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Al-doped ZnO/WO_(3) heterostructure films prepared by magnetron sputtering for isopropanol sensors

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Rare Metals 2024年第1期43卷 247-256页

作者： Wei-Xiang Gao Xue-Ting Chang Xiao-Jie Zhu jun-Feng Li Ying-Chang jiang Dong-Sheng Wang Chuan-Xiao Yang Shi-Bin Sun College of Logistics Engineering Shanghai Maritime UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Institute of Logistics Science and Engineering Shanghai Maritime UniversityShanghai 201306China

Metal oxide semiconductors(MOSs) are ideal sensing materials for detecting volatile organic compounds due to their low cost, diversity, high stability, and ease of production. However, it remains a grand challenge to develop the MOSs-based gas sensors for sensing isopropanol with desired performance via a simple, effective,and controllable method. Herein, we reported the preparation of the Al-doped Zn O(AZO)/WO_(3) heterostructure films by directly depositing the AZO coating onto the WO_(3) coating using a strategy of magnetron sputtering. The AZO/WO_(3) heterostructure films were constructed by numbers of irregular nanoparticles that were interconnected with each other. The AZO/WO_(3) heterostructure films-based gas sensors exhibited excellent isopropanolsensing performance with high response, promising selectivity, low detection limit, fast response rate, wide detection range, and ideal reproducibility. The promising isopropanol-sensing performance of the AZO/WO_(3) heterostructure films arises mainly from their high uniformity, unique microstructures with high surface roughness,and the construction of the heterostructure between the AZO and WO_(3) coatings. This work provides a versatile approach to prepare the MOSs-based heterostructure films for assembling the gas sensors.

关键词： Metal oxide semiconductors Gas sensors Aldoped ZnO/WO_(3) Heterostructure films Isopropanol Magnetron sputtering

Interplay between mesenchymal stem cells and macrophages:Promoting bone tissue repair

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World Journal of Stem Cells 2024年第4期16卷 375-388页

作者： Fei-Fan Zhang Yang Hao Kuai-Xiang Zhang jiang-Jia Yang Zhi-Qiang Zhao Hong-jian Liu Ji-Tian Li Molecular Biology Lab Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

The repair of bone tissue damage is a complex process that is well-orchestrated in time and space,a focus and difficulty in orthopedic *** recent years,the success of mesenchymal stem cells(MSCs)-mediated bone repair in clinical trials of large-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative *** are closely related to *** one hand,MSCs regulate the immune regulatory function by influencing macrophages proliferation,infiltration,and phenotype polarization,while also affecting the osteoclasts differentiation of *** the other hand,macrophages activate MSCs and mediate the multilineage differentiation of MSCs by regulating the immune *** cross-talk between MSCs and macrophages plays a crucial role in regulating the immune system and in promoting tissue *** full use of the relationship between MSCs and macrophages will enhance the efficacy of MSCs therapy in bone tissue repair,and will also provide a reference for further application of MSCs in other diseases.

关键词： Bone tissue damage Inflammation Macrophages Mesenchymal stem cells Tissue regeneration

PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2017年第14期23卷 2585-2591页

作者： Shi-Yuan Liu Wei Chen Ehtesham Annait Chughtai Zhe Qiao jian-Tao jiang Shao-Min Li Wei Zhang Jin Zhang Department of Thoracic Surgery Second Affiliated Hospital of Xi'an Jiaotong University Department of Medical Biochemistry and Molecular Biology School of Basic Medical Sciences Lanzhou University Xi'an Jiaotong University School of Medicine

AIM To evaluate PIK3 CA gene mutational status in Northwest Chinese esophageal squamous cell carcinoma(ESCC) patients, and examine the associations of PIK3 CA gene mutations with clinicopathological characteristics and clinical *** A total of 210 patients with ESCC who underwent curative resection were enrolled in this study. Pyrosequencing was applied to investigate mutations in exons 9 and 20 of PIK3 CA gene in 210 Northwest Chinese ESCCs. The associations of PIK3 CA gene mutations with clinicopathological characteristics and clinical outcome were *** PIK3 CA gene mutations in exon 9 were detected in 48 cases(22.9%) of a non-biased database of 210 curatively resected Northwest Chinese ESCCs. PIK3 CA gene mutations were not associated with sex, tobacco use, alcohol use, tumor location, stage, or local recurrence. When compared with wild-type PIK3 CA gene cases, patients with PIK3 CA gene mutations in exons 9 experienced significantly better disease-free survival and overall survival *** The results of this study suggest that PIK3 CA gene mutations could act as a prognostic biomarker in Northwest Chinese ESCC patients.

关键词： PIK3CA gene mutations Esophageal squamous cell carcinoma Northwest Chinese Prognostic significance

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不确定条件对交通网络设计的影响分析

交通运输系统工程与信息 2014年第3期14卷 85-90,116页

作者：蒋洋孙会君吴建军北京交通大学城市交通复杂系统理论与技术教育部重点实验室北京100044 北京交通大学轨道交通控制与安全国家重点实验室北京100044

在交通网络设计问题中较为关键的问题之一是如何准确合理的反映网络用户出行行为,符合实际的行为描述有助于决策者做出正确的决策.已有文献在用户均衡基础上对网络设计问题做出研究,假设所有用户均为风险中性的,忽略了出行时间不确定性... 详细信息

在交通网络设计问题中较为关键的问题之一是如何准确合理的反映网络用户出行行为,符合实际的行为描述有助于决策者做出正确的决策.已有文献在用户均衡基础上对网络设计问题做出研究,假设所有用户均为风险中性的,忽略了出行时间不确定性给网络设计决策带来的差异性影响.本文在随机路段能力导致的不确定环境下,引入期望出行时间(MTT)、出行时间预算(TTB)和α-可靠性的平均额外行程时间(METT),并采用数据结果对比分析不同用户均衡模式(DUE、DRUE、METTUE)对网络设计问题决策的影响.实验结果表明,在不同路段能力随机变化程度下,考虑用户出行时间的不确定性因素,较传统用户均衡更贴近现实,同时也为网络设计决策提供更准确的指导.

关键词：城市交通交通网络设计路段能力随机变化出行时间可靠性粒子群算法

The chemical constituents of the tissue culture cells of Daphne giraldii cullus

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Chinese Chemical Letters 2009年第11期20卷 1335-1338页

作者： Zhao Hua Wu Li Bo Wang Hui Yuan Gao jian Huang Bo Hang Sun Shu Hui Li Li jun Wu School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China Department of Pharmacology Mudanjiang Medical College Mudanjiang 157001 China

Three compounds were isolated from the tissue culture cells of Daphne giraldii cullus, their structures were identified as daphneolone （1）, S-（＋）-1-（4-hydroxy-3-methoxyphenyl）-3-hydroxy-5-phenyl-l-pentanone （2）, S-（＋）-1-（4-methoxyphenyl）-3- hydroxy-5-phenyl-l-pentanone （3）, and among them, 2 was a new compound, 3 was a novel natural product.

关键词： Tissue culture cells Daphne giraldii cullus Chemical constituents Structural identification

On the Formation of the Double Neutron Star Binary PSR J1846-0513

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Research in Astronomy and Astrophysics 2024年第11期24卷 259-267页

作者： Long jiang Kun Xu Shuai Zha Yun-Lang Guo jian-Ping Yuan Xiang-Li Qian Wen-Cong Chen Na Wang School of Science Qingdao University of TechnologyQingdao 266525China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Physics and Electrical Information Shangqiu Normal UniversityShangqiu 476000China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Department of Astronomy Nanjing UniversityNanjing 210023China Department of Intelligent Engineering Shandong Management UniversityJinan 250357China

The double neutron star PSR J1846-0513 is discovered by the Five-hundred-meter Aperture Spherical radio Telescope(FAST)in Commensal Radio Astronomy FAST *** pulsar is revealed to be harbored in an eccentric orbit with e=0.208 and an orbital period of 0.613 *** total mass of the system is constrained to b2.6287(35)M_(⊙),with a mass upper limit of 1.3455 M_(⊙)for the pulsar and a mass lower limit of 1.2845 M_(⊙)for th companion *** reproduce its evolution history,we perform a 1D model for the formation of PSR J1846-0513whose progenitor is assumed to be neutron star—helium(He)star system via MESA *** the larg eccentricity is widely believed to originate from an asymmetric supernova explosion,we also investigate th dynamical effects of the supernova *** simulated results show that the progenitor of PSR J1846-0513could be a binary system consisting of a He star of 3.3-4.0 M_(⊙)and a neutron star in a circular orbit with an initia period of~0.5 day.

关键词： stars evolution stars neutron (stars:)binaries general stars individual(PSR J1864-0513)

M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats

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Neural Regeneration Research 2023年第10期18卷 2208-2218页

作者： Jia-Gui Huang jiang-Xia Ren Yue Chen Ming-Fen Tian Li Zhou jun Wen Xiao-Song Song You-Lin Wu Qing-Huan Yang Pei-Ran jiang Jia-Ni Wang Qin Yang Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

In the central nervous system, the formation of fibrotic scar after injury inhibits axon regeneration and promotes repair. However, the mechanism underlying fibrotic scar formation and regulation remains poorly understood. M2 macrophages regulate fibrotic scar formation after injury to the heart, lung, kidney, and central nervous system. However, it remains to be clarified whether and how M2 macrophages regulate fibrotic scar formation after cerebral ischemia injury. In this study, we found that, in a rat model of cerebral ischemia induced by middle cerebral artery occlusion/reperfusion, fibrosis and macrophage infiltration were apparent in the ischemic core in the early stage of injury(within 14 days of injury). The number of infiltrated macrophages was positively correlated with fibronectin expression. Depletion of circulating monocyte-derived macrophages attenuated fibrotic scar formation. Interleukin 4(IL4) expression was strongly enhanced in the ischemic cerebral tissues, and IL4-induced M2 macrophage polarization promoted fibrotic scar formation in the ischemic core. In addition, macrophage-conditioned medium directly promoted fibroblast proliferation and the production of extracellular matrix proteins in vitro. Further pharmacological and genetic analyses showed that sonic hedgehog secreted by M2 macrophages promoted fibrogenesis in vitro and in vivo, and that this process was mediated by secretion of the key fibrosis-associated regulatory proteins transforming growth factor beta 1 and matrix metalloproteinase 9. Furthermore, IL4-afforded functional restoration on angiogenesis, cell apoptosis, and infarct volume in the ischemic core of cerebral ischemia rats were markedly impaired by treatment with an sonic hedgehog signaling inhibitor, paralleling the extent of fibrosis. Taken together, our findings show that IL4/sonic hedgehog/transforming growth factor beta 1 signaling targeting macrophages regulates the formation of fibrotic scar and is a potential therap

关键词： central nervous system extracellular matrix fibronectin fibrotic scar macrophage interleukin 4 ischemic cerebral injury neurological function Sonic hedgehog transforming growth factorβ1

Genome-wide association study of berryrelated traits in grape[Vitis vinifera L.]based on genotyping-by-sequencing markers

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Horticulture Research 2019年第1期6卷 1655-1667页

作者： Da-Long Guo Hui-Li Zhao Qiong Li Guo-Hai Zhang jian-Fu jiang Chong-Huai Liu Yi-He Yu College of Forestry Henan University of Science and TechnologyLuoyang 471023 Henan ProvinceChina Zhengzhou Fruit Research Institute Chinese Academy of Agricultural SciencesZhengzhou 450009 Henan ProvinceChina

Deciphering the genetic control of grape berry traits is crucial for optimizing yield,fruit quality,and consumer *** this study,an association panel of 179 grape genotypes comprising a mixture of ancient cultivars,landraces,and modern varieties collected worldwide were genotyped with genotyping-by-sequencing using a genome-wide association approach based on 32,311 single-nucleotide polymorphism(SNP)***-wide efficient mixed-model association was selected as the optimal statistical model based on the results of known control loci of grape berry color *** of the associated SNPs identified in this study were in accordance with the previous QTL analyses using biparental *** grape skin color locus was found to be associated with a mybA transcription factor on chromosome *** strong and distinct association signals associated with berry development periods were found on chromosome *** candidate genes of the interval were highlighted as receptor-like protein *** berry weight,significant association loci were identified on chromosome 18,as previously known,and on chromosome 19 and chromosome 17,as newly *** flesh texture was newly located on chromosome 16;candidate genes in the interval were related to *** flavor was determined on chromosome *** regions were further investigated to reveal candidate *** this work,we identified interesting genetic determinants of grape berry-related *** identification of the markers closely associated with these berry traits may be useful for grape molecular breeding.

关键词： cultivar traits Berry

Fecal microbiota in pouchitis and ulcerative colitis

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World Journal of Gastroenterology 2016年第40期22卷 8929-8939页

作者： Kai-Yu Li jian-Lin Wang jiang-Peng Wei Sen-Yang Gao Ying-Ying Zhang Li-Tian Wang Gang Liu Department of General Surgery Tianjin Medical University General Hospital Department of General Surgery Tianjin NanKai Hospital

AIM To investigate the changes in microbiota in feces of patients with ulcerative colitis(UC) and pouchitis using genomic *** Fecal samples were obtained from UC patients with or without an ileal pouch-anal anastomosis(IPAA) procedure, as well as healthy controls. The touchdown polymerase chain reaction technique was used to amplify the whole V3 region of the 16 S r RNA gene, which was transcribed from DNA extracted from fecal samples. Denaturing gradient gel electrophoresis was used to separate the amplicons. The band profiles and similarity indices were analyzed digitally. The predominant microbiota in different groups was confirmed by sequencing the 16 S rR NA gene. RESULTS Microbial biodiversity in the healthy controls was significantly higher compared with the UC groups(P < 0.001) and IPAA groups(P < 0.001). Compared with healthy controls, the UC patients in remission and those in the mildly active stage, the predominant species in patients with moderately and severely active UC changed obviously. In addition, the proportion of the dominant microbiota, which was negatively correlated with the disease activity of UC(r =-6.591, P < 0.01),was decreased in pouchitis patients. The numbers of two types of bacteria, Faecalibacterium prausnitzii and Eubacterium rectale, were reduced in UC. Patients with pouchitis had an altered microbiota composition compared with UC patients. The microbiota from pouchitis patients was less diverse than that from severely active UC patients. Sequencing results showed that similar microbiota, such as Clostridium perfringens, were shared in both UC and *** Less diverse fecal microbiota was present in patients with UC and pouchitis. Increased C. perfringens in feces suggest its role in the exacerbation of UC and pouchitis.

关键词： Pouchitis Intestinal flora Ulcerative colitis Disease activity index Ileal pouch-anal anastomosis