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A New Fluorescent Sensor for Transition Metal Ions in Aqueous Solution

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Chinese Chemical Letters 2000年第6期11卷 551-554页

作者： li jian jiang Zhi lin WANG Xiao Qing jiang Qin Hui LUO(Coordination Chemistry Institute Nanjing University Nanjing 210093) Coordination Chemistry Institute Nanjing University Nanjing 210093 China

A new fluorescent sensor consisted of fluorenyl and dioxotetraaza unit, dimethyl-6-(9-fluorenyl)-1,4,8,11-tetraazaundencane-5,7-dione (L), was synthesize fluorescent sensor for transition metal ions in aqueous solution.

关键词： fluorenyl dioxotetramine fluorescence sensor transition metal

Transesterified Chinese Spicehush (lindera communis) seed oil as a biodiesel fuel

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Forestry Studies in China 2007年第2期9卷 132-136页

作者： Wang Wei-gang Ma Lei jiang jian-xin jiang li Zhang Zhi-xiang College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Studies were carried out on the transesterification of the Chinese Spicehush （lindera communis） seed （LCS） oil with methanol for the production of biodiesel. The methyl esters of LCS oil were compared with soybean esters to determine biodiesel fuel performance and properties. The fatty acids content in the seed kernel oil （LKO） and coat oil （LCO） were quantified by gas chromatography and mass spectrometry method （C-C-MS）. LKO contains 95.1% saturated acids （capric, lauric, myristic and palmitic） and 2.3% unsaturated acids （oleic）. LCO contains 24.6% saturated acids （palmitic and stearic） and 73.6% unsaturated acids （oleic, linoleic and palmitoleic）. The kinematic viscosity, cold filter plugging point, cloud point, flash point and cetane index were determined. The methyl esters of LKO had a higher kinematic viscosity and a lower cold filter plugging point value, so it has better performance in cold weather. The biodiesel of LCS oil has fuel properties within the limits prescribed by American （ASTM D 6751-02） standards, except for a slightly lower flash point of LKO biodiesel than that prescribed by these standards （130℃）. Thus, LKO and LCO biodiesel have great potential to be used on a large scale as fuel for diesel engines.

关键词： biodiesel lindera communis oil transesterification property

Freestanding carbon fiber-confined yolk-shelled silicon-based anode for promoted lithium storage applications

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Rare Metals 2023年第11期42卷 3718-3728页

作者： Dong-Chen Jia Yuan-Yong Feng Chuan-Long Zhang jian-jiang li Bin-Wei Zhang Yu-Hai Dou Jagadish Chandra Roy Xiao-Yi Zhu Lei Zhang School of Environmental Science and Engineering Qingdao UniversityQingdao266071China Department of Oral and Maxillofacial Surgery The Affiliated Hospital of Qingdao UniversityQingdao266071China Centre for Catalysis and Clean Energy Gold Coast CampusGriffith UniversitySouthportQLD4222Australia Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesSchool of Chemistry and Chemical EngineeringChongqing UniversityChongqing400044China Institute of Energy Materials Science University of Shanghai for Science and TechnologyShanghai200093China

A flexible carbon fiber-confined yolk-shelled silicon-based composite is reported as an anode material for lithium storage *** nanoparticles(Si NPs)are confined by the N-doped hollow carbon cages(SiNHC)and these uniform dispersed yolk-shell-structured Si-NHC units were encapsulated by the carbon fibers within an interconnected three-dimensional(3D)framework(Si-NHC@CNFs).For the encapsulated yolkshelled Si-NHC,the void space between the inner Si NPs and outer NHC can accommodate the structural changes of Si NPs during charging/discharging processes,leading to effectively improved structural stability and cycling *** importantly,all the Si-NHC units were bridged together through a conductive CNFs"highway"to enhance the overall conductivity and tap density *** observed,Si-NHC@CNFs exhibited an initial discharge capacity of 1364.1 mAh·g^(-1)at 1000 mA·g^(-1)and678.9 mAh·g^(-1)at 2000 mA·g^(-1).Furthermore,the reversible capacity was well maintained at 752.2 mAh·g^(-1)at500 mA·g^(-1)after 6000 ultra-long cycles.

关键词： Silicon ZIF-8 Carbon fibers Anode lithium-ion battery(liB)

Completely thoracoscopic lobectomy for the surgical management of bronchiectasis

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Chinese Medical Journal 2013年第5期126卷 875-878页

作者： ZHOU Zu-li ZHAO Hui li Yun li jian-feng jiang Guan-chao WANG Jun Department of Thoracic Surgery Peking University People'sHospital Beijing 100044 China

Background The feasibility of completing a Iobectomy by completely video-assisted thoracoscopic surgery （cVATS） in the management of bronchiectasis is unclear. By retrospectively comparing the outcomes from the Iobectomies that used thoracotomy vs. cVATS, we determined the appropriateness of the minimally invasive cVATS approach in the management of bronchiectasis. Methods Between June 2001 and October 2010, 60 patients with bronchiectasis underwent surgery, of which 56 Iobectomies were performed. All Iobectomies were carried out by either thoracotomy or cVATS approach. Pulmonary vessels and bronchi were manipulated by ligation or stapler in the thoracotomy group, while they were dissected by endo-cutters in the cVATS group. Results There were 21 patients in the thoracotomy group and 35 patients in the cVATS group. Two cVATS patients （5.7%） converted. The difference in operation time, chest tube duration, lengths of hospitalization, and morbidity were not significantly different between the two groups （P 〉0.05）. The blood loss was less in the cVATS group （P=0.015）. A total of 52.4% and 62.9% of patients were postoperatively asymptomatic in the thoracotomy and cVATS groups respectively, and symptomatic improvement was obtained in 38.1% patients by thoracotomy vs. 31.4% patients by cVATS. Conclusion cVATS Iobectomy is safe and effective for the management of bronchiectasis, especially for the patients with localized lesions.

关键词： video-assisted thoracoscopic surgery lobectomy bronchiectasis

PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression

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Cancer Communications 2022年第8期42卷 750-767页

作者： Hong-Yong Cui Wei Wei Mei-Rui Qian Ruo-Fei Tian Xin Fu Hong-Wei li Gang Nan Ting Yang Peng lin Xi Chen Yu-Meng ZhuBin Wang Xiu-Xuan Sun jian-Hua Dou jian-li jiang ling li Shi-Jie Wang Zhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi’anShaanxi 710032P.R.China State Key Laboratory of Cancer Biology and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032P.R.China Department of Clinical Medicine Medical College of Yan’an UniversityYan’anShaanxi 716000P.R.China Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi’anShaanxi 710127P.R.China

Background:The mechanism underlying colorectal cancer(CRC)initiation and progression remains elusive,and overall survival is far from *** studies have shown that PDGFA-associated protein 1(PDAP1)is upregulated in several cancers including ***,we aimed to identify the cause and consequence of PDAP1 dysregulation in CRC and evaluate its role as a potential therapeutic ***:Multi-omics data analysis was performed to identify potential key players in CRC initiation and ***(IHC)staining was applied to determine the expression pattern of PDAP1 in CRC ***1 conditional knockout mice were used to establish colitis and CRC mouse *** sequencing,a phosphoprotein antibody array,western blotting,histological analysis,5-bromo-2′-deoxyuridine(BrdU)incorporation assay,and interactome analysis were applied to identify the underlying mechanisms of PDAP1.A human patient-derived xenograft(PDX)model was used to assess the potential of PDAP1 as a therapeutic ***:PDAP1 was identified as a potential key player in CRC development using multi-omics data ***1 was overexpressed in CRC cells and correlated with reduced overall *** investigation showed that PDAP1 was critical for the regulation of cell proliferation,migration,invasion,and ***,depletion of Pdap1in intestinal epithelial cells impaired mucosal restitution in dextran sulfate sodium salt-induced colitis and inhibited tumor initiation and growth in colitis-associated *** studies showed that c-Myc directly transactivated PDAP1,which contributed to the high PDAP1 expression in CRC ***1 interacted with the juxtamembrane domain of epidermal growth factor receptor(EGFR)and facilitated EGFRmitogen-activated protein kinase(MAPK)signaling activation,which resulted in FOS-related antigen 1(FRA-1)expression,thereby facilitating CRC progres***,silencing of PDAP1 could hinder the

关键词： carcinogenesis colorectal cancer FRA-1 PDAP1 c-Myc

Effects of Aging and Advanced Glycation on Gene Expression in Cerebrum and Spleen of Mice

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Biomedical and Environmental Sciences 2003年第4期16卷 323-332页

作者： YUE-XIN liANG, ZHEN WANG, DIAN-DONG li, jian-MIN jiang,AND RONG-GUANG SHAOInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College 北京 100050

Objective To analyze the effects of aging or advanced glycation on gene expression in the cerebrum and spleen of female C57BL/6J mice. Methods The gene expression profile was determined by using cDNA expression arrays containing 588 cDNA. Results Aging and advanced glycation resulted in differential gene expression patterns of cerebrum and spleen compared with young mice. Among the 80 genes detected in cerebrum, 43 exhibited a change in mRNA ratios with aging or treatment. Thirty-four changes (79%) were common in aged and D-galactose treated mice, whereas the cerebrum from aged and AGE-lysine treated mice showed common changes in expression of 38 genes (88%). Of the 86 genes detected in spleen, 29 (34%) displayed an age-related decrease in expression, whereas 3 (3%) displayed an increase in expression levels with aging. Eighteen genes from the detectable genes exhibited expression changes in both cerebrum and spleen of mice. Conclusions The gene expression profiles of D-galactose and AGE-lysine treated mice resemble those of aged mice. Use of cDNA hybridization arrays may provide a promising tool to explore the mechanism of aging at a molecular level.

