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Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu Bin jiang Lei li Yawei li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

单组分纤维膨胀剂双掺技术在杭州下沙智格地下工程中的应用研究

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混凝土 2009年第12期 71-72,75页

作者：李建江凌金叶德平杭州江南建筑设计院浙江杭州310005 浙江华威建材集团有限公司浙江杭州310000 南京派尼尔科技实业有限公司江苏南京210000

为解决混凝土开裂、渗漏的技术难题,杭州下沙智格小区在地下工程施工时采用了单组分纤维膨胀剂双掺新技术。实践表明:该技术机理成熟,使用方便,是生产高抗裂、高抗渗混凝土的重要技术途径。

关键词：单组分纤维膨胀剂双掺

低碳经济背景下碳金融支持创新型企业技术创新的现状及其对策研究

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科学管理研究 2023年第1期41卷 158-164页

作者：李键江付子甜段玮洁广州中医药大学马克思主义学院广东广州510006 四川农业大学经济学院四川成都611130 西北师范大学经济学院甘肃兰州730070

揭示碳金融支持创新型企业技术创新的影响规律,对于低碳经济背景下促进创新型企业推进绿色技术创新具有重要意义。基于金融支持企业技术创新视角,分别从理论、现实与实践层面,对碳金融支持创新型企业技术创新的理论基础、发展现状和现... 详细信息

揭示碳金融支持创新型企业技术创新的影响规律,对于低碳经济背景下促进创新型企业推进绿色技术创新具有重要意义。基于金融支持企业技术创新视角,分别从理论、现实与实践层面,对碳金融支持创新型企业技术创新的理论基础、发展现状和现实阻碍进行分析,研究发现:融资难、融资渠道窄、资金缺口大和相关法律制度不健全是当前影响我国碳金融支持创新型企业技术创新的现实阻碍,相关部门应予以重视,积极采取放宽碳信贷融资标准,提供风险担保、拓宽企业促进技术创新的碳融资渠道、增加社会力量参与企业碳融资的参与度等举措去着力解决当前制约我国碳金融支持创新型企业技术创新健康发展的现实阻碍。

关键词：碳金融创新型企业技术创新低碳经济

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载脂蛋白AⅡ保护内皮细胞的实验研究

生物化学与生物物理进展 1997年第4期24卷 344-347页

作者：黎健蒋雷刘清华卫生部北京老年医学研究所北京100730

以细胞形态观察、细胞存活率、乳酸脱氢酶释放和前列环素测定等方面研究载脂蛋白AⅡ保护内皮细胞的作用 .结果显示 ,载脂蛋白AⅡ可部分拮抗低密度脂蛋白对内皮细胞的损伤作用 ,维持内皮细胞形态基本正常 ,乳酸脱氢酶释放减少。

关键词：动脉粥样硬化内皮细胞载脂蛋白AⅡ

Recognition System for Pipeline Typical Abnormal Events Based on DSP

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Recognition System for Pipeline Typical Abnormal Events Base...

Non-coding RNAs in acute ischemic stroke:from brain to periphery

2009 9th International Conference on Electronic Measurement & Instruments（ICEMI’2009）

作者： jian li Guoxing jiang Ping Lai Shijiu Jin ( State Key Laboratory of Precision Measuring Technology and Instruments Tianjin University No.92 Nankai District 300072 Tianjin China)

A new technique of designing a recognition system for pipeline typical abnormal events based on DSP is introduced in this paper. The pipeline has been widely used to transport oil and gas in the world. The abnormal events such as man digging and machine digging may cause pipeline leakage or other pipeline damage, which not only causes great loss of economy, but also leads to serious pollution to the environment. The hardware and software of the system are introduced in detail. The information entropy value of abnormal events signal is calculated to identify the event’s type. The experiment proves that the system can recognize pipeline typical abnormal events effectively.

关键词： pipeline abnormal event DSP information entropy.

来源： cnki会议评论

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

OpenMP源程序级同步段负载监测方法与均衡策略

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电子学报 2005年第5期33卷 852-856页

作者：李建江舒继武陈永健王鼎兴清华大学计算机系北京100084

　在详细阐述以同步段为最小分析单位对OpenMP程序进行负载监测与均衡的重要性之后,本文提出了源程序级同步段负载监测方法与均衡策略.其中源程序级同步段负载监测方法以隐含同步的显性化为基础,具有实现简单和易于确定有效监测区域的优... 详细信息

　在详细阐述以同步段为最小分析单位对OpenMP程序进行负载监测与均衡的重要性之后,本文提出了源程序级同步段负载监测方法与均衡策略.其中源程序级同步段负载监测方法以隐含同步的显性化为基础,具有实现简单和易于确定有效监测区域的优点.在获得负载分布信息之后,通过同步段性能评价、筛选、负载扫描与调整实现同步段的负载均衡,这是本文与现有OpenMP性能工具不同的地方.在负载均衡的过程中,根据加权剩余并行效率筛选出需要负载调整的同步段并对其负载进行扫描,最终确定出适合这些同步段的负载调度策略.实际测试结果表明本文提出的同步段负载监测方法与均衡策略是可行的.

关键词： OpenMP 同步段负载监测负载均衡

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燕麦育成品种抗旱性评价及筛选

新疆农业科学 2014年第11期51卷 2150-2155页

作者：梁晓东曾潮武李建疆新疆农业科学院粮食作物研究所乌鲁木齐830091

【目的】以15份燕麦品种为材料,采用干旱水分胁迫和正常灌溉对照研究其抗旱性。【方法】分别利用抗旱指数法和隶属函数法对15份燕麦品种的抗旱性进行评价。【结果】水分胁迫对燕麦农艺性状和产量产生了影响,而不同品种对干旱的反应能力... 详细信息

【目的】以15份燕麦品种为材料,采用干旱水分胁迫和正常灌溉对照研究其抗旱性。【方法】分别利用抗旱指数法和隶属函数法对15份燕麦品种的抗旱性进行评价。【结果】水分胁迫对燕麦农艺性状和产量产生了影响,而不同品种对干旱的反应能力不同;两种研究方法评价燕麦品种的抗旱性得出的结论不完全相同。【结论】裸燕麦参试品种W04-69抗旱性较强,皮燕麦参试品种西燕2号抗旱性较强。

关键词：燕麦抗旱性隶属函数抗旱指数

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao Jing-Wen li Hui Ye Xue-Zhi Zhang jian-Xiang liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly