检索结果-南通市图书馆

Babao Dan Inhibits Gastric Cancer Progression in vivo Through Multiple Signaling Pathways

World Journal of Traditional Chinese Medicine 2024年第1期10卷 14-21页

作者： Hai-Xia Shang Yi Fang Bin guan jian-hua guan Jun Peng Jin-Yan Zhao Jiu-Mao Lin Institute of Oncology of Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianChina Key Laboratory of Integrative Medicine of Fujian Province University Fujian University of Traditional Chinese MedicineFuzhouFujianChina Fujian Key Laboratory of Integrative Medicine on Geriatric Fujian University of Traditional Chinese MedicineFuzhouFujianChina Innovation and Transformation Center Fujian University of Traditional Chinese MedicineFuzhouFujianChina Xiamen Traditional Chinese Medicine Co. Ltd.XiamenFujianChina

Objective:The aim of this study was to explore the effects of Babao dan(BBD),a traditional Chinese medicine,on gastric cancer(GC)progression in *** and Methods:A subcutaneous xenograft mouse model of GC was established using MGC80-3 *** terminal deoxynucleotidyl transferase-mediated dUTP:2'-deoxyuridine 5'-triphosphate-biotin nick-end labeling method was adopted to detect cell apoptosis in *** expression levels of proteins associated with proliferation,apoptosis,and angiogenesis were measured by immunohistochemical staining or western blotting(WB).The activation and protein levels of p-c-Jun N-terminal kinase(JNK),p-p38,p-extracellular-regulated kinase 1/2,p-nuclear factor-κB(NF-κB),and p-STAT3 were examined by Bio-plex and ***:BBD significantly inhibited tumor growth in GC mouse models with no adverse effect on body weight or organ *** was also found that BBD significantly suppressed the proliferation of GC tumor cells,induced the apoptosis of tumor cells,and inhibited angiogenesis through inactivating with mitogen-activated protein kinase,NF-κB,and STAT3 ***:BBD exerts suppressive effects on GC tumor growth by regulating multiple pathways in vivo,which may provide a novel treatment option for GC therapy.

关键词： Babao dan gastric cancer multiple signaling pathways proliferation traditional Chinese medicine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

引用

Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi Liu Zhe-Hao Wang guan-hua Xue Lin Chen Li-hua Yuan Yi-Wen Li Da-Gang Yu jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

引用

Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi Yu Tao Yu jian-hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

引用

Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-hua He jian-Fei Gao Ling-Bin Kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein lysine crotonylation in cellular processions and disease associations

引用

Genes & Diseases 2024年第5期11卷 219-235页

作者： Hongling Zhao Yang Han Pingkun Zhou hua guan Shanshan Gao Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing 100850China

Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological *** e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these *** levels of Kcr modifications have been identified on both histone and non-histone *** present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological *** addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关键词： Cell biology Disease Lysine crotonylation Posttranslational modification Therapeutic target

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Relationship between plasma risperidone concentrations and clinical features in chronic schizophrenic patients in China

引用

World Journal of Psychiatry 2024年第4期14卷 523-532页

作者： Jing-Wen Xu Xiao-Bo guan Xue-Ying Wang Yang Feng Qi Zhang Jun-Juan Zhu jian-hua Chen Department of Medicine Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China The Fourth Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Psychotic DisordersShanghai 200030China The First Sick Ward Shanghai No.3 Mental Health Center of Civil AdministrationShanghai 200435China

BACKGROUND Prior studies have noted great variability in the plasma levels of risperidone(RIS).Plasma concentrations of RIS and its active moiety are highly variable and depend on absorption,metabolism,and other predictors of metabolic dysregulation;however,these factors are poorly understood and the association between metabolic change and change in psychopathology is *** To ascertain the characteristics of chronic schizophrenic patients treated with RIS,and to assess their relationship with plasma RIS *** This was a descriptive cross-sectional study of 50 patients with a diagnosis of schizophrenic psychosis treated with RIS in a psychiatric *** plasma concentrations of RIS and its metabolite 9-hydroxyrisperidone were determined by high performance liquid *** patients’demographic and clinical characteristics,and psychopathologies were assessed,and the associations between clinical variables and plasma levels of RIS were *** Male patients received higher doses of RIS than female ones,but plasma concentrations of RIS and risperidone+9-hydroxyrisperidone(active moiety)were higher in female *** and the mean scores of the general psychopathology subscale of the Positive and Negative Syndrome Scale(PANSS)were significantly positively correlated with plasma concentrations of risperidone+9-hydroxyrisperidone adjusted for weight and dose in all 50 *** male subjects,we found a statistically significant positive correlation between the concentrations of risperidone+9-hydroxyrisperidone in plasma/(dose×kg)and age,mean PANSS negative subscale scores,mean PANSS general psychopathology subscale scores,and mean PANSS total *** Long-term use of RIS should be closely monitored in older patients and females to minimize the risk of high concentrations which could induce side effects.

关键词： Antipsychotics Risperidone 9-hydroxyrisperidone Plasma drug concentration monitoring Chronic schizophrenia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Conversion of Non-Dispersed Polymers into Low-Potassium Anti-Collapse Drilling Fluids

引用

Fluid Dynamics & Materials Processing 2024年第2期20卷 325-335页

作者： Hao Hu jian guan Shanfa Tang Jialuo Rong Yuanpeng Cheng School of Petroleum Engineering Yangzte UniversityWuhan430100China Hubei Key Laboratory of Oil and Gas Drilling and Production Engineering Yangtze UniversityWuhan430100China School of Petroleum Engineering Yangtze UniversityNational Engineering Research Center for Oil&Gas Drilling and Completion TechnologyWuhan430100China Engineering Technology Research Institute of PetroChina Great Wall Drilling Engineering Co. Ltd.Panjin124000China

Different drillingﬂuid systems are designed according to mineral composition,lithology and wellbore stability of different *** the present study,the conversion of a non-dispersed polymer drillingﬂuid into a low potas-sium anti-collapsing drillingﬂuid is *** the two drillingﬂuids belong to completely different types,the key to this conversion is represented by new inhibitors,dispersants and water-loss agents by which a non-dispersed drillingﬂuid can be turned into a dispersed drillingﬂuid while ensuring wellbore stability and reason-able rheology(carrying sand—inhibiting cuttings dispersion).In particular,the(QYZ-1)inhibitors and(FSJSS-2)dispersants are *** former can inhibit the hydration expansion capacity of clay,reduce the dynamic shear force and weaken the viscosity;the latter can improve the sealing effect and reduce theﬁltrate *** results have shown that after adding a reasonable proportion of these substances(QYZ-1:FSJSS-2)to the non-dispersed polymer drillingﬂuid,while the apparent viscosity,plastic viscosity,structural viscosity andﬂuidity index under-went almost negligible changes,the dynamic plastic ratio increased,and theﬁltration loss decreased signiﬁcantly,thereby indicating good *** to the tests(conducted in the Leijia area),the density was 1.293 g/cm3,and after standing for 24 h,the SF(static settlement factor)was ***,theﬁltration loss was reduced to 4.0 mL,the rolling recovery rate reached 96.92%,with excellent plugging and anti-collapse performances.

关键词： Non-dispersed polymer drilling fluid low potassium anti-collapsing drilling fluid drilling fluid conversion drilling fluid reuse filter vector

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pain perception enhancement in consecutive secondeye phacoemulsification cataract surgeries under topical anesthesia

引用

International Journal of Ophthalmology(English edition) 2024年第8期17卷 1510-1518页

作者： Jia-Wei Luo Yan-hua Chen jian-Feng Yu Yi-Xun Chen Min Ji huai-Jin guan Eye Institute Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Nantong Center for Disease Control and Prevention Nantong 226001Jiangsu ProvinceChina

Cataract is the main cause of visual impairment and blindness worldwide while the only effective cure for cataract is still *** phacoemulsification under topical anesthesia has been the routine procedure for cataract ***,patients often grumbled that they felt more painful during the second-eye surgery compared to the first-eye *** intraoperative pain experience has negative influence on satisfaction and willingness for second-eye cataract surgery of patients with bilateral *** ocular pain is a complicated process induced by the nociceptors activation in the peripheral nervous ***,neuropsychological,and pharmacological factors work together in the enhancement of intraoperative *** published literatures have focused on the pain enhancement during the secondeye phacoemulsification *** this review,we searched PubMed database for articles associated with pain perception differences between consecutive cataract surgeries published up to Feb.1,*** summarized the recent research progress in mechanisms and interventions for pain perception enhancement in consecutive secondeye phacoemulsification cataract *** review aimed to provide novel insights into strategies for improving patients’intraoperative experience in second-eye cataract surgeries.

关键词： ocular pain cataract surgery topical anesthesia intraoperative experience second-eye phacoemulsification

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On the Quantum Cohomology of Blow-ups of Four-dimensional Quadrics

引用

Acta Mathematica Sinica,English Series 2024年第1期40卷 313-328页

作者： jian Xun HU hua Zhong KE Chang Zheng LI Lei SONG School of Mathematics Sun Yat-sen UniversityGuangzhou 510275P.R.China

We propose a conjecture relevant to Galkin’s lower bound conjecture,and verify it for the blow-ups of a four-dimensional quadric at a point or along a projective *** also show that Conjecture O holds in these two cases.

关键词： Quantum cohomology blow-up quadric hypersurface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Atomic force microscopy-based nanoscale infrared techniques for liquid environments

引用

Science Bulletin 2024年第2期69卷 151-153页

作者： jian Li Jing Liang Mu-Hao Lan Xing-hua Xia State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Infrared(IR)light energy matches well with the vibration and rotation of chemical bonds in molecules,hence IR spectroscopy is commonly used for accurate molecular identification[1].Conventional IR analysis involves bulk samples,providing averaged information of the entire *** spatially-resolved investigation of heterogeneous sample properties is constrained by the micrometer-level spatial resolution of optical IR microscopy.

关键词： spatially hence rotation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：