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Cauda equina syndrome： a review of clinical progress

Chinese Medical Journal 2009年第10期122卷 1214-1222页

作者： MA Bin WU hong JIA Lian-shun YUAN Wen SHI Guo-dong SHI jian-gang Division of Orthopedics Orthopedics Institute of PLA Changzheng Hospital Second Military Medical University Shanghai 200003 China Division of Endocrinology Changhai Hospital Second Military Medical University Shanghai 200433 China

Objective To review the literature on the clinical progress in cauda equina syndrome （CES）, including the epidemic history, pathogenesis, diagnosis, treatment policy and prognosis. Data sources All reports on CES in the literature were searched in PubMed, Ovid, Springer, Elsevier, and the Chinese Biomedical Literature Disk using the key terms ＂cauda equina syndrome＂, ＂diagnosis＂, ＂treatment＂, ＂prognosis＂ and ＂evidence-based medicine＂. Study selection Original milestone articles and critical reviews written by major pioneer investigators about the cauda equina syndrome were selected. Results CES is rare, both atraumatically and traumatically. CES is variable, depending on the etiology of the syndrome. Males and females are equally affected. The incidence of The most common cause of CES is herniation of a lumbar intervertebral disc. CES symptoms may have sudden onset and evolve rapidly or sometimes chronic ally. Each type of CES has different typical signs and symptoms. Low back pain may be the most significant symptoms, accompanied by sciatica, lower extremities weakness, saddle or perianal hypoesthesia, sexual impotence, and sphincter dysfunction. MRI is usually the preferred investigation approach. Patients who have had CES are difficult to return to a normal status. Conclusions The diagnosis of CES is primarily based on a careful history inquiry and clinical examination, assisted by elective radiologic investigations. Early diagnosis and early surgical decompression are crucial for a favorable outcome in most CES cases.

关键词： cauda equina syndrome diagnosis treatment prognosis evidence-based medicine

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Prediction of mechanical properties of Al alloys with change of cooling rate

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China Foundry 2012年第4期9卷 381-386页

作者： Quan-Zhi dong Young-Sire Choi Jun-Ho hong Ho-Young Hwang Dept.of Virtual Engineering University of Science and TechnologyIncheon 406-840Korea e-Design Center Korea Institute of Industrial TechnologyIncheon 406-840Korea

The solidification process significantly affects the mechanical properties and there are lots of factors that affect the solidification *** progress has been made in the research on the effect of solidification on mechanical *** them,the PF(Phase Field) model and CA(Cellular Automata) model are widely used as simulation methods which can predict nucleation and its growth,and the size and morphology of the grains during *** they can give accurate calculation results,it needs too much computational memory and calculation *** it is difficult to apply the simulation to the real production *** this study,a more practical simulation approach which can predict the mechanical properties of real aluminum alloys is proposed,by identifying through experiment the relationship between cooling rate and SDAS(Secondary Dendrite Arm Spacing) and mechanical *** experimentally measured values and the values predicted by simulation have relatively small differences and the mechanical properties of a variety of Al alloys are expected to be predicted before casting through use of the simulation.

关键词： mechanical properties dendrite structure aluminum alloy cooling rate solidification castingsimulation

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Oxidative stress affects retinal pigment epithelial cell survival through epidermal growth factor receptor/AKT signaling pathway

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 507-514页

作者： Xiao-dong Chen Ming-Yang Su Tao-Tao Chen Hai-Yan hong Ai-dong Han Wen-Sheng Li Xiamen Eye Center of Xiamen University Xiamen University Department of Ophthalmology Xi’an No.1 HospitalShaanxi Institute of OphthalmologyShaanxi Provincial Key Laboratory of Ophthalmology State Key Laboratory for Cellular Stress Biology School of Life SciencesXiang’an CampusXiamen UniversityXiang’an District

AIM：To investigate the cross-talk between oxidative stress and the epidermal growth factor receptor（EGFR）/AKT signaling pathway in retinal pigment epithelial（ RPE） ***：Human RPE cell lines（ARPE-19 cell） were treated with different doses of epidermal growth factor（EGF） and hydrogen peroxide（H2O2）.Cell viability was determined by a methyl thiazolyl tetrazolium *** proliferation was examined by a bromodeoxyuridine（Brd U） incorporation ***/AKT signaling was detected by Western *** localization was also detected by *** addition,EGFR/AKT signaling was intervened upon by EGFR inhibitor（erlotinib）,PI3 K inhibitor（A66） and AKT inhibitor（MK-2206）,respectively.H2O2-induced oxidative stress was blocked by antioxidant N-acetylcysteine（NAC）.RESULTS：EGF treatment increased ARPE-19 cell viabili ty and proliferation through inducing phosphorylation of EGFR and AKT.H2O2 inhibited ARPE-19 cell viability and proliferation and also suppressed EGF-stimulated increase of RPE cell viability and proliferation by affecting the EGFR/AKT signaling *** inhibitor erlotinib blocked EGF-induced phosphorylation of EGFR and AKT,while A66 and MK-2206 only blocked EGF-induced phosphorylation of ***-induced phosphorylation andendocytosis of EGFR were also affected by H2O2 *** addition,antioxidant NAC attenuated H2O2-induced inhibition of ARPE-19 cell viability through all eviating reduction of EGFR,and phosphorylated and total AKT ***：Oxidative stress affects RPE cell viability and proliferation through interfering with the EGFR/AKT signaling *** EGFR/AKT signaling pathway may be an important target in oxidative stress-induced RPE cell dysfunction.

关键词： oxidative stress epidermal growth factor receptor AKT retinal pigment epithelial cell

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A New Approach for Refining Carbide Dimensions in M42 Super Hard High-speed Steel

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Journal of Iron and Steel Research International 2016年第8期23卷 800-807页

作者： Xue-feng ZHOU Wang-long ZHU hong-bing jianG Feng FANG Yi-you TU jian-qing jianG jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast University Nanjing 211189 Jiangsu China jiangsu Engineering Research Center of Tool and Die Steel Danyang 212312 Jiangsu China Nanjing University of Information Science and Technology Nanjing 210044 Jiangsu China

Obtaining small carbides is crucial but difficult for high-speed steels.A new approach for refining carbide dimensions in M42 super hard high-speed steel by increasing cooling rate and spheroidizing treatment was *** morphologies and properties of eutectic carbides formed at different cooling rates were investigated by means of scanning electron microscopy（SEM）,energy dispersive spectroscopy（EDS）,X-ray diffraction（XRD）,transmission electron microscopy（TEM）,electron back-scattered diffraction（EBSD）and differential scanning calorimeter（DSC）.The results show that eutectic carbides change from a lamellar shape into a curved-rod shape as cooling rate *** different morphologies,the two carbides are both of M2C type with a hexagonal close-packed structure and display a single crystal orientation in one eutectic *** morphology of M2C mainly depends on the growing process of eutectic carbides,which is strongly influenced by cooling *** with lamellar carbides,M2C carbides with curved-rod shapes are less stable,and decompose into M6 C and MC at lower *** are more inclined to spheroidize during heating,which ultimately and distinguishably refines the carbide *** small carbides are much easier to dissolve into matrices during austenization,the process described herein improves the supersaturation of alloying elements in martensite,which leads to an increment of hardness in M42 steel.

关键词： eutectic lamellar hexagonal carbide heating calorimeter curved dispersive dimensions decompose

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含Ho镁合金的研究现状

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稀土 2024年第1期45卷 47-62页

作者：冷航李全安陈晓亚朱宏喜鲍键李向宇陈培军河南科技大学材料科学与工程学院河南洛阳471023 有色金属新材料与先进加工技术省部共建协同创新中心河南洛阳471023 洛阳铜加工集团有限责任公司河南洛阳471003 洛阳晟雅镁合金科技有限公司河南洛阳471921

镁合金作为轻质金属结构材料目前已获得广泛的研究应用,新型稀土镁合金的开发是进一步提高镁合金应用价值的重要体现。Ho在Mg中具有较高的固溶度,能显著细化晶粒,提高合金的室温和高温力学性能,增强合金的耐腐蚀性。本文主要从Mg-Ho二... 详细信息

镁合金作为轻质金属结构材料目前已获得广泛的研究应用,新型稀土镁合金的开发是进一步提高镁合金应用价值的重要体现。Ho在Mg中具有较高的固溶度,能显著细化晶粒,提高合金的室温和高温力学性能,增强合金的耐腐蚀性。本文主要从Mg-Ho二元合金、Mg-Ho-X(RE,Zn)、Mg-X-Ho(X=Al,Zn,RE)系合金进行了综述。对目前含Ho镁合金的研究现状进行了归纳总结,指出了目前含Ho镁合金的优势及不足之处,希望能对含Ho镁合金的研究提供新的思路。

关键词： Mg-Ho系合金微观组织力学性能强化机制

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三段接力针刺法联合作业训练治疗卒中后单侧忽略的临床观察

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广州中医药大学学报 2024年第2期41卷 366-372页

作者：吕彩虹吴李秀吴淑俭俞坤强丽水市第二人民医院康复医学科浙江丽水323000

【目的】观察三段接力针刺法联合作业训练治疗卒中后单侧忽略的临床疗效。【方法】将104例卒中后单侧忽略患者随机分为观察组和对照组,每组各52例,对照组给予常规作业训练,观察组在对照组治疗的基础上,给予头皮针三段接力针刺法治疗。... 详细信息

【目的】观察三段接力针刺法联合作业训练治疗卒中后单侧忽略的临床疗效。【方法】将104例卒中后单侧忽略患者随机分为观察组和对照组,每组各52例,对照组给予常规作业训练,观察组在对照组治疗的基础上,给予头皮针三段接力针刺法治疗。连续治疗8周。治疗8周后,评价2组临床疗效,观察2组患者治疗前后凯瑟琳-波哥量表评分、数字删除试验评分、画钟实验评分的变化情况,以及简化Fugl-Meyer运动功能评分、功能独立性评定量表评分的情况。比较2组患者治疗前后血清S100β蛋白、谷氨酸、胶质纤维酸性蛋白因子,以及全血低切黏度、全血高切黏度、血浆黏度的变化情况。并评价2组的安全性及不良反应的发生情况。【结果】(1)研究过程中,观察组失访1例,对照组失访1例。最终观察组51例、对照组51例纳入疗效统计。(2)观察组总有效率为94.12%(48/51),对照组为80.39%(41/51)。观察组疗效优于对照组,差异有统计学意义(P0.05)。【结论】三段接力针刺法联合作业训练治疗卒中后单侧忽略可有效降低单侧空间忽略严重程度,提高肢体运动功能,降低血液黏度,降低血清脑损伤因子,临床疗效显著。

关键词：三段接力针刺法作业训练脑卒中单侧忽略肢体运动功能临床观察

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三重目标约束下的进口药品费用:药价改革中的结构调整与改进优化

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管理世界 2024年第2期40卷 149-171页

作者：袁雪丹毛振华王健武汉大学董辅礽经济社会发展研究院上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所) 中国人民大学经济学院

药品进口贸易的增长满足了我国药品市场对高价值药品的需求,但是进口药品的价格和费用长期居高不下,给医保基金和人民群众带来了沉重的经济负担。为了在药品费用可控的范围内,促进高质量药品进口,保障药品供应和公平可及,本文提出了我... 详细信息

药品进口贸易的增长满足了我国药品市场对高价值药品的需求,但是进口药品的价格和费用长期居高不下,给医保基金和人民群众带来了沉重的经济负担。为了在药品费用可控的范围内,促进高质量药品进口,保障药品供应和公平可及,本文提出了我国药品进口的科技性、公共性和资本性目标,并根据三重目标的理论内涵对其进行测度,构建了嵌入三重目标的药品进口贸易引力模型和优化的特征价格模型,实证分析了与三重目标相关的主要因素对进口药品费用和价格的影响。研究发现:我国进口药品费用的增长方向和资本性目标的发展方向基本一致,公共性目标的发展方向不利于药品进口贸易增长,而科技性目标基本不起作用。三重目标之间的耦合协调度在2017年以后随着公共性目标的改变而快速下降,从2016年的0.9074下降至2018年的0.2995。公共性目标导向政策降低进口药品价格的效果受到市场竞争程度影响。本研究成果为完善药品进口政策,减轻人民群众用药负担提供了参考和借鉴。

关键词：进口药品三重目标药品费用

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The circular RNA circCPE regulates myoblast development by sponging miR-138

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Journal of Animal Science and Biotechnology 2022年第1期13卷 66-81页

作者： Wenxiu Ru Ao Qi Xuemei Shen Binglin Yue Xiaoyan Zhang jian Wang Hui Cao hong Chen Key laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100ShaanxiChina Shaanxi Kingbull Livestock co. LTDYangling 712100ShaanxiChina

Background:Skeletal muscle development,a long-term and complex process,is controlled by a set of the myogenic *** RNAs(circRNAs),a class of noncoding RNA,have been shown to regulate various biological *** studies indicate circRNAs may be involved in myogenesis,but the role and regulatory mechanism of circRNAs in myogenesis is largely *** the present study,circCPE was firstly found to promote the bovine myoblast proliferation and inhibit cell apoptosis and differentiation by influencing the expression of FOXC1 in a miR138-mediated *** in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle ***:We identified a novel circular RNA circCPE by analyzing circRNAs sequencing data of bovine muscle *** verification,RNase R treatment and Actinomycin D treatment confirmed the circular nature of circCPE in bovine *** assays showed that overexpression of circCPE could inhibit bovine myoblast apoptosis and differentiation,as well as facilitate cell ***,in vivo experiments revealed that overexpression of circCPE attenuates skeletal muscle *** consideration of circRNA action as miRNAs sponge,we found that circCPE harbors miR-138 binding sites and absorbed ***,the rescue experiments showed that the overexpression of circCPE can counteract the inhibitory effect of miR-138 on the cell proliferation and the accelerated effects on the differentiation and ***,we found that circCPE sequester the inhibitory effect of miR-138 on FOXC1 so as to involve in ***:Collectively,we constructed a novel circCPE/miR-138/FOXC1 regulatory network in bovine myogenesis,which further provide stronger evidence that circRNA involved in muscle development acting as miRNA sponge.

关键词： Apoptosis Bovine CircRNA Differentiation MiR-138 Proliferation

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Novel and Self-Consistency Analysis of the QCD Running Coupling α_(s)(Q) in Both the Perturbative and Nonperturbative Domains

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Chinese Physics Letters 2022年第7期39卷 30-35页

作者： Qing Yu Hua Zhou Xu-dong Huang jian-Ming Shen Xing-Gang Wu Department of Physics Chongqing Key Laboratory for Strongly Coupled PhysicsChongqing UniversityChongqing 401331China Department of Physics Norwegian University of Science and TechnologyHøgskoleringen 5N-7491 TrondheimNorway School of Physics and Electronics Hunan UniversityChangsha 410082China

The quantum chromodynamics(QCD) coupling αs is the most important parameter for achieving precise QCD predictions. By using the well measured effective coupling α_(s)^(g)1)(Q) defined from the Bjorken sum rules as a basis, we suggest a novel self-consistency way to fix the αs at all scales: The QCD light-front holographic model is adopted for its infrared behavior, and the fixed-order p QCD prediction under the principle of maximum conformality(PMC) is used for its high-energy behavior. Using the PMC scheme-and-scale independent perturbative series,and by transforming it into the one under the physical V scheme, we observe that a precise αs running behavior in both the perturbative and nonperturbative domains with a smooth transition from small to large scales can be achieved.

关键词： PAA PMC Novel and Self-Consistency Analysis of the QCD Running Coupling in Both the Perturbative and Nonperturbative Domains QCD

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Effects of returns on composition,microstructure and mechanical properties of GH4169 superalloy

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China Foundry 2017年第4期14卷 244-250页

作者： Yong-liang Pu Sheng-zhong Kou Zhi-dong Zhang Tian-wen dong Xiao-fan Guo hong-xia Qu State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou Universityof TechnologLanzhou 730050China Key Laboratory of Non-ferrous Metal Alloys and Processing of the Ministry of Education Lanzhou University of TechnologyLanzhou 730050China

To recycle the returned alloy effectively, effects of returns proportion on alloy composition, microstructure and compression properties of superalloy GH4169 were studied by means of scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and thermal-mechanical simulator. The results show that returns addition has no significant effect on the main alloy elements content and the principle precipitates, but increases the volume fraction of Al_2O_3 inclusions, resulting in the increase of oxygen level of GH4169 alloy. Returns addition does not change the elastic and plastic deformation process at room temperature or at 1,150 °C, but high returns proportion GH4169 alloy shows improved compression strength and yield strength. The alloy with 100% returns shows a maximum compression strength 1,153.45 MPa at room temperature, while the alloy with 80% returns has a maximum value 69.3 MPa at 1,150 °C. Returns addition increases fluctuation range and reduces the stability of yield strength and compression strength of GH4169 alloy at room temperature. It is noted that the volume fraction and the size of Al_2O_3, and the fraction of Laves phase reach their maximum values in the GH4169 alloy with 60% returns, which exhibits maximum yield strength of 516.65 MPa at room temperature and 62.17 MPa at 1,150 °C.

关键词： superalloy returns proportion composition microstructure mechanical properties

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