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糖尿病肾病血液透析继发肺部感染患者免疫球蛋白及炎症因子和T细胞亚群水平

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中华医院感染学杂志 2024年第17期34卷 2617-2620页

作者：张俊伟窦婧韩慧仙王惠任建光张晓东太原市中心医院肾内科山西太原030009 太原市中心医院血液透析室山西太原030009 太原市中心医院实验室山西太原030009

目的分析免疫球蛋白、降钙素原(PCT)、C-反应蛋白(CRP)和T细胞亚群在糖尿病肾病血液透析继发肺部感染患者中的水平变化特点。方法选取2021年3月-2023年2月太原市中心医院收治的102例接受血液透析的糖尿病肾病患者,根据患者血液透析后是... 详细信息

目的分析免疫球蛋白、降钙素原(PCT)、C-反应蛋白(CRP)和T细胞亚群在糖尿病肾病血液透析继发肺部感染患者中的水平变化特点。方法选取2021年3月-2023年2月太原市中心医院收治的102例接受血液透析的糖尿病肾病患者,根据患者血液透析后是否发生肺部感染,分为感染组45例和未感染组57例,分析肺部感染对患者免疫球蛋白及炎症因子和T细胞亚群水平的影响。结果感染组患者外周血CD_(3)^(+)、CD_(4)^(+)表达水平(70.63±14.02)%、(38.50±9.15)%和CD_(4)^(+)/CD_(8)^(+)(1.47±0.27)水平高于未感染组(P<0.05),CD_(8)^(+)表达水平比较差异无统计学意义;感染组患者血清免疫球蛋白G(IgG)、IgA、IgM水平高于未感染组(P<0.05);感染组患者血清PCT、CRP水平高于未感染组(P<0.05)。结论糖尿病肾病血液透析继发肺部感染患者免疫功能较差、炎症反应明显。临床上可根据免疫球蛋白、PCT、CRP和T细胞亚群水平变化监测患者病情。

关键词：糖尿病肾病血液透析肺部感染免疫球蛋白降钙素原 C-反应蛋白

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Efficacy and safety of Kangxian Huanji Granule as adjunctive treatment in acute exacerbation of idiopathic pulmonary fibrosis:An exploratory randomized controlled trial

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Journal of Integrative Medicine 2023年第6期21卷 543-549页

作者： jian-sheng Li Hai-long Zhang Wen Guo Lu Wang dong Zhang Li-min Zhao Miao Zhou Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of China Henan Key Laboratory of Chinese Medicine for Respiratory DiseasesHenan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Respiratory Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000Henan ProvinceChina Department of Respiratory and Critical Care Medicine Henan Provincial People’s HospitalZhengzhou 463599Henan ProvinceChina Respiratory Department the Third Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450003Henan ProvinceChina

Background:Acute exacerbation of idiopathic pulmonary fibrosis(AE-IPF)is an important occurrence in the natural history of idiopathic pulmonary fibrosis(IPF),associated with high hospitalization rates,high mortality and poor *** present,there is no effective treatment for *** herbal medicine has some advantages in treating IPF,but its utility in AE-IPF is ***:The treatment of AE-IPF with Kangxian Huanji Granule(KXHJ),a compound Chinese herbal medicine,lacks an evidence-based *** study explores the efficacy and safety of KXHJ in patients with ***,setting,participants and interventions:Wedesigned a randomized,double-blind,placebo-controlled,exploratory clinical trial.A total of 80 participants diagnosed with AE-IPF were randomly assigned to receive KXHJ or a matching placebo;the treatment included a 10 g dose,administered twice daily for 4 weeks,in addition to conventional *** were followed up for 12 weeks after the *** outcome measures:The primary endpoints were treatment failure rate and all-cause *** endpoints included the length of hospitalization,overall survival,acute exacerbation rate,intubation rate,the modified British Medical Research Council(mMRC)score,and the St George’s Respiratory Questionnaire for IPF(SGRQ-I)***:The rate of treatment failure at 4 weeks was lower in the intervention groupcompared to the control group(risk ratio[RR]:0.22;95%confidence interval[CI]:0.051 to 0.965,P=0.023).There was no significant difference in all-causemortality at 16 weeks(RR:0.75;95%CI:0.179 to 3.138;P>0.999)or in the acute exacerbation rate during the 12-week follow-up period(RR:0.69;95%CI:0.334 to 1.434;P=0.317).The intervention group had a shorter length of hospitalization than the control group(mean difference[MD]:–3.30 days;95%CI,–6.300 to–0.300;P=0.032).Significant differences in the mean change from baseline in the mMRC(between-group difference:–0.67;

关键词： Idiopathic pulmonary fibrosis Acute exacerbation Chinese herbal medicine Integrative medicine Randomized controlled trial

Microvascular decompression for a patient with oculomotor palsy caused by posterior cerebral artery compression:A case report and literature review

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World Journal of Clinical Cases 2022年第20期10卷 7138-7146页

作者： jian Zhang Zheng-Jun Wei Hang Wang Yan-Bing Yu hong-Tao Sun Tianjin Key Laboratory of Neurotrauma Repair Institute of Traumatic Brain Injury and NeuroscienceCharacteristic Medical Center of Chinese People’s Armed Police ForceTianjin 300162China Department of Neurosurgery China-Japan Friendship HospitalBeijing 100069China

BACKGROUND Aneurysm compression,diabetes,and traumatic brain injury are well-known causative factors of oculomotor nerve palsy(ONP),while cases of ONP induced by neurovascular conflicts have rarely been reported in the medical ***,we report a typical case of ONP caused by right posterior cerebral artery(PCA)compression to increase neurosurgeons’awareness of the disease and reduce misdiagnosis and *** SUMMARY A 54-year-old man without a known medical history presented with right ONP for the past 5 *** patient presented to the hospital with right ptosis,diplopia,anisocoria(rt 5 mm,lt 2.5 mm),loss of duction in all directions,abduction,and light impaired pupillary *** resonance angiography and computed tomography venography examinations showed no phlebangioma,aneurysm,or intracranial *** conducting oral glucose tolerance and prostigmin tests,diabetes and myasthenia gravis were *** nerve magnetic resonance imaging showed that the right PCA loop was in direct contact with the cisternal segment of the right oculomotor nerve(ON).Microvascular decompression(MVD)of the culprit vessel from the ON through a right subtemporal craniotomy was carried out,and the ONP symptoms were significantly relieved after 3 *** Vascular compression of the ON is a rare pathogeny of ONP that may be refractory to drug therapy and ophthalmic strabismus *** is an effective treatment for ONP induced by neurovascular compression.

关键词： Microvascular decompression Oculomotor nerve palsy Oculomotor nerve Magnetic resonance imaging Posterior cerebral artery Neurovascular conflict Case report

Analyzing the differences of brackish-water in the Badain Lake by geophysical exploration method

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Journal of Groundwater Science and Engineering 2018年第3期6卷 187-192页

作者： SONG hong-wei MU Hai-dong XIA Fan The Institute of Hydrogeology and Environmental Geology CAGSShijiazhuang 050061China Hebei Provincial of Academy of Environmental Sciences Shijiazhuang 050031China

BadainJ aran Desert of Inner Mongolia is arid and rainless all the year around,with much more evaporation than *** the special groundwater recharge mechanism contributes to the generation of several lakes of different sizes that have never not dried up for years,among which there are many freshwater *** the research object in this paper,East Badain Lake and West Badain Lake in the southeast of the desert,which are less than 50m away from each other,show the considerable difference in *** fact,one is a freshwater lake,but the other is a brackish-water *** the underground aquifer structure of BadainJ aran Desert and the special formation structure the particularity of the stratigraphic structure around Badain Lake,the author uses AMT(audio magneto telluric)method and ultra-high density resistivity method to analyze the difference in mineralization of East Badain Lake and West Badain Lake from the perspective of geophysical prospecting methods.

关键词： AMT Badain Jaran Desert Super density electrical method Geophysics

A Meloidogyne incognita effector Minc03329 suppresses plant immunity and promotes parasitism

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Journal of Integrative Agriculture 2023年第3期22卷 799-811页

作者： ZHOU Jing-jing ZHANG Xiao-ping LIU Rui LING jian LI Yan YANG Yu-hong XIE Bing-yan ZHAO jian-long MAO Zhen-chuan State Key Laboratory of Vegetable Biobreeding Institute of Vegetables and FlowersChinese Academy of Agricultural SciencesBeijing 100081P.R.China

Meloidogyne incognita is a devastating plant-parasitic *** play important roles during the stages of nematodes infection and parasitism,but their molecular functions remain largely *** this study,we characterized a new effector,Minc03329,which contains signal peptide for secretion and a C-type lectin *** yeast signal sequence trap experiments indicated that the signal peptide of Minc03329 is *** situ hybridization showed that Minc03329 was specifically expressed in the subventral esophageal ***-time qPCR confirmed that the expression level of Minc03329 transcript was significantly increased in pre-parasitic and parasitic second-stage juveniles(pre-J2s and par-J2s).Tobacco rattle virus(TRV)-mediated gene silencing of Minc03329 in host plants largely reduced the pathogenicity of *** the contrary,ectopic expression of Minc03329 in Arabidopsis thaliana significantly increased plant susceptibility to *** expression of Minc03329 in Nicotiana benthamiana leaves suppressed the programmed cell death triggered by the pro-apoptotic protein ***,the transcriptome analysis of Minc03329-transgenic Arabidopsis and wild type revealed that many defense-related genes were significantly ***,some different expressed genes were involved in the formation of nematode feeding *** results revealed that Minc03329 is an important effector for ***,suppressing host defense response and promoting pathogenicity.

关键词： Meloidogyne incognita effector C-type lectin pathogenicity plant immunity

Autophagy Elicits Neuroprotection at the Subacute Phase of Transient Cerebral Ischaemia but Has Few Effects on Neurological Outcomes After Permanent Ischaemic Stroke in Rats

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Current Medical Science 2021年第4期41卷 803-814页

作者： Tao GUO Yi-hao DENG Ling-ling dong Lu REN hong-yun HE Department of Basic Medicine Medical SchoolKunming University of Science and TechnologyKunming 650500China

Objective Autophagy was prominently activated by cerebral *** study was to investigate the exact role of autophagy in ischaemic *** Two rat models of transient middle cerebral artery occlusion(tMCAO)and permanent MCAO(pMCAO)were *** brain tissues in the penumbra were obtained to observe the dynamic variations of autophagy activity with Beclin1 and LC3 antibodies by Western *** the characteristic time points,when autophagy activity was markedly elevated or reduced,the autophagy activation signaling was intervened with rapamycin and 3-methyladenine,***,key proteins in the autopahgic/lysosomal pathway were detected with the antibodies of LC3,p62,ubiquitin,LAMP-1 and cathepsin ***,TTC staining,neurological score and immunofluorescence were performed to evaluate brain infarct volume,neurological deficit and neuron survival,*** Both Beclin1 and LC3 expression levels were remarkably altered at 6 h,12 h,2 days and 7 days after ***,the dynamic changes of autophagy activity following pMCAO were identical to those after *** autophagy induction nor autophagy inhibition was able to ameliorate the pMCAO-induced neurological injury due to lysosomal dysfunction,as indicated by low levels of LAMP-1 and cathepsin B,accompanied with the accumulation of LC3-II,ubiquitin and insoluble ***,autophagy induction elicited overt neuroprotection at 2 and 7 days after tMCAO,and this neuroprotection might be elicited by the enhancement of autophagy *** Our study suggests that autophagy confers neuroprotection at the subacute phase of tMCAO but has few effects on neurological outcomes after pMCAO.

关键词： permanent cerebral stroke transient cerebral ischaemia autophagy induction autophagy inhibition neuroprotection

Cu和Zr元素取代对Sm_(2)Co_(7)快淬带磁性能的影响

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稀有金属与硬质合金 2024年第2期52卷 50-54页

作者：侯永杰左建华李敏敏薄宇章明董福海白锁内蒙古科技大学理学院内蒙古包头014010

采用感应熔炼和熔体快淬技术制备了Sm_(2)Co_(7-x)R_(x)(R=Cu、Zr;x=0、0.1、0.2、0.3、0.4)快淬带,研究了取代元素、取代量和快淬速度对快淬带磁性能、晶粒间相互作用和不可逆翻转场的影响规律。磁性能测试结果表明,Cu和Zr取代在快淬... 详细信息

采用感应熔炼和熔体快淬技术制备了Sm_(2)Co_(7-x)R_(x)(R=Cu、Zr;x=0、0.1、0.2、0.3、0.4)快淬带,研究了取代元素、取代量和快淬速度对快淬带磁性能、晶粒间相互作用和不可逆翻转场的影响规律。磁性能测试结果表明,Cu和Zr取代在快淬带内引起了强烈的钉扎效应,有助于提升快淬带的矫顽力,且均在x=0.3时获得最大矫顽力;Cu取代量x=0.1、0.2、0.4时快淬带的剩磁与最大磁能积随快淬速度逐渐降低,取代量x=0.3时表现为逐渐升高;Zr取代量x=0.1~0.4时快淬带的剩磁与最大磁能积均随快淬速度的增加先升高后降低。Henkel曲线测试结果表明,对于Cu元素和Zr元素取代,δM值均在x=0.3时达到最大,表明此时快淬带晶粒间的交换耦合作用最强;Sm_(2)(Co, Cu)_(7)和Sm_(2)(Co, Zr)_(7)快淬带的最大δM值分别为1.48和1.04。适量Cu、Zr元素取代可以提高Sm_(2)Co_(7)磁体在反磁化过程中的不可逆翻转场H_(n)。

关键词： Sm_(2)Co_7 快淬带 Cu和Zr取代快淬速度磁性能交换耦合不可逆翻转场

A Simple and Rapid Method for Synthesis of N,2-Diaryl Diazcnecarboxamides

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Chinese Chemical Letters 1999年第5期10卷 351-352页

作者： jian Ping LI’ hong WANG Yu Lu WANG Xiao Yang WANG Cat Lan WANG dong Lan MA(Department of Chemistry, Henan Normal University, Xinxiang 453002 Department of Chemistry, Lanzhou University, Lanzhou 730000) Department of Chemistry Henan Normal University Xinxiang 453002 China Department of Chemistry Lanzhou University Lanzhou 730000 China

Using Fe2(SO4)3/H2SO4 as oxidant, nine N,2-diaryl diazcnecarboxamides weresynthesized from diaryl substituted semicarbazides in excellent yield under mild conditions for thefirst time. This method is simple, convenien... 详细信息

关键词： Oxidant synthesis semicarbazides, N,2-diaryl diazenecarboxamides

Inhibitory effects of dobutamine on human gastric adenocarcinoma

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World Journal of Gastroenterology 2014年第45期20卷 17092-17099页

作者： Hui-Xia Zheng Li-Na Wu hong Xiao Qian Du jian-Fang Liang Department of Pathology The First Hospital Shanxi Medical University

AIM: To explore the inhibitory effects of dobutamine on gastric adenocarcinoma cells.

关键词： Dobutamine Gastric adenocarcinoma cells Yes-associated protein Hippo pathway Human gastric adenocarcinoma cell line SGC-7901 Therapy