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Camrelizumab-induced anaphylactic shock in an esophageal squamous cell carcinoma patient:A case report and review of literature

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World Journal of Clinical Cases 2022年第18期10卷 6198-6204页

作者： kai Liu jian-Feng Bao Tao Wang Hao yang Bao-Ping Xu Department of Radiotherapy Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina Department of Immuno-logy Xixi Hospital of Hangzhou affiliated to Zhejiang University of Traditional Chinese MedicineHangzhou 310023Zhejiang ProvinceChina Department of Urology Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese MedicineZhongshan 528401Guangdong ProvinceChina Department of Critical Care Medicine Traditional Chinese Hospital of Lu’an affiliated to Anhui University of Traditional Chinese MedicineLu’an 237000Anhui ProvinceChina

BACKGROUND Camrelizumab(SHR-1210),an immune checkpoint inhibitor,is clinically used as a therapeutic option for various types of ***,reports of adverse reactions associated with camrelizumab are gradually *** shock due to camrelizumab has not been reported previously,until *** report here,for the first time,a case of anaphylactic shock associated with camrelizumab in a patient with esophageal squamous cell *** SUMMARY An 84-year-old male esophageal cancer patient received radiotherapy and chemotherapy 11 years *** was diagnosed with advanced esophageal squamous cell carcinoma with liver metastasis(Tx N1 M1)and received the first immunotherapy(camrelizumab 200 mg/each time,once every 3 wk)dose in December 2020,with no adverse *** weeks later,a generalized rash was noted on the chest and upper limbs;palpitations and breathing difficulties with a sense of dying occurred 10 min after the patient had been administered with the second camrelizumab *** monitoring revealed a 70 beats/min pulse rate,69/24 mm Hg(1 mm Hg=0.133 k Pa)blood pressure,28 breaths/min respiratory rate,and 86%pulse oximetry in room *** patient was diagnosed with anaphylactic shock and was managed with intravenous fluid,adrenaline,dexamethasone sodium phosphate,calcium glucosate,and *** 2 h after treatment,the patient’s anaphylactic shock symptoms had been completely *** Due to the widespread use of camrelizumab,attention should be paid to anti-programmed cell death 1 antibody therapy-associated hypersensitivity or anaphylactic shock.

关键词： Camrelizumab Anaphylactic shock Anti-programmed cell death one antibodies Immunotherapy Case report

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MT1M and MT1G promoter methylation as biomarkers for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第16期20卷 4723-4729页

作者： Xiang-Fen Ji Yu-Chen Fan Shuai Gao yang yang jian-Jun Zhang kai Wang Department of Hepatology Qilu Hospital of Shandong University Institute of Hepatology Shandong University

AIM: To investigate the potential of promoter methylation of two tumor suppressor genes (TSGs) as biomarkers for hepatocellular carcinoma (HCC).

关键词： MT1M MT1G Methylation Serum biomarker Hepatocellular carcinoma

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Hematuria after nocturnal exercise of a man: A case report

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World Journal of Clinical Cases 2024年第5期12卷 1025-1028页

作者： Ming-jian Bai Song-Tao yang Xue-kai Liu Department of Clinical Laboratory Aerospace Center HospitalBeijing 100049China Department of Nephrology Aerospace Center HospitalBeijing 100049China

BACKGROUND A man experienced multiple episodes of macroscopic hematuria following nocturnal *** stones and tumors were considered the two most likely *** patient had two hobbies:Consuming health care products in large quantities and engaging in late-night *** SUMMARY Health care products contain a large amount of calcium phosphate,and we hypothesize that this could induce the formation of small phosphate *** exercise,the urinary system is abraded,resulting in *** patient was advised to stop using the health care ***,the aforementioned symptoms disappeared ***,the patient resumed the above two habits one year later;correspondingly,the macroscopic hematuria *** This finding further confirmed the above inference and allowed for a new avenue to determine the cause of the patient’s hematuria.

关键词： Hematuria Health care products Exercise Case report

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Deployment simulation of cable-strut structures considering cable sliding

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Science China(Technological Sciences) 2012年第12期55卷 3263-3269页

作者： CAI jianGuo FENG jian WANG kai Key Laboratory of Concrete and Prestressed Concrete Structures of Ministry of Education Southeast UniversityNanjing 210096China National Engineering Research Center for Prestress Southeast UniversityNanjing 210096China

The influence of cable sliding on the deployment of foldable cable-strut structures was studied in this paper. In order to develop an effective program for the cable sliding program, two-node cable element based on the analytical solution of elastic cate- nary was studied. Then the cable sliding stiffness was defined as the ratio of the variation of the cable force to the variation of the cable length. To validate the proposed numerical method, analyses of two examples given in references were carried out. The results show that the method given in this paper is accurate and effective, which can be used to model the cable sliding in cable structures. Finally, the deployment process of a foldable cable-strut structure, which is composed of four-bar linkages and cables, was discussed. It can be found that the effect of cable sliding on the behavior of cable-strut structures is significant. The length changes of active cables are smaller when the cable sliding is considered. Moreover, the nodal coordinate changes also become faster when the numerical model is with cable sliding.

关键词： deployment elastic catenary cable-strut structures cable sliding nonlinear analysis

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The transcription factor ICE1 functions in cold stress response by binding to the promoters of CBF and COR genes

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Journal of Integrative Plant Biology 2020年第3期62卷 258-263页

作者： kai Tang Lun Zhao Yuying Ren Shuhua yang jian-Kang Zhu Chunzhao Zhao Shanghai Center for Plant Stress Biology and CAS Center for Excellence in Molecular Plant Sciences Chinese Academy of SciencesShanghai 200032China Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907USA University of the Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China

A recent paper by Kidokoro et al.(2020)in The Plant Cell reported a transgene-dependent transcriptional silencing phenomenon in the dominant ice1-1 Arabidopsis mutant containing the CBF3-LUC reporter,and questioned whether ICE1 may regulate CBF genes and may be involved in plant cold ***,we evaluate available evidence supporting the involvement of ICE1 in plant cold response,and provide ChIP-seq data showing ICE1 binding to the promoters of CBF genes and other regulatory genes known to be critical for cold response as well as to the promoters of some COR genes.

关键词： ICE1 CBF stress

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Sunspot rotation and magnetic transients associated with flares in NOAAAR 11429

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Research in Astronomy and Astrophysics 2017年第8期17卷 47-56页

作者： jian-Chuan Zheng Zhi-Liang yang jian-Peng Guo kai-Ming Guo Hui Huang Xuan Song Wei-Xing Wan Department of Astronomy Beijing Normal University Beijing 100875 China Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy ofSciences Beijing 100029 China College of Earth Sciences University of Chinese Academy of Sciences Beijing 100049 China

We analyze sunspot rotation and magnetic transients in NOAA AR 11429 during two X-class(X5.4 and X1.3)flares using data from the Helioseismic and Magnetic Imager on board the Solar Dynamics Observatory.A large leading sunspot with positive magnetic polarity rotated *** expected,the rotation was significantly affected by the two *** transients induced by the flares were clearly evident in the sunspots with negative *** were moving across the sunspots with speed of order 3-7 km ***,the trend of magnetic flux evolution in these sunspots exhibited changes associated with the *** results may shed light on understanding the evolution of sunspots.

关键词： sunspots—Sun rotation—Sun magnetic fields

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Regularity analysis of wrinkles under the action of capillary force in an annular thin film

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1574-1580页

作者： ZHANG BingFeng LI kai ZHAO jian Department of Water Conservancy and Hydropower Engineering Hohai University Department of Civil Engineering Anhui University of Architecture

The wrinkling law of annular sheet which is induced by capillary force with inner liquid film is analyzed in this *** results show that the inner liquid film can wrinkle the annular sheet when the surface tension of the liquid film reaches a critical value,and the critical value can be dramatically altered by changing the geometry and properties of the annular *** results obtained in this article may hold potential applications in generating three-dimensional structures through capillary effects.

关键词： wrinkling capillary force multi-field coupling annular sheet liquid film

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A relative quantitative method to detect OCT4A gene expression by exon-junction primer and locked nucleic acid-modified probe

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第2期12卷 149-155页

作者： jian-jun REN Xing-kai MENG Department of General Surgery Xuanwu Hospital Capital Medical University Beijing 100053 China Department of General Surgery Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050 China

Objective: OCT4A has been known to play a critical role in the maintenance of pluripotency of embryonic stem cells. Recent research has shown that OCT4A is also expressed in partial tumor cell lines and tissues. This study is aimed to develop a real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay for relative quantitative detection of OCT4A mRNA and discrimination from OCT4B, pseudogene, and genomic contaminations. Methods: A locked nucleic acid (LNA)-modified probe was designed to discern the single base difference 352A/C to identify OCT4A mRNA. An exon-junction primer was designed to avoid false positive caused by genomic contaminations. In addition, a house keeping gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was measured in parallel to normalize the differences between samples and operations. Results: Experiments showed that the newly established RT-PCR assay amplified the OCT4A mRNA selectively; OCT4A analogues gave negative signals. Cell lines nTERA-2 and HepG2 showed positive results in OCT4A expression, while for HeLa and 293 cell lines, as well as primary peripheral blood mononuclear cells (PBMCs), OCT4A expression was negative. Additionally, the relative quantity of OCT4A mRNA was calculated by cycle threshold (Ct) method and house keeping gene normalization. Conclusions: This technique proved to be effective for relative quantitation of OCT4A mRNA with high specificity.

关键词： OCT4A. Locked nucleic acid (LNA). Real-time Dolvmerase chain reaction (PCR)

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Metabasin dynamics of supercooled polymer melt

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Chinese Physics B 2019年第12期28卷 268-272页

作者： jian Li Bo-kai Zhang Department of Physics and Electronic Engineering Heze UniversityHeze 274015China Department of Physics Zhejiang Sci-Tech UniversityHangzhou 310018China

We employ molecular dynamic simulation to investigate metabasin dynamics for supercooled polymer melt. We find that, in a small system, the α-relaxation process is composed of a few crossing events that the monomers hops from one metabasin to another. Each crossing event is very rapid and involves a democratic movement of many particles,whereas such collective motion is not string-like. Evaluation on the contributions of metabasin exploration and democratic movement shows that the structural relaxation is mostly governed by the latter. Our calculated results show that the metabasin–metabasin transitions are not the main reason of spatially dynamical heterogeneity. It is different from the binary Lennard–Jones mixture model in which the metabasin–metabasin transitions are relevant for the spatially dynamical heterogeneity.

关键词： metabasin dynamics distance matrix democratic movement dynamic heterogeneity

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On Rough Marcinkiewicz Integrals along Surfaces

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Acta Mathematica Sinica,English Series 2010年第4期26卷 717-730页

作者： Huo Xiong WU jian kai XU School of Mathematical Sciences Xiamen University Xiamen 361005 P. R. China

In this paper, the authors establish the LP-mapping properties of certain classes of Marcinkiewicz integral operators along surfaces with rough kernels. The results in this paper essentially extend as well as improve ... 详细信息

关键词： Marcinkiewicz integrals surfaces maximal operator Hardy space rough kernel

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