关键词： Aging Galactose Advanced glycation Gene expression DNA microarrays Cerebrum Spleen

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1135-1152页

作者： Jia-Jia Zhang Chang-Geng Song Miao Wang Gai-Qin Zhang Bin Wang Xi Chen Peng lin Yu-Meng Zhu Zhi-Chuan Sun Ya-Zhou Wang jian-li jiang ling li Xiang-Min Yang Zhi-Nan Chen National Translational Science Center for Molecular Medicine&Department of Cell Biology Fourth Military Medical UniversityXi'an710032China Department of Neurology Xijing HospitalFourth Military Medical UniversityXi'an710032China Key Laboratory of Synthetic and Natural Functional Molecule of the Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an710032China Department of Neurosurgery Xi'an Daxing HospitalXi'an710032China Department of Neurobiology and Institute of Neurosciences Collaborative Innovation Center for Brain ScienceSchool of Basic MedicineFourth Military Medical UniversityXi'an710032China

Morphine is a frequently used analgesic that activates the mu-opioid receptor(MOR),which has prominent side effects of *** the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance,currently,there is no effective therapy to treat morphine *** the current study,we aimed to develop a monoclonal antibody(mAb)precisely targeting MOR and to determine its therapeutic efficacy on morphine tolerance and the underlying molecular *** successfully prepared a mAb targeting MOR,named 3A5C7,by hybridoma technique using a strategy of deoxyribonucleic acid immunization combined with cell immunization,and identified it as an immunoglobulin G mAb with high specificity and affinity for MOR and binding ability to antigens with spatial *** of two cell lines,HEK293T and SH-SY5Y,with 3A5C7 enhanced morphine-induced MOR endocytosis via a G protein-coupled receptor kinase 2(GRK2)/b-arrestin2-dependent mechanism,as demonstrated by immunofluorescence staining,flow cytometry,Western blotting,coimmunoprecipitation,and small interfering ribonucleic acid(siRNA)-based *** mAb also allowed MOR recycling from cytoplasm to plasma membrane and attenuated morphine-induced phosphorylation of *** established an in vitro morphine tolerance model using differentiated SH-SY5Y cells induced by retinoic *** blot,enzyme-linked immunosorbent assays,and siRNA-based knockdown revealed that 3A5C7 mAb diminished hyperactivation of adenylate cyclase,the in vitro biomarker of morphine tolerance,via the GRK2/b-arrestin2 ***,in vivo hotplate test demonstrated that chronic intrathecal administration of 3A5C7 significantly alleviated morphine tolerance in mice,and withdrawal jumping test revealed that both chronic and acute 3A5C7 intrathecal administration attenuated morphine ***,intrathecal electroporation of silencing short hairpin RNA illustrated that the in v

关键词： Morphine tolerance Mu-opioid receptor Endocytosis Monoclonal antibody Physical dependence

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一种基于动态规划的并行构件资源选择算法

电子学报 2011年第4期39卷 887-893页

作者：李建江崔健严林李福林北京科技大学信息工程学院计算机科学与技术系北京100083 中国白城兵器试验中心吉林白城137001

当前,多种硬件体系结构并存,传统的并行构件资源管理却不能充分利用并行构件的属性以适应底层硬件的多样性,可扩展性比较差.在研究基于CCA规范的并行构件执行集成平台的基础上,本文提出了一种层次化并行构件资源管理模型,并提出了一种... 详细信息

当前,多种硬件体系结构并存,传统的并行构件资源管理却不能充分利用并行构件的属性以适应底层硬件的多样性,可扩展性比较差.在研究基于CCA规范的并行构件执行集成平台的基础上,本文提出了一种层次化并行构件资源管理模型,并提出了一种基于动态规划的并行构件资源选择算法.实验结果表明,相对于通常使用的CPU频率优先、CPU Cache值优先与通信优先策略,本文提出的基于动态规划的并行构件资源选择算法不仅能够更加精确地选择计算节点资源,而且具有良好的可扩展性.

关键词：并行构件资源管理层次化模型动态规划

Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes