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基于指导语句的CUDA程序性能分析工具研究与实现

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电子科技大学学报 2012年第2期41卷 280-284页

作者：李建江路川张磊北京科技大学计算机科学与技术系北京海淀区100083

近年来,GPU的快速发展与NVIDIA公司推出的CUDA技术,推动着GPU在高性能计算领域中的应用。研究并实现CUDA程序性能分析工具,对充分利用GPU的计算优势和提高CUDA架构下并行程序的执行性能具有重要的意义。该文分析了GPU硬件平台的特点和C... 详细信息

近年来,GPU的快速发展与NVIDIA公司推出的CUDA技术,推动着GPU在高性能计算领域中的应用。研究并实现CUDA程序性能分析工具,对充分利用GPU的计算优势和提高CUDA架构下并行程序的执行性能具有重要的意义。该文分析了GPU硬件平台的特点和CUDA并行编程模型,结合CPU集群环境下并行程序的性能分析,设计并实现了一种基于指导语句的CUDA程序性能分析工具,并实验验证了其在不同GPU硬件平台上的有效性。

关键词： CUDA 指导语句高性能计算性能分析程序优化

Application of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lesions

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Chinese Medical Journal 2011年第23期124卷 3988-3992页

作者： ZHAO Hui WANG Jun ZHOU Zu-li li Yun BU liang YANG Fan SUI Xi-zhao CHEN Ke-zhong li Xiao liU Jun li jian-feng jiang Guan-chao Department of Thoracic Surgery Peking University People＇s Hospital Beijing 100044 China

Background Mediastinal lesions are often difficult to diagnose in clinical practice because of the unique anatomical position of the mediastinum, which makes performance of biopsy difficult. The value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer and mediastinal lymph node staging has been widely accepted. However, few studies have been conducted on the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of mediastinal lesions. The current study was conducted to investigate the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of isolated mediastinal lesions without lung abnormalities. Methods We retrospectively analyzed the data of patients with isolated mediastinal lesions without lung abnormalities for whom endobronchial ultrasound-guided transbronchial needle aspiration examination was performed at the Department of Thoracic Surgery of Peking University People＇s Hospital, between September 2009 and December 2010. For patients who could not be diagnosed with endobronchial ultrasound-guided transbronchial needle aspiration, surgical biopsy or more than 6 months of clinical and imaging follow-up was carried out. Results Endobronchial ultrasound-guided transbronchial needle aspiration was performed for 60 patients with isolated mediastinal lesions. Correct diagnosis was made in 48 cases. Nineteen cases were malignant, and 29 were benign. The rate of correct diagnosis was 80%. The sensitivity, specificity, and accuracy of endobronchial ultrasound-guided transbronchial needle aspiration in distinguishing benign from malignant mediastinal lesions were 95%, 100%, and 98%, respectively. The examination was tolerable for all patients. No associated complications were observed. Conclusion Endobronchial ultrasound-guided transbronchial needle aspiration is a safe and effective method of di

关键词： endobronchial ultrasound transbronchial needle aspiration mediastinal lesion diagnosis

CD 147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2521-2535页

作者： Hong-Yong Cui Shi-Jie Wang Fei Song Xu Cheng Gang Nan Yu Zhao Mei-Rui Qian Xi Chen Jia-Yue li Fen-ling liu Yu-Meng Zhu Ruo-Fei Tian Bin Wang Bin Wu Yang Zhang Xiu-Xuan Sun Ting Guo Xiang-Min Yang Hai Zhang ling li Jing Xu Hui-Jie Bian jian-li jiang Zhi-Nan Chen National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Urology Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina College of Chemistry and Materials Science Northwest UniversityXi'anChina National Facility for Protein Science Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Medical Research Center Southern University of Science and Technology HospitalShenzhenChina

Major gaps in understanding the molecular mechanisms of colorectal cancer(CRC)progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal *** factor 3(TFF3)has been reported to be involved in CRC progression and intestinal mucosal repair;however,how TFF3 drives tumors to become more aggressive or metastatic and how TFF3 promotes intestinal mucosal repair are still poorly ***,we found that the upregulated TFF3 in CRC predicted a worse overall survival ***3 deficiency impaired mucosal restitution and ***147,a membrane protein,was identified as a binding partner for *** binding to CD147,TFF3 enhanced CD147-CD44s interaction,resulting in signal transducer and activator of transcription 3(STAT3)activation and prostaglandin G/H synthase 2(PTGS2)expression,which were indispensable for TFF3-induced migration,proliferation,and ***2-derived PGE2 bound to prostaglandin E2 receptor EP4 subtype(PTGER4)and contributed to TFF3-stimulated CRC *** NMR studies of the TFF3-CD147 interaction revealed the key residues critical for TFF3 binding and the induction of PTGS2 *** ability of TFF3 to enhance mucosal restitution was weakened by a PTGS2 *** of TFF3-CD147 signaling using competitive inhibitory antibodies or a PTGS2 inhibitor reduced CRC lung metastasis in *** findings bring strong evidence that CD147 is a novel receptor for TFF3 and PTGS2 signaling is critical for TFF3-induced mucosal restitution and CRC progression,which widens and deepens the understanding of the molecular function of trefoil factors.

关键词： TFF3 colorectal impaired

Effect of lamellarization on the microstructure and mechanical properties of marine 10Ni5CrMoV steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 402-413页

作者： Tao Zou Yanwu Dong Zhouhua jiang Shuyang Du Yushuo li School of Metallurgy Northeastern UniversityShenyang 110819China Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Key Laboratory for Ecological Metallurgy of Multimetallic Ores(Ministry of Education) Northeastern UniversityShenyang 110819China

Multistage heat treatment involving quenching(Q),lamellarizing(L),and tempering(T)is applied to marine 10Ni5CrMoV *** microstructure and mechanical properties were studied by multiscale characterizations,and the kinetics of reverse austenite transformation,strain hardening behavior,and toughening mechanism were further *** lamellarized specimens possess low yield strength but high toughness,especially cryogenic *** leads to the development of film-like reversed austenite at the martensite block and lath boundaries,refining the martensite structure and lowering the equivalent grain *** analysis of austenite reversion based on the JMAK model shows that the isothermal transformation is dominated by the growth of reversed austenite,and the maximum transformation of reversed austenite is reached at the peak temperature(750℃).The strain hardening behavior based on the modified Crussard-Jaoul analysis indicates that the reversed austenite obtained from lamellarization reduces the proportion of martensite,significantly hindering crack propagation via martensitic transformation during the *** a consequence,the QLT specimens exhibit high machinability and low yield *** with the QT specimen,the ductile-brittle transition temperature of the QLT specimens decreases from-116 to-130℃due to the low equivalent grain size and reversed austenite,which increases the cleavage force required for crack propagation and absorbs the energy of external load,*** work provides an idea to improve the cryogenic toughness of marine 10Ni5CrMoV steel and lays a theoretical foundation for its industrial application and comprehensive performance improvement.

关键词： 10Ni5CrMoV steel lamellarizing reversed austenite cryogenic toughness ductile-brittle transition temperature

Characterization of Hepatic Drug-metabolizing Activities of Bama Miniature Pigs (Sus Scrofa Domestica): Comparison with Human Enzyme Analogs

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Characterization of Hepatic Drug-metabolizing Activities of ...

一种简易顶装机在装配LG956装载机上、下铰接销时的应用

中国实验动物学会第七届学术年会

作者： jian li, Yong liu, jiang-wei Zhang, Hong Wei, and ling Yang

We used various substrates and selective inhibitors of human cytochrome P450 (CYP) isozymes as probes to study the metabolism of liver microsomes from Chinese Bama miniature pigs. Nifedipine oxidation (NOD) and testosterone 6β-hydroxylation (6β-OHT) activities were similar between human liver microsomes and those from Bama miniature pigs. However, compared with those from humans, liver microsomes from Bama miniature pigs showed decreased phenacetin O-deethylation, coumarin 7-hydroxylation, and chlorzoxazone 6-hydroxylation activities, whereas dextromethorphan O-demethylation activity was increased. Ketoconazole selectively inhibited NOD and 6β-OHT activities in microsomes from Bama pigs, and 8-methoxypsoralen and tranylcypromine inhibited coumarin 7-hydroxylation in pig microsomes. However, furafylline and quinidine failed to selectively inhibit phenacetin O-deethylation and dextromethorphan O-demethylation in microsomes from Bama pigs, whereas chlormethiazole more efficiently inhibited coumarin 7-hydroxylation activity than chlorzoxazone 6-hydroxylation in pig microsomes. Our results suggest that liver microsomes from Chinese Bama miniature pigs are similar to those from humans in regard to metabolism of nifedipine and testosterone (both are probe substrates for human CYP3A4). In addition, chemical inhibitors used as specific probes for human P450 enzymes did not always show the same selectivity toward corresponding enzyme activities in liver microsomes from Bama pigs. However, ketoconazole (a potent inhibitor of human CYP3A4) could be used as a selective inhibitor probe for the NOD and 6β-OHT activities in liver microsomes from Chinese Bama miniature pigs.

