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Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion

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World Journal of Gastroenterology 2021年第32期27卷 5404-5423页

作者： Zi-Yi Wang jian-yu lin Yang-Rong Feng De-Shun Liu Xu-Zi Zhao Tong Li Si-yuan Li Jing-Chao Sun Shu-Feng Li Wen-Yan Jia Hui-Rong Jing Emergent Intensive Care Unit The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Department of Gastrointestinal Surgery Weihai Central HospitalWeihai 264200Shandong ProvinceChina Graduate College Shandong First Medical UniversityJinan 271000Shandong ProvinceChina Department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina Department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100000China Department of General Surgery Qingdao Municipal HospitalQingdao UniversityQingdao 266071Shandong ProvinceChina Physiological Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal barrier breakdown,a frequent complication of intestinal ischemiareperfusion(I/R)including dysfunction and the structure changes of the intestine,is characterized by a loss of tight junction and enhanced permeability of the intestinal barrier and increased *** develop effective and novel therapeutics is important for the improvement of outcome of patients with intestinal barrier *** human angiopoietin-like protein 4(rhANGPTL4)is reported to protect the blood-brain barrier when administered exogenously,and endogenous ANGPTL4 deficiency deteriorates radiationinduced intestinal *** To identify whether rhANGPTL4 may protect intestinal barrier breakdown induced by I/*** Intestinal I/R injury was elicited through clamping the superior mesenteric artery for 60 min followed by 240 min *** epithelial(Caco-2)cells and human umbilical vein endothelial cells were challenged by hypoxia/reoxygenation to mimic I/R in *** Indicators including fluorescein isothiocyanate-conjugated dextran(4 kilodaltons;FD-4)clearance,ratio of phosphorylated myosin light chain/total myosin light chain,myosin light chain kinase and loss of zonula occludens-1,claudin-2 and VE-cadherin were significantly increased after intestinal I/R or cell hypoxia/***4 treatment significantly reversed these indicators,which were associated with inhibiting the inflammatory and oxidative cascade,excessive activation of cellular autophagy and apoptosis and improvement of survival *** results were observed in vitro when cells were challenged by hypoxia/reoxygenation,whereas rhANGPTL4 reversed the indicators close to normal level in Caco-2 cells and human umbilical vein endothelial cells *** rhANGPTL4 can function as a protective agent against intestinal injury induced by intestinal I/R and improve survival via maintenance of intestinal barrier structure and functions.

关键词： Angiopoietin-like protein 4 Intestinal ischemia/reperfusion COVID-19 Myosin light chain kinase Intestinal barrier breakdown

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Investigating Periodic Dependencies to Improve Short-Term Load Forecasting

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Energy Engineering 2024年第3期121卷 789-806页

作者： Jialin yu Xiaodi Zhang Qi Zhong jian Feng State Grid Zhejiang Jiaxing Electric Power Co. Ltd.Jiaxing314000China State Grid Zhejiang Electric Power Co. Ltd.Hangzhou310000China

With a further increase in energy flexibility for customers,short-term load forecasting is essential to provide benchmarks for economic dispatch and real-time alerts in power *** electrical load series exhibit periodic patterns and share high associations with metrological ***,current studies have merely focused on point-wise models and failed to sufficiently investigate the periodic patterns of load series,which hinders the further improvement of short-term load forecasting ***,this paper improved Autoformer to extract the periodic patterns of load series and learn a representative feature from deep decomposition and *** addition,a novel multi-factor attention mechanism was proposed to handle multi-source metrological and numerical weather prediction data and thus correct the forecasted electrical *** paper also compared the proposed model with various competitive *** the experimental results reveal,the proposed model outperforms the benchmark models and maintains stability on various types of load consumers.

关键词： Load forecasting transformer attention mechanism power grid

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Photocatalytic dicarboxylation of strained C-C bonds with CO_(2) via consecutive visible-light-induced electron transfer

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Chinese Chemical Letters 2024年第6期35卷 268-273页

作者： Yi Liu Zhe-Hao Wang Guan-Hua Xue lin Chen Li-Hua yuan Yi-Wen Li Da-Gang yu jian-Heng Ye Key Laboratory of Green Chemistry&Technology of Ministry of Education College of ChemistrySichuan UniversityChengdu 610064China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Dicarboxylic acids have a wide range of applications in the polymer industry to construct valuable *** has recently emerged as an efficient and sustainable strategy to generate dicarboxylic ***,photocatalytic dicarboxylation with CO_(2) is mainly limited to unsaturated bonds,and the dicarboxylation of C-C single bonds still remains a ***,we report a photocatalytic dicarboxylation of C-C single bonds in strained rings with CO_(2) units via consecutive photo-induced electron transfer(ConPET).It is also the first photocatalytic reductive ring-opening reaction of ***,this transition-metal-free protocol exhibits good functional group tolerance,broad substrate scope,facile scalability,and easy product ***,diacids can easily be derivatized to mainchain liquid crystalline polyesters.

关键词： Consecutive photo-induced electron transfer Visible-light catalysis Dicarboxylation Carbon dioxide Cyclopropanes

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Terrain or climate factor dominates vegetation resilience?Evidence from three national parks across different climatic zones in China

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Forest Ecosystems 2024年第4期11卷 526-542页

作者： Shuang Liu lingxin Wu Shiyong Zhen Qinxian lin Xisheng Hu jian Li College of Transportation and Civil Engineering Fujian Agriculture and Forestry UniversityFuzhou 350002China College of JunCao Science and Ecology Fujian Agriculture and Forestry UniversityFuzhou 350002China College of Forestry Fujian Agriculture and Forestry UniversityFuzhou 350002China

Vegetation resilience(VR),providing an objective measure of ecosystem health,has received considerable attention,however,there is still limited understanding of whether the dominant factors differ across different climate *** took the three national parks(Hainan Tropical Rainforest National Park,HTR;Wuyishan National Park,WYS;and Northeast Tiger and Leopard National Park,NTL)of China with less human interference as cases,which are distributed in different climatic zones,including tropical,subtropical and temperate monsoon climates,***,we employed the probabilistic decay method to explore the spatio-temporal changes in the VR and their natural driving patterns using Geographically Weighted Regression(GWR)model as *** results revealed that:(1)from 2000 to 2020,the Normalized Difference Vegetation Index(NDVI)of the three national parks fluctuated between 0.800 and 0.960,exhibiting an overall upward trend,with the mean NDVI of NTL(0.923)>HTR(0.899)>WYS(0.823);(2)the positive trend decay time of vegetation exceeded that of negative trend,indicating vegetation gradual recovery of the three national parks since 2012;(3)the VR of HTR was primarily influenced by elevation,aspect,average annual temperature change(AATC),and average annual precipitation change(AAPC);the WYS'VR was mainly affected by elevation,average annual precipitation(AAP),and AAPC;while the terrain factors(elevation and slope)were the main driving factors of VR in NTL;(4)among the main factors influencing the VR changes,the AAPC had the highest proportion in HTR(66.7%),and the AAP occupied the largest area proportion in WYS(80.4%).While in NTL,elevation served as the main driving factor for the VR,encompassing 64.2%of its ***,our findings indicated that precipitation factors were the main driving force for the VR changes in HTR and WYS national parks,while elevation was the main factors that drove the VR in *** research has promoted a deeper understanding of the dri

关键词： National parks Vegetation resilience NDVI Probabilistic decay model Driving factors

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Concerted Steric and Electronic Strategy in Thermostable Salicylaldiminato Nickel Catalysts for Ethylene(Co)polymerization

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Chinese Journal of Polymer Science 2024年第8期42卷 1085-1092页

作者： Hong-yu Ji Hong-Liang Mu Chun-Feng Tang yu-Xing Zhang yue Chi Zhong-Bao jian Key Laboratory of Advanced Structural Materials Ministry of EducationSchool of Materials Science and EngineeringChangchun University of TechnologyChangchun 130012China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Olefin polymerization is one of the most im portant chemical reactions in *** work presents a strategy that emphasizes the synergistic meta/poro-steric hindrance of N-aryl groups and electronic effects in newly synthesized neutral salicylaldiminato nickel *** nickel(Ⅱ)catalysts exhibit exceptional thermostability,ranging from 30℃to 130℃,demonstrating enhanced catalytic activities and broadly regulated polyethylene molecular weights(3-341 kg·mol^(-1))and controlled polymer branch density(2-102 brs/1000C).The preferred catalyst Ni3 with concerted steric and electronic effects enables the production of solid-state semi-crystalline polyethylene materials at temperatures below 90℃.Notably,Ni3 exhibits an impressive tolerance of 110℃and can withstand even the challenging polymerization temperature of 130℃,leading to the production of polyethylene wax and ***,functionalized polyethylene is produced.

关键词： Polyolefin Salicylaldiminato ligand Nickel catalyst Oil Wax

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Self-Driven Photo-Polarized Water Molecule-Triggered Graphene-Based Photodetector

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Research 2024年第2期2023卷 273-283页

作者： Shisheng lin Chang Liu Xin Chen Yi Zhang Hongtao lin Xutao yu yujiao Bo Yanghua Lu College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027P.R.China Hangzhou Gelanfeng Technology Co.Ltd Hangzhou 310051P.R.China State Key Laboratory of Modern Optical Instrumentation Zhejang UniversityHangzhou 310027P.R.China Key Laboratory of Wide Bandgap Semiconductor Materials and Devices HCSemitek CorporationYiwu 322009P.R.China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100P.R.China

Flowing water can be used as an energy source for generators,providing a major part of the energy for daily ***,water is rarely used for information or electronic ***,we present the feasibility of a polarized liquid-triggered photodetector in which polarized water is sandwiched between graphene and a *** to the polarization and depolarization processes of water molecules driven by photogenerated carriers,a photo-sensitive current can be repeatedly produced,resulting in a high-performance *** response wavelength of the photodetector can be fine-tuned as a result of the free choice of semiconductors as there is no requirement of lattice match between graphene and the *** zero voltage bias,the responsivity and specific detectivity of Gr/NaCl(0.5 M)W/N-GaN reach values of 130.7 mA/W and 2.3×10^(9)Jones under 350 nm illumination,***,using a polar liquid photodetector can successfully read the photoplethysmography signals to produce accurate oxygen blood saturation and heart *** with the commercial pulse oximetry sensor,the average errors of oxygen saturation and heart rate in the designed photoplethysmography sensor are~1.9%and~2.1%,*** study reveals that water can be used as a high-performance photodetector in informative industries.

关键词： polarization polarized saturation

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MADRL-based UAV swarm non-cooperative game under incomplete information

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Chinese Journal of Aeronautics 2024年第6期37卷 293-306页

作者： Ershen WANG Fan LIU Chen HONG Jing GUO lin ZHAO jian XUE Ning HE School of Electronic and Information Engineering Shenyang Aerospace UniversityShenyang 110136China College of Robotics Beijing Union UniversityBeijing 100101China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China College of Smart City Beijing Union UniversityBeijing 100101China

Unmanned Aerial Vehicles(UAVs)play increasing important role in modern *** this paper,considering the incomplete observation information of individual UAV in complex combat environment,we put forward an UAV swarm non-cooperative game model based on Multi-Agent Deep Reinforcement Learning(MADRL),where the state space and action space are constructed to adapt the real features of UAV swarm air-to-air *** multi-agent particle environment is employed to generate an UAV combat scene with continuous observation *** recently popular MADRL methods are compared extensively in the UAV swarm noncooperative game model,the results indicate that the performance of Multi-Agent Soft Actor-Critic(MASAC)is better than that of other MADRL methods by a large *** swarm employing MASAC can learn more effective policies,and obtain much higher hit rate and win *** under different swarm sizes and UAV physical parameters are also performed,which implies that MASAC owns a well generalization ***,the practicability and convergence of MASAC are addressed by investigating the loss value of Q-value networks with respect to individual UAV,the results demonstrate that MASAC is of good practicability and the Nash equilibrium of the UAV swarm non-cooperative game under incomplete information can be reached.

关键词： UAV swarm Reinforcement learning Deep learning Multi-agent Non-cooperative game Nash equilibrium

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Allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain

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Acta Pharmaceutica Sinica B 2024年第1期14卷 67-86页

作者： Chunhao Zhu Xiaobing Lan Zhiqiang Wei jianqiang yu jian Zhang School of Pharmacy Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China School of Basic Medical Science Ningxia Medical UniversityYinchuan 750004China Medicinal Chemistry and Bioinformatics Center Ocean University of ChinaQingdao 266100China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Neuropathic pain is a debilitating pathological condition that presents significant therapeutic challenges in clinical ***,current pharmacological treatments for neuropathic pain lack clinical efficacy and often lead to harmful adverse *** G protein-coupled receptors(GPCRs)are widely distributed throughout the body,including the pain transmission pathway and descending inhibition pathway,the development of novel neuropathic pain treatments based on GPCRs allosteric modulation theory is gaining *** research has shown that allosteric modulators targeting GPCRs on the pain pathway can effectively alleviate symptoms of neuropathic pain while reducing or eliminating adverse *** review aims to provide a comprehensive summary of the progress made in GPCRs allosteric modulators in the treatment of neuropathic pain,and discuss the potential benefits and adverse factors of this *** will also concentrate on the development of biased agonists of GPCRs,and based on important examples of biased agonist development in recent years,we will describe universal strategies for designing structure-based biased *** is foreseeable that,with the continuous improvement of GPCRs allosteric modulation and biased agonist theory,effective GPCRs allosteric drugs will eventually be available for the treatment of neuropathic pain with acceptable safety.

关键词： Neuropathic pain Allosteric modulators G protein-coupled receptors Analgesia

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一种新型机械过冷喷射制冷系统的理论研究

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哈尔滨工业大学学报 2008年第1期40卷 164-168页

作者：任云锋鱼剑琳厉彦忠西安交通大学制冷及低温研究所西安710049

提出了一种新型机械过冷喷射制冷系统（NERS）．该循环系统引入了一个辅助的液体-气体射流泵，通过消耗少量泵功，对冷凝器出来的液体进行过冷．与常规喷射制冷系统（CERS）相比，该系统可以有较大的过冷度．建立了新系统的数学模型，... 详细信息

提出了一种新型机械过冷喷射制冷系统（NERS）．该循环系统引入了一个辅助的液体-气体射流泵，通过消耗少量泵功，对冷凝器出来的液体进行过冷．与常规喷射制冷系统（CERS）相比，该系统可以有较大的过冷度．建立了新系统的数学模型，并针对环保制冷荆R600a和R152a两种工质进行了模拟计算．重点分析了发生器温度和机械过冷度对新循环性能的影响，并与常规喷射制冷循环进行了性能比较．计算结果表明，新循环能有效提高系统的性能系数（COP）．对于制冷剂R600a和R152a，新循环COP比常规循环可分别提高约12％和11％．尽管新循环消耗的泵功稍有增加，但从炯的角度分析，新循环可以节约7％-8％的输入（火用）．对一定的制冷剂和工况．有相应的最佳机械过冷度存在．

关键词：机械过冷喷射制冷射流泵

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Immune checkpoint inhibitor-associated gastritis:Patterns and management

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World Journal of Gastroenterology 2024年第14期30卷 1941-1948页

作者： Jing lin Zhong-Qiao lin Shi-Cheng Zheng yu Chen Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina Phase I Clinical Trial Ward Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou 350000Fujian ProvinceChina School of Basic Medical Sciences Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina

Immune checkpoint inhibitors(ICIs)are widely used due to their effectiveness in treating various ***-related adverse events(irAEs)are defined as adverse effects resulting from ICI *** irAEs are a common type of irAEs characterized by intestinal side effects,such as diarrhea and colitis,which may lead to the cessation of *** irAE gastritis is rarely reported,it may lead to serious complications such as ***,irAE gastritis is often difficult to identify early due to its diverse *** steroid hormones and immunosuppressants are commonly used to reverse irAEs,the best regimen and dosage for irAE gastritis remains *** addition,the risk of recurrence of irAE gastritis after the reuse of ICIs should be *** this editorial,strategies such as early identification,pathological diagnosis,mana-gement interventions,and immunotherapy rechallenge are discussed to enable clinicians to better manage irAE gastritis and improve the prognosis of these patients.

关键词： Immunotherapy Immune checkpoint inhibitor Immune-related adverse events Immune checkpoint inhibitor-related gastritis

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