methods: C57BL/6 mice were selected as the blank group. The apolipoprotein E-deficient(Apo E-/-) mice were randomly divided into the model group, traditional Chinese medicine（TCM） group, and control group. The general condition of the mice was determined by the mouse's state and liver weight. Liver hematoxylin and eosin staining and Oil Red O staining were used to observe the pathological changes and lipid droplet deposition of the liver. The protein expression levels of SREBP2, HMGCR, and LDLR were detected by Western blotting and polymerase chain reaction. Results:（1） The rats in the model group were in poor condition, and their liver weight increased significantly. Compared with the model group, the condition of the TCM group and the control group improved to varying degrees, and their liver weight decreased significantly.（2） Compared with the normal group, the hepatocytes in the model group were arranged in a disorderly manner,and the red-stained lipids of stem cells increased significantly. Compared with the model group, the degree of liver lesions in the control group and TCM group was reduced, and the red-stained lipid of hepatocytes was significantly reduced.（3） Compared with the blank group, the expression of SREBP2 and HMGCR protein in the model group increased significantly, and the expression of LDLR protein decreased significantly（P he model group, the expression of SREBP2 and HMGCR protein in the TCM group decreased significantly, and the expression of LDLR protein increased significantly（P he method detailed in this paper can increase the expression of SREBP2 and HMGCR prot

关键词： ApoE-/-mice lipid metabolism liver sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl coenzyme a reductase/low-density lipoprotein receptor signaling pathway Xiaozheng Tongluo method

Low dose effects on cultured mammalian cells...

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2000年第4期11卷 276-279页

作者： WANG Ju-Fang, LI Wen-jian, ZHOU Guang-ming, he Jing, LI Qiang, DANG Bing-Rong, LI Xing-Lin, XIE Hong-Mei, WEI Zeng-Quan (Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000) 中科院近代物理所甘肃兰州 730000

The low dose effects induced by carbon ions on Chinese hamster V79 cells and murine melanoma B16 cells were investigated in this paper. Both cell lines were divided into four groups for irradiation: (1) control, (2) 0.02 Gy or 0.05 Gy(D1), (3) 1 Gy(D2), (4) D1+D2. The survivors and micronuclei were studied as biological endpoints. The results of group (1) and group (2) showed that there were no obvious differences on micronucleus frequency but there were significant increases when irradiation dose was 0.02Gy on colony formation efficiency. Although low dose ion irradiation could not contribute to DNA damages, it could enhance the colony formation efficiency. In the study of group (3) and (4), when the ion dose was 0.02 Gy, there were evident increases on surviving fraction and decreases on micronucleus frequency, but there were no statistical changes on these endpoints when the ion dose was 0.05Gy. This meant that high LET radiation could induce the adaptive response of cultured cells, furthermore, in the range of inducing ion dose , low dose irradiation was more profitable than high dose one.

关键词：哺乳动物细胞 DNA 离子辐射低剂量效应辐射效应碳离子

Simultaneous Determination of Two Major Triterpenoid Saponins:Celosins Ⅰ and Ⅱ in Celosiae Semen by HPLC-ELSD

在线全文

学校读者我要写书评

暂无评论

Chinese herbal Medicines 2015年第2期7卷 185-190页

作者： Rui-bing Chen Yu-yang Zhang jian-ming he Wen-dan Wu Mei-li Guo Department of Pharmacognosy School of Pharmacy Second Military Medical University health Team of Zhoucun Airforce Station

Objective To establish an analytical method for the simultaneous determination of celosin Ⅰ and celosin Ⅱ, two major triterpenoids in Celosia Semen and compare the contents of celosin Ⅰ and celosin Ⅱ from different habitats to screen the resources of elite germplasm for further applications. Methods A sensitive and simple high- performance liquid chromatography coupled with evaporative light-scattering detector（HPLC-ELSD） method was developed for the first time for the simultaneous determination of celosin Ⅰ and celosin Ⅱ. Using this method, 21 batches of Celosiae Semen were determined from different habitats in China. Results There was an obvious difference in the contents of celosin Ⅰ and celosin Ⅱ among Celosiae Semen species from various habitats across China. The crude drug from Yongzhou, Hunan province, Zhuhai, Guangdong province, and Nanning, Guangxi province showed the highest contents of all habitats, while Anguo, hebei province, Haidian, Beijing, and Zhengzhou, henan province showed the lowest content. The results also showed that geographical location had a great influence on the contents of the two compounds. The batches from lower latitudes were higher in contents of celosin Ⅰ and celosin Ⅱ. Conclusion The sun light may be a key factor influencing the contents of the two saponins, indicating that the environment has a great impact on the quality of Celosiae Semen.

关键词： Celosiae Semen HPLC-ELSD quantitative determination triterpenoids celosin

Testing for additivity with B-splines

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2007年第6期50卷 841-858页

作者： heng-jian CUI, Xu-ming he & Li LIU Department of Statistics and Financial Mathematics, School of Mathematical Sciences, Beijing Normal University, Beijing 100875, China Department of Statistics, University of Illinois, Champaign, IL 61820, USA National Institute of Statistical Science, Durham, NC 27709, USA Department of Statistics Financial Mathematics School of Mathematical Sciences Beijing Normal University Beijing 100875 China Department of Statistics University of Illinois Champaign IL 61820 USA National Institute of Statistical Science Durham NC 27709 USA

Regression splines are often used for fitting nonparametric functions, and they work especially well for additivity models. In this paper, we consider two simple tests of additivity: an adaptation of Tukey’s one degree of freedom test and a nonparametric version of Rao’s score test. While the Tukey-type test can detect most forms of the local non-additivity at the parametric rate of O(n-1/2), the score test is consistent for all alternative at a nonparametric rate. The asymptotic distribution of these test statistics is derived under both the null and local alternative hypotheses. A simulation study is conducted to compare their finite-sample performances with some existing kernel-based tests. The score test is found to have a good overall performance.

关键词： additivity B-splines dimension reduction score test smoothing Tukey test 62G10 62G20 62G07

The Chinese classification system compared with TNM staging in prognosis of patients with primary hepatic carcinoma after resection

在线全文

学校读者我要写书评

暂无评论

hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 561-564页

作者： jian-ming Sheng, Wen-he Zhao, Fu-Sheng Wu, Zhi-Min Ma, Yi-Zheng Feng, Xing-Ren Zhou and Li-Song Teng Department of Oncological Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China Department of Oncological Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China. sjm418@***

BACKGROUND: The life expectancy of a patient with primary hepatic carcinoma (PHC) is hard to predict, and it is related to many prognostic factors. The Chinese classification system including five parameters: tumor, vascular thrombosis, lymph node metastasis, distant metastasis and Child-Pugh stage developed in 1999 was adopted by the 8th National Conference on liver Cancer of the Chinese Anti-Cancer Association in 2001. In this study, the discriminatory ability of the Chinese classification system -was compared with that of the TNM staging in patients for resection of PHC, in addition to the evaluation of prognostic value. METHODS: The data of 246 patients who had undergone resection of PHC from January 1986 to December 2000 (average age, 51 years; male/female ratio, 213/33) were retrospectively studied. Among the 246 patients, 227 were followed up for at least 3 years. RESULTS: The 1-, 3-, 5-, 7-, and 10-year tumor-free survival rates were 55% , 30% , 25% , 20% and 18% , respectively. The Chinese classification system was better than the TNM staging system in predicting survival rate of patients with PHC, as confirmed by survival curves shown by the Kaplain-Meier method. The mean survival time was 155, 70, 39, 16, and 4 months in patients with die Chinese classification stages Ⅰa, Ⅰb, Ⅱa,Ⅱb, and Ⅲ, respectively. The 1-, 3-, 5-, 7-, and 10-year tumor-free survival rates of the Chinese classification system and TNM staging were statistically significant and had a slightly positive relationship. The predictive capacity of the Chinese classification system was confirmed in any two subgroups of patients undergoing operation. COX proportional hazards regression analysis showed that the Chinese classification system was the only independent prognostic factor for survival. CONCLUSIONS: Taking both tumor extension and liver function into account, we consider that the Chinese classification system making up for the deficiency of UICC TNM staging is more precise in predictin

关键词： primary liver cancer staging system liver functional status prognosis

在线全文

学校读者我要写书评

暂无评论

可减少模型简化误差的边折叠简化算法及应用

计算机科学 2004年第1期31卷 142-144页

作者：王健何明一西北工业大学陕西省信息获取与处理重点实验室西安710072

基于三角形网格边折叠简化思想,提出一种基于边顶点重要度简化算法,简化算法能有效保持模型局部特征,减小简化模型和原始模型之间的误差;采用一种改进的三角形网格数据结构,利用二叉树对顶点重要度进行快速排序并记录三角形合并关系,得... 详细信息

基于三角形网格边折叠简化思想,提出一种基于边顶点重要度简化算法,简化算法能有效保持模型局部特征,减小简化模型和原始模型之间的误差;采用一种改进的三角形网格数据结构,利用二叉树对顶点重要度进行快速排序并记录三角形合并关系,得到所需分辨率下的近似网格模型。数据结构具有层次清楚、操作简单、可扩充性等特点,能有效支持多分辨率简化与快速可视化。

关键词：三角形网格边折叠简化算法数据结构二叉树分辨率拓扑结构顶点重要度

在线全文

学校读者我要写书评

暂无评论

无绝缘区间设备系统可靠性分析

铁道学报 1999年第5期21卷 112-114页

作者：陈建明何春明张仲义北方交通大学自动化研究所北京100044

我国的铁路区间信号设备采用集中放置于室内的形式，这对系统的维护和维修提供了很大的方便。为了提高系统可靠性，节省投资，采用Ｎ＋１热备方式。本文从可靠性理论出发，详细分析并计算了Ｎ＋１热备方式下系统的可靠性指标。

关键词：铁路无绝缘轨道电路 N+1热备方式系统可靠性

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-ming Pan Wei Li Rui-Qiong Ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

棉籽油脚复合改性膨润土应用于混凝土脱模剂的工艺研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

粮食与油脂 2017年第6期30卷 66-68页

作者：姜丽娜但建明何良波美丽伊犁职业技术学院新疆伊犁835000 石河子大学化学化工学院新疆石河子832000 伊犁庆华集团新疆伊犁835000

为探究皂化棉籽油脚与改性膨润土复合的最佳工艺,通过单因素试验和正交试验研究分析了膨润土添加量、皂化棉籽油脚添加量、棉籽油添加量、搅拌时间和搅拌温度对复合工艺的影响。结果表明,最佳工艺参数为膨润土添加量1.0 g、皂化棉籽油... 详细信息

为探究皂化棉籽油脚与改性膨润土复合的最佳工艺,通过单因素试验和正交试验研究分析了膨润土添加量、皂化棉籽油脚添加量、棉籽油添加量、搅拌时间和搅拌温度对复合工艺的影响。结果表明,最佳工艺参数为膨润土添加量1.0 g、皂化棉籽油脚添加量1.5 g、棉籽油添加量3 mL、搅拌温度80℃、搅拌时间1.0h,产品满足相关技术要求。

关键词：棉籽油脚膨润土混凝土脱模剂