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Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma

World Journal of Gastroenterology 2006年第3期12卷 465-467页

作者： jian-lun liu Lian-ying Ge Gui-nian Zhang Department of Gastrointestinal and Breast Surgery the Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021 Guangxi Zhuang Autonomous Region China Department of Endoscope the Affiliated CancerHospital of Guangxi Medical University Nanning 530021Guangxi Zhuang Autonomous Region China Department-of Gastrointestinal Surgery Guangxi Zhuang Autonomous Region Hospital Narming 530021Guangxi Zhuang Autonomous Region China

AIM： To study the activity of telomerase and the expression of human telomerase reverse transcriptase （hTERT） in colorectal carcinoma and its adjacent tissues, normal mucosa and adenomatoid polyp, and to evaluate their relation with carcinogenesis and progression of colorectal carcinoma. METHODS： Telomerase activity and hTERT expression were determined in 30 samples of colorectal carcinoma and its adjacent tissues, normal mucosa and 20 samples of adenomatoid polyp by modified telomeric repeat amplification protocol （TRAP）, enzyme-linked immunosorbent assay （ELISA） and immunohistochemical method. RESULTS： Telomerase activity and hTERT expression were 83.33% （25/30） and 76.67% （23/30） respectively in colorectal carcinoma, which were obviously higher than those in paracancerous tissues （13.33%, 16.67%）, normal mucosa （3.33%, 3.33%） and adenomatoid polyp （10%, 10%）. There was a significant difference between colorectal carcinoma and other tissues （P=0.027）. The telomerase activity and hTERT expression were higher in colorectal carcinoma with lymphatic metastasis than in that without lymphatic metastasis （P=0.034）. When the histological classification and clinical stage were greater, the telomerase activity and hTERT expression increased, but there was no significant difference between them. In colorectal carcinoma, the telomerase activity was correlated with hTERT expression （positive vs negative expression of telomerase activity and hTERT, P=0.021）. CONCLUSION： Telomerase activity is closely correlated with the occurrence, development and metastasis of colorectal carcinoma. Overexpression of hTERT may play a critical role in the regulation of telomerase activity.

关键词： Colorectal carcinoma Telomerase activity hTERT expression

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Highly Accurate Golden Section Search Algorithms and Fictitious Time Integration Method for Solving Nonlinear Eigenvalue Problems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1317-1335页

作者： Chein-Shan liu jian-Hung Shen Chung-lun Kuo Yung-Wei Chen Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina Department of Marine Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina

This study sets up two new merit functions,which are minimized for the detection of real eigenvalue and complex eigenvalue to address nonlinear eigenvalue *** each eigen-parameter the vector variable is solved from a nonhomogeneous linear system obtained by reducing the number of eigen-equation one less,where one of the nonzero components of the eigenvector is normalized to the unit and moves the column containing that component to the right-hand side as a nonzero input vector.1D and 2D golden section search algorithms are employed to minimize the merit functions to locate real and complex ***,the real and complex eigenvectors can be computed very accurately.A simpler approach to the nonlinear eigenvalue problems is proposed,which implements a normalization condition for the uniqueness of the eigenvector into the eigenequation *** real eigenvalues can be computed by the fictitious time integration method(FTIM),which saves computational costs compared to the one-dimensional golden section search algorithm(1D GSSA).The simpler method is also combined with the Newton iterationmethod,which is convergent very *** the proposed methods are easily programmed to compute the eigenvalue and eigenvector with high accuracy and efficiency.

关键词： Nonlinear eigenvalue problem quadratic eigenvalue problem two new merit functions golden section search algorithm fictitious time integration method

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Relationship between hydrogenation degree and pyrolysis performance of jet fuel

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Chinese Journal of Chemical Engineering 2024年第4期68卷 35-42页

作者： Qing liu Tinghao Jia lun Pan Jijun Zou Xiangwen Zhang Key Laboratory for Green Chemical and Technology School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China Zhejiang Institute of Tianjin University Ningbo 315201China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China

Understanding the relationship between the chemical composition and pyrolysis performance of endothermic hydrocarbon fuel(EHF) is of great significance for the design and optimization of advanced EHFs. In this work, the effect of deep hydrogenation on the pyrolysis of commercial RP-3 is *** with different hydrogenation degrees were obtained by the partially and completely catalytic hydrogenation and their pyrolysis performances were investigated using an apparatus equipped with an electrically heated tubular reactor. The results show that with the increase of hydrogenation degree, fuel conversion almost remains constant during the pyrolysis process(500-650°C, 4 MPa);however, the heat sink increases slightly, and the anti-coking performance significantly improves, which are highly related to their H/C ratios. Detailed characterisations reveal that the difference of the pyrolysis performance can be ascribed to the content of aromatics and cycloalkanes: the former are prone to initiate secondary reactions to form coking precursors, while the latter could act as the hydrogen donor and release hydrogen, which will terminate the radical propagation reactions and suppress the coke deposition. This work should provide the guidance for upgrading EHFs by modulating the composition of EHFs.

关键词： RP-3 Fuel Pyrolysis Hydrogenation Deposition

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Automated,economical,and environmentally-friendly asphalt mix design based on machine learning and multi-objective grey wolf optimization

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 381-405页

作者： jian liu Fangyu liu Linbing Wang Department of Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA School of Environmental CivilAgricultural and Mechanical EngineeringUniversity of GeorgiaAthensGA 30602USA Illinois Center for Transportation Department of Civil and Environmental EngineeringUniversity of Illinois Urbana-ChampaignUrbanaIL 61801USA

The increasing impact of the greenhouse effect on ecosystems is prompting transportation agencies to seek methods for reducing CO_(2)emissions during pavement construction and ***,the laboratory mix design process,which involves selecting aggregate gradation and binder content,is time-consuming and *** accelerate the traditional mix design procedure,this study presented a mix design procedure that can automatically determine gradation and binder content based on machine learning(ML)and a meta-heuristic ***,ML approaches were employed to model the relationship between volumetric properties(mixture bulk specific gravity(Gmb)and air void(VV))and both mixture component properties and mixture proportion,based on a dataset collected from literature with 660 mixture *** with the prediction of ML models and the modified multi-objective grey wolf optimization(MOGWO)algorithm,an automatic asphalt mix design was proposed to pursue three goals,including VV,cost,and CO_(2)*** results indicated that least squares support vector regression(LSSVR)and e Xtreme gradient boosting(XGBoost)achieved the highest prediction accuracies(correlation coefficient:0.92 for VV and 0.96 for Gmb).The MOGWO algorithm successfully found the 26 optimal mix designs for the case of VV *** ***_(2)*** to the traditional laboratory design,the optimal mixture with VV of4%achieves a cost saving of 2.46%and a reduction of 4.03%in carbon *** volumetric properties of the mixtures output by the approach also align closely with values measured in a laboratory.

关键词： Asphalt mix design Machine learning MOGWO CO_(2)emission Volumetric properties

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An Industrial Intrusion Detection Method Based on Hybrid Convolutional Neural Networks with Improved TCN

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Computers, Materials & Continua 2024年第1期78卷 411-433页

作者： Zhihua liu Shengquan liu jian Zhang College of Computer Science and Technology Xinjiang UniversityXinjiang Uygur Autonomous RegoinUrumqi830000China

Network intrusion detection systems(NIDS)based on deep learning have continued to make significant ***,the following challenges remain:on the one hand,simply applying only Temporal Convolutional Networks(TCNs)can lead to models that ignore the impact of network traffic features at different scales on the detection *** the other hand,some intrusion detection methods considermulti-scale information of traffic data,but considering only forward network traffic information can lead to deficiencies in capturing multi-scale temporal *** address both of these issues,we propose a hybrid Convolutional Neural Network that supports a multi-output strategy(BONUS)for industrial internet intrusion ***,we create a multiscale Temporal Convolutional Network by stacking TCN of different scales to capture the multiscale information of network ***,we propose a bi-directional structure and dynamically set the weights to fuse the forward and backward contextual information of network traffic at each scale to enhance the model’s performance in capturing the multi-scale temporal features of network *** addition,we introduce a gated network for each of the two branches in the proposed method to assist the model in learning the feature representation of each *** experiments reveal the effectiveness of the proposed approach on two publicly available traffic intrusion detection datasets named UNSW-NB15 and NSL-KDD with F1 score of 85.03% and 99.31%,respectively,which also validates the effectiveness of enhancing the model’s ability to capture multi-scale temporal features of traffic data on detection performance.

关键词： Intrusion detection industrial internet channel spatial attention multiscale features dynamic fusion multi-output learning strategy

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Automatic modulation recognition of radio fuzes using a DR2D-based adaptive denoising method and textural feature extraction

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Defence Technology（防务技术） 2024年第4期34卷 328-338页

作者： Yangtian liu Xiaopeng Yan Qiang liu Tai An jian Dai Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China China Research and Development Academy of Machinery Equipment Beijing 100089China

The identification of intercepted radio fuze modulation types is a prerequisite for decision-making in interference ***,the electromagnetic environment of modern battlefields is complex,and the signal-to-noise ratio(SNR)of such environments is usually low,which makes it difficult to implement accurate recognition of radio *** solve the above problem,a radio fuze automatic modulation recognition(AMR)method for low-SNR environments is ***,an adaptive denoising algorithm based on data rearrangement and the two-dimensional(2D)fast Fourier transform(FFT)(DR2D)is used to reduce the noise of the intercepted radio fuze intermediate frequency(IF)***,the textural features of the denoised IF signal rearranged data matrix are extracted from the statistical indicator vectors of gray-level cooccurrence matrices(GLCMs),and support vector machines(SVMs)are used for *** DR2D-based adaptive denoising algorithm achieves an average correlation coefficient of more than 0.76 for ten fuze types under SNRs of-10 d B and above,which is higher than that of other typical *** trained SVM classification model achieves an average recognition accuracy of more than 96%on seven modulation types and recognition accuracies of more than 94%on each modulation type under SNRs of-12 d B and above,which represents a good AMR performance of radio fuzes under low SNRs.

关键词： Automatic modulation recognition Adaptive denoising Data rearrangement and the 2D FFT(DR2D) Radio fuze

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Janus mesoporous nanoparticles enable building biological logic systems

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Science China Chemistry 2024年第1期67卷 316-318页

作者： Haitao Li jian liu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

This highlight is inspired by a recent article in Nature Chemistry[1],in which Zhao and co-workers from Fudan University developed an innovative emulsion-orientated anisotropic assembly method for the controllable fabrication of MSN&mPDA(mesoporous silica nanoparticles=MSN,mesoporous polydopamine=mPDA)Janus mesoporous nanoparticles and used them to build biological logic *** reported Janus mesoporous nanoparticles have delicate structures and are well-controlled,and the authors also demonstrated the unique performance of this material at the application end.

关键词： enable emulsion silica

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Optimal Shape Factor and Fictitious Radius in the MQ-RBF:Solving Ill-Posed Laplacian Problems

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 3189-3208页

作者： Chein-Shan liu Chung-lun Kuo Chih-Wen Chang Center of Excellence for Ocean Engineering Taiwan Ocean UniversityKeelung202301TaiwanChina Department of Mechanical Engineering National United UniversityMiaoli36063TaiwanChina

To solve the Laplacian problems,we adopt a meshless method with the multiquadric radial basis function(MQRBF)as a basis whose center is distributed inside a circle with a fictitious radius.A maximal projection technique is developed to identify the optimal shape factor and fictitious radius by minimizing a merit function.A sample function is interpolated by theMQ-RBF to provide a trial coefficient vector to compute the merit *** can quickly determine the optimal values of the parameters within a preferred rage using the golden section search *** novel method provides the optimal values of parameters and,hence,an optimal MQ-RBF;the performance of the method is validated in numerical ***,nonharmonic problems are transformed to the Poisson equation endowed with a homogeneous boundary condition;this can overcome the problem of these problems being *** optimal MQ-RBF is extremely *** further propose a novel optimal polynomial method to solve the nonharmonic problems,which achieves high precision up to an order of 10^(−11).

关键词： Laplace equation nonharmonic boundary value problem Ill-posed problem maximal projection optimal shape factor and fictitious radius optimal MQ-RBF optimal polynomial method

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Multicolored Bipartite Ramsey Numbers of Large Cycles

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 347-357页

作者： Shao-qiang liu Yue-jian PENG College of Mathematics and Statistics Hanshan Normal UniversityChaozhou 521041China School of Mathematics Hunan UniversityChangsha 410082China

For an integer r≥2 and bipartite graphs Hi,where 1≤i≤r,the bipartite Ramsey number br(H1,H2,…,Hr)is the minimum integer N such that any r-edge coloring of the complete bipartite graph KN;N contains a monochromatic subgraph isomorphic to Hi in color i for some 1≤i≤*** show that if r≥3;α1,α2>0,αj+2≥[(j+2)!-1]Σi=1^(j+1)α1 for j=1,2…r-2,then br(C2[α1n],C2[α2n],…,C2[αrn]=(Σ=j=1^(r)a j+o(1))n.

关键词： ramsey number bipartite ramsey number regularity lemma

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Changes of China’s Status in the Global System and Its Influencing Factors:A Multiple Contact Networks Perspective

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Chinese Geographical Science 2024年第2期34卷 265-279页

作者： liu jian liu Jibin YANG Qingshan CAI Sikai liu Jie School of Geographical Sciences Northeast Normal UniversityChangchun 130024China Key Laboratory of Geographical Processes and Ecological Security of Changbai Mountains Ministry of EducationChangchun 130024China School of Architecture and Planning Jilin Jianzhu UniversityChangchun 130118China School of Geographical Sciences Liaoning Normal UniversityDalian 116029China

Clarifying China’s position in the global system is an important logical basis for developing national *** much research has been done on China’s development status,most studies have been based on country comparisons or institutional *** today’s networked era in which the global economy,trade,personnel,and information are closely connected,studies on China’s global position and its status changes and influencing factors in multiple contact networks are still *** this study,from the perspective of diverse global contact networks,we constructed economic,cultural,and political influence indices to explore the changes and influencing factors on China’s status in the global system from 2005 to *** results show that during the study period,China’s global influence in the fields of economic ties,cultural exchanges,and political contacts increased significantly,but its influ-ence in the fields of cultural exchanges and political contacts lagged far economic *** pattern of China’s economic influence on various economies around the world has shown a transformation from an‘upright pyramid’to an‘inverted pyramid’*** proportion of these economies in low-influence zones has decreased from more than 60%in 2005 to less than 20%in ***’s cultural and political influence on various economies around the world has increased significantly;however,for the former,the percentage of high-influence areas is still less than 20%,whereas for the latter the percentage of these economies in medium-and high-influence areas is still less than 50%.Analyses such as a scatter plot matrix show that geographical proximity,economic globalization,close cooperation with developing countries,and a proactive and peaceful foreign policy are important factors in improving China’s status in the diverse global network system.

关键词： global system economic ties cultural exchanges political contacts multiple contact networks China’s status

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