检索结果-南通市图书馆

Pathogen-induced methylglyoxal negatively regulates rice bacterial blight resistance by inhibiting OsCDR1 protease activity

引用

Molecular Plant 2024年第2期17卷 325-341页

作者： Zheng-Wei Fu jian-Hui Li Xiang Gao Shi-Jia Wang Ting-Ting yuan Ying-Tang Lu State Key Laboratory of Hybrid Rice College of Life SciencesRenmin Hospital of Wuhan UniversityWuhan UniversityWuhan 430072China Key Laboratory of Biology and Genetic Improvement of OilCrops Ministry of Agriculture and Rural AffairsOilCrops Research Institute of the Chinese Academy of Agricultural SciencesWuhan 430062China

Xanthomonas oryzae ***(Xoo)causes bacterial blight(BB),a globally devastating disease of rice(Oryza sativa)that is responsible for significant crop *** and sugar metabolites are important for pathogen infection,providing energy and regulating events associated with defense responses;howev-er,the mechanisms by which they regulate such events in BB are *** an inevitable sugar metabolite,methylglyoxal(MG)is involved in plant growth and responses to various abiotic stresses,but the underlying mechanisms remain *** and how MG functions in plant biotic stress responses is almost completely ***,we report that the Xoo strain PXO99 induces OsWRKY62.1 to repress transcrip-tion of OsGLY Il genes by directly binding to their promoters,resulting in overaccumulation of *** negatively regulates rice resistance against Pxo99:osglyll2 mutants with higher MG levels are more sus-ceptible to the pathogen,whereas OsGLYIl2-overexpressing plants with lower MG content show greater resistance than the wild *** of OsGLYll2 to prevent excessive MG accumulation confers broad-spectrum resistance against the biotrophic bacterial pathogens Xoo and Xanthomonas oryzae *** and the necrotrophic fungal pathogen Rhizoctonia solani,which causes rice sheath *** evidence shows that MG reduces rice resistance against PXO99 through CONSTITUTIVE DISEASE RESISTANCE 1(OsCDR1).MGmodifies the Arg97 residue of OsCDR1to inhibit its aspartic protease activ-ity,which is essential for OsCDR1-enhanced *** together,these findings illustrate how Xoo promotes infection by hijacking a sugar metabolite in the host plant.

关键词： Oryza sativa bacterial blight OsWRKY62.1 methylglyoxal OsCDR1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Outcomes of using Firebird rapamycin eluting stents in routine coronary intervention practice: one-year results from the pilot study of Firebird in China registry

引用

Chinese Medical Journal 2006年第7期119卷 609-611页

作者： LIU Hai-bo XU Bo GAO Run-lin YANG Yue-jin YAO Min QIN Xue-wen WU Yong-jian yuan jin-qing MA Wei-hua QIAO Shu-bin CHEN Ji-lin Cardiovascular Institute and Fuwai Hospital Chinese Academy ofMedical Sciences Peking Union Medical College Beijing 100037China

Recent clinical trials with rapamycin-eluting stents ,have shown very low restenosis ***, the higher penetration of drug eluting stent （DES） in China is being limited by the high costs of these imported devices, especially when considering multiple stenting. Firebird （Microport Co. Ltd., China） is a rapamycin （Huadong Pharmaceutical, China） polymer-based eluting stent with reasonable cost. The objective of this study was to evaluate the safety and efficacy of using Firebird stents in routine interventional practice.

关键词： stents clinical trial percutanous coronary intervention

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combined intestinal microbiota and transcriptomic analysis to investigate the effect of different stocking densities on the ability of Pacific white shrimp(Litopenaeus vannamei)to utilize Chlorella sorokiniana

引用

Animal Nutrition 2024年第3期18卷 203-219页

作者： Hang yuan Minghua Xie jian Chen Naijie Hu Honming Wang Beiping Tan Lili Shi Shuang Zhang College of Fisheries Guangdong Ocean UniversityZhanjiangChina College of Fisheries and Life Science Dalian Ocean UniversityDalianChina Zhanjiang Experimental Station Chinese Academy of Tropical Agricultural SciencesZhanjiangChina

Aiming to investigate the impact of different stocking densities on the ability of Pacific white shrimp(Litopenaeus vannamei)to utilize Chlorella sorokiniana(CHL),a 3×2 factorial design stocking experiment was used in this ***,shrimp was fed with two dietary protein sources(fishmeal[FM]and CHL)at low(LSD;100 per m^(3)),medium(MSD;200 per m^(3))and high(HSD;300 per m^(3))stocking densities for 8 *** growth performance and resistance to Vibrio parahaemolyticus(1.0×10^(7) CFU/mL)of shrimp decreased with the increase of stocking density,but dietary CHL improved this *** between the CHL and FM groups for *** resistance were significant only under high-density conditions(P<0.05).Significant interactions between stocking density and protein source were found on the activities of catalase(CAT),superoxide dismutase(SOD)and phenol oxidase(PO),and the contents of malondialdehyde(MDA)in the hepatopancreas and the activities of intestinal amylase,most of which were significantly different between CHL and FM groups only at high stocking density(P<0.05).Analysis of 16S rDNA sequencing showed that dietary CHL increased the alpha diversity of intestinal microbiota,inhibited the colonization of pathogenic bacteria and enhanced the abundance of beneficial *** results showed that at high stocking densities,differentially expressed genes(DEGs)in the FM vs CHL group were mostly upregulated and primarily enriched in immune and metabolic related pathways including Toll,immune deficiency(Imd)and glycolysis–gluconeogenesis *** correlation analysis revealed significant correlation between the top ten intestinal bacteria at the genus level and markedly enriched DEGs,also more were detected under high density *** conclusion,CHL has great potential as a novel protein source in the intensive farming of shrimp.

关键词： Chlorella sorokiniana Stocking density Microbiota structure Transcriptomic profile Litopenaeus vannamei

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Design and Application of an S-band Fast Radio Bursts Search Pipeline for the Nanshan 26 m Radio Telescope

引用

Research in Astronomy and Astrophysics 2024年第7期24卷 111-117页

作者： Yan-Ling Liu Mao-Zheng Chen jian Li jian-Ping yuan Rai Yuen Zhi-Yong Liu Hao Yan Wen-Long Du Nan-Nan Zhai Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of Microwave Technology Urumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

Fast radio bursts(FRBs)are among the most studied radio transients in astrophysics,but their origin and radiation mechanism are still *** is a challenge to search for FRB events in a huge amount of observational data with high speed and high *** the rapid advancement of the FRB research process,FRB searching has changed from archive data mining to either long-term monitoring of the repeating FRBs or all-sky surveys with specialized ***,establishing a highly efficient and high quality FRB search pipeline is the primary task in FRB *** learning techniques provide new ideas for FRB search *** have detected radio bursts from FRB 20201124A in the L-band observational data of the Nanshan 26 m radio telescope(NSRT-26m)using the constructed deep learning based search pipeline named dispersed dynamic spectra search(DDSS).Afterwards,we further retrained the deep learning model and applied the DDSS framework to S-band *** this paper,we present the FRB observation system and search pipeline using the S-band *** carried out search experiments,and successfully detected the radio bursts from the magnetar SGR J1935+2145and FRB *** experimental results show that the search pipeline can complete the search efficiently and output the search results with high accuracy.

关键词： radio continuum general-methods data analysis-methods observational

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A comparison of angiographic and clinical outcomes after sirolimus-eluting versus paclitaxel-eluting stents for the treatment of in-stent restenosis

引用

Chinese Medical Journal 2006年第13期119卷 1059-1064页

作者： LI jian-jun XU Bo YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bing QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian yuan jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin Department of Cardiology Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100037 China

Background In-stent restenosis （ISR） remains a challenge for interventional cardiologists. Some data suggest that drug-eluting stents （DES） represent a promising new option for the treatment of patients with ISR. Currently, 2 DES platforms are available [sirolimus-eluting stents （SES） and paclitaxel-eluting stents （PES） ], but the superiority of either approach for treating ISR has not been convincingly demonstrated. The aim of the present study was to retrospectively compare angiographic and clinical outcomes after treatment of ISR with SES or PES in a series of consecutive patients with ISR.

关键词： coronary artery disease drug-eluting stent restenosis angiography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of sirolimus-eluting stent on calcified coronary lesions

引用

Chinese Medical Journal 2008年第1期121卷 6-11页

作者： LI jian-jun XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bing MA Wei-hua QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian yuan jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin Department of Cardiology Fuwai Hospital Chinese Academy ofMedical Sciences Peking Union Medical College Beijing 100037China

Background Calcified coronary lesions carry the risk of suboptimal stent expansion, subsequently leading to restenosis. The effectiveness of sirolimus-eluting stents （SES） for the treatment of calcified lesion has not been fully investigated. In the present study, therefore, we evaluated the effectiveness of SES implantation for the treatment of calcified coronary *** A total of 333 consecutive patients with 453 lesions were enrolled in this study. They were divided into two groups according to whether the lesion treated with SES was calcified or not; no calcification group （n=-264） and calcification group （n=-189）. Lesions treated with SES were subjected to quantitative coronary angiography （QCA） immediately and 8 months following stenting. Results Baseline clinical, demographic or angiographic characteristics were well balanced in both groups. Angiographic follow-up at 8 months, the in-stent restenosis and in-segment restenosis rates were not significantly different between the two groups; instent restenosis： 3.8% vs 4.2%; P=0.081; in-segment restenosis： 8.7% vs 10.6%, P=0.503. The target lesion revascularization （TLR） was also not significantly different between the two groups; 4.9% vs 6.9%, P=0.378. In addition, the in-stent late loss was similar in both groups; （0.16±0.40） mm vs （0.17±0.33） mm, P〉0.05. Meantime, overall thrombosis rates were also similar in both groups; 1.6% vs 1.6%, P〉0.05. Conclusion Although calcified coronary lesion was hard to stent, successful percutaneous coronary intervention with SES stenting for calcified lesions was conferred by the similar favorable results that were seen when comparing non-calcified and calcified coronary lesions.

关键词： sirolimus-eluting stent calcification restenosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of long-term clinical outcome after successful implantation of Firebird sirolimus-and Taxus paclitaxel-eluting stents in Chinese population： analysis of a large single center registry

引用

Chinese Medical Journal 2010年第7期123卷 810-815页

作者： DOU Ke-fei XU Bo YANG Yue-jin CHEN Ji-lin QIAO Shu-bin WANG Yang LI jian-jun QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian CHEN Jue yuan jin-qing YOU Shi-jie LI Wei GAO Run-lin Department of Cardiology Cardiovascular Institute and Fu Wai Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100037 China

Background Recent studies have shown that drug eluting stent （DES） implantation improved clinical outcome concerning efficacy compared with bare-metal stent （BMS） implantation, and sirolimus-eluting stent （SES） seemed superior to paclitaxel-eluting stent （PES） in improving the outcomes. Firebird SES is the most widely used SES in China. Long-term comparison of safety and efficacy between Firebird SES and Taxus PES in Chinese popuation is still not available. The aim of this research was to compare the safety and efficacy at 24 months after the successful implantation of Firebird SES and TAXUS PES in Chinese *** From April 2004 to October 2006, 3110 consecutive patients who underwent successful DES （Firebird SES 2274; Taxus PES 836） implantation were prospectively enrolled into this study. All enrolled patients were divided into two groups based on stent type. By outpatient clinic visit and telephone interview, we obtained 24-month clinical outcome including death, myocardial infarction （Ml）, thrombosis, target lesion revascularization （TLR）, target vessel revascularization （TVR）, and major adverse cardiac events （MACE, the composite of death, Ml, and TVR）. We used Cox＇s proportional-hazards models to assess relative risks of all the outcome measures before and after propensity match. Results Unadjusted clinical outcomes indicated that the patients treated with Firebird SES were associated with lower risk of TLR （HR0.38, 95%CI 0.26-0.54）, TVR （HR 0.51,95%CI 0.38-0.68） and MACE （HR 0.53, 95%CI 0.41-0.68）. The results after propensity match were consistent with that before matching, lower risk of TLR （HR 0.33, 95%CI 0.19-0.58）, TVR （HR 0.41, 95%CI 0.26-0.64）, MACE （HR 0.48, 95%CI 0.33-0.68） in Firebird *** Compared with Taxus PES, the use of domestic Firebird SES may decrease the risk of TLR, TVR and MACE in daily practice.

关键词： treatment outcome Firebird sirolimus-eluting stent Taxus paclitaxel-eluting stent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Malicious webshell family dataset for webshell multi-classification research

引用

Visual Informatics 2024年第1期8卷 47-55页

作者： Ying Zhao Shenglan Lv Wenwei Long Yilun Fan jian yuan Haojin jiang Fangfang Zhou School of Computer Science and Engineering Central South UniversityChangshaHunanChina Alibaba Cloud Intelligence Business Group Alibaba CloudBeijingChina

Malicious webshells currently present tremendous threats to cloud *** relevant studies and open webshell datasets consider malicious webshell defense as a binary classification problem,that is,identifying whether a webshell is malicious or ***,a fine-grained multi-classification is urgently needed to enable precise responses and active defenses on malicious webshell *** paper introduces a malicious webshell family dataset named MWF to facilitate webshell multiclassification *** dataset contains 1359 malicious webshell samples originally obtained from the cloud servers of Alibaba *** of them is provided with a family *** samples of the same family generally present similar characteristics or *** dataset has a total of 78 families and 22 ***,this paper introduces the human–machine collaboration process that is adopted to remove benign or duplicate samples,address privacy issues,and determine the family of each *** paper also compares the distinguished features of the MWF dataset with previous datasets and summarizes the potential applied areas in cloud security and generalized sequence,graph,and tree data analytics and visualization.

关键词： Open dataset Webshell Webshell family Cloud security

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A single center investigation of bare-metal or drug-eluting stent restenosis from 1633 consecutive Chinese Han ethnic patients

引用

Chinese Medical Journal 2006年第7期119卷 533-538页

作者： XU Bo LI jian-jun YANG Yue-jin MA Wei-hua CHEN Ji-lin QIAO Shu-bin QIN Xue-wen YAO Min LIU Hai-bo WU Yong-jian yuan jin-qing CHEN Jue YOU Shi-jie DAI Jun XIA Ran GAO Run-lin Department of Cardiology Fuwai Hospital Chinese Academy ofMedical Sciences Peking Union Medical College Beijing 100037China

Background Stents are widely used in China but the clinical impression is somehow that restenosis is less common because of the lower prevalence of coronary artery disease （CAD） and associated risk factors in Chinese populations. However, no large-sample published studies are available on angiographic stent restenosis including those of bare-metal stent （BMS） or drug-eluting stent （DES） in Chinese Han ethnic population. Mothods A total of 1633 consecutive patients with CAD who had undergone coronary stenting, quantitative coronary angiography （QCA） were retrospectively studied. At the time of stent implantation and at 7 months post-stenting 675 patients had a follow-up angiography. Statistical analysis was made with the chi-square test for categorical variables, unpaired t test for continuous variables, univariate or multivariate regression for baseline and angiographic characteristics and the Kaplan-Meier method for rate of target lesion revascularization （TLR）. Results Stent restenosis was defined as ≥50% diameter stenosis in the dilated segment. A total of 675 patients with 1074 lesions were subjected to angiographic follow-up for 7 months on average, Of these lesions, 448 were implanted with BMS whereas 626 lesions with DES. At 7 months, bare-metal in-stent restenosis occured in 148 lesions （33.0%）, and bare metal in-segment restenosis in 155 lesions （34.6%） in contrast to drug-eluting in-stent restenosis in 48 lesions （7.7%） and drug-eluting in-segment restenosis in 73 lesions （11.7%）（P〈0.001 compared with BMS respectively）. Late loss in both in-stent and in segment was higher in BMS than in DES groups [（1.00±0.69） vs （0.28±0.52）; （0.78±0.71） vs （0.21±0.52）, P〈0.001 respectively]. Angulated lesion, lesion length, pre-procedural minimal luminal diameter （MLD）, and BMS were independent predictors for TLR, （P〈0.01 respectively）, whereas current smoker, ostial lesion, and stent overlapping, post-procedure in-stent MLD, lesion length, and stent types were indep

关键词： stent coronary artery disease angiography restenosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Species-level Microbiota of Biting Midges and Ticks from Poyang Lake

引用

Biomedical and Environmental Sciences 2024年第3期37卷 266-277,I0001-I0003页

作者： GONG jian WANG Fei Fei LIU Yang Qing PU Ji DONG Ling Zhi ZHANG Si Hui HUANG Zhen Zhou HUANG Yu yuan LI Ya Ben YANG Cai Xin TAO yuan Meihui ZHAO Li Jun jin Dong LIU Li Yun YANG jing LU Shan Department of Epidemiology School of Public HealthShanxi Medical UniversityTaiyuan 030001ShanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China jiangxi Provincial Key Laboratory of Animal-Origin and Vector-Borne Diseases Nanchang Center for Disease Control and PreventionNanchang 330038JiangxiChina Research Units of Discovery of Unknown Bacteria and Function Chinese Academy of Medical SciencesBeijing 100730China

Objective The purpose of this study was to investigate the bacterial communities of biting midges and ticks collected from three sites in the Poyang Lake area,namely,Qunlu Practice Base,Peach Blossom Garden,and Huangtong Animal Husbandry,and whether vectors carry any bacterial pathogens that may cause diseases to humans,to provide scientific basis for prospective pathogen discovery and disease prevention and *** Using a metataxonomics approach in concert with full-length 16S rRNA gene sequencing and operational phylogenetic unit(OPU)analysis,we characterized the species-level microbial community structure of two important vector species,biting midges and ticks,including 33 arthropod samples comprising 3,885 individuals,collected around Poyang *** A total of 662 OPUs were classified in biting midges,including 195 known species and 373 potentially new species,and 618 OPUs were classified in ticks,including 217 known species and 326 potentially new ***,OPUs with potentially pathogenicity were detected in both arthropod vectors,with 66 known species of biting midges reported to carry potential pathogens,including Asaia lannensis and Rickettsia bellii,compared to 50 in ticks,such as Acinetobacter lwoffii and Staphylococcus *** found that Proteobacteria was the most dominant group in both midges and ***,the outcomes demonstrated that the microbiota of midges and ticks tend to be governed by a few highly abundant *** sp7 was predominant in biting midges,while Coxiella sp1 was enriched in ***,Coxiella spp.,which may be essential for the survival of Haemaphysalis longicornis Neumann,were detected in all tick *** identification of dominant species and pathogens of biting midges and ticks in this study serves to broaden our knowledge associated to microbes of arthropod *** Biting midges and ticks carry large numbers of known and potentially novel bacteria,and carry a wide

关键词： Biting midge Tick Microbiota Pantoea Coxiella

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：