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Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury

Virologica Sinica 2024年第2期39卷 309-318页

作者： jian-Bo Cao Shu-Tong Zhu Xiao-Shan huang Xing-Yuan wang Meng-Li Wu Xin Li Feng-Liang Liu Ling Chen Yong-Tang Zheng jian-hua wang Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhou 510530China School of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230026China Key Laboratory of Bioactive Peptides of Yunnan Province Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of SciencesKIZCUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesCenter for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunming 650223China University of Chinese Academy of Sciences Beijing 101408China

SARS-CoV-2 infection-induced hyper-inflammation is a key pathogenic factor of COVID-19.Our research,along with others',has demonstrated that mast cells(MCs)play a vital role in the initiation of hyper-inflammation caused by SARS-CoV-2.In previous study,we observed that SARS-CoV-2 infection induced the accumulation of MCs in the peri-bronchus and bronchioalveolar-duct junction in humanized mice.Additionally,we found that MC degranulation triggered by the spike protein resulted in inflammation in alveolar epithelial cells and capillary endothelial cells,leading to subsequent lung injury.The trachea and bronchus are the routes for SARS-CoV-2 transmission after virus inhalation,and inflammation in these regions could promote viral spread.MCs are widely distributed throughout the respiratory tract.Thus,in this study,we investigated the role of MCs and their degranulation in the development of inflammation in tracheal-bronchial epithelium.Histological analyses showed the accumulation and degranulation of MCs in the peri-trachea of humanized mice infected with SARS-CoV-2.MC degranulation caused lesions in trachea,and the formation of papillary hyperplasia was observed.Through transcriptome analysis in bronchial epithelial cells,we found that MC degranulation significantly altered multiple cellular signaling,particularly,leading to upregulated immune responses and inflammation.The administration of ebastine or loratadine effectively suppressed the induction of inflammatory factors in bronchial epithelial cells and alleviated tracheal injury in mice.Taken together,our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue lesions.Furthermore,our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation,thereby preventing tissue damage caused by hyper-inflammation.

关键词： SARS-CoV-2 Mast cell(MC) Bronchial epithelial cell Inflammation Tracheal injury

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Full waveform inversion based on hybrid gradient

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Petroleum Science 2024年第3期21卷 1660-1670页

作者： Chuang Xie Zhi-Liang Qin jian-hua wang Peng Song Heng-Guang Shen Sheng-Qi Yu Ben-Jun Ma Xue-Qin Liu Qingdao Innovation and Development Base Harbin Engineering University Qingdao Innovation and Development Center Harbin Engineering University CNOOC Research Institute Co. Ltd. College of Marine Geoscience Ocean University of China Weihai Sunfull Geophysical Exploration Equipment Co. Ltd.

The low-wavenumber components in the gradient of full waveform inversion(FWI) play a vital role in the stability of the inversion. However, when FWI is implemented in some high frequencies and current models are not far away from the real velocity model, an excessive number of low-wavenumber components in the gradient will also reduce the convergence rate and inversion accuracy. To solve this problem, this paper firstly derives a formula of scattering angle weighted gradient in FWI, then proposes a hybrid gradient. The hybrid gradient combines the conventional gradient of FWI with the scattering angle weighted gradient in each inversion frequency band based on an empirical formula derived herein.Using weighted hybrid mode, we can retain some low-wavenumber components in the initial lowfrequency inversion to ensure the stability of the inversion, and use more high-wavenumber components in the high-frequency inversion to improve the convergence rate. The results of synthetic data experiment demonstrate that compared to the conventional FWI, the FWI based on the proposed hybrid gradient can effectively reduce the low-wavenumber components in the gradient under the premise of ensuring inversion stability. It also greatly enhances the convergence rate and inversion accuracy,especially in the deep part of the model. And the field marine seismic data experiment also illustrates that the FWI based on hybrid gradient(HGFWI) has good stability and adaptability.

关键词： Full waveform inversion Hybrid gradient Scattering angle weighted Low-wavenumber component

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Scale effects on bow wave breaking of KCS ship model:Insights from DDES investigations

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Journal of Hydrodynamics 2023年第4期35卷 668-678页

作者： jian-hua wang Wen-tao wang De-cheng Wan Computational Marine Hydrodynamics Laboratory(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China China Ship Scientific Research Center Wuxi214082China

Ship bow wave breaking is a common phenomenon during navigation,involving complex multi-scale flow interactions.However,the understanding of this intense free surface flow issue is not sufficiently deep,especially regarding the lack of research on the impact of scale effects on bow wave breaking.This paper focuses on the benchmark ship model KCS and conducts numerical simulations and comparative analyses of bow wave breaking for three model scales under the condition of Fr=0.35.The numerical calculations were performed using the in-house computational fluid dynamics(CFD)solver naoe-FOAM-SJTU,which is developed on the open source platform OpenFOAM.Delayed detached eddy simulation(DDES)method is utilized to calculate the viscous flow field around the ship hull.The present method was validated through measurement data of wave profiles and wake flows obtained from model tests.Flow field results for three different scales,including bow wave profiles,vorticity at various sections,and wake distribution,were presented and analyzed.The results indicate that there is small difference in the bow wave overturning and breaking for the first two occurrences across different scales.However,considerable effects of scale are observed on the temporal and spatial variations of the free surface breaking pattern after the second overturning.The findings of this study can serve as valuable data references for the analysis of scale effects in ship bow wave breaking phenomena.

关键词： Scale effects wave pattern bow wave breaking KRSIO Container Ship(KCS) delayed detached eddy simulation(DDES)approach

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Numerical analysis of turbulent fluctuations around an axisymmetric body of revolution based on wall-modeled large eddy simulations

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Journal of Hydrodynamics 2023年第6期35卷 1041-1051页

作者： Kang-jian He Fu-chang Zhou Wei-wen Zhao jian-hua wang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Wuhan Second Ship Design and Research Institute Wuhan430205China

Wall-modeled large eddy simulation(WMLES)is used to investigate turbulent fluctuations around an axisymmetric body of revolution.This study focuses on evaluating the ability of WMLES to predict the fluctuating flow over the axisymmetric hull and analyzing the evolution of turbulent fluctuations around the body.The geometry is the DARPA SUBOFF bare model and the Reynolds number is 1.2×10^(7),based on the free-stream velocity and the length of the body.Near-wall flow structures and complex turbulent fluctuation fields are successfully captured.Time-averaged flow quantities,such as time-averaged pressure and skin-friction coefficients,and time-averaged velocity profiles on the stern,achieved great agreements between WMLES results and experimental data.Self-similarity of time-averaged velocity defects within a self-similar coordinate up to twelve diameters from the tail.A comprehensive analysis of second-order statistics in the mid-body,stern,and wake regions is condutced.Numerical results agree well with experimental data and previous wall-resolved large eddy simulation(WRLES)results about root mean square(rms)of radial and axial fluctuating velocities at the stern.Turbulent fluctuations including turbulent kinetic energy(TKE)and second-order velocity statistics are identified as dual peak behavior and non-self-similar over the wake length,consistent with previous findings in the literature.This assessment enhances the understanding of WMLES capabilities in capturing complex fluctuating flow around axisymmetric geometries.

关键词： Turbulent fluctuations wall-modeled large eddy simulation(WMLES) turbulent boundary layer wake

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Diagnostic performance of texture analysis in the differential diagnosis of perianal fistulising Crohn’s disease and glandular anal fistula

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 882-891页

作者： Xin Zhu Dan-Dan Ye jian-hua wang Jing Li Shao-Wei Liu Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Radiology Quanzhou Orthopedic-Traumatological HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Perianal fistulising Crohn's disease(PFCD)and glandular anal fistula have many similarities on conventional magnetic resonance imaging.However,many patients with PFCD show concomitant active proctitis,but only few patients with glandular anal fistula have active proctitis.AIM To explore the value of differential diagnosis of PFCD and glandular anal fistula by comparing the textural feature parameters of the rectum and anal canal in fat suppression T2-weighted imaging(FS-T2WI).METHODS Patients with rectal water sac implantation were screened from the first part of this study(48 patients with PFCD and 22 patients with glandular anal fistula).Open-source software ITK-SNAP(Version 3.6.0,http://***/)was used to delineate the region of interest(ROI)of the entire rectum and anal canal wall on every axial section,and then the ROIs were input in the Analysis Kit software(version V3.0.0.R,GE Healthcare)to calculate the textural feature parameters.Textural feature parameter differences of the rectum and anal canal wall between the PFCD group vs the glandular anal fistula group were analyzed using Mann-Whitney U test.The redundant textural parameters were screened by bivariate Spearman correlation analysis,and binary logistic regression analysis was used to establish the model of textural feature parameters.Finally,diagnostic accuracy was assessed by receiver operating characteristic-area under the curve(AUC)analysis.RESULTS In all,385 textural parameters were obtained,including 37 parameters with statistically significant differences between the PFCD and glandular anal fistula groups.Then,16 texture feature parameters remained after bivariate Spearman correlation analysis,including one histogram parameter(Histogram energy);four grey level co-occurrence matrix(GLCM)parameters(GLCM energy_all direction_offset1_SD,GLCM entropy_all direction_offset4_SD,GLCM entropy_all direction_offset7_SD,and Haralick correlation_all direction_offset7_SD);four texture parameters(Correlation_all direction_offset1_SD,cluster prominenc

关键词： Anal fistula Crohn’s diseases Magnetic resonance imaging Texture analysis Differential diagnosis

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Photo-stability and Photo-damage of SPASER Nanoparticles under Nanosecond Pulsed-laser

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Chinese Journal of Chemistry 2022年第4期40卷 507-514页

作者： jian-hua wang Shao-Peng wang Pavel N.Melentiev Bin Kang Jing-Juan Xu Hong-Yuan Chen State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China Institute of Spectroscopy of the Russian Academy of Sciences TroitskMoscow 108840Russia

Comprehensive Summary SPASER nanoparticle(NP),with small size,ultranarrow spectral-line and good biocompatibility,is a potential biomedical nanoprobe.However,owning to the striking light absorption capacity of Au-resonator,huge energy could accumulate under strong pumping-laser,which would lead to poor photo-stability and unexpected photo-damage to SPASER NP,and is harmful to its future practical application but hasn't been systematically studied in experiment.

关键词： SPASER Nanoparticles Probe Laser spectroscopy Photophysics

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Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice

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Zoological Research 2022年第3期43卷 457-468页

作者： Meng-Li Wu Feng-Liang Liu Jing Sun Xin Li jian-Ru Qin Qi-Hong Yan Xia Jin Xin-Wen Chen Yong-Tang Zheng Jin-Cun Zhao jian-hua wang College of Life Science Henan Normal UniversityXinxiangHenan 453007China Guangzhou Institutes of Biomedicine and Health Chinese Academy of SciencesGuangzhouGuangdong 510530China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510182China University of Chinese Academy of Sciences Beijing 100049China

COVID-19 is an immune-mediated inflammatory disease caused by SARS-CoV-2 infection,the combination of anti-inflammatory and antiviral therapy is predicted to provide clinical benefits.We recently demonstrated that mast cells(MCs)are an essential mediator of SARS-CoV-2-initiated hyperinflammation.We also showed that spike protein-induced MC degranulation initiates alveolar epithelial inflammation for barrier disruption and suggested an off-label use of antihistamines as MC stabilizers to block degranulation and consequently suppress inflammation and prevent lung injury.In this study,we emphasized the essential role of MCs in SARS-CoV-2-induced lung lesions in vivo,and demonstrated the benefits of co-administration of antihistamines and antiviral drug remdesivir in SARS-CoV-2-infected mice.Specifically,SARSCoV-2 spike protein-induced MC degranulation resulted in alveolar-capillary injury,while pretreatment of pulmonary microvascular endothelial cells with antihistamines prevented adhesion junction disruption;predictably,the combination of antiviral drug remdesivir with the antihistamine loratadine,a histamine receptor 1(HR1)antagonist,dampened viral replication and inflammation,thereby greatly reducing lung injury.Our findings emphasize the crucial role of MCs in SARS-CoV-2-induced inflammation and lung injury and provide a feasible combination antiviral and anti-inflammatory therapy for COVID-19 treatment.

关键词： SARS-CoV-2 Mast cell Remdesivir Antihistamine Combinational therapy

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Eco-friendly aqueous foam stabilized by cellulose microfibers with great salt tolerance and high temperature resistance

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Petroleum Science 2023年第4期20卷 2499-2511页

作者： Li-Li Yang Xian-Bo He Yi-Xiu Cheng Guan-Cheng jiang Ze-Yu Liu Shi-Bo wang Shi-Xin Qiu jian-hua wang Wei-Guo Tian MOE Key Laboratory of Petroleum Engineering State Key Laboratory of Petroleum Resources and EngineeringChina University of Petroleum(Beijing)Changping DistrictBeijing102249China Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Engineering PlasticsInstitute of Chemistry Chinese Academy of Sciences(CAS)Haidian DistrictBeijing100190China MOE Key CNPC Drilling Research Institute Changping DistrictBeijing102206China

A low-cost eco-friendly aqueous foam,especially the robust foam with great tolerance to high salinity and high temperature,is in great demand in the oil industry,e.g.,oil and gas well or geothermal well drilling.Herein,an ultra-stable aqueous foam was developed using the biodegradable cellulose microfiber(CMF)as a foam stabilizer.The foam stabilized by CMF shows excellent tolerance to the high concentration of NaCl(6.0 wt%)and CaCl_(2)(0.25 wt%)and the related drainage half-life times(T_(0.5))reach 1750 and 2340 s respectively.By contrast,the foams without CMF are completely drained(T_(0.5)=0 s)when NaCl concentration is greater than 6.0 wt%or CaCl_(2) concentration is greater than 0.20 wt%.Notably,T0.5 of the foams stabilized by CMF at these saline concentrations still can maintain above 1000 s even after aging at 120℃ for 16 h,exhibiting an outstanding foam-stabilizing performance at high temperature.Experimental results suggest that the salt and high-temperature tolerance of CMF in foam stabilization is attributed to the electrically uncharged surfaces,the formation of a gel-like structure and the excellent thermal stability.This work not only provides a promising candidate of aqueous foam stabilizer to deal with high temperature and high salinity but also presents a natural-based solution for an environmentally friendly drilling industry in the future.

关键词： Aqueous foam Foam stabilizer Cellulose microfiber Salt tolerance Sustainable

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Extension of Isometries Between the Unit Spheres of Normed Space E and C(Ω)

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1819-1824页

作者： Xi Nian FANG jian hua wang Department of Applied Mathematics Nanjing Audit University Nanjing 210029 P. R. China Department of Mathematics Anhui Normal University Wuhu 241000 P. R. China

In this paper, we study the extension of isometries between the unit spheres of normed space E and C（Ω）. We obtain that any surjective isometry between the unit spheres of normed space E and C（Ω） can be extended to be a linear isometry on the whole space E and give an affirmative answer to the corresponding Tingley＇s problem （where Ω be a compact metric space）.

关键词： isometric mapping isometric extension Tingley＇s problem

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Vortex identification methods in marine hydrodynamics

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Journal of Hydrodynamics 2020年第2期32卷 286-295页

作者： Wei-wen Zhao jian-hua wang De-cheng Wan Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringState Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai200240China

In this paper,several commonly used vortex identification methods for marine hydrodynamics are revisited.In order to extract and analyse the vortical structures in marine hydrodynamics,the Q,λ2-criterion and modified normalized Liutex/RortexΩR method are utilized for vortex identification for propeller open water test,ship drag test,ship propeller-rudder interaction,VIV of a marine riser and VIM of a Spar platform.The limitation of Q andλ2-criterion is discussed.The Liutex/RortexΩR method is promising for convenient and accurate vortex identification and visualization.However,care should be taken when choosing the small parameter b0 forΩR.We proposed recommended values of b0 for marine hydrodynamic problems.

关键词： Marine hydrodynamics vortex identification Omega Liutex/Rortex naoe-FOAM-SJTU solver OpenFOAM

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