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Fluorite REE characteristics of the Diyanqinamu Mo deposit,Inner Mongolia, China

Chinese Journal Of Geochemistry 2015年第4期34卷 610-619页

作者： Long jian Hairui Sun jian'guo gao Faculty of Land Resource Engineering Kunming University of Science and Technology Development and Research Center of China Geological Survey National Exploration and Development Planning Technical Guidance Center in Ministry of Land and Resorces China University of Geosciences State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences

The Diyanqinamu Mo deposit, a newly discovered porphyry deposit in the northern-central part of the Great Xing'an Range, Inner Mongolia, China, is characterized by widely distributed fluorite. It is important to note that almost all the fluorite that is paragenetic with molybdenite is purple. The Tb/Ca–Tb/La ratios of these purple fluorite samples show that they have a hydrothermal *** unidirectional solidification texture at the apex of the aplitic granite and the low F contents in the andesite suggest that most of F in fluorite was derived from granitic melts. These observations suggest that the fluorite was related to the magmatic-hydrothermal fluids. All the fluorite separates have consistent total REE contents with LREE-depleted, HREE-enriched, negative Eu anomaly,unapparent Ce anomaly and positive Y anomaly. These characteristics are significantly different than those of country granite, andesite and tuff whole-rock. The positive Y anomaly of the fluorite separates implies that the hydrothermal fluids migrated a long distance, as suggested by the fact that the fluorite-molybdenite veins were mostly hosted in andesite and tuff, far from the Mo ore-forming granites. The features of LREE-depleted and HREE-enriched fluorite are due to the REE-complex in the F-enriched fluids during migration. The stronger negative Eu anomaly of fluorite than those of country rocks suggests that the Eu anomaly of the original hydrothermal fluid was enhanced by the high temperature(generally above 200 or250 °C). The widespread magnetite in the studied deposit indicates that the magmatic-hydrothermal fluid was oxidized at early stage. On the other hand, the pyrite was also paragenetic, with the molybdenite and unapparent Ce anomaly implying that the hydrothermal fluid probably experienced oxygen fugacity decreasing during migration,which is important for Mo mineralization.

关键词：钼矿床稀土元素特征内蒙古萤石中国热液成因岩浆热液迁移过程

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Applying Humboldt’s holistic perspective in China’s sustainability

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Geography and Sustainability 2021年第2期2卷 123-126页

作者： jian-guo gao Department of Ecology Peking UniversityBeijingChina

Alexander von Humboldt,was a great German geobotanist,educator and naturalist who greatly influenced sci-ence and humanities for more than two hundred *** addition to scientific contributions(such as the un-derstanding of vegetation distribution,the concepts of isotherm and pressure contours,and the initial concept of continental drift theory),he firmly believed in the concept of the interconnection of everything and the method-ological approach of a holistic perspective to development,which has significance in achieving the UN Sustainable Development Goals,because they include both synergy and trade-offs among these *** has undergone tremendous changes since its reform and opening up in 1978 and now faces severe challenges in sustainable *** scientific methods applied by Chinese scientists in sustainability fulfil the Humboldtian holistic perspective of *** I provide four successful cases and their significant implications for addressing the increasingly severe water shortage,biological conservation,and conflicts between human well-being and *** four examples discussed in this article are enlightened to establish a strong,just,and influential government and require empirical research to implement sustainable development plans.I believe that it’s vital to encourage and supervise public participation for a successful program;for example,the participants should not be restricted to project executors,i.e.,farmers or workers,but also students and *** poverty must be priori-tized,and well-being is the ultimate goal for sustainable *** review article provides an extremely valuable reference for other developing or even developed countries to address sustainability challenges.

关键词： Biological conservation Climate change Energy Food security Holistic perspective Water resource Sustainable development goals

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Investigation on the flow control of micro-vanes on a supersonic spinning projectile

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Defence Technology（防务技术） 2016年第3期12卷 227-233页

作者： Jie MA Zhi-hua CHEN Zhen-gui HUANG jian-guo gao Qiang ZHAO Key Laboratory of Transient Physics Nanjing University of Science and Technology

Studies have shown that micro-wedge vortex generators(MVG)can effectively control the flow separation of supersonic boundary *** order to improve the flight stability of spinning projectile,the original standard 155 mm projectile was taken as an example,and the micro-vanes were mounted at the projectile shoulder to investigate the separation control on the aerodynamic characteristics of *** simulations were performed with the use of DES method for the flow fields of projectiles with and without micro-vanes,and the characteristics of the boundary layer structures and aerodynamic data were compared and *** results show that the micro-vanes can be used to inhibit separation of fluid on projectile surface,and improve the flight stability and firing dispersion of projectile.

关键词： Spinning projectile Micro-vane Stability Aerodynamic characteristics Fluid control

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ABSORPTION SPECTRA OF 4f ELECTRON TRANSITIONS OF NEODYMIUM COMPLEX WITH 8-HYDROXYQUINOLINE AND OCTYLPHENOL POLY(ETHYLENEGLYCOL)ETHER

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Chinese Chemical Letters 1992年第10期3卷 855-856页

作者： Nai Xing WANG jian guo gao Department of Chemistry Shandong UniversityJinan250100 Research Institute of Qilupetro-Chemical Co Zibo255434

In this paper the absorption spectra of 4f electron transitions of the neodymlum complex with 8-hydroxyquinoline and octylphenol poly(ethyleneglycol)ether have been studied. The marked intensification of the band at low octylphenol poly(ethyleneglycol)ether concentration is found normally at 575 nm, and its resolution into three sharp bands centering at 572, 580 and 584 nm. The absorbances of the absorption maxima are 3.5 (at 572 nm), 7.2 (at 580 nm) and 10.2 (at 584 nm) times greater than that of the chloride.

关键词： ABSORPTION SPECTRA OF 4f ELECTRON TRANSITIONS OF NEODYMIUM COMPLEX WITH 8-HYDROXYQUINOLINE AND OCTYLPHENOL POLY ETHYLENEGLYCOL)ETHER

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Current status of Helicobacter pylori eradication and risk factors for eradication failure

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World Journal of Gastroenterology 2020年第32期26卷 4846-4856页

作者： Tian-Lian Yan jian-guo gao Jing-Hua Wang Dan Chen Chao Lu Cheng-Fu Xu Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The Helicobacter pylori(***)eradication rate is decreasing in the general population of *** To evaluate the *** eradication status in real-world clinical practice and to explore factors related to eradication *** Patients with *** infection who were treated with standard 14-d quadruple therapy and received a test of cure at a provincial medical institution between June 2018 and May 2019 were *** and clinical data were *** rates were calculated and compared between regimens and *** analysis was performed to identify predictors of eradication *** Of 2610 patients enrolled,eradication was successful in 1999(76.6%)***-containing quadruple regimens showed a higher eradication rate than other quadruple therapy regimens(83.0%vs 69.0%,P<0.001).The quadruple therapy containing amoxicillin plus clarithromycin achieved the highest eradication rate(83.5%).Primary therapy had a higher eradication rate than rescue therapy(78.3%vs 66.5%,P<0.001).In rescue therapy,the amoxicillinand furazolidone-containing regimens achieved the highest eradication rate(80.8%).Esomeprazole-containing regimens showed a higher eradication rate than those containing other proton pump inhibitors(81.8%vs 74.9%,P=0.001).Multivariate regression analysis found that older age,prior therapy,and use of omeprazole or pantoprazole were associated with an increased risk of eradication CONCLUSION The total eradication rate is 76.6%.Amoxicillin-containing regimens are superior to other ***,prior therapy,and use of omeprazole or pantoprazole are independent risk factors for eradication failure.

关键词： Helicobacter pylori Eradication Quadruple therapy Proton pump inhibitor Retrospective study

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Transurethral seminal vesiculoscopy in the diagnosis and treatment of persistent or recurrent hemospermia： a single- institution experience

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Asian Journal of Andrology 2009年第5期11卷 566-570,I0002页

作者： Zhi-Yong Liu Ying-Hao Sun Chuan-Liang Xu jian-guo Hou Xu gao Xin Lu Hua-Mao Ye Lin-Hui Wang Xiao-Feng gao Shanghai Changhai Hospital the Second Military Medical University Shanghai 200433 China

The diagnosis and treatment of hemospermia presents significant difficulty, especially if it persists or recurs. In this retrospective study, we assessed whether transurethral seminal vesiculoscopy is feasible and effective in the diagnosis and treatment of hemospermia. To address this complex condition, we report our experience in a population of patients treated with transurethral seminal vesiculoscopy. From February 2006 to July 2008, 72 hemospermic patients underwent transurethral seminal vesiculoscopy examination and treatment at our urology center. Transurethral seminal vesiculoscopy was performed by a 7-F or 8-F rigid ureteroscope. The endoscopic procedure was conducted through the normal anatomic route of the seminal tracts. In this series, the mean follow-up period was 21.7 months. Definite diagnosis was made for 93.1% patients, and 94.4% patients were cured or showed a decrease in their symptoms. Postoperative complications were not observed in the study. Our study proves that transurethral seminal vesiculoscopy is effective in the diagnosis and treatment of hemospermia with minimal complication.

关键词： diagnosis hemospermia transurethral seminal vesiculoscopy treatment

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Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity

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World Journal of Gastroenterology 2020年第26期26卷 3750-3766页

作者： jian-guo gao Mo-Sang Yu Meng-Meng Zhang Xue-Wei Gu Yue Ren Xin-Xin Zhou Dong Chen Tian-Lian Yan You-Ming Li Xi Jin Department of Gastroenterology The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Conventional Crohn’s disease(CD)treatments are supportive rather than curative and have serious side ***-derived mesenchymal stem cells(ADSCs)have been gradually applied to treat various *** therapeutic effect and underlying mechanism of ADSCs on CD are still not *** To investigate the effect of ADSC administration on CD and explore the potential *** Wistar rats were administered with 2,4,6-trinitrobenzene sulfonic acid(TNBS)to establish a rat model of CD,followed by tail injections of green fluorescent protein(GFP)-modified *** cytometry,qRT-PCR,and Western blot were used to detect changes in the Wnt signaling pathway,T cell subtypes,and their related *** The isolated cells showed the characteristics of ADSCs,including spindle-shaped morphology,high expression of CD29,CD44,and CD90,low expression of CD34 and CD45,and osteogenic/adipogenic *** therapy markedly reduced disease activity index and ameliorated colitis severity in the TNBS-induced rat model of ***,serum anti-sacchromyces cerevisiae antibody and panti-neutrophil cytoplasmic antibody levels were significantly reduced in ADSCtreated ***,the GFP-ADSCs were colocalized with intestinal epithelial cells(IECs)in the CD rat ***-ADSC delivery significantly antagonized TNBS-induced increased canonical Wnt pathway expression,decreased noncanonical Wnt signaling pathway expression,and increased apoptosis rates and protein level of cleaved caspase-3 in *** addition,ADSCs attenuated TNBS-induced abnormal inflammatory cytokine production,disturbed T cell subtypes,and their related markers in *** Successfully isolated ADSCs show therapeutic effects in CD by regulating IEC proliferation,the Wnt signaling pathway,and T cell immunity.

关键词： Crohn’s disease Adipose-derived mesenchymal stem cell Intestinal epithelial cell Wnt pathway T cell Inflammation

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Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways

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World Journal of Gastroenterology 2019年第34期25卷 5120-5133页

作者： Chun-Xiao Li jian-guo gao Xing-Yong Wan Yi Chen Cheng-Fu Xu Ze-Min Feng Hang Zeng Yi-Ming Lin Han Ma Ping Xu Chao-Hui Yu You-Ming Li Department of Gastroenterology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Clinical Research Center for Hepatobiliary and Pancreatic Diseases of Zhejiang Province Hangzhou 310003Zhejiang ProvinceChina

BACKGROUND Allyl isothiocyanate(AITC),a classic anti-inflammatory and antitumorigenic agent,was recently identified as a potential treatment for obesity and insulin ***,little is known about its direct impact on the *** To investigate the effect and underlying mechanism of AITC in nonalcoholic fatty liver disease(commonly referred to as NAFLD).METHODS To establish a mouse and cellular model of NAFLD,C57BL/6 mice were fed a high fat diet(HFD)for 8 wk,and AML-12 cells were treated with 200μM palmitate acid for 24 *** AITC treatment,mice were administered AITC(100 mg/kg/d)orally and AML-12 cells were treated with AITC(20μmol/L).RESULTS AITC significantly ameliorated HFD-induced weight gain,hepatic lipid accumulation and inflammation in ***,serum alanine aminotransferase and aspartate aminotransferase levels were markedly reduced in AITC-treated ***,AITC significantly downregulated the protein levels of sterol regulatory elementbinding protein 1(SREBP1)and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acidβ-oxidation,as well as the upstream mediators Sirtuin 1(Sirt1)and AMPactivated protein kinaseα(AMPKα),in the livers of HFD-fed *** also attenuated the nuclear factor kappa B(NF-κB)signaling ***,AITC relieved palmitate acid-induced lipid accumulation and inflammation in AML-12 cells in vitro through the Sirt1/AMPK and NF-κB signaling ***,further studies showed that the curative effect of AITC on lipid accumulation was abolished by siRNA-mediated knockdown of either Sirt1 or AMPKαin AML-12 *** AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-κB ***,AITC is a potential therapeutic agent for NAFLD.

关键词： Allyl isothiocyanate Nonalcoholic fatty liver disease Hepatic steatosis Liver inflammation

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High-fat diet aggravates colitis via mesenteric adipose tissue derived exosome metastasis-associated lung adenocarcinoma transcript 1

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World Journal of Gastroenterology 2022年第29期28卷 3838-3853页

作者： Dong Chen Miao-Miao Lu Jin-Hai Wang Yue Ren Ling-Ling Xu Wei-Xin Cheng Sai-Sai Wang Xiao-Lin Li Xiao-Fei Cheng jian-guo gao Farhin Shaheed Kalyani Xi Jin Department of Colorectal Surgery The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Medicine Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Emergency The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Obesity is associated with an increased risk of developing Crohn’s disease(CD),higher disease activity,and comparatively worse clinical *** To investigate the role of mesenteric adipose tissue-derived exosomes in the pathogenesis of CD aggravation in obese *** First,we induced colitis in mice initiated on high-fat and normal diets and compared the severity of *** then extracted and identified exosomes from mesenteric adipose tissue and determined the levels of metastasis-associated lung adenocarcinoma transcript 1(MALAT1)in mesenteric adipose tissue-derived exosomes and the ***,we demonstrated an interaction between MALAT1 and the miR-15a-5p/activating transcription factor 6(ATF6)***,we explored the effects of mesenteric adipose tissue-derived exosomes extracted from mice fed a high-fat or normal diet on the severity of 2,4,6-trinitrobe-nzenesulfonic acid(TNBS)-induced colitis and ATF6-related endoplasmic reticulum stress *** High-fat diet was found to aggravate TNBS-induced colitis in *** expression of MALAT1 in mesenteric adipose tissue-derived exosomes of high-fat diet-fed mice *** increased expression of MALAT1 in colon tissue exacerbated TNBS-induced colitis and activated the ATF6 endoplasmic reticulum stress *** effect was partially reversed by the reduced expression of MALAT1 and overexpression of *** Mesenteric adipose tissue-derived exosome-encapsulated long noncoding RNAs MALAT1 targets the colon and aggravates TNBS-induced colitis in obese mice,which may potentially act on the miR-15a-5p/ATF6 axis and activate endoplasmic reticulum stress.

关键词： Metastasis-associated lung adenocarcinoma transcript Crohn’s disease miR-15a-5p Mesenteric adipose tissue Obesity Colitis Inflammatory bowel disease

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Palmitoylation in Crohn’s disease:Current status and future directions

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World Journal of Gastroenterology 2021年第48期27卷 8201-8215页

作者： Wei-Xin Cheng Yue Ren Miao-Miao Lu Ling-Ling Xu jian-guo gao Dong Chen Farhin Shaheed Kalyani Zi-Yan Lv Chun-Xiao Chen Feng Ji He-Ning Lin Xi Jin Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Wenzhou Medical University Renji College Wenzhou 325035Zhejiang ProvinceChina Department of Chemistry and Chemical Biology Howard Hughes Medical InstituteCornell UniversityIthacaNY 14853United States

S-palmitoylation is one of the most common post-translational modifications in nature;however,its importance has been overlooked for ***’s disease(CD),a subtype of inflammatory bowel disease(IBD),is an autoimmune disease characterized by chronic inflammation involving the entire gastrointestinal *** damage and subsequent disabilities caused by CD are a growing global health ***-acknowledged risk factors for CD include genetic susceptibility,environmental factors,such as a westernized lifestyle,and altered gut ***,the pathophysiological mechanisms of this disorder are not yet comprehensively *** the rapidly increasing global prevalence of CD and the evident role of S-palmitoylation in CD,as recently reported,there is a need to investigate the relationship between CD and *** this review,we summarize the concept,detection,and function of S-palmitoylation as well as its potential effects on CD,and provide novel insights into the pathogenesis and treatment of CD.

关键词： S-palmitoylation Crohn’s disease STING Pathogenesis Signaling pathway Drug therapy

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