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Application of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in curative surgery for esophageal cancer:A metaanalysis

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 214-233页

作者： Mao-Xiu Yuan Qi-Gui Cai Zhen-Yang Zhang jian-zhong zhou Cai-Yun Lan jiang-Bo Lin The Graduate School Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350000Fujian ProvinceChina

BACKGROUND The effectiveness of neoadjuvant therapy in esophageal cancer(EC)treatment is still a subject of *** To compare the clinical efficacy and toxic side effects between neoadjuvant chemoradiotherapy(nCRT)and neoadjuvant chemotherapy(nCT)for locally advanced EC(LAEC).METHODS A comprehensive search was conducted using multiple databases,including PubMed,EMBASE,MEDLINE,Science Direct,The Cochrane Library,China National Knowledge Infrastructure,Wanfang Database,Chinese Science and Technology Journal Database,and Chinese Biomedical Literature Database *** up to December 2022 comparing nCRT and nCT in patients with EC were *** The analysis revealed significant differences between nCRT and nCT in terms of disease-free *** results indicated that nCRT provided better outcomes in terms of the 3-year overall survival rate(OSR)[odds ratio(OR)=0.95],complete response rate(OR=3.15),and R0 clearance rate(CR)(OR=2.25).However,nCT demonstrated a better 5-year OSR(OR=1.02)than ***,when compared to nCRT,nCT showed reduced risks of cardiac complications(OR=1.15)and pulmonary complications(OR=1.30).CONCLUSION Overall,both nCRT and nCT were effective in terms of survival outcomes for ***,nCT exhibited better performance in terms of postoperative complications.

关键词： Esophageal cancer Neoadjuvant chemoradiotherapy Radical resection for esophageal cancer Neoadjuvant chemotherapy Meta-analysis

Effects of laser shock processing,solid solution and aging,and cryogenic treatments on microstructure and thermal fatigue performance of ZCuAl_(10)Fe_(3)Mn_(2)alloy

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China Foundry 2021年第2期18卷 155-162页

作者： Guang-lei Liu Yu-hao Cao Lu-xin Shi Meng-jie Zhang Zhi-qiang Ye Ling Zhao jian-zhong zhou Nai-chao Si School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013China

The materials used in variable temperature conditions are required to have excellent thermal fatigue *** effects of laser shock processing(LSP),solid solution and aging treatment(T6),and cryogenic treatment(CT)on both microstructure and thermal fatigue performance of ZCuAl_(10)Fe_(3)Mn_(2) alloys were *** and crack morphology were then examined by scanning electron microscopy(SEM)and energy-dispersive X-ray spectroscopy(EDS).The result showed that,after being subjected to the combination treatment of T6+CT+LSP,the optimal mechanical properties and thermal fatigue performance were obtained for the ZCuAl_(10)Fe_(3)Mn_(2) alloy with the tensile strength,hardness,and elongation of 720 MPa,300.16 HB,and 16%,respectively,and the thermal fatigue life could reach 7,100 cycles when the crack length was 0.1 ***,the ZCuAl_(10)Fe_(3)Mn_(2) after combination treatment shows high resistance to oxidation,good adhesion between the matrix and grain boundaries,and dramatically reduced growth rate of *** thermal fatigue testing,under the combined action of thermal and alternating stresses,the microstructure around the sample notch oxidized and became loose and porous,which then converted to *** crack expanded along the grain boundary in the early *** the later stage,under the cyclic stress accumulation,the oxidized microstructure separated from the matrix,and the fatigue crack expanded in both intergranular and transgranular *** main crack was thick,and the path was meandering.

关键词： ZCuAl_(10)Fe_(3)Mn_(2)alloy laser shock processing T6 treatment cryogenic treatment microstructure thermal fatigue crack initiation and propagation

Effect of kappa elastin on melanogenesis in A375 human melanoma cells and its related mechanism

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Chinese Medical Journal 2012年第22期125卷 4088-4092页

作者： TIAN Shan HE Pei-ying ZHANG jian-zhong CHEN zhou Peking Univ Peoples Hosp Dept Dermatol Beijing 100044 Peoples R China Peking Univ Peoples Hosp Cent Lab Beijing 100044 Peoples R China

Background Elastin derived peptides can regulate melanocyte precursor development. Ultraviolet irradiation, infrared radiation and heat can increase the synthesis of tropoelastin in human skin epidermis. The aim of this study was to investigate whether the over expressed tropoelastin in epidermis has some role in melanogenesis of melanocytes. Methods A375 human melanoma cells were treated with different concentrations of kappa elastin for 24 hours. A375 human melanoma cells were randomly assigned to control, kappa elastin, and lactose pre-incubated groups. The cell viabilities were detected by the methyl thiazoleterazolium assay. Melanin content and tyrosinase activity in A375 melanoma cells were measured. The expressions of endothelin B receptor （ETBR） mRNA and c-kit mRNA in A375 melanoma cells were measured by quantative reverse transcription polymerase chain reaction. Results Fifty pg/ml of kappa elastin significantly increased the melanin content by 56.64% compared with the control （P 〈0.05）. Kappa elastin increased cellular tyrosinase activity by 46.73% compared with the control at 24 hours （P 〈0.05）. Kappa elastin increased the expressions of ETBR and c-kit mRNA levels by 2.13-fold and 2.47-fold compared with the controls, respectively. When pre-incubating cells with a lactose solution （10 mmol/L）, the inhibition on melanin production was 34.96% compared with the kappa elastin group （P 〈0.05）, tyrosinase activity was inhibited by 29.93% compared with kappa elastin group （P 〈0.05）, and the expressions of ETBR mRNA and c-kit mRNA were decreased by 1.56-fold and 0.82-fold compared with kappa elastin group, respectively. Conclusion Kappa elastin increased the melanogenesis in A375 melanoma cells via the stimulation of tyrosinase activity and the expression of ETBR and c-kit. The over expressed tropoelastin produced by keratinocytes might play a role in melanogenesis of epidermal melanocytes.

关键词： kappa elastin melanin tyrosinase activity endothelin B receptor c-kit

Synthesis of poly（lactide-co-glycolide） with high viscosity-average molecular weight

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Journal of Chemistry and Chemical Engineering 2009年第4期3卷 18-25页

作者： FAN Xin CHEN jian RUAN jian-ming zhou zhong-chen ZOU jian-peng State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China

In the present paper, poly（lactide-co-glycolide）（PLGA） with high viscosity-average molecular weight was fabricated with L-lactide （LLA） and glycolide （GA） as monomers via opening-ring polymerization. Fourier transform Infrared （FTIR） spectroscopy, ~H-NMR, X-ray diffraction （XRD） and scanning electron microscopy （SEM） were applied to characterize the products. Viscosity method was used to determine the viscosity-average molecular weight of the PLGA copolymers. Moreover, the mechanical strength of PLGA was investigated. The results showed that the highly pure LLA and GA were prepared. The as-fabricated PLGA was typical semicrystalline copolymer with the crystallinity of 18.72%. Both viscosity-average molecular weight and mechanical strength of PLGA decreased gradually with the increase of GA content. In addition, the higher the viscosity-average molecular weight was, the more the microcracks and holes on the cross-section of PLGA copolymer materials were, the smoother the cross-sections were.

关键词： high molecular weight PLGA synthesis characterization

Thermal fatigue crack growth behavior of ZCuAlFeMn alloy strengthened by laser shock processing

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Transactions of Nonferrous Metals Society of China 2021年第4期31卷 1023-1030页

作者： Guang-lei LIU Yu-hao CAO Kun YANG Wei GUO Xiao-xuan SUN Ling ZHAO Nai-chao SI jian-zhong zhou School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China School of Mechanical Engineering Jiangsu UniversityZhenjiang 2120013China

The effect of laser shock processing(LSP) on the hardness, surface morphology, residual stress, and thermal fatigue properties of a ZCuAl10Fe3Mn2 alloy was investigated to improve the thermal fatigue performance and decrease the surface crack of high-temperature components. The microstructure and crack morphology were analyzed by scanning electron microscopy(SEM) and energy dispersive spectroscopy(EDS). The results showed that laser shock could significantly improve the thermal fatigue performance of the alloy at a pulse energy of 4 J. Under the effect of thermal stress and alternating stress, microstructure around the specimen notch was oxidized and became porous, leading to the formation of multiple micro-cracks. The micro-cracks in the vertical direction became the main cracks, which mainly expanded with the conjoining of contiguous voids at the crack tip front. Micro-cracks in other directions grew along the grain boundaries and led to material shedding.

关键词： copper alloy laser shock strengthening surface morphology thermal fatigue properties crack initiation crack propagation

Prussian Blue Analogue‑Templated Nanocomposites for Alkali‑Ion Batteries:Progress and Perspective

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Nano-Micro Letters 2025年第1期17卷 216-261页

作者： jian‑En zhou Yilin Li Xiaoming Lin Jiaye Ye Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006People’s Republic of China School of Chemistry and Physics Faculty of ScienceQueensland University of Technology2 George StreetBrisbaneQLD 4000Australia Centre for Materials Science Queensland University of Technology2 George StreetBrisbaneQLD 4000Australia

Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium *** enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal *** review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these *** on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.

关键词： Prussian blue analogues Self-sacrificial template Lithium-ion batteries Sodium-ion batteries Potassium-ion batteries

Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou Wei Yang Di Zhu Bi-Fei Wu Hai-Bin Shi Sheng Liu Wei-zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Exploring the performance of large language models on hepatitis B infection-related questions:A comparative study

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World Journal of Gastroenterology 2025年第3期31卷 103-112页

作者： Yu Li Chen-Kai Huang Yi Hu Xiao-Dong zhou Cong He Jia-Wei zhong Department of Gastroenterology Jiangxi Provincial Key Laboratory of Digestive DiseasesJiangxi Clinical Research Center for GastroenterologyDigestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina HuanKui Academy Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Patients with hepatitis B virus(HBV)infection require chronic and personalized care to improve *** language models(LLMs)can potentially provide medical information for *** To examine the performance of three LLMs,ChatGPT-3.5,ChatGPT-4.0,and Google Gemini,in answering HBV-related *** LLMs’responses to HBV-related questions were independently graded by two medical professionals using a four-point accuracy scale,and disagreements were resolved by a third *** question was run three times using three *** was assessed via the Gunning Fog index and Flesch-Kincaid grade *** Overall,all three LLM chatbots achieved high average accuracy scores for subjective questions(ChatGPT-3.5:3.50;ChatGPT-4.0:3.69;Google Gemini:3.53,out of a maximum score of 4).With respect to objective questions,ChatGPT-4.0 achieved an 80.8%accuracy rate,compared with 62.9%for ChatGPT-3.5 and 73.1%for Google *** the six domains,ChatGPT-4.0 performed better in terms of diagnosis,whereas Google Gemini demonstrated excellent clinical ***,in the readability analysis,the mean Gunning Fog index and Flesch-Kincaid grade level scores of the three LLM chatbots were significantly higher than the standard level eight,far exceeding the reading level of the normal *** Our results highlight the potential of LLMs,especially ChatGPT-4.0,for delivering responses to HBV-related *** may be an adjunctive informational tool for patients and physicians to improve ***,current LLMs should not replace personalized treatment recommendations from physicians in the management of HBV infection.

关键词： ChatGPT-3.5 ChatGPT-4.0 Google Gemini Hepatitis B infection Accuracy

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电石渣催化煤燃烧特性的影响因素分析

燃料化学学报 2004年第1期32卷 37-42页

作者：程军周俊虎刘建忠周志军曹欣玉岑可法浙江大学能源洁净利用与环境工程教育部重点实验室浙江杭州310027

用热重法研究了不同条件下电石渣的催化煤燃烧特性,发现电石渣对晋城煤的着火温度和固定碳燃尽率都具有一定的促进作用,而且随添加量的增加助燃作用增强。采用干法混合方式添加0 5%电石渣的助燃作用很小,而采用浆状混合方式则具有较为... 详细信息

用热重法研究了不同条件下电石渣的催化煤燃烧特性,发现电石渣对晋城煤的着火温度和固定碳燃尽率都具有一定的促进作用,而且随添加量的增加助燃作用增强。采用干法混合方式添加0 5%电石渣的助燃作用很小,而采用浆状混合方式则具有较为明显的助燃效果。添加0 5%电石渣能使晋城无烟煤的着火温度由582℃降低到576℃,使潞安贫煤的固定碳燃尽率由89 41%提高到94 84%,而对长广高灰烟煤的着火和燃尽特性都影响很小。

关键词：煤燃烧催化电石渣着火温度燃尽率