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2019—2020年160例儿童肺炎链球菌脑膜炎临床流行病学多中心研究

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中国当代儿科杂志 2024年第2期26卷 131-138页

作者：王彩云许红梅刘钢刘静俞蕙陈必全郑帼舒敏杜丽君徐志伟黄丽素李海波汪东白松婷单庆文朱春晖田健美郝建华林爱伟林道炯吴谨准张新华曹清陶仲宾陈源朱国龙薛萍汤正珍苏学文曲政海赵仕勇庞琳邓慧玲舒赛男陈英虎浙江大学医学院附属儿童医院感染科浙江杭州310052 重庆医科大学附属儿童医院感染科重庆400014 首都医科大学附属北京儿童医院感染科北京100045 湖南省儿童医院感染科湖南长沙410007 复旦大学附属儿科医院感染科上海201102 安徽省儿童医院感染科安徽合肥230022 南京医科大学附属儿童医院神经科江苏南京210008 四川大学华西第二医院儿科四川成都610044 山西省儿童医院神经内科山西太原030006 温州医科大学附属第二医院/育英儿童医院普儿科浙江温州325027 上海交通大学医学院附属新华医院感染科上海200092 吉林大学第一医院儿科门诊吉林长春130061 西安交通大学附属儿童医院陕西西安710002 郑州大学第一附属医院儿科河南郑州450052 广西医科大学第一附属医院儿科广西南宁530021 江西省儿童医院感染科江西南昌330006 苏州大学附属儿童医院感染科江苏苏州215002 河南开封市儿童医院感染科河南开封475000 山东大学儿童院感染科山东济南250022 海南省妇幼保健院感染科海南海口571103 厦门大学附属妇女儿童医院儿科福建厦门361003 山西省儿童医院新生儿科山西太原030006 上海交通大学医学院附属上海儿童医学中心感染科上海200127 兰州大学第一医院儿科甘肃兰州730013 河北医科大学第二医院儿科河北石家庄050004 青海省妇女儿童医院感染消化科青海西宁810007 太原市妇幼保健院儿内科山西太原030012 遵义市第一人民医院儿科贵州遵义563099 内蒙古自治区人民医院儿科内蒙古呼和浩特750306 青岛大学附属医院儿科山东青岛266003 杭州市儿童医院感染科浙江杭州310005 首都医科大学附属北京地坛医院儿科北京100102 西安市中心医院儿科陕西西安710004 华中科技大学同济医学院附属同济医院儿科湖北武汉430030

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿... 详细信息

目的研究中国儿童肺炎链球菌脑膜炎(pneumococcal meningitis,PM)的临床特征、转归和分离菌株肺炎链球菌(Streptococcus pneumoniae,SP)的药物敏感性。方法回顾性分析2019年1月—2020年12月全国33家三级甲等医院160例<15岁的PM住院患儿的临床信息、实验室资料和微生物学资料。结果160例PM患儿中,男103例,女57例;年龄15 d至15岁,其中3月龄至<3岁109例(68.1%)。脑脊液培养分离SP菌株95例(59.4%),血培养分离SP菌株57例(35.6%)。脑脊液宏基因组二代测序和脑脊液SP抗原检测阳性率分别为40%(35/87)、27%(21/78)。55例(34.4%)患儿存在1个或多个化脓性脑膜炎高危因素;113例(70.6%)患儿有1个或多个颅外感染病灶;18例(11.3%)有明确基础疾病。临床症状以发热最常见(147例,91.9%),其次是精神萎靡(98例,61.3%)、呕吐(61例,38.1%)等。69例(43.1%)患儿住院期间发生颅内并发症,常见并发症为硬膜下积液和/或积脓(43例,26.9%)、脑积水(24例,15.0%)、脑脓肿(23例,14.4%)、脑出血(8例,5.0%)。硬膜下积液和/或积脓和脑积水主要发生在<1岁患儿,分别为91%(39/43)、83%(20/24)。SP菌株对万古霉素(100%,75/75)、利奈唑胺(100%,56/56)、厄他培南(100%,6/6)完全敏感;对左氧氟沙星(81%,22/27)、莫西沙星(82%,14/17)、利福平(96%,25/26)和氯霉素(91%,21/23)敏感率高;对青霉素(16%,11/68)、克林霉素(6%,1/17)敏感率低;对红霉素完全耐药(100%,31/31)。痊愈和好转出院率分别为22.5%(36/160)、66.2%(106/160);18例(11.3%)出现不良结局。结论儿童PM多见于3月龄至<3岁婴幼儿,颅内并发症多发生在<1岁患儿,发热是PM患儿最常见的临床表现,硬膜下积液和/或积脓、脑积水是最常见的并发症。脑脊液非培养检测方法有助于提高病原菌检出率。超过10%PM患儿出现不良结局。SP菌株对万古霉素、利奈唑胺、厄他培南、左氧氟沙星、莫西沙星、利福平、氯霉素敏感率高。

关键词：肺炎链球菌脑膜炎流行病学多中心研究儿童

The effect of hydrophobic-lipophilic interactions on chemical reactivity——*** of lipophilic interactions to the binding of hydrocarbon substrates by amylose-type hosts and of hydrophobic interactions to the binding of fluorocarbon surfactan

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Acta Chimica Sinica(English Edition) 1987年第1期5卷 329-337页

作者： jianG Xi-Kui GU jian-Hua CHENG Xian-En HUI Yong-zheng Shanghai Institute of Organic Chemistry,Academia Sinica,Shanghai Shanghai Institute of Organic Chemistry Academia Sinica Shanghai

With cyclodextrins（α-and β-CD）and sodium carboxymethylamylose（Na-CMA）ashosts,and with H（CF2）12CO2K（1）,CH3（CH2）10CO2K（2）,Cl（CF2）8CH2CH2N+Me-3I-（3）,CH3（CH2）8-CH2N+Me3I-（4）,CI（CF2）10CH2CH2N+Me3I-（5）and CH3（CH2）10CH2N+Me3I-（6）as guest sub-strates,the different behaviors of fluorocarbon and hydrocarbon surfactants have been studied by sur-face tension *** cavity size prevents the inclusion of fluorocarbon surfactants byα-CD,but the binding byβ-CD is stronger for the fluorocarbon substrate 3 than that for its hydrocarbonanalog 4.A comparison of the thermodynamic parameters of the β-CD binding process for 3and 6 reveals that for the former the binding is driven by entropy or hydrophobic forces,butfor the latter the process is ***,Na-CMA fails to bind the fluorocarbonsubstrates.A crucial difference between the cyclodextrins and the amylose-type hosts lies in the factthat the former hosts possess pre-organized cavities whereas the latter have to readjust their confor-mations from loose and extended helices with random coils to interrupted helices during the process ***,this extra energy requirement demands contributions from lipophilic interactionswhich do not exist between fluorocarbon chains and the *** lipophilic forces are significantin hydrophobic-lipophilic interactions.

关键词： The effect of hydrophobic-lipophilic interactions on chemical reactivity Contributions of lipophilic interactions to the binding of hydrocarbon substrates by amylose-type hosts and of hydrophobic inter type

Practice of improving the hot blast temperature for the 2500 m^3 BF

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baosteel Technical Research 2008年第2期2卷 31-35页

作者： Li Yiwei Shi jian＇ en bao Lei Wang Yi Ironmaking Plant Stainless Steel Branch Baoshan Iron ＆ Steel Co. Ltd. Shanghai 200431 China

A high blast temperature is an effective measure that improves pulverized coal injection （PCI）and energy consumption,decreases the cost of blast furnaces （BF）. Apart from using technology such as the increased vault temperature of the hot-blast stove, the increased temperature of the waste gas, the preheating of combustion air and gas, and fully closed mixed air valves, other measures, such as using an oxygen-enriched blast stove, burning high heating value converter gas, increasing the number of stove changes to reduce the time needed for stove blasts, were taken to increase the blast temperature of the 2 500 m3 BF in recent years. The blast temperature of the 2 500 m3 BF was continuously increased in these years. The monthly average temperature of the 2 500 m3 BF reached 1 158℃, with the highest blast temperature reaching 1 195 ℃ in 2006. This technique of increased blast temperatures has reached an advanced level in China.

关键词： hot blast stove high blast temperature oxygen-enriched stove converter gas

Different clinical characteristics and outcomes of hypertrophic cardiomyopathy with and without hypertension:seeking the truth

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Journal of Geriatric Cardiology 2023年第2期20卷 109-120页

作者： Yu ZHANG Ming-Hao LIU Mo ZHANG Gui-Xin WU Jie LIU Ji-zheng WANG Xiao-Lu SUN Wen jianG Dong WANG Lian-Ming KANG Xue-Yi WU Yu-bao ZOU Lei SONG State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Cardiomyopathy Ward Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVE To determine the different clinical characteristics and outcomes of hypertrophic cardiomyopathy(HCM)patients with and without hypertension(HT).METHODS A total of 696 HCM patients were included in this study and all HCM diagnoses were confirmed by the genetic *** were analyzed separately in the septal reduction therapy(SRT)cohort and the non-SRT *** primary endpoint was cardiovascular death and the secondary endpoint was all-cause *** analyses were conducted to evaluate the associations between HT and outcomes in *** before enrollment and at discharge were collected in the post-hoc *** HCM patients without HT were younger,had a lower body mass index,were more likely to have a family history of HCM,and had a smaller left ventricular(LV)end-diastolic diameter than those with HT in both cohorts.A thicker LV wall,a higher level of N-terminal pro-B-type natriuretic peptide,and a higher extent of LV late gadolinium enhancement were additionally observed in patients without HT in the non-SRT *** presence of HT did not alter the distribution pattern of late gadolinium enhancement,as well as the constituent ratio of eight disease-causing sarcomeric gene variants in both *** analyses showed that in the non-SRT cohort,patients without HT had higher risks of cardiovascular death(HR=2.537,P=0.032)and all-cause death(HR=3.309,P=0.032).While such prognostic divergence was not observed in the SRT *** post-hoc analyses in the non-SRT cohort found that patients without HT received fewer non-dihydropyridine calcium channel blockers and angiotensinconverting enzyme inhibitors/angiotensin receptor blockers before enrollment and at *** HCM patients without HT had worse clinical conditions and higher mortality than patients with HT overall,which may result from active medical therapy in HT *** SRT may have a substantial de-risking effect on patients meeting the indicati

关键词： clinical hypertension cardiomyopathy

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基于LabVIEW的瞬变电磁接收系统设计

吉林大学学报（工学版） 2016年第5期46卷 1725-1731页

作者：于生宝苏发郑建波朱占山吉林大学仪器科学与电气工程学院长春130026

针对瞬变电磁仪器晚期信噪比低、抗干扰能力差的问题,介绍了一种基于LabVIEW控制USB4432采集卡的瞬变电磁仪器接收系统。为了便于使用,系统采用GPS同步;针对晚期信号弱、噪声大的问题,采用低噪声放大器搭建了双路差分前置放大器电路,并... 详细信息

针对瞬变电磁仪器晚期信噪比低、抗干扰能力差的问题,介绍了一种基于LabVIEW控制USB4432采集卡的瞬变电磁仪器接收系统。为了便于使用,系统采用GPS同步;针对晚期信号弱、噪声大的问题,采用低噪声放大器搭建了双路差分前置放大器电路,并利用UAF42设计了四阶低通滤波器压制高频噪声;为了提高系统的稳定性和功能可扩展性,利用图形化语言G语言编写系统上位机程序。测试结果表明,该系统具有工作稳定、噪声水平低的优点,可用于瞬变电磁信号的采集。

关键词：仪器仪表技术瞬变电磁 LabVIEW 接收系统前置放大器

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二元混合液体闪点的计算

中国安全科学学报 2010年第6期20卷 57-62页

作者：包洪政赤峰学院化学系

以混合溶液纯组分易燃液体闪点的饱和蒸气压为基础,应用乌拉尔定律、双液系的气-液相平衡理论,运用Le Chatelier方程和安托因方程导出二元混合液的闪点计算方法。并例举易燃液体与易燃液体组成的理想混合液、易燃液体与易燃液体组成的... 详细信息

以混合溶液纯组分易燃液体闪点的饱和蒸气压为基础,应用乌拉尔定律、双液系的气-液相平衡理论,运用Le Chatelier方程和安托因方程导出二元混合液的闪点计算方法。并例举易燃液体与易燃液体组成的理想混合液、易燃液体与易燃液体组成的非理想混合液、易燃液体与不燃液体组成的非理想混合液的计算过程。乙醇溶液闪点的计算结果与现有的文献资料比较,误差在允许范围内。计算数据用Excel处理,快捷准确,用于确定二元混合液体的火灾危险性。

关键词：易燃液体二元混合液蒸气压闪点计算

论列宁的报刊活动及其历史贡献——写在列宁诞辰150周年之际

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现代传播（中国传媒大学学报） 2020年第3期42卷 1-8页

作者：郑保卫广西大学新闻与传播学院中国人民大学新闻学院

列宁作为马克思主义宣传家和报刊活动家,其报刊活动为其革命活动提供了思想武器,为其新闻思想奠定了实践基础,同时丰富了无产阶级政党报刊的办报经验,开创了社会主义新闻事业的发展基业,在世界无产阶级新闻事业发展史上有着重要地位和... 详细信息

列宁作为马克思主义宣传家和报刊活动家,其报刊活动为其革命活动提供了思想武器,为其新闻思想奠定了实践基础,同时丰富了无产阶级政党报刊的办报经验,开创了社会主义新闻事业的发展基业,在世界无产阶级新闻事业发展史上有着重要地位和影响。

关键词：列宁报刊活动新闻思想历史贡献

Pericarp and seed of litchi and longan fruits:constituent, extraction, bioactive activity, and potential utilization

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第6期20卷 503-512页

作者： Xiang-rong ZHU Hui WANG jian SUN bao YANG Xue-wu DUAN Yue-ming jianG Key Laboratory of Plant Resource Conservation and Sustainable Utilization Key Laboratory of Post-Harvest Handling of FruitsMinistry of AgricultureSouth China Botanical GardenChinese Academy of Sciences Institute of Post-harvest Technology of Agricultural Products College of Food ScienceFujian Agriculture and Forestry University Agro-food Science and Technology Research Institute Guangxi Academy of Agricultural Sciences

Litchi(Litchi chinensis Sonn.)and longan(Dimocarpus longan Lour.)fruits have a succulent and white aril with a brown seed and are becoming popular *** two fruits have been used in traditional Chinese medicine as popular herbs in the treatment of neural pain,swelling,and cardiovascular *** pericarp and seed portions as the by-products of litchi and longan fruits are estimated to be approximately 30%of the dry weight of the whole fruit and are rich in bioactive *** the recent years,many biological activities,such as tyrosinase inhibitory,antioxidant,anti-inflammatory,immunomodulatory,anti-glycated,and anti-cancer activities,as well as memory-increasing effects,have been reported for the litchi and longan pericarp and seed extracts,indicating a potentially significant contribution to human *** the increasing production of litchi and longan fruits,enhanced utilization of the two fruit by-products for their inherent bioactive constituents in relation to pharmacological effects is urgently *** paper reviews the current advances in the extraction,processing,identification,and biological and pharmacological activities of constituents from litchi and longan *** utilization of litchi and longan pericarps and seeds in relation to further research is also discussed.

关键词： Bioactive compound Extraction Litchi Longan Pharmacological activity Utilization

Enhancement of thermoelectric properties of SrTiO3/LaNb–SrTiO3 composite by different doping levels

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Chinese Physics B 2018年第4期27卷 117-122页

作者： Ke-Xian Wang Jun Wang Yan Li Tao Zou Xiao-Huan Wang jian-Bo Li zheng Cao Wen-Jing Shi Xinba Yaer School of Materials Science and Engineering Inner Mongolia University of Technology Hohhot 010051 Inner Mongolia Autonomous Region China School of Chemical Engineering Kang Ba Shi Qu Ordos Ordos Institute of Technology Ordos 017000 Inner Mongolia Autonomous Region China Beijing Center for Physical & Chemical Analysis No. 27 Xi Sanhuan Road Haidian District Beijing 100089 China

Strontium titanate（STO）is an n-type oxide thermoelectric material,which has shown great prospects in recent *** doping of La and Nb into STO can improve its power factor,whereas its thermal conductivity is still very ***,in order to obtain a high thermoelectric figure-of-merit z T,it is very important to reduce its thermal *** this paper,using a combination of a hydrothermal method and a high-efficiency sintering method,we succeed in preparing a composite of pure STO and La Nb-doped STO,which simultaneously realizes lower thermal conductivity and higherSeebeck coefficient,therefore,the thermoelectric properties of STO are significantly *** the SrTiO3/La Nb–SrTiO3 bulk samples,the lowest thermal conductivity is 2.57 W·m^-1·K^-1 and the highest z T is 0.35 at 1000 K for the STO/La（10）Nb（20）–STO sample.

关键词： thermoelectric materials SrTiO3/LaNb-SrTiO3 composite hydrothermal method strontium titanate