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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin jian-jian Chen Nai-jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao jian-bing wu Song Wang Xu Zhu jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-bing Xu jian Xu Qing-Hua wu Huan-Zhang Niu jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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Nimesulide联合奥沙利铂对人肝癌细胞增殖与凋亡的影响

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世界华人消化杂志 2008年第36期16卷 4041-4045页

作者：刘利珍简捷吴建兵黄龙璋史芳南昌大学第二附属医院肿瘤科江西省分子医学重点实验室江西省南昌市330006 南昌大学第二附属医院消化内科江西省分子医学重点实验室江西省南昌市330006

目的:探讨选择性环氧合酶-2(cyclooxy-genase-2,COX-2)抑制剂Nimesulide联合奥沙利铂(Oxaliplatin,L-OHP)对人肝癌细胞株SMMC-7721增殖与凋亡的影响,为肝癌的药物治疗提供依据.方法:预实验筛选Nimesulide有效终浓度与不同浓度L-OHP(0.5、1.0、2.0、5.0mg/L)联合处理肝癌细胞48h;另外选取L-OHP有效终浓度与Nimesulide筛选的浓度单独或联合处理肝癌细胞24h、48h、72h;采用倒置显微镜观察细胞形态学改变,四氮唑盐比色法(MTT法)观察细胞增殖活力的改变,流式细胞仪检测细胞凋亡率.结果:不同浓度Nimesulide及L-OHP对SMMC-7721表现出一定程度的生长抑制作用,并呈剂量依赖性.Nimesulide(50mmol/L)或L-OHP(1mg/L)单用时可显著抑制SMMC-7721细胞的增殖,选用Nimesulide 50mmol/L与L-OHP(0.5、1.0、2.0、5.0mg/L)联合使用时,联合抑制作用呈现协同作用(Q>1.15).L-OHP 1mg/L、Nimesulide 50mmol/L及两药联合处理SMMC-7721细胞24h、48h、72h,各处理组各时间点对肝癌细胞的抑制作用随着时间的延长而增大,并且两药联合作用有协同作用(Q>1.15).流式细胞仪检测分析发现两种药物均可有效诱导SMMC-7721细胞的凋亡,且在上述浓度联合应用时具协同效应.结论:Nimesulide与L-OHP对人肝癌细胞株SMMC-7721均有抑制增殖和促进凋亡作用,而且两者联合应用有协同作用.

关键词： Nimesulide 奥沙利铂细胞增殖凋亡

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基于Web的在线考试系统的研究

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机械管理开发 2002年第4期17卷 46-47页

作者：林健武兵林楠太原理工大学网络中心山西太原030024 山西迅潮电子有限公司山西太原030002 太原化工学校山西太原030021

介绍了在线考试系统理论(主要是项目反映理论和组卷理论),在线考试系统的模块,画出了系统运行流程图;使读者对系统有所基本理解,并在远程教学中运用。

关键词： Web 在线考试系统项目分析组卷理论

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Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing Xu Da-jian wu Ying Cheng Xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure

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Validation and evaluation of clinical prediction systems for first and repeated transarterial chemoembolization in unresectable hepatocellular carcinoma: A Chinese multicenter retrospective study

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World Journal of Gastroenterology 2020年第6期26卷 657-669页

作者： Zhe-Xuan Wang En-Xin Wang Wei Bai Dong-Dong Xia Wei Mu Jing Li Qiao-Yi Yang Ming Huang Guo-Hui Xu Jun-Hui Sun Hai-Liang Li Hui Zhao jian-bing wu Shu-Fa Yang Jia-Ping Li Zi-Xiang Li Chun-Qing Zhang Xiao-Li Zhu Yan-Bo Zheng Qiu-He Wang Jing Li Jie Yuan Xiao-Mei Li Jing Niu Zhan-Xin Yin Jie-Lai Xia Dai-Ming Fan Guo-Hong Han China HCC-TACE Study Group Department of Liver Disease and Digestive Interventional Radiology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Radiology the Southwest HospitalThird Military Medical UniversityChongqing 400037China Department of Hepatobiliary Surgery the Second Affiliated Hospital of Third Military Medical UniversityChongqing 400037China Department of Minimally Invasive International Therapy the Third Affiliated Hospital of Kunming UniversityTumor Hospital of Yunnan ProvinceKunming 650000Yunnan ProvinceChina Department of Interventional Radiology Tumor Hospital of Sichuan ProvinceChengdu 610000Sichuan ProvinceChina Department of Hepatobiliary and Pancreatic Interventional Cancer the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Interventional Radiology Henan Cancer Hospitalthe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008Henan ProvinceChina Department of Interventional Radiology the Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Oncology the Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Interventional Radiology the Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Interventional Radiology the First Affiliated Hospital of Sun Yatsen UniversityGuangzhou 510080Guangdong ProvinceChina Department of Interventional Medical Center the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Gastroenterology and Hepatology Shandong Province Hospital affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina Department of Interventional Radi

BACKGROUND The treatment outcome of transarterial chemoembolization(TACE)in unresectable hepatocellular carcinoma(HCC)varies greatly due to the clinical heterogeneity of the ***,several prognostic systems have been proposed for risk stratification and candidate identification for first TACE and repeated TACE(re-TACE).AIM To investigate the correlations between prognostic systems and radiological response,compare the predictive abilities,and integrate them in sequence for outcome *** This nationwide multicenter retrospective cohort consisted of 1107 unresectable HCC patients in 15 Chinese tertiary hospitals from January 2010 to May *** Hepatoma Arterial-embolization Prognostic(HAP)score system and its modified versions(mHAP,mHAP2 and mHAP3),as well as the six-and-twelve criteria were compared in terms of their correlations with radiological response and overall survival(OS)prediction for first *** same analyses were conducted in 912 patients receiving re-TACE to evaluate the ART(assessment for re-treatment with TACE)and ABCR(alpha-fetoprotein,Barcelona Clinic Liver Cancer,Child-Pugh and Response)systems for post re-TACE survival(PRTS).RESULTS All the prognostic systems were correlated with radiological response achieved by first TACE,and the six-and-twelve criteria exhibited the highest correlation(Spearman R=0.39,P=0.026)and consistency(Kappa=0.14,P=0.019),with optimal performance by area under the receiver operating characteristic curve of 0.71[95%confidence interval(CI):0.68-0.74].With regard to the prediction of OS,the mHAP3 system identified patients with a favorable outcome with the highest concordance(C)-index of 0.60(95%CI:0.57-0.62)and the best area under the receiver operating characteristic curve at any time point during follow-up;whereas,PRTS was well-predicted by the ABCR system with a C-index of 0.61(95%CI:0.59-0.63),rather than ***,combining the mHAP3 and ABCR systems identified candidates suitable for TA

关键词： Transarterial chemoembolization Hepatocellular carcinoma Prognostic system Radiological response Overall survival Predictive ability

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian wu Xiaohui Huang Ajing Xu Yan Liu jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian wu Hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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骨形态发生蛋白2、6在肝癌中的表达及意义

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世界华人消化杂志 2009年第8期17卷 834-837页

作者：吴建兵傅华群黄龙璋刘安文张吉翔南昌大学第二附属医院肿瘤科江西省分子医学重点实验室江西省南昌市330006 南昌大学第二附属医院肝胆外科江西省分子医学重点实验室江西省南昌市330006 南昌大学第二附属医院消化内科江西省分子医学重点实验室江西省南昌市330006

目的:研究骨形态发生蛋白2、6(BMP-2、6)在肝癌组织中的表达,并探讨其与肝癌生物学行为的关系.方法:应用半定量逆转录聚合酶链反应(RT-PCR)和Westernblot检测30例正常肝脏组织和30例肝癌组织的BMP-2、6的表达水平.结果:正常肝脏组织BMP-... 详细信息

目的:研究骨形态发生蛋白2、6(BMP-2、6)在肝癌组织中的表达,并探讨其与肝癌生物学行为的关系.方法:应用半定量逆转录聚合酶链反应(RT-PCR)和Westernblot检测30例正常肝脏组织和30例肝癌组织的BMP-2、6的表达水平.结果:正常肝脏组织BMP-2、6mRNA相对表达量显著低于肝癌组织(0.3245±0.1127vs0.8298±0.1187,0.2947±0.1853vs0.7145±0.1373,均P<0.05),Ⅲ、Ⅳ期肝癌组织BMP-2、6mRNA相对表达量显著高于Ⅰ、Ⅱ期(0.92431±0.1234vs0.69355±0.19250.8354±0.1423vs0.6043±0.1234,均P<0.05)Westernblot检测有远处转移的肝癌组织BMP-2、6表达高于无远处转移的肝癌组织(0.9854±0.2888vs0.6244±0.3087,0.9076±0.1276vs0.5678±0.2493,均P<0.01).结论:BMP-2、6在肝癌中表达上调,可能在肝癌的发生发展中起着重要的作用,其表达上调可能促进肝癌的浸润和转移.

关键词：癌肝细胞骨形态发生蛋白逆转录-聚合酶链反应蛋白质印迹

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Non-uniform Gradient Estimates for SDEs with Local Monotonicity Conditions

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Acta Mathematica Sinica,English Series 2021年第3期37卷 458-470页

作者： jian WANG bing Yao wu College of Mathematics and Informatics&Fujian Key Laboratory of Mathematical Analysis and Applications(FJKLMAA)&Center for Applied Mathematics of Fujian Province(FJNU) Fujian Normal UniversityFuzhou 350007P.R.China College of Mathematics and Informatics Fujian Normal UniversityFuzhou 350007P.R.China

By using the coupling method and the localization technique, we establish non-uniform gradient estimates for Markov semigroups of diffusions or stochastic differential equations driven by pure jump Le′vy noises, wher... 详细信息

关键词： Gradient estimate Markov semigroup monotonicity condition coupling stochastic differential equation Lévy process

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