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阿尔茨海默病及其他痴呆诊断与治疗临床转化研究进展

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中国现代神经疾病杂志 2018年第2期18卷 95-98页

作者：李彬寅徐玮邓钰蕾马建芳王刚汤荟冬丁健青程琦陈生弟上海交通大学医学院附属瑞金医院神经科上海交通大学医学院神经病学研究所 200025

阿尔茨海默病是临床最常见的神经变性病,通常65岁以后缓慢起病,表现为以记忆障碍为主的认知功能障碍,进行性加重并难以逆转,最终导致痴呆和功能障碍,故早期诊断、及时治疗和有效预防成为重要临床和科研问题。我国国民经济和社会发展第... 详细信息

阿尔茨海默病是临床最常见的神经变性病,通常65岁以后缓慢起病,表现为以记忆障碍为主的认知功能障碍,进行性加重并难以逆转,最终导致痴呆和功能障碍,故早期诊断、及时治疗和有效预防成为重要临床和科研问题。我国国民经济和社会发展第十二个五年规划(简称"十二五")时期,上海交通大学医学院附属瑞金医院陈生弟教授研究团队长期致力于阿尔茨海默病的诊断与治疗研究,开展包括发病机制、流行病学和危险因素筛查、神经心理学测验、影像学和生物学标志物、早期干预等研究,本文拟就上述研究成果进行简要综述。

关键词：阿尔茨海默病痴呆中国综述

出口食品生产企业如何有效开展危害分析与关键控制点重新评估

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食品安全质量检测学报 2017年第6期8卷 2325-2329页

作者：刘建芳王浪李红权刘芳胡大伟湛江出入境检验检疫局湛江524022

目的使已经建立危害分析与关键控制点(hazard analysis critical control point,HACCP)体系的食品生产企业能结合自身发展实际,确定HACCP重新评估的要素,有效开展HACCP重新评估,真正运行HACCP体系,不断提升产品的质量安全。方法对50家... 详细信息

目的使已经建立危害分析与关键控制点(hazard analysis critical control point,HACCP)体系的食品生产企业能结合自身发展实际,确定HACCP重新评估的要素,有效开展HACCP重新评估,真正运行HACCP体系,不断提升产品的质量安全。方法对50家出口食品生产企业进行调研,通过面谈品管主管、发放调查问卷以及查看HACCP重新评估记录,分析其HACCP重新评估的有效性。结果约2/5的食品企业在生产加工方面有变化,但几年来HACCP体系基本未发生任何变化,企业未能有效评估其运行的HACCP体系。结论食品生产企业在进行HACCP重新评估之前,应有明确的评估原因、目的、详细的评估内容、方式并具备一定资质的评估人员,即明确了4W1H(Who、When、Why、What、How)等方面,才能进行有效的HACCP重新评估。

关键词：有效开展危害分析与关键控制点重新评估

Enzymatic Determination of Glucose by Optical-Fiber Sensor Sequential Injection Renewable Surface Spectrophotometry

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Chemical Research in Chinese Universities 2006年第3期22卷 287-291页

作者： wang jian-ya fang Zhao-lun Research Center for Analytical Sciences Northeastern University Shenyang 110006 P. R. China School of Petrochemical Engineering Shenyang University of Technology Shenyang 111003 P. R. China

On the basis of oxidative decoloration of bromopyrogallol red （BPR） with H2O2, catalyzed by horseradish peroxidase（ HRP）, and the sequential injection renewable surface technique（ SI-RST）, a highly sensitive optical-fiber sensor spectrophotometric method for the enzymatic determination of hydrogen peroxide was proposed. By coupling with a glucose oxidase（GOD）-catalyzed reaction, the method was used to determine glucose in human serum. The considerations in system and flow cell design, and factors that influence the determination performance are discussed. With 100μL of sample loaded and 0. 6 mg of bead trapped, the linear response range from 5.0 × 10^-8 to 5.2 × 10^-6 mol/L BPR with a detection limit（3σ） of 2. 5 ×10 ^-8 mol/L BPR, and a precision of 1.1% RSD（ n = 11 ） and a throughput of a 80 samples per hour can be achieved. Under the conditions of a 8. 7 × 10^ -6 mol/L BPR substrate, 0. 04 unit/mL HRP, 600 s reaction time and a reaction temperature of 37℃, the linear response range for H2O2 was from 5.0 × 10^-8 to 7.0 × 10^-6 mol/L with a detection limit（3σ） of 1.0 × 10^-8 mol/L and a precision of 3.7% RSD （ n = 11 ）. The linear response range by coupling with a GOD-catalyzed reaction was from 1.0 × 10^-7 to 1.0 × 10^-5 mol/L. The method was directly applied to determine glucose in human serum. Glucose contents obtained by the proposed procedure were compared with those obtained by using the phenol-4-AAP method, the error was found to be less than 3%.

关键词： Sequential injection renewable surface Optical-fiber sensor Enzymatic reaction Glucose

小区域Ad Hoc网络路由发现过程建模与分析

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上海大学学报（自然科学版） 2004年第4期10卷 346-351页

作者：方建超王汉兴上海大学理学院上海200436

AdHoc网络因无需固定机站、移动方便,已成为无线网络的研究热点.该文(1)分析了小区域AdHoc网络路由发现过程的特点,构建了称为Sm AHF的描述模型;(2)论述了Sm AHF模拟器的设计和实现;(3)模拟并讨论了平均泛洪距离等网络参数与N,p(网络规... 详细信息

AdHoc网络因无需固定机站、移动方便,已成为无线网络的研究热点.该文(1)分析了小区域AdHoc网络路由发现过程的特点,构建了称为Sm AHF的描述模型;(2)论述了Sm AHF模拟器的设计和实现;(3)模拟并讨论了平均泛洪距离等网络参数与N,p(网络规模、连通概率)之间的关系;(4)将实验数据与理论结果作了比较.

关键词：小区域Ad Hoc网络路由发现平均泛洪距离建模与分析

Highly Sensitive Spectrofluorimetric Determination of Trace Amounts of Indium(Ⅲ) with Salicylaldehyde Salicyloylhydrazone

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Chemical Research in Chinese Universities 2002年第2期18卷 183-188页

作者： HAN fang wang Hong jian TANG Bo Department of Chemistry Shandong Normal UniversityJinan 250014P.R.China

The fluorescent reaction of salicylaldehyde salicyloylhydrazone(SASH) with indium(Ⅲ) was studied in detail. Based on this chelation reaction, a sensitive spectrofluorimetric method was developed for the determination of indium in a water ethanol(volume ratio 3∶7) medium at pH 4 0. Under the condition, the In SASH complex displays an excitation and emission maxima at 396 and 461 nm, respectively. The linear range of the method is from 4 7 to 1000 ng/mL and the detection limit is 0 94 ng/mL. The molar ratio of indium to the reagent is 1∶1. The interferences of other ions were studied. The method was successfully applied to the determination of indium in the chemical reagents of lead, tin, zinc, zinc chloride and geological samples by standard addition method.

关键词： Indium determination Salicylaldehyde salicyloylhydrazone Spectrofluorimetry

Adaptive Backstepping Sliding Mode Control of Uncertain Semi-Strict Nonlinear Systems and Application to Permanent Magnet Synchronous Motor

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Journal of Systems Science & Complexity 2021年第2期34卷 552-571页

作者： wang fang wang jian-mei wang Kun ZONG Qun HUA Changchun School of Science Yanshan UniversityQinhuangdao 066004China School of Electrical and Information Engineering Tianjin UniversityTianjin 300072China School of Electrical and Engineering Yanshan UniversityQinhuangdao 066004China

A disturbance observer(DOB)based-backstepping sliding mode control scheme is discussed for a class of semi-strict nonlinear system with unknown parameters and mismatched ***,adaptive technique and DOB are respectively applied to tackle the unknown parameters and mismatched uncertainty,where the DOB can effectively alleviate the chattering problem of sliding mode control(SMC).Then,exponential sliding mode surface is proposed to improve the convergence rate of the sliding mode ***‘explosion of complexity’problem inherent in conventional backstepping control is overcome by designing the novel first-order *** stability of the closed-loop system is analyzed in the framework of Lyapunov stability theory,in which the tracking error converges to an arbitrarily small neighborhood around zero(ASNZ).At last,two examples are given to illustrate the effectiveness of the proposed control strategy.

关键词： Adaptive law DOB filter semi-strict nonlinear system SMC

Histogram-kernel Error and Its Application for Bin Width Selection in Histograms

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 607-624页

作者： Xiu-xiang wang jian-fang Zhang Department of Mathematics Graduate University of Chinese Academy of SciencesBeijing 100049China Coltege of Management Graduate University of Chinese Academy of SciencesBeijing 100190China

Histogram and kernel estimators are usually regarded as the two main classical data-based nonparametric tools to estimate the underlying density functions for some given data sets. In this paper we will integrate them and define a histogram-kernel error based on the integrated square error between histogram and binned kernel density estimator, and then exploit its asymptotic properties. 3ust as indicated in this paper, the histogram-kernel error only depends on the choice of bin width and the data for the given prior kernel densities. The asymptotic optimal bin width is derived by minimizing the mean histogram-kernel error. By comparing with Scott＇s optimal bin width formula for a histogram, a new method is proposed to construct the data-based histogram without knowledge of the underlying density function. Monte Carlo study is used to verify the usefulness of our method for different kinds of density functions and sample sizes.

关键词： Histogram binned kernel density estimator bin width histogram-kernel error integrated square error

An Adaptive Substructure-Based Model Order Reduction Method for Nonlinear Seismic Analysis in OpenSees

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Computer Modeling in Engineering & Sciences 2020年第7期124卷 79-106页

作者： jian wang Ming fang Hui Li Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin150090China Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin150090China College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China.

Structural components may enter an initial-elastic state,a plastic-hardening state and a residual-elastic state during strong seismic *** the residual-elastic state,structural components keep in an unloading/reloading stage that is dominated by a tangent stiffness,thus structural components remain residual deformations but behave in an elastic *** has a great potential to make model order reduction for such structural components using the tangent-stiffness-based vibration modes as a reduced order *** this paper,an adaptive substructure-based model order reduction method is developed to perform nonlinear seismic analysis for structures that have a priori unknown damage *** method is able to generate time-varying substructures and make nonlinear model order reduction for substructures in the residual-elastic *** finite element program OpenSees has been extended to provide the adaptive substructure-based nonlinear seismic *** the low level of OpenSees framework,a new abstract layer is created to represent the time-varying substructures and implement the modeling process of *** the high level of OpenSees framework,a new transient analysis class is created to implement the solving process of substructure-based governing *** with the conventional time step integration method,the adaptive substructure-based model order reduction method can yield comparative results with a higher computational efficiency.

关键词： Adaptive substructure modeling model order reduction nonlinear seismic

Extension of Isometries Between the Unit Spheres of Normed Space E and C(Ω)

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1819-1824页

作者： Xi Nian fang jian Hua wang Department of Applied Mathematics Nanjing Audit University Nanjing 210029 P. R. China Department of Mathematics Anhui Normal University Wuhu 241000 P. R. China

In this paper, we study the extension of isometries between the unit spheres of normed space E and C（Ω）. We obtain that any surjective isometry between the unit spheres of normed space E and C（Ω） can be extended to be a linear isometry on the whole space E and give an affirmative answer to the corresponding Tingley＇s problem （where Ω be a compact metric space）.

关键词： isometric mapping isometric extension Tingley's problem