关键词： 6β-OHT, testosterone 6β-hydroxylation CH, coumarin 7-hydroxylation CYP, cytochrome P450 CZH, chlorzoxazone 6-hydroxylation DMOD, dextromethorphan O-demethylation HPLC, high-performance liquid chromotography NOD, nifedipine oxidation POD, phenacetin O-deethylation UV, ultraviolet

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液压与气动 2008年第11期32卷 58-59页

作者：李建江山东临工工程机械有限公司

该文介绍了在装配装载机上、下铰接销时的一种简易顶装机的设计过程及其成功应用。

关键词：装载机装配液压

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异构多核上多级并行模型支持及性能优化

软件学报 2013年第12期24卷 2782-2796页

作者：李士刚胡长军王珏李建江北京科技大学计算机与通信工程学院北京100083 中国科学院计算机网络信息中心中国科学院超级计算中心北京100190

低功耗及廉价性使得异构多核在超级计算机计算资源中占有重要比例.然而,异构多核具有高带宽及松耦合一致性等特点,获得理想的存储及计算性能需要更多地考虑底层硬件细节.实现了一种针对典型的异构多核Cell BE处理器的多级并行模型CellM... 详细信息

低功耗及廉价性使得异构多核在超级计算机计算资源中占有重要比例.然而,异构多核具有高带宽及松耦合一致性等特点,获得理想的存储及计算性能需要更多地考虑底层硬件细节.实现了一种针对典型的异构多核Cell BE处理器的多级并行模型CellMLP,通过C语言扩展编译指导语句,实现了对数据并行、任务并行以及流水并行编程模型的支持,提高了并行程序生产率.运行支持优化方面,数据并行采用SPE并行数据传输、双缓冲等优化手段来提高数据传输带宽;任务并行使用一种新式混合任务队列以支持异步任务窃取,降低SPE线程间竞争,提高了任务并行的可扩展性;流水并行首次使用阻塞信号传输机制实现SPE线程间的低开销同步操作.实验对Stream,NAS Benchmark及BOTS等应用进行了测试,结果表明,CellMLP可对多种典型并行应用进行高效支持.与目前同类编程模型SARC及CellSs进行性能对比,其结果表明,CellMLP实际数据传输带宽以及非规则应用的支持方面具有明显优势.

关键词：异构多核数据并行任务并行流水并行非规则应用编译优化

Inhibition of rejection in murine islet xenografts by CTLA41g and CD40lig gene transfer

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Chinese Medical Journal 2010年第21期123卷 3106-3109页

作者： ZHANG jian li Hua jiang Nan WANG Guo-ying FU Bin-sheng WANG Gen-shu YANG Yang CHEN Gui-hua J liver Transplantation Center the Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Costimulatory signals play a vital role in T cell activation. Blockade of costimulatory pathway by CTLA4Ig or CD40lig have enhanced graft survival in experimental transplantation models yet mechanisms remain *** investigated the effects of CTLA4Ig and CD40lig gene transfer on islet xenografts rejection in *** Human islets were infected with recombinant adenoviruses containing CTLA4Ig and CD40lig genes and implanted beneath the kidney capsule of diabetic rats. Levels of blood sugar, morphological changes, and survival of grafts were recorded. Expressions of CTLA4Ig, CD40lig and insulin were detected by immunohistochemical staining and cytokines levels were quantified by enzyme-linked immunosorbent assay （EliSA）.Results Blood glucose levels in transplant rats decreased to normal level on the 2nd day post transplantation. The mean blood glucose in the control group, CTLA4Ig transfected group, CD40lig transfected group and CTLA4Ig ＋CD40lig cotransfected group increased on days 8, 24, 21, 68, post transplantation respectively. The grafts in control group, CTLA4Ig transfected group, CD40lig transfected group and CTLA4Ig ＋ CD40lig cotransfected group survived for （8±1）, （29±4）, （27±3）, and （74±10） days, respectively. Survival in CTLA4Ig ＋ CD40lig cotransfected group was significantly longer. Survivals of CTLA4Ig transfected group and CD40lig transfected group were significantly longer than control group. In controJ animals, serum interleukin-2 and tumor necrosis factor a concentration significantly increased within seven days post transplantation. Haematoxylin eosin staining of grafts showed live islets in situ of transplant rats without inflammatory cell infiltration. Immunohistochemical staining confirmed the expression of insulin at islets in all experimental *** Transfer of CTLA4Ig and CD40Llg genes, especially the cotransfer of both, inhibits rejection of murine islet xenografts. Downregulated expressions of Th1 cells rel

关键词： transplantation islet of Langerhans CTLA4Ig CD40lig immune tolerance

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale liu Lei Bai Xiang li Zhengquan Yu Haiying li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PliN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PliN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PliN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing