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Significance and relationship between infiltrating inflammatory cell and tumor angiogenesis in hepatocellular carcinoma tissues

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World Journal of Gastroenterology 2005年第41期11卷 6521-6524页

作者： Shao-Hua Peng Hong Deng jian-feng yang Ping-Ping Xie Cheng Li Hao Li De-Yun feng Department of Pathology Medical CollegeHunan Normal University Changsha 410006 Hunan ProvinceChina Department of Pathology Xiangya School of Medicine Central South University Changsha 410078 Hunan Province China

AIM: To investigate the relationship between infiltrating inflammatory cell and tumor angiogenesis in hepatocellular carcinoma (HCC) tissues and their clinicopathological ***: The paraffin-embedded specimens from 70 cases with HCC were stained using EliVision immunohistochemistry with mAbs against CD68, tryptase,and CD34. The counts of tumor-associated macrophage (TAM), mast cell (MC) and tumor microvessel (MV) were performed in the tissue ***: The mean counts of TAM, MC, and MV in HCC tissues were significantly higher than those in pericarcinomatous liver tissues (TAM: 69.31± 11.58 vs 40.23±10.36; MC: 16.74±5.67 vs 7.59±4.18; MV:70.11±12.45 vs 38.52± 11.16, P＜0.01). The MV count in the patients with metastasis was markedly higher than that with non-metastasis (P＜0.01). In addition, the MC count in the patients with poorly differentiated HCC was obviously higher than that with well differentiated HCC (P＜ 0.01). The correlation analysis showed that the TAM count was significantly correlated with the count of MV(r=0.712, P＜0.01), and the MC count was obviously correlated with the MV count (r= 0.336, P＜ 0.05).CONCLUSION: TAM and MC might be closely related to the enhancement of tumor angiogenesis. The MV count might be associated with tumor invasion and ***, the MC count might be associated with tumor differentiation and prognosis of HCC.

关键词： Hepatocellular carcinoma Mast cell Microvessel Macrophage

Imaging findings of primary gastric plasmacytoma:A case report

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World Journal of Gastroenterology 2014年第29期20卷 10202-10207页

作者： Zhen-Hua Zhao jian-feng yang Jin-Dao Wang jian-Guo Wei Fang Liu Bo-Yin Wang Department of Radiology Shaoxing People’s Hospital Shaoxing Hospital of Zhejiang University Department of Gastroenterology Shaoxing People’s Hospital Department of Pathology Shaoxing People’s Hospital

Primary gastric plasmacytoma (GP) is a rare extramedullary plasmacytoma with clinical and imaging features that are common among other gastric tumors, such as gastric adenocarcinomas, gastric stromal tumors, and lymphomas. Here, we present a histologically conﬁrmed case of primary GP examined with biphasic computed tomography (CT), magnetic resonance imaging (MRI), and endosonography. A well-circumscribed extraluminal mass appearing as homogeneous attenuation/intensity with gradual enhancement was identified on biphasic enhancement CT and MRI. This mass was hyperintense on diffusion-weighted imaging and hypointense on the apparent diffusion coefficient map, implying that water diffusion in the mass was restricted. In addition, endosonography indicated a low echogenic mass in the gastric wall. These imaging findings increase the available knowledge about imaging of this disease and provide valuable information for differentiating primary GP from common gastric tumors.

关键词： Stomach Plasmacytoma Computed tomography, X-ray Magnetic resonance imaging Diffusion Endosonography

The alignment of AlN platelets in polymer matrix and its anisotropic thermal properties

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Journal of Materiomics 2019年第4期5卷 679-687页

作者： Chang-Yeoul Kim Thi My Linh Dang Yaming Zhang jian-feng yang Bo Wang Nano-Convergence Materials Team Korea Institute of Ceramic Engineering and Technology Jinju-siGyeongsangnam-do660-031South Korea State Key Laboratory of Mechanical Behavior of Materials Xi'an Jiaotong UniversityXi'an71004China

The thermal conductivity of polymer composites can be enhanced by the vertical alignment of anisotropic aluminum nitride(AlN)platelet fillers in polymer *** AlN platelets in polymer matrix were aligned in the direction of in-plane and out-of-plane by using the doctor blading and the lamination *** alignment of AlN plates in the out-of-plane or the in-plane direction has been confirmed by XRD and FE-SEM *** polymer composite with the out-of-plane aligned AlN platelets showed almost 1.5 times or 2 times higher thermal conductivity than those with the AlN spheres or the in-plane aligned AlN platelets at the same filler content,*** result could be attributed to the improvement of thermal pathway generated along the plane of platelets and the decrease of interfaces between the filler and the polymer.

关键词： Thermal conductivity Aluminum nitride plate Polymer composite Alignment Out-of-direction In-plane direction

A method and results of color calibration for the Chang'e-3 terrain camera and panoramic camera

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Research in Astronomy and Astrophysics 2014年第12期14卷 1557-1566页

作者： Xin Ren Chun-Lai Li jian-Jun Liu Fen-Fei Wang jian-feng yang En-Hai Liu Bin Xue Ru-Jin Zhao Key Laboratory of Lunar and Deep Space Exploration National Astronomical ObservatoriesChinese Academy of Sciences Xi’an Institute of Optics and Precision Mechanics Chinese Academy of Sciences Institute of Optics and Electronics Chinese Academy of Sciences

The terrain camera （TCAM） and panoramic camera （PCAM） are two of the major scientific payloads installed on the lander and rover of the Chang＇e 3 mission re- spectively. They both use a Bayer color filter array covering CMOS sensor to capture color images of the Moon＇s surface. RGB values of the original images are related to these two kinds of cameras. There is an obvious color difference compared with human visual perception. This paper follows standards published by the International Commission on Illumination to establish a color correction model, designs the ground calibration experiment and obtains the color correction coefficient. The image qual- ity has been significantly improved and there is no obvious color difference in the corrected images. Ground experimental results show that：（1） Compared with uncor- rected images, the average color difference of TCAM is 4.30, which has been reduced by 62.1%. （2） The average color differences of the left and right cameras in PCAM are 4.14 and 4.16, which have been reduced by 68.3% and 67.6% respectively.

关键词： Moon -- methods: data analysis -- techniques: image processing

Inverse Calculation and Regularization Process for the Solar Aspect System(SAS) of HXI Payload on ASO-S Spacecraft

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Research in Astronomy and Astrophysics 2024年第4期24卷 13-34页

作者： Ji-Rui Yu Ping Ruan yang Su Ying-Hong He Jin-You Tao Zhe Zhang Song Guo Bin Xue jian-feng yang Xi'an Institute of Optics and Precision Mechanics of Chinese Academy of Sciences Xi'an 710119China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 20034China School ofAstronomy and Space Science Universityof Science and Technology of ChinaHefei 230026China

For the ASO-S/HXI payload, the accuracy of the flare reconstruction is reliant on important factors such as the alignment of the dual grating and the precise measurement of observation orientation. To guarantee optimal functionality of the instrument throughout its life cycle, the Solar Aspect System (SAS) is imperative to ensure that measurements are accurate and reliable. This is achieved by capturing the target motion and utilizing a physical model-based inversion algorithm. However, the SAS optical system’s inversion model is a typical ill-posed inverse problem due to its optical parameters, which results in small target sampling errors triggering unacceptable shifts in the solution. To enhance inversion accuracy and make it more robust against observation errors, we suggest dividing the inversion operation into two stages based on the SAS spot motion model. First, the as-rigid-aspossible (ARAP) transformation algorithm calculates the relative rotations and an intermediate variable between the substrates. Second, we solve an inversion linear equation for the relative translation of the substrates, the offset of the optical axes, and the observation orientation. To address the ill-posed challenge, the Tikhonov method grounded on the discrepancy criterion and the maximum a posteriori (MAP) method founded on the Bayesian framework are utilized. The simulation results exhibit that the ARAP method achieves a solution with a rotational error of roughly±3 5 (1/2-quantile);both regularization techniques are successful in enhancing the stability of the solution, the variance of error in the MAP method is even smaller—it achieves a translational error of approximately±18μm (1/2-quantile) in comparison to the Tikhonov method’s error of around±24μm (1/2-quantile). Furthermore, the SAS practical application data indicates the method’s usability in this study. Lastly, this paper discusses the intrinsic interconnections between the regularization methods.

关键词： methods:data analysis Sun:flares Sun:X-rays gamma rays

Design and verification of the HXI collimator on the ASO-S mission

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Research in Astronomy and Astrophysics 2021年第6期21卷 241-252页

作者： Deng-Yi Chen Yi-Ming Hu Tao Ma yang Su jian-feng yang jian-Ping Wang Guang-Zhou Xu Xian-Kai jiang jian-Hua Guo Yong-Qiang Zhang Yan Zhang Wei Chen Jin Chang Zhe Zhang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210023China University of Science and Technology of China Hefei 230026China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201210China

A space-borne hard X-ray collimator,comprising 91 pairs of grids,has been developed for the Hard X-ray Imager(HXI).The HXI is one of the three scientific instruments onboard the first Chinese solar mission:the Advanced Space-based Solar Observatory(ASO-S).The HXI collimator(HXI-C)is a spatial modulation X-ray telescope designed to observe hard X-rays emitted by energetic electrons in solar *** paper presents the detailed design of the HXI-C for the qualification model that will be inherited by the flight *** tests on the HXI-C qualification model are reported to verify the ability of the HXI-C to survive the launch and to operate normally in on-orbit ***,results of the X-ray beam test for the HXI-C are presented to indirectly identify the working performance of the HXI-C.

关键词： Solar observation ASO-S X-ray telescope the collimator verification

Four-sample lactose hydrogen breath test for diagnosis of lactose malabsorption in irritable bowel syndrome patients with diarrhea

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World Journal of Gastroenterology 2015年第24期21卷 7563-7570页

作者： jian-feng yang Mark Fox Hua Chu Xia Zheng Yan-Qin Long Daniel Pohl Michael Fried Ning Dai Department of Gastroenterology The First People’s Hospital of Hangzhou Department of Gastroenterology Sir Run Run Shaw Hospital affiliated to College of Medicine Zhejiang University Division of Gastroen- terology and Hepatology University Hospital Zürich NIHR Nottingham Digestive Diseases Biomedical Research Unit Queen’s Medical Centre

AIM: To validate 4-sample lactose hydrogen breath testing(4SLHBT) compared to standard 13-sample LHBT in the clinical ***: Irritable bowel syndrome patients with diarrhea(IBS-D) and healthy volunteers(HVs) were enrolled and received a 10 g, 20 g, or 40 g doselactose hydrogen breath test(LHBT) in a randomized, double-blinded, controlled trial. The lactase gene promoter region was sequenced. Breath samples and symptoms were acquired at baseline and every 15 min for 3 h(13 measurements). The detection rates of lactose malabsorption(LM) and lactose intolerance(LI) for a 4SLHBT that acquired four measurements at 0, 90, 120, and 180 min from the same data set were compared with the results of standard ***: Sixty IBS-D patients and 60 HVs were studied. The genotype in all participants was C/C-13910. LM and LI detection rates increased with lactose dose from 10 g, 20 g to 40 g in both groups(P < 0.001). 4SLHBT showed excellent diagnostic concordance with standard LHBT(97%-100%, Kappa 0.815-0.942) with high sensitivity(90%-100%) and specificity(100%) at all three lactose doses in both ***: Reducing the number of measurements from 13 to 4 samples did not significantly impact on the accuracy of LHBT in health and IBS-D. 4SLHBT is a valid test for assessment of LM and LI in clinical practice.

关键词： Lactose hydrogen breath test Diagnosis Lactose malabsorption Lactose intolerance Irritablebowel syndrome

Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第13期22卷 3652-3662页

作者： jian-feng yang Zhen-Hua Zhao Yu Zhang Li Zhao Li-Ming yang Min-Ming Zhang Bo-Yin Wang Ting Wang Bao-Chun Lu Department of Radiology Second Affliated Hospital College of Medicine Zhejiang University Hangzhou 310009 Zhejiang Province China Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China Department of Radiology Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China Department of Hepatobiliary Surgery Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University) Shaoxing 312000 Zhejiang Province China

AIM: To investigate the feasibility of a dual-input two-compartment tracer kinetic model for evaluating tumorous microvascular properties in advanced hepatocellular carcinoma(HCC). METHODS: From January 2014 to April 2015, we prospectively measured and analyzed pharmacokinetic parameters [transfer constant(K_(trans)), plasma flow(F_p), permeability surface area product(PS), efflux rate constant(k_(ep)), extravascular extracellular space volume ratio(V_e), blood plasma volume ratio(V_p), and hepatic perfusion index(HPI)] using dual-input two-compartment tracer kinetic models [a dual-input extended Tofts model and a dual-input 2-compartment exchange model(2CXM)] in 28 consecutive HCC patients. A well-known consensus that HCC is a hypervascular tumor supplied by the hepatic artery and the portal vein was used as a reference standard. A paired Student's t-test and a nonparametric paired Wilcoxon rank sum test were used to compare the equivalent pharmacokinetic parameters derived from the two models, and Pearson correlation analysis was also applied to observe the correlations among all equivalent parameters. The tumor size and pharmacokinetic parameters were tested by Pearson correlation analysis, while correlations among stage, tumor size and all pharmacokinetic parameters were assessed by Spearman correlation analysis. RESULTS: The F_p value was greater than the PS value(F_P = 1.07 m L/m L per minute, PS = 0.19 m L/m L per minute) in the dual-input 2CXM; HPI was 0.66 and 0.63 in the dual-input extended Tofts model and the dualinput 2CXM, respectively. There were no significant differences in the K_(ep), V_p, or HPI between the dual-input extended Tofts model and the dual-input 2CXM(P = 0.524, 0.569, and 0.622, respectively). All equivalent pharmacokinetic parameters, except for V_e, were correlated in the two dual-input two-compartment pharmacokinetic models; both Fp and PS in the dualinput 2CXM were correlated with K_(trans) derived from the dual-input extended Tofts

关键词： Hepatocellular carcinoma Dynamic contrastenhanced magnetic resonance imaging Pharmacokinetics

Endoscopic submucosal tunnel dissection of upper gastrointestinal submucosal tumors: A comparative study of hook knife vs hybrid knife

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World Journal of Gastroenterology 2017年第10期23卷 1843-1850页

作者： Jie-qiong Zhou Xiao-Wei tang Yu-tang Ren Zheng-Jie Wei Si-lin Huang qiao-ping Gao Xiao-feng Zhang jian-feng yang Wei Gong Bo jiang Guangdong Provincial key laboratory of Gastroenterology Department of Gastroenterology Nanfang Hospital Southern Medical University Department of Gastroenterology Beijing Tsinghua Changgung Hospital Medical Center Tsinghua University Department of Gastroenterology Hangzhou First People’s Hospital Nanjing Medical University

AIM to compare the efficacy and safety of a hook knife(HO) with a hybrid knife(HK) during endoscopic submucosal tunnel dissection(EStD) *** Between August 2012 and December 2015, the ESt D procedure was performed for 83 upper GI submucosal lesions, which originated from the muscularis propria layer identified by upper endoscopy and endoscopic ultrasonography. Of these, 34 lesions were treated by a HO, whereas 49 lesions were treated by a HK. Data regarding age, gender, presenting symptoms, tumor location and size, procedure time, complications, en bloc resection rate and others were analyzed and compared between the two *** there were no significant differences in the age, gender, presenting symptoms and tumor location between the two groups. EStD was successfully completed in all the patients, and no case was converted to laparoscopy. the mean procedure time was significantly shorter in the HK group than in the HO group(41.3 ± 20.3 min vs 57.2 ± 28.0 min, p = 0.004). the mean frequency of device exchange was 1.4 ± 0.6 in the HK group and significantly less than 3.3 ± 0.6 in the HO group(p < 0.001). the differences in tumor size and histopathological diagnoses were not significant between the two groups(p = 0.813, p = 0.363, respectively). Both groups had an equal en bloc resection rate and complete resection rate. Additionally, the complication rate was similar between the two groups(p = 0.901). During the follow-up, no recurrence occurred in either *** We demonstrate for the first time that HO and HK do not differ in efficacy or safety, but HK reduces the frequency of device exchange and procedure time.

关键词： Endoscopic submucosal tunnel dissection submucosal tumor hook knife hybrid knife clinical outcome