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典型岩溶矿区地表水和地下水补给来源及水化学演化机制

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环境科学 2024年第9期45卷 5264-5276页

作者：周智强黄奇波汪玉松罗飞梁建宏熊江俣中国地质大学(武汉)环境学院武汉430074 中国地质科学院岩溶地质研究所桂林541004

为研究香花岭矿区岩溶地下水与地表水补给来源、水化学特征及演化过程,在矿区周边采集了32组岩溶地下水与地表水样品,基于多元统计分析、Piper三线图、Gibbs图和离子比例系数等方法,分析了香花岭矿区岩溶地下水与地表水水文地球化学特征... 详细信息

为研究香花岭矿区岩溶地下水与地表水补给来源、水化学特征及演化过程,在矿区周边采集了32组岩溶地下水与地表水样品,基于多元统计分析、Piper三线图、Gibbs图和离子比例系数等方法,分析了香花岭矿区岩溶地下水与地表水水文地球化学特征,系统揭示了两者的补给来源、补给年代及水化学演化规律.结果表明,香花岭矿区岩溶地下水与地表水呈弱碱性,主要阴阳离子为HCO_(3)^(−)和Ca^(2+),水化学类型以HCO_(3)-Ca型、HCO_(3)-Ca·Mg型和HCO_(3)·SO_(4)^(-)Ca·Mg型为主.大气降水是岩溶地下水与地表水的主要补给来源,在径流过程中一定程度上受到了蒸发作用的影响,但岩溶地下水所受蒸发作用影响相对较小,与现代水水力联系较为密切,循环更替过程更加迅速.岩溶地下水与地表水的水化学演化特征主要受岩石风化作用、阳离子交替吸附作用、矿物溶解作用及人类活动(农业活动、矿业活动)的共同影响,Ca^(2+)、Mg^(2+)和HCO_(3)^(−)主要源于碳酸盐岩矿物的溶解,少部分源于硅酸盐岩矿物的风化溶解,Na^(+)与Cl^(−)主要源于岩盐的溶解,其中Cl^(−)、NO_(3)^(−)和SO_(4)^(2−)受到农业活动、生活污水排放与矿业活动的外源输入的影响较大.研究结果对香花岭矿区岩溶地下水与地表水循环演化过程、水资源保护利用有重要意义.

关键词：香花岭矿区岩溶地下水水化学特征水岩作用氢氧同位素演化机制

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病

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Science Bulletin 2024年第8期69卷 1137-1152页

作者：苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝 Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China school of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430030China Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Department of Physiology and PathophysiologySchool of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453003China Department of Pathophysiology School of Basic Medical SciencesWuhan UniversityWuhan 430030China Department of Anesthesiology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China The Core Facility and Technical Support Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430030China Research Center for Medicine and Structural Biology Wuhan UniversityWuhan 430030China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesPeking UniversityKey Laboratory for NeuroscienceMinistry of Education/National Health CommissionBeijing 100083China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other *** elimination of hyperphosphorylated tau is promising for the therapy of these *** have conceptualized a strategy,named dephosphorylation-targeting chimeras(DEPTACs),for specifically hijacking phosphatases to tau to debilitate its ***,we conducted the step-by-step optimization of each constituent motif to generate DEPTACs with reasonable effectiveness in facilitating the dephosphorylation and subsequent clearance of pathological ***,for one of the selected chimeras,D16,we demonstrated its significant efficiency in rescuing the neurodegeneration caused by neurotoxic K18-tau seeds in ***,intravenous administration of D16 also alleviated tau pathologies in the brain and improved memory deficits in AD *** results suggested DEPTACs as targeted modulators of tau phosphorylation,which hold therapeutic potential for AD and other tauopathies.

关键词： tau Dephosphorylation-targeting chimeras Therapeutic potential Tauopathy

The In-Flight Realtime Trigger and Localization Software of GECAM

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Research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi Peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-Yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi Peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-Shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang Rui Qiao Xiang Ma Xiao-Bo Li Ping Wang Xin-Ying Song Li-Ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen jian-jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-Yuan Yang Zhi-Long Wen Zhi Chang Yuan-Yuan Du Rui Gao Xiao-fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-Peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of sciences Chinese Academy of SciencesBeijing 100049China school of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar Physics and Department of Physics Xiangtan UniversityXiangtan 411105China Physics and Space Science College China West Normal UniversityNanchong 637002China Department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and Technology Changchun 130022China Chinese Academy of sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

Realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CPU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Status of aquatic organisms resources and their environments in Yangtze River system(2017-2021)⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile Yang Li Shen Yongfeng He Huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei Lin Wang Tingbing Zhu feifei Hu Jinling Gong Hongchun Du Xinbin Duan Huatang Deng Daoqun Wang Fengyue Zhu Yunfeng Li Fan Wu Huijun Ru Yan Zhang Junyi Li Junlin Yang Yuntao Zhou Dongdong Fang Yinping Wang Danqing Lin Yanping Yang Peijie Li Silei Liu jian Yang Ping Zhuang Sikai Wang Tao Zhang Gang Yang Wenbo Yang Lilai Yuan Kun Cao Shuo Xu Huiyuan Liu Zhiqiang Liang Chongrui Wang Hong Li Xiping Yuan Xin Yang Yilong Fu Yanping Zhang Haixin Zhang Zhiying Tao Sheng Wang Xiaoping Gao Binsong Jin Kemao Li Guojie Wang Shenglong jian Yingqin Li Chenjiang Xue Chunyun Lei Shaowei Xue Yi Sun Bin Zhu Ke Shao Xingkun Hu Meihua xiong Jun Du Bin He Tao Yan Yingying Huang Yuanchao Zou Biwen Xie Yongming Wang Bin Li fei Liu Yaoyao Zhang fei Fan Zhijian Wang Jing Huang Haoran Gu Hailong Ge Yan Dan Yan Li Shuqiao Wang Chuang Zhang Lu Zhou Xue Wang Sheng Zeng Yan Xiang Xugang He jianhui Qin Chengxing Xia Jie Hou Yifu Shi Lifang Gao Zhiqiang Zhu Hongbao Shen Yun Du Xuejun Duan Jiawu xiong Deguo Yang Shaoping Liu Zhaohui Ni Hui Zhang Kai Liu Feng Zhao Yingren Li jianwei Wang Qiwei Wei Yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East china Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science Institute Changsha410153China jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery sciences Jiujiang332000China school of Life sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery Technology Extension Center Xining810012China Yunnan Academy of Fishery sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China school of Life sciences Neijiang Normal UniversityNeijiang641100China school of Life sciences Southwest UniversityChongqing400715China Chongqing Fishery sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and Limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of State Forestry and Grassland Administration Changsha410014China

The Yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of Yangtze Fisheries Resources and Environment Investigation(2017-2021)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 24 institutes and universities that located in the Yangtze River basin surveys the status of(1)fish species composition and spatial distribution,(2)current fish abundance,(3)endangered fishes,(4)Yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the Yangtze River mainstream and 10 of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 163 genus,37 families,and 18 orders)before 2017,but only 323 fish species(including 15 new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole Yangtze River *** is estimated that there were 886 million individuals weighing 124.8 million kg,merely equivalent to 27.3%of the resources in 1950s,30.9%of the resources in 1960s,or 58.7%of the resources in *** the new list of protected fishes that recorded in the Yangtze River system,only 15 of 29 were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes Yangtze finless porpoise Resources Aquatic ecosystem Fisheries Background investigation Yangtze river system

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao jiang Xiao-Ming Li Xue-fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu Yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao Zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng Liu fei-Yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang Yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-Di Liu Zhi-Gang Chen xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu school of Materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong school of Materials Science and Engineering Tianjin University school of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University school of Mechanics and Civil Engineering China University of Mining and Technology school of Physical sciences Great Bay University school of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong school of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong jian jianhua Chen Gongyan Chen Yuping Sun Yinghua Ji ZipingWang jianhua Shi Junguo Lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang Xiangdong Zhou XiaohongWu Chengping Hu Zhihong Zhang You Lu Yanping Hu Liyan jiang Qiming wang Renhua Guo jianying Zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen Zhang JieWeng Weidong Li jianping xiong Xianwei Ye jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

Structural regulation of single-atom catalysts for enhanced catalytic oxidation performance of volatile organic compounds

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Nano Research 2023年第2期16卷 1967-1983页

作者： fei jiang Zhiyuan Zhou Chao Zhang Chao Feng Gaoyan xiong Yunxia Wang Zhaoyang fei Yunqi Liu Yuan Pan State Key Laboratory of Heavy Oil Processing China University of Petroleum(East China)Qingdao 266580China Heavy Oil Processing Laboratory Petrochemical Research InstitutePetroChinaBeijing 102206China school of Material Science&Engineering Tianjin University of TechnologyTianjin 300384China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing Technology UniversityNanjing 211816China

The catalytic oxidation of volatile organic compounds(VOCs)is considered a feasible method for VOCs treatment by virtue of its low technical cost,high economic efficiency,and low additionally produced pollutants,which is of important social *** catalysts(SACs)with 100%atom utilization and uniform active sites usually have high activity and high product selectivity,and promise a broad range of *** regulation of the microstructures of SACs by means of defect engineering,interface engineering,and electronic effects can further improve the catalytic performance of VOCs *** this review,we introduce the mechanisms of VOCs oxidation,and systematically summarize the recent research progress of SACs in catalytic VOCs total oxidation into CO_(2)and H_(2)O,and then discuss the effects of various structural regulation strategies on the catalytic ***,we summarize the current problems yet to be solved and challenges currently faced in this field,and propose future design and research ideas for SACs in catalytic oxidation of VOCs.

关键词： single-atom catalysts structure regulation active site volatile organic compounds catalytic oxidation reaction

Derepression of tPA expression by knocking out NRSF enhances mature BDNF and upregulates hippocampal LTP

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Derepression of tPA expression by knocking out NRSF enhances...

Introduction to the Special Issue on Mechanics of Composite Materials and Structures

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xue-Wen CHENG,Lei CAI,Bin LU,Da-Feng XU,Li HUANG,Li XU,Jing ZHENG,jian fei,Zhi-Qi xiong~(1*) 1 Institute of Neuroscience,State Key Laboratory of Neuroscience,Shanghai Institutes for Biological sciences,Chinese Academy of sciences,320 Yueyang Road,Shanghai 200031,china 2school of Life sciences and Technology,Tongji university,1239 Siping Road,Shanghai 200092,china 3school of Pharmacy,East china university of Science and Technology,130 Meilong Road,Shanghai 200237,china

＜正＞Neuronal restrictive silencing factor（NRSF）is an epigenetic repressor with important role in regulating neurogenesis and ***,the physiological function of NRSF in postnatal brain remains an interesting ***,we reported that activity-dependent synaptic plasticity was suppressed by *** cre/ loxP system,nrsf was conditionally knockout（cko）in forebrain excitatory *** recording of hippocampus CA1 radiatum area revealed a significantly upregulated long-term potentiation（LTP）.We also found that activity stimulation led to significant enhancement of mature BDNF in cko mice,and this enhancement was mediated by the increased level of tissue plasminogen activator（tPA）.Moreover,we found tPA was transcriptionally repressed by NRSF through direct binding to RE1 sequence in tPA *** of tPA activity abolished the upregulation of LTP in nrsf-cko *** findings provide an NRSF mediated epigenetic mechanism that moderates LTP in the hippocampus CA3-CA1 pathway.

关键词： NRSF LTP tPA synaptic plasticity

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Computer Modeling in Engineering & sciences 2022年第8期132卷 357-359页

作者： jian xiong Jinshui Yang Hui Li Wu Xu Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin150001China qingdao Innovation and Development Base Harbin Engineering UniversityQingdao266000China school of Mechanical Engineering and Automation Northeastern UniversityShenyang110819China school of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Plate,shell and panel are basic structures used in engineering and *** structures play an important role as main supporting component in all kinds of structures in machinery,civil engineering,ship building,flight vehicle manufacturing,*** materials and structures are widely used in aerospace,marine,automobile industries due to their designable characteristic,lightweight advantageous,high specific strength and *** configurations include laminated materials,hybrid layered materials,sandwich core materials and structures(foam,honeycomb,corrugated and lattice cores,etc.).How to establish an accurate analytical and numerical model is one of the most important subjects in composite materials and *** topics discussed in this special issue include aspects of core-face bonding and reinforcement,enhancement of core mechanical properties and panel performance(including the role of structural hierarchy),and multifunctional advantages offered by different core *** addition,the special issue discusses potential applications,including in morphing wing design,impact resistance and ultralightweight *** research directions are discussed.

关键词： laminated sandwich bonding