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Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

Signal Transduction and Targeted Therapy 2021年第5期6卷 1546-1558页

作者： Hao Li Xia-Ming jiang Ning Cui Chun Yuan Shao-fei Zhang Qing-Bin Lu Zhen-Dong Yang Qin-Lin Xin Ya-Bin Song Xiao-Ai Zhang Hai-Zhou Liu Juan Du Xue-Juan Fan Lan Yuan Yi-Mei Yuan Zhen Wang Juan Wang Lan Zhang Dong-Na Zhang Zhi-Bo Wang Ke Dai Jie-Ying Bai Zhao-Nian Hao Hang Fan Li-Qun Fang Gengfu Xiao Yang Yang Ke Peng Hong-Quan Wang jian-xiong Li Lei-Ke Zhang Wei Liu Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and BiosecurityBeijingP.R.China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiP.R.China The 154 Hospital Peopled Liberation ArmyXinyangHenanP.R.China school of Public Health Peking UniversityBeijingP.R.China lnstitute of Molecular Medicine Peking UniversityBeijingP.R.China Rongji Medical College Huazhong University of Science and TechnologyWuhanP.R.China Department of Biostatistics and Emerging Pathogens Institute University of FloridaGainesvilleFLUSA Department of Cancer People's Liberation Army General HospitalBeijingP.R.China Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases BeijingP.R.China

Severe fever with thrombocytopenia syndrome(SFTS)virus(SFTSV)is an emerging tick-borne virus with high fatality and an expanding ***,effective anti-SFTSV intervention remains ***(T-705)was recently reported to show in vitro and in animal model antiviral efficacy against ***,we conducted a single-blind,randomized controlled trial to assess the efficacy and safety of T-705 in treating SFTS(Chinese Clinical Trial Registry website,number ChiCTR1900023350).From May to August 2018,laboratory-confirmed SFTS patients were recruited from a designated hospital and randomly assigned to receive oral T-705 in combination with supportive care or supportive care *** outcome occurred in 9.5%(7/74)of T-705 treated patients and 18.3%(13/71)of controls(odds ratio,0.466,95%Cl,0.174-1.247).Cox regression showed a significant reduction in case fatality rate(CFR)with an adjusted hazard ratio of 0.366(95%Cl,0.142-0.944).Among the low-viral load subgroup(RT-PCR cycle threshold>26),T-705 treatment significantly reduced CFR from 11.5 to 1.6%(P=0.029),while no between-arm difference was observed in the high-viral load subgroup(RT-PCR cycle threshold<26).The T-705-treated group showed shorter viral clearance,lower incidence of hemorrhagic signs,and faster recovery of laboratory abnormities compared with the *** in vitro and animal experiments demonstrated that the antiviral efficacies of T-705 were proportionally induced by SFTSV mutation rates,particularly from two transition mutation *** mutation analyses on T-705-treated serum samples disclosed a partially consistent mutagenesis pattern as those of the in vitro or animal experiments in reducing the SFTSV viral loads,further supporting the anti-SFTSV effect of T-705,especially for the low-viral loads.

关键词： effect faster supporting

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Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation

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International Journal of Oral Science 2016年第3期8卷 182-190页

作者： fei Teng Tao He Shi Huang Cun-Pei Bo Zhen Li Jin-Lan Chang Ji-Quan Liu Duane Charbonneau jian Xu Rui Li Jun-Qi Ling Department of Operative Dentistry and Endodontics Guanghua School and Hospital of StomatologySun Yat-sen University Single-Cell Center and Shandong Key Laboratory of Energy Genetics Qingdao Institute of Bioenergy and Bioprocess TechnologyChinese Academy of Sciences Department of Oral Care Clinical Operation Procter & Gamble Mason Business Center Sino-Danish Center for Education and Research University of Chinese Academy of Science Department of Stomatology Peking Union Medical College Hospital Global Microbiology Capability Organization Procter & Gamble Innovation Center Global Microbiology Capability Organization Procter & Gamble International Operations SA Singapore Branch

Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride （CPC）, can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a double- blinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were profiled via 16S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index. Cetylpyridinium chloride conferred gingival benefits, as progression of gingival inflammation resulting from a lack of dental hygiene was significantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque a and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitis- enriched taxa. The findings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population.

关键词： cetylpyridinium chloride oral microbiota oral rinse

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4个草品种种子发芽及幼苗生长对汞胁迫的响应及汞富集能力

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西南农业学报 2021年第9期34卷 1969-1976页

作者：杜建雄任尉香李剑峰张淑卿周丕飞贵州财经大学公管学院贵州贵阳550025 贵州师范大学外国语学院贵州贵阳550025 贵州师范学院喀斯特生境土壤与环境生物修复研究所贵州贵阳550018

【目的】探明不同草坪草及牧草品种种子发芽及幼苗生长对汞胁迫的响应及富集能力,为抗汞胁迫及汞富集力强的草品种选择提供依据。【方法】选取前期通过汞胁迫发芽试验筛选而得的多花黑麦草(Lolium multiflorum Lam.)的盛宴(Feast)、紫羊... 详细信息

【目的】探明不同草坪草及牧草品种种子发芽及幼苗生长对汞胁迫的响应及富集能力,为抗汞胁迫及汞富集力强的草品种选择提供依据。【方法】选取前期通过汞胁迫发芽试验筛选而得的多花黑麦草(Lolium multiflorum Lam.)的盛宴(Feast)、紫羊茅(Festuca rubra L.)的派尼(Pernille)和传奇(Legend)3个草坪草品种及多年生紫花苜蓿(Medicago sativa L.)的金黄后(Golden empress)1个牧草品种为试验材料,以0~180 mg/L 7个Hg^(2+)浓度梯度进行发芽试验,考察4个草品种的种子发芽期对汞的耐受性;再以0~181 mg/kg 5个Hg^(2+)浓度梯度对4个草品种进行土培盆栽试验,考察其苗期生长对汞胁迫的响应及富集能力。【结果】发芽期汞耐受性:随Hg^(2+)浓度升高,4个草品种的发芽率、发芽势、发芽指数、活力指数均不同程度降低,下降幅度因品种存在差异,传奇和派尼的发芽相关指标较金皇后和盛宴的下降幅度大;苗期汞耐受性:随Hg^(2+)浓度升高,4个草品种的出苗率、株高、根长、鲜重、叶面积均不同程度下降,传奇和派尼的生长受抑制程度更大,低浓度Hg^(2+)对金皇后、盛宴和派尼的生长有一定促进作用;4个草品种的汞富集系数随Hg^(2+)浓度升高而明显下降,其中金皇后汞富集能力最强,盛宴和传奇次之,派尼最弱。【结论】4个草品种在不同浓度Hg^(2+)胁迫下,金皇后和盛宴比派尼和传奇受到的伤害程度低,显示出较强的抗汞胁迫能力,同时,金皇后和盛宴具有较好的汞富集能力,可选择为汞污染土壤植物修复的先锋草品种。

关键词：汞胁迫草坪草牧草发芽率生物量汞富集系数

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Mineralization of phenol by ozone combined with activated carbon:Performance and mechanism under different pH levels

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Environmental Science and Ecotechnology 2020年第1期1卷 28-36页

作者： Wei xiong Weihua Cui Rui Li Chuanping Feng Yang Liu Ningping Ma jian Deng Linlin Xing Yu Gao Nan Chen school of Water Resources and Environment MOE Key Laboratory of Groundwater Circulation and Environment EvolutionChina University of Geosciences(Beijing)Beijing100083China State Environmental Protection Key Laboratory of Simulation and Control of Groundwater Pollution Chinese Research Academy of Environmental SciencesBeijing100012China Beijing BHZQ Environmental Engineering Technology.Co. LTDBeijing100176China College of Chemical and Environmental Engineering Shandong University of Science and TechnologyQingdao266590China

The degradation of phenol using ozone with activated carbon(O_(3)/AC system)was investigated in this *** O_(3)/AC system was also compared with the single O_(3) and AC *** total organic carbon(TOC)removal efficiency in the O_(3)/AC system was roughly 26%and 30%higher than the single AC and O_(3) systems,*** was demonstrated that the phenol degradation rate and TOC removal efficiency were significantly affected by the ozone concentration,AC dosage,and solution *** pseudo-first-order and pseudo-second-order kinetic models were fitted to identify the mechanisms of the phenol removal *** results of Scanning Electron Microscopy,Brunauer-Emmett-Teller,and Fourier-transform infrared spectroscopy of raw and used AC indicated that the surface morphology,microstructure,and functional group properties had been changed during the reaction *** possible O_(3)/AC system mineralization mechanism for phenol removal was tentatively proposed using scavenging active species such as·OH,O_(2)^(·-),and H_(2)O_(2).The transformation byproducts generated during the application of the O_(3)/AC system were identified by High Performance Liquid Chromatography and Gas Chromatography-Mass Spectrometry ***,the mineralization pathway of phenol in detail was proposed in acidic(pH 3.0)and alkaline(pH 11.0)*** study provided a more systematic explanation of the mineralization mechanism for phenol in the O_(3)/AC system.

关键词： Activated carbon Ozone Mineralization pathway Free radicals pH

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城轨铝合金制动盘成形仿真和缺陷预测

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铸造 2020年第4期69卷 412-417页

作者：王朝涛杨智勇张雄飞赵海芹韩建民中车青岛四方机车车辆股份有限公司山东青岛266111 北京交通大学机械与电子控制工程学院北京00044

发展城轨列车是缓解城市交通拥堵的重要途径。列车运行速度提高到120 km/h以上时,传统的闸瓦-车轮踏面制动已不能满足列车制动的要求。针对140~160 km/h城轨列车用SiC_p/A356复合材料制动盘,利用ProCAST凝固模拟软件对制动盘的真空调压... 详细信息

发展城轨列车是缓解城市交通拥堵的重要途径。列车运行速度提高到120 km/h以上时,传统的闸瓦-车轮踏面制动已不能满足列车制动的要求。针对140~160 km/h城轨列车用SiC_p/A356复合材料制动盘,利用ProCAST凝固模拟软件对制动盘的真空调压成形工艺进行仿真分析,基于流场、缩孔缩松、凝固时间及固相率等模拟结果,确定了制动盘内部成形质量良好的浇注系统和浇注工艺参数,成形了内在质量完好的SiC_p/A356制动盘。

关键词： SiC_p/A356制动盘真空调压成形成形工艺 X射线探伤数值模拟

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多壁碳纳米管/羟基磷灰石/聚醚醚酮三元纳米复合物的制备与性能研究

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塑料工业 2018年第6期46卷 113-116,123页

作者：曹剑飞鲁越陈和春张丽芳熊成东中国科学院成都有机化学研究所四川成都610041 中国科学院大学北京100049 四川理工学院材料科学与工程学院四川自贡643000 常州化学研究所江苏常州213164

聚醚醚酮(PEEK)是一种刚性的热塑性工程塑料。由于具有优异的力学性能,PEEK被认为是理想的骨修复材料。但是PEEK本身的生物惰性却阻碍了其在生物材料领域中的应用。通过预混与注塑加工,本课题组成功制备出具有生物活性的多壁碳纳米管(MW... 详细信息

聚醚醚酮(PEEK)是一种刚性的热塑性工程塑料。由于具有优异的力学性能,PEEK被认为是理想的骨修复材料。但是PEEK本身的生物惰性却阻碍了其在生物材料领域中的应用。通过预混与注塑加工,本课题组成功制备出具有生物活性的多壁碳纳米管(MWCNTs)/羟基磷灰石(HA)/聚醚醚酮三元纳米复合物。结果表明,MWCNTs/HA/PEEK三元复合材料的力学性能优于传统的HA/PEEK二元复合材料。此外,该复合材料在模拟体液(SBF)中浸泡1~2周后,材料表面能够自发沉积出磷灰石层,显示出良好的生物活性与骨诱导性。

关键词：聚醚醚酮三元复合物多壁碳纳米管生物材料性能

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基于伴随仿真的偏振复用超构透镜

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中国光学 2021年第4期14卷 754-763页

作者：刘永健张飞谢婷蒲明博赵泽宇李雄马晓亮沈同圣罗先刚中国科学院光电技术研究所微细加工光学技术国家重点实验室四川成都610209 中国科学院大学光电学院北京100049 中国人民解放军军事科学院国防科技创新研究院北京100071

偏振成像技术在目标探测、生物医学等领域具有重要应用价值,基于超构表面设计的偏振成像系统可以有效避免传统偏振成像系统存在的结构复杂、体积和质量大等问题,有利于实现光学系统微型化、轻量化和集成化。然而,传统超构表面设计方法... 详细信息

偏振成像技术在目标探测、生物医学等领域具有重要应用价值,基于超构表面设计的偏振成像系统可以有效避免传统偏振成像系统存在的结构复杂、体积和质量大等问题,有利于实现光学系统微型化、轻量化和集成化。然而,传统超构表面设计方法忽略了超构表面结构的局部非周期性引起的近场电磁耦合,在大数值孔径的条件下会严重影响器件的衍射效率。为了解决这个问题,本文提出了一种基于边界优化的偏振复用超构透镜设计方法,并由此设计了一种能对x和y偏振光独立调控的大数值孔径(~0.94)偏振成像超构透镜。在基于人工择优初始结构的优化设计中,通过参数扫描、人工择优的传统设计方法得到超构透镜初始结构,然后通过边界优化方法对超构透镜进行进一步的优化,其衍射效率相比于优化前可以提高20%左右;在基于均匀阵列初始结构的优化设计中,通过20次左右的迭代,超构透镜衍射效率可以达到92%左右。本文提出的优化设计方法可有效提高偏振复用超构表面器件效率,并且能够简化多功能超构表面的设计步骤,在偏振成像、光通信等领域具有应用前景。

关键词：超构表面伴随优化边界优化偏振成像

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聚乙烯醇修饰氧化镁/聚ε-己内酯纳米复合物性能研究

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塑料工业 2018年第6期46卷 82-85页

作者：鲁越曹剑飞袁明伟熊左春陈和春熊成东陈栋梁中国科学院成都有机化学研究所四川成都610041 四川理工学院材料科学与工程学院四川自贡643000 中国科学院大学北京100049 常州化学研究所江苏常州213164

使用超声分散方法制备了聚乙烯醇(PVA)修饰的氧化镁(MgO)/聚ε-己内酯(PCL)纳米复合物。用傅里叶变换红外光谱、热重分析仪、电子万能试验机、场发射扫描电镜对纳米粒子及复合物进行了表征。结果表明,PVA被成功地修饰到了MgO纳米粒子表... 详细信息

使用超声分散方法制备了聚乙烯醇(PVA)修饰的氧化镁(MgO)/聚ε-己内酯(PCL)纳米复合物。用傅里叶变换红外光谱、热重分析仪、电子万能试验机、场发射扫描电镜对纳米粒子及复合物进行了表征。结果表明,PVA被成功地修饰到了MgO纳米粒子表面;MgO纳米粒子、PVA、PCL之间存在氢键的相互作用;当MgO-PVA添加量为2%时,MgO-PVA在PCL中能够很好地分散,并使得PCL的拉伸强度提高10%、断裂伸长率提高13.7%,但是当添加量为5%和10%时,由于纳米粒子的团聚,造成了力学性能急剧下降。

关键词：氧化镁纳米粒子聚乙烯醇表面修饰纳米复合物聚ε-己内酯

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Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection:a randomized trial

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Signal Transduction and Targeted Therapy 2021年第10期6卷 3009-3018页

作者： Jun Liu Dan-Dan Li Wei Dong Yu-Qi Liu Yang Wu Da-Xuan Tang Fu-Chun Zhang Meng Qiu Qi Hua Jing-Yu He Jun Li Bai Du Ting-Hai Du Lin-Lin Niu Xue-Jun jiang Bo Cui jiang-Bin Chen Yang-Gan Wang Hai-Rong Wang Qin Yu Jing He Yi-Lin Mao Xiao-Fang Bin Yue Deng Yu-Dan Tian Qing-Hua Han Da-Jin Liu Li-Qin Duan Ming-Jun Zhao Cui-Ying Zhang Hai-Ying Dai Ze-Hua Li Ying Xiao You-Zhi Hu Xiao-Yu Huang Kun Xing Xin jiang Chao-Feng Liu Jing An Feng-Chun Li Tao Tao Jin-Fa jiang Ying Yang Yao-Rong Dong Lei Zhang Guang Fu Ying Li Shu-Wei Huang Li-Ping Dou Lan-Jun Sun Ying-Qiang Zhao Jie Li Yun Xia Jun Liu Fan Liu Wen-Jin He Ying Li jian-Cong Tan Yang Lin Ya-Bin Zhou jian-fei Yang Guo-Qing Ma Hui-Jun Chen He-Ping Liu Zong-Wu Liu jian-xiong Liu Xiao-Jia Luo Xiao-Hong Bin Ya-Nan Yu Hai-Xia Dang Bing Li fei Teng Wang-Min Qiao Xiao-Long Zhu Bing-Wei Chen Qi-Guang Chen Chun-Ti Shen Yong-Yan Wang Yun-Dai Chen Zhong Wang Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Dongfang Hospital Affiliated to Beijing University of Chinese MedicineBeijingChina Department of Geratology Peking University Third HospitalBeijingChina Department of Cardiology Xuan Wu HospitalCapital Medical UniversityBeijingChina Department of Cardiology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijingChina Department of Cardiology First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenanChina Department of Cardiology Wuhan University Renmin HospitalWuhanHubeiChina Department of Cardiology Wuhan University Zhongnan HospitalWuhanHubeiChina Affiliated Zhongshan Hospital of Dalian university DalianLiaoningChina Department of Cardiology Second Affiliated Hospital to Hunan University of Chinese MedicineChangshaHunanChina Department of Cardiology First Affiliated Hospital to Changchun University of Chinese MedicineChangchunJilinChina Department of Cardiology First Affiliated Hospital to Shanxi Medical UniversityTaiyuanShanxiChina Department of Cardiology Affiliated Hospital of Shanxi University of Chinese MedicineXianyangShanxiChina Department of Cardiology Changsha Central HospitalChangshaHunanChina Department of Cardiology Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina Department of Cardiology Shanxi Provincial People's HospitalXi'anShanxiChina Department of Cardiology Shanxi Province Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Xi'an City Hospital of Traditional Chinese MedicineXi'anShanxiChina Department of Cardiology Shanghai Tongji HospitalShanghaiChina Department of Cardiology Shanghai Municipal Hospital of Traditional Chinese MedicineShanghaiChina Department of Cardiology The First Hospital of ChangshaChangshaHunanChina Department of Cardiology Xinhua Hospi

It's a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in thedfferentiated populations with complex diseases,as stable coronary heart ***,in an adaptive,31-center,randomized,double-blind trial invoving 920 patients with moderate symptomatic stable angina treated by 14-day Danhong injection(DHI),a kind of polyphamacological drug with high quality control,or placebo(0.9%saline),with 76-day following-up,we firstly confrmed that DHl couldincrease the proportion of patients with clinically significant changes on angina-frequency assessed by Seattle Angina Questionnaire(ASAQ-AF220)(12.78%at Day 30,95%confidence interval[C]5.86-19.71%,P=0.0003,13.82%at Day 6C0,95%CI 6.82-20.82%,P=0.0001and 8.95%at Day 90,95%CI 2.06-15.85%,P=0.01).We also found that there were no significant differences in new-onset major vascularevents(P=0.8502)and serious adverse events(P=0.9105)between DHl and *** performing the RNA sequencing in 62 selectedpatients,we developed a systemic modular approach tp identfy differentilly expressed modules(DEMs)of DHI with the Z_(summay)valueless than 0 compared with the control group,calculated by weighted gene co-expression network analysis(WGCNA),and sketched out thebasic framework on a modular map with 25 functional modules targeted by ***,the effective therapeutic module(ETM),defined as the highest corelation value with the phenotype alteration(SAQ-AF,the change in SAQ-AF at Day 30 from baseline)calculatedby WGCNA,was identifed in the population with the best effect(ASAQ-AF240),which is related to anticoagulation and regulation ofcholesterol *** assessed the modular flexbility of this ETM using the global topological D value based on Euclidean distance,which is corelated with phenotype alteration(r^(2):0.8204,P=0.019)by linear *** study identified the ant-angina therapeuticmodule in the effective population treated by the multi-target

关键词： angina injection sketch

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碳纳米管增强的羟基磷灰石/聚醚醚酮牙种植体材料的理化性质研究

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塑料科技 2023年第5期51卷 42-46页

作者：庞恋苏李萌崛曹剑飞张新星鲁越熊左春熊成东解放军总医院海南医院海南三亚572000 成都工业学院材料与环境工程学院四川成都611730 琼台师范学院理学院海南海口570100 四川轻化工大学材料科学与工程学院四川自贡643000 中国科学院成都有机化学研究所四川成都610041

聚醚醚酮(PEEK)在力学强度和生物相容性方面还不能完全满足临床要求。利用多壁碳纳米管(MWCNTS)对羟基磷灰石/聚醚醚酮(HA/PEEK)复合材料进行增强。通过共混-注塑成型制备MWCNTS/HA/PEEK复合材料。探究HA/PEEK和MWCNTS/HA/PEEK复合材料... 详细信息

聚醚醚酮(PEEK)在力学强度和生物相容性方面还不能完全满足临床要求。利用多壁碳纳米管(MWCNTS)对羟基磷灰石/聚醚醚酮(HA/PEEK)复合材料进行增强。通过共混-注塑成型制备MWCNTS/HA/PEEK复合材料。探究HA/PEEK和MWCNTS/HA/PEEK复合材料的力学性能、表面亲水性、表面粗糙度、热力学性质和成骨细胞相容性。结果表明:MWCNTS与PEEK基体存在较强的结合力。4%MWCNTS/30%HA/PEEK复合材料的拉伸模量(8.1 GPa)与拉伸强度(78 MPa)均满足人体密质骨的力学强度要求。MWCNTS和HA共同提高了PEEK的结晶温度(T c)与熔融温度(Tm),提升了PEEK的热稳定性。成骨细胞在MWCNTS/HA/PEEK复合材料表面生长与分化情况良好,证明制备的三元复合材料有良好的生物相容性。

关键词：多壁碳纳米管羟基磷灰石聚醚醚酮力学性能生物活性

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