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Synchronous parathyroid adenoma, papillary thyroid carcinoma and thyroid adenoma in pregnancy: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5426-5431页

作者： Qiang Li Xiao-Zhang Xu jian-hua shi Department of Breast and Thyroid Surgery The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai'an 223300Jiangsu ProvinceChina

BACKGROUND There is a common pathologic relationship between parathyroid adenoma and thyroid cancer,but this relationship is infrequent in pregnant patients with primary hyperparathyroidism(PHPT).CASE SUMMARY A 27-year-old gravida 1 woman was transferred to our hospital at 16 wk of *** was diagnosed with parathyroidoma,papillary carcinoma of the thyroid and thyroid adenoma and was managed *** the mother and the newborn were stable after a right inferior parathyroidectomy and total *** healthy infant was delivered at the 40th week of *** mother had no evidence of recurrence over three years of *** Awareness of concomitant PHPT and thyroid diseases may help in managing patients with a history of hypercalcemia.

关键词： Primary hyperparathyroidism Pregnancy Papillary thyroid carcinoma Parathyroid adenoma Thyroid adenoma Case report

Synthesis of Nitroanilines Catalyzed by Horseradish Peroxidase in the Presence of NaNO2 and H2O2

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Chemical Research in Chinese Universities 2013年第6期29卷 1164-1166页

作者： LIU Cong DAI Rong-ji LIN Jie SUN jian-hua CHEN shi DENG Yu-lin School of Life Science Beijing Institute of Technology Beijing 100081 P.R.China

The synthesis of nitroanilines catalyzed by horseradish peroxidase（HRP） in the presence of sodium nitrite and hydrogen peroxide was investigated, o-Nitroaniline and p-nitroaniline were found in the nitrated products. 2-Aminotoluene and 4-aminotoluene could also be nitrated to give corresponding nitrated products. This protocol has great potentials to open new avenues useful for the synthesis of nitroaniline and its derivatives.

关键词： Nitroaniline Horseradish peroxidase Phenylamine Nitration Enzyme

Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death

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World Journal of Gastroenterology 2018年第43期24卷 4920-4927页

作者： Liang-Shuo Hu Yi-Chao Chai Jie Zheng jian-hua shi Chun Zhang Min Tian Yi Lv Bo Wang Ai Jia Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong University Clinical Research Center First Affiliated Hospital of Xi’an Jiaotong University Department of Gastroenterology First Affiliated Hospital of Xi’an Jiaotong University

AIM To describe the prevalence of posttransplant metabolic syndrome(PTMS) after donation after cardiac death(DCD) liver transplantation(LT) and the pre-and postoperative risk *** One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre-and post-transplantation were collected for both recipients and donors. PTMS was defined according to the 2004 Adult Treatment Panel-Ⅲ criteria. All subjects were followed monthly for the initial 6 mo after discharge, and then, every 3 mo for 2 years. The subjects were followed every 6 mo or as required after 2 years *** The prevalence of PTMS after DCD donor orthotopic LT was 20/147(13.6%). Recipient's body mass index(P = 0.024), warm ischemia time(WIT)(P = 0.045), and posttransplant hyperuricemia(P = 0.001) were significantly associated with PTMS. The change in serum uric acid levels in PTMS patients was significantly higher than that in non-PTMS patients(P < 0.001). After the 1 s t mo, the level of serum uric acid of PTMS patients rose continually over a period, while it was unaltered in non-PTMS patients. After transplantation, the level of serum uric acid in PTMS patients was not associated with renal *** PTMS could occur at early stage after DCD LT with growing morbidity with the passage of time. WIT and post-LT hyperuricemia are associated with the prevalence of PTMS. An increased serum uric acid level is highly associated with PTMS and could act as a serum marker in this disease.

关键词： Posttransplant metabolic syndrome Liver transplantation Donation after cardiac death Uric acid Warm ischemia time

Synthesis of Ni/Al System Intermetallic Compound Under the Influence of Pulsating Electric Current

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Journal of Wuhan University of Technology(Materials Science) 2003年第2期18卷 38-40页

作者：胡建华 Wuhan University of Technology

Synthesis of Ni/Al system intermetallic compound under the influence of pulsating electric current is *** of Ni/Al system intermetallic compound are *** is found that solid-state reactions occur at Ni/Al interface and the main way of reactions is atoms diffusing each other under the influence of a high-density pulsating electric current.

关键词： pulsating electric current self-propagating high-temperature synthesis Ni/Al system intermetallic compound

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A STUDY ON THE LOW SPEED shiP THEORY

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Journal of Hydrodynamics 1989年第2期1卷 45-54页

作者： Wu jian-hua Li shi-mo Wuhan Institute of water Transportation Engineering,Wuhan,P.R.China

Based on Baba's assumption,the linearized free-surface boundary conditions at low speed are discussed in order to demonstrate the differences between Baba's and Dawson's free-surface boundary *** using Fourier integral transfor- mation,a method of computing wave velocity potential ,which satisfies the boundary conditions of free-surface and hull surface,is *** solution of is found with the powerful technique of asymptotic *** order comparison method,it is found that the hull surface boundary conditions can be neglected when only the ship wave resistance is *** exact analytical solution of two-dimensional slow ship wave velocity potential is derived by neg- lecting hull *** results show that the inhomogeneous effect of free-surface is not negligible in the boundary value problems of slow ship velocity potential.

关键词： Wave exp A STUDY ON THE LOW SPEED shiP THEORY

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Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection:How to achieve a better outcome

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1833-1848页

作者： Fan Mu Liang-Shuo Hu Kun Xu Zhen Zhao Bai-Cai Yang Yi-Meng Wang Kun Guo jian-hua shi Yi Lv Bo Wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Anaesthesiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gynaecology Wenzhou Medical University Affiliated Jiaxing Women and Children HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)have been proven,researchers have not con-firmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time(at least 24 wk)and patients who received remedial antiviral therapy just before radical resection for HBV-related *** To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related *** A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was *** the history of antiviral therapy,patients were assigned to remedial antiviral therapy and preoperative antiviral therapy *** Kaplan–Meier analysis revealed significant differences in overall survival(P<0.0001)and disease-free survival(P=0.035)between the two *** analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival(hazard ratio=0.27;95%confidence interval:0.08-0.88;P=0.030).CONCLUSION In patients with HBV-related HCC,it is ideal to receive preoperative long-term antiviral therapy,which helps patients tolerate more extensive hepatectomy;however,remedial antiviral therapy,which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL,can also result in improved outcomes.

关键词： Hepatectomy Hepatitis B virus Antiviral therapy Hepatocellular carcinoma Hepatitis B virus-DNA

Hypothermic machine perfusion with metformin-University of Wisconsin solution for ex vivo preservation of standard and marginal liver grafts in a rat model

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World Journal of Gastroenterology 2017年第40期23卷 7221-7231页

作者： Yi-Chao Chai Guo-Xin Dang Hai-Qi He jian-hua shi Hong-Ke Zhang Rui-Tao Zhang Bo Wang Liang-Shuo Hu Yi Lv Department of Hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University Institute of Advanced Surgical Techniques and Engineering Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province Xi'an Jiaotong University Department of Hepatobiliary and Vascular Surgery the 521 Hospital of Ordnance Industry

AIM To compare the effect of University of Wisconsin(UW) solution with or without metformin, an AMP-activated protein kinase(AMPK) activator, for preserving standard and marginal liver grafts of young and aged rats ex vivo by hypothermic machine perfusion(HMP).METHODS Eighteen young(4 mo old) and 18 aged(17 mo old)healthy male SD rats were selected and randomly divided into three groups: control group, UW solution perfusion group(UWP), and UW solution with metformin perfusion group(MUWP). Aspartate aminotransferase(AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH), interleukin-18(IL-18), and tumor necrosis factor-alpha(TNF-α) in the perfused liquid were tested. The expression levels of AMPK and endothelial nitric oxide synthase(e NOS) in liver sinusoidal endothelial cells were also ***, microscopic evaluation of the harvested perfused liver tissue samples was done. RESULTS AST, ALT, LDH, IL-18 and TNF-α levels in the young and aged liver-perfused liquid were, respectively,significantly lower in the MUWP group than in the UWP group(P < 0.05), but no significant differences were found between the young and aged MUWP *** increased the expression of AMPK and e NOS protein levels, and promoted the extracellular release of nitric oxide through activation of the AMPK-e NOS mediated pathway. Histological examination revealed that in the MUWP group, the extent of liver cells and tissue damage was significantly reduced compared with the UWP *** The addition of metformin to the UW preservative solution for ex vivo HMP can reduce rat liver injury during cold ischemia, with significant protective effects on livers, especially of aged rats.

关键词： Metformin AMP-activated protein kinase Cold ischemia injury Hypothermic machine perfusion Liver Grafts

Diagnosis and treatment of acute graft-versus-host disease after liver transplantation:Report of six cases

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World Journal of Clinical Cases 2021年第30期9卷 9255-9268页

作者： Min Tian Yi Lyu Bo Wang Chang Liu Liang Yu jian-hua shi Xue-Min Liu Xiao-Gang Zhang Kun Guo Yu Li Liang-Shuo Hu Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Graft-versus-host disease(GVHD)following liver transplantation(LT)is an unpredictable complication with poor ***,consensus regarding the diagnosis and therapeutic regimen for the disease is yet *** present study summarized the clinical experience on the diagnosis and treatment of acute GVHD(aGVHD)following LT and reviewed the pertinent *** SUMMARY Between January 1^(st),2000 and December 31^(st),2020,a total of 1053 LT were performed in the First Affiliated Hospital of Xi’an Jiaotong *** recipients developed aGVHD with clinical symptoms of fever,rash,diarrhea,and *** incidence of aGVHD was 0.57%.The median time from LT to the clinical presentation of aGVHD was 22.17 *** median time from the beginning of the clinical symptom to histopathological diagnosis was 7.5 *** six cases underwent treatment of immunosuppressant adjustment,corticosteroids,human normal immunoglobulin,and antithymocyte globulin/IL-2 *** intensive treatment strategies,4 patients were deceased due to sepsis,multiple organ failure,and cerebral *** remaining two cases were discharged as treatment ***,one died because of tuberculosis infection on the 6 th month of follow-up,the other one was alive healthy during 30 mo of *** The rapid diagnosis of aGVHD is mainly based on the time from the first symptom,histopathological features,and the donor T-lymphocyte *** cases report highlights massive corticosteroid therapy and age difference between donors and recipients could accelerate to ***,gut microbial interventions and donor-targeted serotherapy may provide novel therapeutics.

关键词： Graft-versus-host disease Liver transplantation Donor T-lymphocytes chimerism Gut microbiota Donor-targeted serotherapy Case report

Inhibitory effects of idoxifene on hepatic fibrosis in rats

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Acta Pharmacologica Sinica 2005年第5期26卷 581-586页

作者： Ya-jun ZHOU~2,Dong-mei YIN,Hong-shan CHEN,jian-hua shi,Bao-xi SHA,Xing WANGDepartment of Biochemistry & Molecular Biology Medical College,Nan Tong University,Nantong 226001,China DepartmentofBiochemistry&MolecularBiology MedicalCollegeNanTongUniversityNantong226001China

Aim:To investigate the effects of a tissue-specific selective estrogen receptormodulator,idoxifene,on hepatic fibrosis in ***:Hepatic fibrosis wasinduced by dimethylnitrosamine(DMN)in male *** DMN model of hepaticfibrosis and the hepatocytes undergoing oxidative stress were treated withidoxifene *** effect of idoxifene on hepatic fibrosis in the DMNmodel was examined by *** of idoxifene on antioxi-dant enzyme levels of copper,zinc-dependent superoxide dismutase(CuZn-SOD),and cellular glutathione peroxidase(GSHPx)were measured by *** ofidoxifene on activation,proliferation,and apoptosis of culture-activated hepaticstellate cells(HSC)were analysed by immunohistochemistry,bromodeoxyuridine(BrdU)uptake,and flow cytometry, respectively. Results:Idoxifene could mark-edly suppress DMN-induced hepatic fibrosis in male rats.A treatment of 0.4mg·kg-1·d-1of idoxifene reduced the protein levels of collagen in the DMN modelby 41.19%(P<0.05).Protein level of CuZn-SOD and activitiy of GSHPx in livertreated with DMN plus 0.4 ***-1·d-1of idoxifene were 2.65 times(P<0.05)and2.08 times greater(P<<0.05)than that of liver treated with DMN alone *** protein level of CuZn-SOD and activity of GSHPx in cultured rat hepatocytestreated with ferric nitrilotriacetate(FeNTA)plus 1×10-7mol/L of idoxifene were3.43 times(P<0.05)and 2.52 times(P<0.05)greater than that treated with *** could inhibit HSC *** with the control,theuptake of BrdU in HSC cultured with 1×10-7mol/L of idoxifene was reduced by51.87%(P<0.05),and the number of apoptotic HSCs cultured with 1×10-7mol/L ofidoxifene increased by 94.52%(P<0.05).Conclusion:Idoxifene showed inhibi-tory action on hepatic fibrosis in male rats.

关键词： fibrosis idoxifene oxidative stress hepatic stellate cell liver