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Energy spectrum computed tomography multi-parameter imaging in preoperative assessment of vascular and neuroinvasive status in gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2511-2520页

作者： Jing Wang jian-cheng liang Fa-Te Lin Jun Ma Department of Radiology Pingluo County People's HospitalShizuishan 753400Ningxia Hui Autonomous RegionChina Department of Gastrointestinal Surgery Jiangsu Provincial People's HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Vascular and nerve infiltration are important indicators for the progression and prognosis of gastric cancer(GC),but traditional imaging methods have some limitations in preoperative *** recent years,energy spectrum computed tomography(CT)multiparameter imaging technology has been gradually applied in clinical practice because of its advantages in tissue contrast and lesion detail *** To explore and analyze the value of multiparameter energy spectrum CT imaging in the preoperative assessment of vascular invasion(LVI)and nerve invasion(PNI)in GC *** Data from 62 patients with GC confirmed by pathology and accompanied by energy spectrum CT scanning at our hospital between September 2022 and September 2023,including 46 males and 16 females aged 36-71(57.5±9.1)years,were retrospectively *** patients were divided into a positive group(42 patients)and a negative group(20 patients)according to the presence of LVI/*** CT values(CT40 keV,CT70 keV),iodine concentration(IC),and normalized IC(NIC)of lesions in the upper energy spectrum CT images of the arterial phase,venous phase,and delayed phase 40 and 70 keV were measured,and the slopes of the energy spectrum curves[K(40-70)]from 40 to 70 keV were *** Core Tip:To investigate the application value of multiparameter energy spectrum computed tomography(CT)imaging in the preoperative assessment of vascular and nerve infiltration in patients with gastric cancer(GC).The imaging data of GC patients were retrospectively analyzed to evaluate the accuracy and sensitivity of CT for identifying and quantifying vascular and nerve infiltration and for comparison with postoperative pathological *** purpose of this study was to verify the clinical feasibility and potential advantages of multiparameter energy spectrum CT imaging in guiding preoperative diagnosis and treatment decision-making and to provide a new imaging basis for improving the diagnostic accuracy

关键词： Tomography X-ray computer Energy spectrum computed tomography Gastric cancer Vascular invasion Nerve invasion Cross-sectional study

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Mechanism for capacity fading of 18650 cylindrical lithium ion batteries

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Transactions of Nonferrous Metals Society of China 2017年第7期27卷 1602-1607页

作者： jian-liang cheng Xin-hai LI Zhi-xing WANG Hua-jun GUO School of Metallurgy and Environment Central South University Changsha 410083 China

The mechanism for capacity fading of18650lithium ion full cells under room-temperature(RT)is *** capacity loss of18650cells is about12.91%*** cells after cycles are analyzed by XRD,SEM,EIS and *** measurement shows an overall increase in the cell resistance upon ***,it also presents anincreased charge-transfer resistance(Rct)for the cell cycled at *** test shows that the reversibility of lithium ioninsertion/extraction reaction is *** capacity fading for the cells cycled can be explained by taking into account the repeatedfilm formation over the surface of anode and the side *** products of side reactions deposited on separator are able toreduce the porosity of *** a result,the migration resistance of lithium ion between the cathode and anode would beincreased,leading the fading of capacity and potential.

关键词： 18650 lithium ion battery capacity fading cycle performance

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Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells

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Nano Research 2014年第9期7卷 1327-1336页

作者： Shuai Fang Chao Wang jian Xiang liang cheng Xuejiao Song Ligeng Xu Rui Peng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Suzhou Jiangsu 215123 China

Detection of circulating tumor cells （CTCs） plays an important role in cancer diagnosis and prognosis. In this study, aptamer-conjugated upconversion nano- particles （UCNPs） are used for the first time as nanoprobes to recognize tumor cells, which are then enriched by attaching with magnetic nanoparticles （MNPs） and placing in the presence of a magnetic field. Owing to the autofluorescence- free nature of upconversion luminescence imaging, as well as the use of magnetic separation to further reduce background signals, our technique allows for highly sensitive detection and collection of small numbers of tumor cells spiked into healthy blood samples, and shows promise for CTC detection in medical diagnostics.

关键词： circulating tumar cell (CTC)detection upconversion nanoparticles magnetic nanoparticles aptamer

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Ensemble projections of climate and streamflow in a typical basin of semi-arid steppes in Mongolian Plateau of 2021-2100

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Advances in Climate Change Research 2024年第2期15卷 230-243页

作者： Hang PAN jian-Ping TANG liang cheng Man-Chun LI jiangsu Provincial Key Laboratory of Geographic Information Science and Technology Nanjing UniversityNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China

The Kherlen River is the main water source for Hulun Lake,the largest lake in northern *** to reduced inflow from the Kherlen River,Hulun Lake experienced rapid shrinkage at the beginning of the 21st century,posing a serious threat to the ecological security of northern ***,there is still a significant lack of projections regarding future climate change and its hydrological response in the Kherlen River *** study analyzed the projected climate and streamflow changes in the Kherlen River basin,a vital yet vulnerable international semi-arid steppes type basin.A combination of multi-model ensemble projection techniques,and the soil and water assessment tool(SWAT)model was employed to examine the spatio-temporal changes in precipitation,temperature,streamflow,and the associated uncertainties in the *** temperature(an increase of 1.84-6.42℃)and the precipitation(an increase of 15.0-46.0 mm)of Kherlen River basin are projected to increase by 2100,leading to a rise in streamflow(1.08-4.78 m^(3) s^(-1)).The upstream of the Kherlen River exhibits remarkable increasing trends in precipitation,which has a dominant influence on streamflow of Kherlen *** increases in streamflow are observed in April,August,September,and October compared to the reference period(1971-2000).These findings suggest a partial alleviation of water scarcity in the Kherlen River,but also an increased likelihood of hydrological extreme *** projected temperature increase in the Kherlen River basin exhibits the smallest uncertainty,while more pronounced uncertainties are found in precipitation and *** spread among the results of CMIP6 models is greater than that of CMIP5 models,with lower signal-to-noise ratio(SNR)values for temperature,precipitation,and streamflow.

关键词： Climate change Flow projection Uncertainty SWAT Mongolian Plateau

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Interface interaction between SiO_(2) and magnetite under high temperature:particle migration and inhibition mechanism

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Journal of Iron and Steel Research International 2024年第3期31卷 561-572页

作者： Yao-zu Wang jian-liang Zhang Qiang cheng Hui-qing jiang Zheng-jian Liu Yu-bo Tan School of Intelligent Science and Technology University of Science and Technology BeijingBeijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China School of Advanced Engineering University of Science and Technology BeijingBeijing 100083China

Silicon is one of the main gangue components in iron ore,usually in the form of quartz and *** studies have shown that SiO_(2) has a two-sided effect on the consolidation of pellets during high-temperature oxidation roasting of ***,it is very difficult to capture the structural evolution and migration mechanisms during high-tem-perature roasting process by existing experimental ***,the influence of SiO_(2) on the consolidation behavior of magnetite was studied through a series of roasting experiments and molecular dynamic *** results show that the consolidation index and particle growth index decrease with the increase in SiO_(2) content in the *** 1573 K,the liquid phase promotes the recrystallization growth of hematite at high *** dynamic study shows that it is difficult for quartz SiO_(2) to form sintering neck with Fe_(2)O_(3).When the calcination temperature is higher than 1400 K,the Fe_(2)O_(3)-Fe_(2)SiO_(4) system produces a considerable sintering neck structure after *** atomic migration ability of Fe_(2)SiO_(4) is much higher than that of Fe_(2)O_(3).The higher atomic migration ability of Fe_(2)SiO_(4) is the main reason for the formation of the sintering neck.

关键词： Sintering neck Crystal growth Consolidation Molecular dynamics SiO_(2)

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Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2727-2741页

作者： Hui-Ying jian Zi-cheng liang Huan Wen Zhen Zhang Pu-Hua Zeng Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Hospital of Integrated Traditional Chinese and Western Cancer Research Institute of Hunan Academy of Traditional Chinese MedicineHunan Academy of Chinese MedicineChangsha 410006Hunan ProvinceChina

BACKGROUND Previous studies have shown that the Shi-pi-xiao-ji(SPXJ)herbal decoction formula is effective in suppressing hepatocellular carcinoma(HCC),but the underlying mechanisms are not ***,this study investigated whether the antitumor effects of the SPXJ formula in treating HCC were mediated by acetyl-coA acetyltransferase 1(ACAT1)-regulated cellular *** a series of experiments,we concluded that SPXJ inhibits the progression of HCC by upregulating the expression level of ACAT1,lowering the level of cholesterol in the cell membrane,and altering the cellular stiffness,which provides a new idea for the research of traditional Chinese medicine against *** To investigate the anti-tumor effects of the SPXJ formula on the malignant progression of *** HCC cells were cultured in vitro with SPXJ-containing serum prepared by injecting SPXJ formula into wild-type *** apoptotic rate and proliferative,invasive,and migratory abilities of control and SPXJ-treated HCC cells were *** force microscopy was used to determine the cell surface morphology and the Young’s modulus values of the control and SPXJ-treated HCC *** membrane cholesterol levels in HCC cells were detected using the Amplex Red cholesterol detection ***1 protein levels were estimated using western *** Compared with the vehicle group,SPXJ serum considerably reduced proliferation of HCC cells,increased stiffness and apoptosis of HCC cells,inhibited migration and invasion of HCC cells,decreased plasma membrane cholesterol levels,and upregulated ACAT1 protein ***,treatment of HCC cells with the water-soluble cholesterol promoted proliferation,migration,and invasion of HCC cells as well as decreased cell stiffness and plasma membrane cholesterol levels,but did not alter the apoptotic rate and ACAT1 protein expression levels compared with the vehicle *** SPXJ formula inhibited proliferation,invasion,and migration

关键词： Shi-pi-xiao-ji formula Hepatocellular carcinoma Cellular stiffness Plasma membrane cholesterol level AcetylcoA acetyltransferase 1

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Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： jian-Hu Gong Zheng-Ming Zhang cheng-liang Zhang Peng-Qiang Hu Chao Zhou Dun-Hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

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The higher-order topological pumping explored in the 2D acoustic crystal

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 127-133页

作者： Yanqiu Wang Bin liang jianchun cheng Key Laboratory of Modern Acoustics Ministry of EducationInstitute of AcousticsDepartment of PhysicsNanjing UniversityNanjing 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

The topological pumping has been instrumental in advancing our understanding of topological phase transitions in various physical systems,which can be extended to uncover intriguing higher-order topological phases in the lower-dimensional ***,we propose a theoretical exploration of topological dipole pumping on an acoustic square superlattice by cyclically modulating intracell couplings,which shares the topological nature of an extended three-dimensional system with chiral hinge *** the multipole chiral numbers,we characterize the higher-order topological phases that arise during the *** evolution of topological phase transitions is verified by numerical simulations and shows corner states are transferred across the *** findings can inspire the construction of chiral hinge states in artificial crystals,opening up new possibilities for the design of devices allowing the unidirectional propagation of sound.

关键词： topological phases of matter Thouless pumping acoustic metamaterial

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Reconstruction of biomimetic ionic channels within covalent organic frameworks for ultrafast and selective uranyl capture

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Science China Chemistry 2024年第10期67卷 3423-3431页

作者： cheng-Rong Zhang Xiao-Juan Chen cheng-Peng Niu cheng Meng Shun-Mo Yi Xin Liu Jia-Xin Qi Qiu-Xia Luo Ru-Ping liang jian-Ding Qiu State Key Laboratory of Nuclear Resources and Environment East China University of Technology College of Chemistry and Chemical Engineering Nanchang University

The efficient extraction of uranium, as the primary component of nuclear energy, holds significant implications. Drawing inspiration from the charge interaction observed in biological ion channels, we encapsulated negatively charged polystyrene sulfonate(PSS) or sodium polystyrene carboxylate(PVBA) into the nanochannels of amidoxime functionalized covalent organic framework(COF-AO) in-situ to alter the cavity environment of COF-AO. The synthesized COF-AO-PSS and COF-AO-PVBA are used for ultra-fast and highly selective uranium recovery. The negatively charged PSS/PVBA was confined in the COF-AO channel providing the driving force for uranium transport and blocking other ions, thus creating a highly selective “uranium highway”. Additionally, introducing sulfonate groups or carboxyl groups into COF-AO offers supplementary coordination environments and weak interactions with uranium. Due to charge-assisted migration and various interaction mechanisms, both COF-AO-PSS and COF-AO-PVBA exhibit faster adsorption kinetics and higher selectivity compared to COF-AO alone. Their adsorption capacities are 3.8 times and 2.4 times that of COF-AO alone respectively which highlights the necessity for constructing biomimetic ion channels in uranium adsorption processes. This work presents a bionic adsorbent based on covalent organic frameworks(COFs) for the first time, overcoming environmental and equipment limitations associated with traditional photocatalysis and electrocatalysis methods for uranium capture, opening up new avenues for designing multifunctional materials that mimic biological systems.

关键词： covalent organic frameworks Uranium biomimetic ion-channels adsorption

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A nonradical oxidation process initiated by Ti-peroxo complex showed high specificity toward the degradation of tetracycline antibiotics

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Chinese Chemical Letters 2024年第5期35卷 366-370页

作者： jian Peng Yue jiang Shuangyu Wu Yanran cheng Jingyu liang Yixin Wang Zhuo Li Sijie Lin College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalTongji UniversityShanghai 200092China Key Laboratory of Yangtze River Water Environment Shanghai Institute of Pollution Control and Ecological SecurityTongji UniversityShanghai 200092China

Nonradical oxidation has received wide attention in advanced oxidation processes for environmental *** the relationship between material characteristics and their ability to initiate nonradical oxidation processes is the key to better material design and ***,a novel titanium-based metal-organic framework MIL-125-Ti/H_(2)O_(2) system was established to show a highly selective degradation efficacy toward tetracycline ***-125-Ti with the abundance of TiO6 octahedra units was found to effectively activate H_(2)O_(2) under dark conditions by forming an oxidative Ti-peroxo *** presence of the Ti-peroxo complex,confirmed by UV-visible spectrophotometer,fourier transform infrared spectroscopy,and X-ray photoelectron spectroscopy characterizations,showed superior degradation(>95%removal rate)of oxytetracycline hydrochloride(OTC),doxycycline hydrochloride,chlortetracycline hydrochloride,and *** functional theory calculations were performed to assist the elucidation on the mechanism of H_(2)O_(2) activation and antibiotics *** MIL-125-Ti/H_(2)O_(2) system was highly resistant to halogens and background organics,and could well maintain its original catalytic activity in actual water *** retained the ability to degrade 75%of OTC within ten test *** study provides new insight into the nonradical oxidation process initiated by the unique Ti-peroxo complex of Ti-based MOF.

关键词： Nonradical oxidation Metal-organic frameworks Advanced oxidation process Ti-peroxo complex Antibiotics degradation

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