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Epidemiology,clinical and laboratory characteristics of currently alive HIV-1 infected former blood donors naive to antiretroviral therapy in Anhui Province,China

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Chinese Medical Journal 2006年第23期119卷 1941-1948页

作者： XU jian-qing wang jian-jun HAN Li-feng XU Chen RUAN Yu-hua XU Zhen-hou CHEN xi LIU Zhen-dong wang Jun SU Bing DING xin-ping GAO Bing GU Yong-bin cao xiao-yun xiNG Hui HONG Kun-xue PENG Hong ZHAO quan-bi YUAN Lin FENG Yi ZHANG Gui-yun MA Li-ying WU Lan SHAO Yi-ming State Key Laboratory for Infectious Disease Prevention and Control National Center for MDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Reference Laboratory National Center for MDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Anhui Provincial Center for Disease Control and Prevention Hefei230000 China Fuyang Center for Disease Control and Prevention Fuyang 236000 China yingzhou Center for Disease Control and Prevention Fuyang 236000 China Funan Center for Disease Control and Prevention Fuyang 236000 China

Background Unregulated commercial blood/plasma collection among farmers occurred between 1992 and 1995 in central China and caused the second major epidemic of human immunodeficiency virus type 1 （HIV-1） infection in China. It is important to characterize HIV-l-infected former blood donors and to study characteristics associated with disease progression for future clinical intervention and vaccine development. Methods A cross-sectional study was performed on HIV-l-infected former blood donors （FBDs） and age-matched HIV-seronegative local residents. Demographic, epidemiologic, clinical and key laboratory data were collected from all study participants. Both unadjusted and adjusted multivariate linear regressions were employed to analyze the association of the decrease of CD4^＋ T-cell counts with other characteristics. Results Two hundred and ninety-four HIV-l-infected FBDs and 59 age-matched HIV-seronegative local residents were enrolled in this study. The unregulated blood/plasma collection occurred more than a decade （10.8 --12.8 years） ago, which caused the rapid spread of HIV-1 infection and the high prevalence of co-infection with hepatitis C virus （HCV, 89.5%）, hepatitis B virus （HBV） co-infection was observed in only 11 HIV＋participants （3.7%）. Deterioration in both clinical manifestation and laboratory parameters and increase of viral loads were observed in parallel with the decrease of CD4^＋ T-cell counts. The decrease of total lymphocyte counts （P〈0.001） and hemoglobin levels （P〈0.001） and the appearance of dermatosis （P=0.03） were observed in parallel with the decrease of CD4^＋ T-cell counts whereas viral loads （P〈0.001） and CD8^＋ T-cell counts （P=0.01） were inversely associated with CD4^＋ T-cell counts.Conclusions Co-infection with HCV but not HBV is highly prevalent among HIV-l-infected FBDs. CD4^＋ T-cell counts is a reliable indicator for disease progression among FBDs. Total lymphocyte counts, hemoglobin level and appearance of dermatosis were po

关键词： human immunodeficiency virus blood donors disease progression co-infection hepatitis C

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糕模艺术元素在现代家具设计中的应用

林产工业 2021年第6期58卷 46-50页

作者：章鉴烽曹权玺桂林理工大学艺术学院广西桂林541006

通过对糕模纹样形态特征、工艺特色及材料特征的分析研究,提出了糕模艺术对现代家具设计形式的几点启示,并从主题风格的确立、装饰纹样的重构、材料的合理搭配与意蕴内涵的沿袭等方面,结合设计实践案例进行论证。实践表明:对糕模艺术元... 详细信息

通过对糕模纹样形态特征、工艺特色及材料特征的分析研究,提出了糕模艺术对现代家具设计形式的几点启示,并从主题风格的确立、装饰纹样的重构、材料的合理搭配与意蕴内涵的沿袭等方面,结合设计实践案例进行论证。实践表明:对糕模艺术元素进行提炼、转译,创新应用,可拓展现代家具设计创新路径,对于传承与保护民间民俗文化具有重要意义。

关键词：家具设计糕模艺术启示应用设计实践

中国中西医结合学会神经科专业委员会第七次学术会议纪要

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中国中西医结合杂志 2009年第10期29卷 953-954页

作者：赵建国苏全喜天津中医药大学第一附属医院天津300193 广东药学院附属第一医院

由中国中西医结合学会神经科专业委员会主办、广东省中西医结合学会神经科专业委员会承办的中国中西医结合学会神经科专业委员会第七次学术会议于2009年6月25-27日在广东省广州市召开,来自全国20多个省、市、自治区的300余名代表参加了... 详细信息

由中国中西医结合学会神经科专业委员会主办、广东省中西医结合学会神经科专业委员会承办的中国中西医结合学会神经科专业委员会第七次学术会议于2009年6月25-27日在广东省广州市召开,来自全国20多个省、市、自治区的300余名代表参加了会议.大会共收到学术论文554篇.会议采取专题报告、大会发言等形式进行学术交流和研讨,内容涉及中西医结合神经病学领域的基础和临床研究进展.现将会议内容简介如下.

关键词：中国中西医结合学会学术会议纪要专业委员会神经科学术论文专题报告学术交流临床研究

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蕨类植物花青素和原花青素成分及含量分析

植物科学学报 2020年第6期38卷 820-830页

作者：陈雪菲张映雪黄贤燕王全喜曹建国王幼芳上海师范大学生命科学学院上海200234 华东师范大学生命科学学院上海200062 上海植物园上海200231 上海辰山植物园上海资源植物功能基因组重点实验室上海201602

以7目14科共44种蕨类植物为材料,对它们的花青素、原花青素和总黄酮含量进行检测。结果显示,44种蕨类植物均含有花青素,较为进化的水龙骨目植物的总花青素平均含量明显高于其它蕨类植物。矢车菊素、飞燕草素和天竺葵素是蕨类植物主要的... 详细信息

以7目14科共44种蕨类植物为材料,对它们的花青素、原花青素和总黄酮含量进行检测。结果显示,44种蕨类植物均含有花青素,较为进化的水龙骨目植物的总花青素平均含量明显高于其它蕨类植物。矢车菊素、飞燕草素和天竺葵素是蕨类植物主要的花青素类型,其中乌毛蕨科植物富含矢车菊素,鳞毛蕨科植物富含飞燕草素。本研究中大部分蕨类含有原花青素,水龙骨目植物的原花青素平均含量高于其它蕨类。研究结果表明,蕨类植物中花青素和原花青素等黄酮类化合物的分布与植物科属相关,推测花青素与蕨类植物的生长发育和抗逆过程相关。

关键词：蕨类植物花青素原花青素高效液相色谱

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin Ling Qiao-Nan Shan Xu-Yong Wei Rui wang Chang-Ku Jia Li Zhuang Tian Shen Li-Min Ding Zhi-Dan Xu Lai-Bang Luo Li-Bo Sun Guang-Ming Li Tai-Shi Fang Nan jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang Tao jiang Qiang He Lin-Sen Ye yang yang Yu-Ting He Wen-Zhi guo Liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian jian-Hua Shi Bo wang jiang Liu Qian Lu Wei Rao Jin-Zhen Cai Tao Lv Jia-Yin yang Pu-Sen wang Lin Zhong Jing-Sheng Ma Qi-Gen Li Sheng-Dong Wu Chang-jiang Lu Cai-De Lu Dong-Hua Zhang Xuan wang Zi-Qiang Li Mu-jian Teng Jun-Jie Li Wen-Tao jiang jian-Hua Li quan-Bao Zhang Ning-Qi Zhu Zheng-xin wang Kang He Qiang xia Shao-Hua Song Zhi-Ren Fu Wei Qiu guo-Yue Lv Rui-Peng Song Ji-Zhou wang Zheng wang jian Zhou Gang Chen ying-Peng Zhao Li Li Ze-Min Hu Qi-Jie Luo Zhong-Zhou Si Bin xie xiao-Shun He Zhi-Yong guo Shu-Sen Zheng xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China Liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma Liver transplantation Conversion

绵马鳞毛蕨精母细胞和游动精子超微结构特征的研究(英文)

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西北植物学报 2005年第4期25卷 761-769页

作者：曹建国何群王全喜田国伟包文美上海师范大学生命与环境科学学院哈尔滨学院生物系哈尔滨师范大学生命与环境科学学院哈尔滨师范大学生命与环境科学学院哈尔滨150080

应用电镜技术对蕨类植物绵马鳞毛蕨DryopteriscrassirhizomaNakai精母细胞和游动精子的超微结构特征进行了研究.精母细胞为多边形,细胞质内含有丰富的线粒体、质体、内质网、高尔基体等常见的细胞器,在细胞质中还可见到一些同心圆膜状结... 详细信息

应用电镜技术对蕨类植物绵马鳞毛蕨DryopteriscrassirhizomaNakai精母细胞和游动精子的超微结构特征进行了研究.精母细胞为多边形,细胞质内含有丰富的线粒体、质体、内质网、高尔基体等常见的细胞器,在细胞质中还可见到一些同心圆膜状结构,位于质膜的附近或精母细胞的角偶.同心圆膜状结构由双层膜环绕构成,外被1层单位膜.精母细胞与精子器的璧细胞之间形成了分离腔,在精母细胞质膜外形成了嗜锇层,这些结构的形成说明精母细胞已经开始与雄配子体逐渐分离,进入独立发育的阶段.尽管精母细胞之间也有嗜锇层的形成,但嗜锇层是不连续的,其上有一些空隙,精母细胞之间可通过空隙进行物质和信息的交流.成熟的精子细胞外被1层透明的薄膜,里面为游动精子,螺旋状,由环状细胞器环绕3～4圈构成,这些环状细胞器包括多层结构、微管带、巨大线粒体、鞭毛带和1个长形浓缩的细胞核.游动精子的后端为一些泡囊化的细胞质,其中包括一些残存的线粒体、造粉质体及大的囊泡等.当成熟的精子细胞排出精子器后,其内的游动精子挣脱透明质膜的束缚,摆脱后端的囊泡,成为1条游动精子.本文还对绵马鳞毛蕨和其它蕨类植物精子的超微结构特征进行了比较.

关键词：绵马鳞毛蕨精母细胞游动精子超微结构

SrTiO_3氧气传感器的贵金属催化特性研究

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压电与声光 2009年第1期31卷 74-76页

作者：李恒喜曹全喜姚娇艳郭明光西安电子科技大学技术物理学院陕西西安710071

对于SrTiO3氧气传感器,氧离子在材料表面的吸附控制着材料表面电导率的变化,所以吸附和脱附速率决定氧敏材料的响应时间。研究表明,贵金属作为表面催化剂,可加快气体分子的吸附和脱附速率,提高气敏元件的响应特性。该文在SrTiO3的n型掺... 详细信息

对于SrTiO3氧气传感器,氧离子在材料表面的吸附控制着材料表面电导率的变化,所以吸附和脱附速率决定氧敏材料的响应时间。研究表明,贵金属作为表面催化剂,可加快气体分子的吸附和脱附速率,提高气敏元件的响应特性。该文在SrTiO3的n型掺杂基础上,加入贵金属Pd作为表面催化剂。实验结果表明,以Pd作为催化剂的样品,其响应时间缩短,接近气体传感器的实用要求。

关键词：氧气传感器 SrTiO3 贵金属催化

成肌干细胞在透明质酸凝胶载体中诱导分化为软骨细胞的研究

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解放军医学杂志 2010年第7期35卷 829-832页

作者：李全双梅晰凡郭占鹏王滢丽秦书俭辽宁医学院附属第一医院骨科辽宁锦州121000 辽宁医学院附属第一医院内分泌科辽宁锦州121000 辽宁医学院解剖教研室辽宁锦州121000

目的探讨以透明质酸钠凝胶作为组织工程软骨载体、以成肌干细胞作为种子细胞诱导分化形成软骨细胞的可行性。方法体外分离培养兔成肌干细胞,采用结蛋白(Desmin)细胞化学染色进行鉴定,并观察兔成肌干细胞在不同浓度透明质酸钠凝胶中的生... 详细信息

目的探讨以透明质酸钠凝胶作为组织工程软骨载体、以成肌干细胞作为种子细胞诱导分化形成软骨细胞的可行性。方法体外分离培养兔成肌干细胞,采用结蛋白(Desmin)细胞化学染色进行鉴定,并观察兔成肌干细胞在不同浓度透明质酸钠凝胶中的生长状态。在5%透明质酸钠凝胶中以骨形态发生蛋白2(BMP-2)诱导兔成肌干细胞,倒置相差显微镜观察细胞生长情况,并通过甲苯胺蓝染色、免疫细胞化学及RT-PCR技术对诱导后的细胞进行鉴定。结果原代培养兔成肌干细胞Desmin细胞化学染色呈阳性表达,且在不同浓度透明质酸钠凝胶中均生长良好。BMP-2诱导培养1d后,成肌干细胞即开始于透明质酸钠凝胶中伸展生长,诱导培养10d后,细胞形态由梭形向多边多角形转化,甲苯胺蓝染色阳性,Ⅱ型胶原免疫荧光检测阳性,RT-PCR检测Ⅱ型胶原和聚焦蛋白聚糖mRNA呈阳性表达。结论兔成肌干细胞可在适当浓度BMP-2诱导下分化为软骨样细胞,透明质酸钠凝胶可作为软骨组织工程的良好载体。

关键词：成肌细胞骨形态发生蛋白质类透明质酸细胞分化

Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： Xue-Mei Lu xiao-Fen Yu guo-Qiang Li Ming-Hao Qu Huan wang Chuang Liu Yu-Ping Man xiao-Han jiang Mu-Zi Li jian wang Qi-Qi Chen Rui Lei Cheng-Cheng Zhao Yun-Qiu Zhou Zheng-wang jiang Zuo-Zhou Li Shang Zheng Chang Dong Bai-Lin wang Yan-xiang Sun Hui-Qin Zhang Jie-Wei Li quan-Hui Mo ying Zhang xin Lou Hai-Xu Peng Ya-Ting Yi He-xin wang xiu-Jun Zhang Yi-Bo wang Dan wang Li Li Qiong Zhang Wen-xia wang Yongbo Liu Lei Gao Jin-Hu Wu Yan-Chang wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina College of Life Sciences University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina College of Agricultural Sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina College of Life Sciences Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina College of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3)or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening