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Journal of Integrative Plant Biology 2007年第7期49卷 1024-1031页

作者： jian-you li ai-liang jiang hai-yan chen ying wang wei zhang Department of Biochemistry and Molecular Biology College of Life Science Nanjing Agricultural University Nanjing 210095 China

In a previous study, a salt stress-induced programmed cell death （PCD） model was established in rice root tip cells. Here, by using Wuyunjing 8th rice seedlings, the effects of lanthanum on salt stress-induced PCD early events were studied. The results indicated that low concentrations （10 μmol/L）, but not high concentrations （100 μmol/L） of LaCl3 could effectively prevent salt stress-induced PCD. Further study demonstrated that in the early stages of salt-induced PCD process, 10 μmol/L of La^3＋ could prevent the increase of cytoplasmic calcium levels, inhibit reactive oxygen species （ROS） production, and enhance the ROS-scavenging enzyme activities such as superoxide dismutases （SOD） and ascorbate peroxidase （APX）. Imidazole （20 mmol/L）, the inhibitor of nicotinamide adenine dinucleotide phosphate-oxidase （NADPH oxidase）, could alleviate the occurrence of PCD obviously, and such alleviation could be enhanced by the addition of La^3＋, indicating the involvement of NADPH oxidase in the salt stress-induced PCD process. Taken together, lanthanum could prevent salt stress-induced PCD occurrence in the rice root tip cells by blocking the calcium influx under stress, which was followed by inhibiting calcium-dependent NADPH oxidase activity to prevent O2^·- production and, enhancing the cytosolic antioxidative enzyme activities to scavenge the reactive oxygen species.

关键词： Ca^2+ Oryza sativa programmed cell death reactive oxygen species salt stress.

Recent progress in metal-organic frameworks(Part II—material application)

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Science China Chemistry 2025年

作者： jiandong Pang Wentao jiang Xue-Wen zhang Hao-Long Zhou Yuxiu Sun wei Gong Bin wang Fuyin Ma linwei He Long chen Qiang chen He-Qi Zheng Yuanjing Cui Wen-Jie Shi Chao zhang Mei wang Yue-Biao zhang Jie-Peng zhang Chongli Zhong Yong Cui Shuao wang jian-Rong li Guodong Qian Tong-Bu Lu Huan Pang Xian-He Bu Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology School of Chemistry and Chemical Engineering Yangzhou University School of Materials Science and Engineering Nankai University School of Physical Science and Technology ShanghaiTech University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry GBRCE for Functional Molecular Engineering School of Chemistry IGCMESun Yat-sen University Department of Chemistry Shantou University School of Chemical Engineering and Technology Tiangong University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences Soochow University College of Materials Science & Engineering Beijing University of Technology State Key Laboratory of Silicon and Advanced Semiconductor Materials Cyrus Tang Center for Sensor Materials and ApplicationsSchool of Materials Science & Engineering Zhejiang University

As a class of functional crystalline porous materials, metal-organic frameworks(MOFs) gained rapid development in the past three decades and a large number of MOFs with ordered structures, high surface areas, and functionalized channels have been investigated. MOFs and MOF-derived/composite materials show great potential in many application fields. In this review, we discussed the main applications of MOFs and MOF-derived/composite materials in small molecule storage, separation, luminescence, sensing, multitype catalysis, and energy storage. In addition, challenges and problems in the future research of MOFsrelated fields are also discussed.

关键词：

A score model for predicting post-liver transplantation survival in HBV cirrhosis-related hepatocellular carcinoma recipients: a single center 5-year experience

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Hepatobiliary & Pancreatic Diseases International 2015年第1期14卷 43-49页

作者： li-ying wang Shu-Sen Zheng Xiao Xu wei-lin wang jian Wu Min zhang yan Shen Sheng yan hai-yang Xie Xin-Hua chen Tian-An jiang Fen chen Division of Hepatobiliary and Pancreatic Surgery Department of Surgery First Affiliated Hospital Zhejiang University School of Medicine Key Laboratory of Combined Multi-Organ Transplantation Ministry of Health

BACKGROUND： The prognostic prediction of liver transplantation（LT） guides the donor organ allocation. However, there is currently no satisfactory model to predict the recipients’ outcome, especially for the patients with HBV cirrhosis-related hepatocellular carcinoma（HCC）. The present study was to develop a quantitative assessment model for predicting the post-LT survival in HBV-related HCC ***： Two hundred and thirty-eight LT recipients at the liver Transplant Center, First Affiliated Hospital, Zhejiang University School of Medicine between 2008 and 2013 were included in this study. Their post-LT prognosis was recorded and multiple risk factors were analyzed using univariate and multivariate analyses in Cox ***： The score model was as follows： 0.114×（Child-Pugh score）-0.002×（positive HBV DNA detection time）＋0.647×（number of tumor nodules）＋0.055×（max diameter of tumor nodules）＋0.231×ln AFP＋0.437×（tumor differentiation grade）.The receiver operating characteristic curve analysis showed that the area under the curve of the scoring model for predicting the post-LT survival was 0.887. The cut-off value was 1.27, which was associated with a sensitivity of 72.5% and a specificity of 90.7%, ***： The quantitative score model for predicting post-LT survival proved to be sensitive and specific.

关键词： HBV cirrhosis hepatocellular carcinoma liver transplantation Hangzhou criteria post-LT survival

Simultaneously Improved Curing,Mechanical,Antioxidative Properties and Reduced ZnO Loading of Silica Filled NR Composites by Incorporation of Low-cost Crude Carbon Dots via Conventional Melt-milling Method

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Chinese Journal of Polymer Science 2024年第6期42卷 815-825页

作者： Chao-ying Sun hai-Jun Ji li-wei li Hui yang Xiao-Peng An Yi-Ping chen Ming-jian Han Can jiang li-Qun zhang Peng Yu Run-Guo wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China School of Materials Science and Engineering Wuhan Institute of TechnologyWuhan430205China

Rubbers or elastomers play an important role in hi-tech technology and civilian daily life because of their unique and strategical ***,the rubber additives are essential components for rubbers’practical ***,developing novel multifunctional additives has attracted increasing research *** this work,low-cost crude carbon dots(CCDs)were used as multifunctional additives for natural rubber/silica system(without any additional modification)through industrial compatible melt-mixing *** results revealed that the CCDs could disperse well in the NR/silica system,and they could not only endow the rubber compound with excellent anti-aging capability due to CCDs’radical scavenging activity because of their plenty of nitrogen-containing species,but also improve the curing rate and mechanical performance of the rubber ***,the CCDs could reduce the rolling resistance of the rubber composites(tanδvalue at 7%strain of the rubber composite could be decreased by 34%),which is promising for the application of energy-saving tire ***,the addition of CCDs could effectively reduce the ZnO dosage by at least 40%in the rubber composite without deteriorating its ***,this work provides valuable guidance to develop novel cheap yet effective additives for the elastomer.

关键词： Natural rubber Crude carbon dots Antioxidant ZnO reduction Vulcanization

Fabrication and characterization of AleCuO nanocomposites prepared by sol-gel method

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Defence Technology（防务技术） 2021年第4期17卷 1307-1312页

作者： Yue-ting wang Xiao-ting zhang jian-bing Xu Yun Shen cheng-ai wang Fu-wei li Ze-hua zhang jian chen ying-hua Ye Rui-qi Shen Department of Applied Chemistry School of Chemical EngineeringNanjing University of Science and TechnologyNanjing210094China Anhui Xinhe Defense Equipment Technology Corporation limited Anhui230000China

In this study,AleCuO nanocomposites were fabricated by sol-gel *** a contrast,the thermite was prepared by physical mixing at the equivalence ratio of 0.5,1,2,*** intermediates and samples as prepared were characterized by SEM and *** exothermic properties of the two samples prepared at different equivalence ratios were tested and the reaction products were characterized by *** SEM results show that the sample prepared by the sol-gel method demonstrates a micron-sized agglomerated sphere formed by a mutual wrapping of Al NPs and CuO NPs,and the particles are evenly distributed in the *** addition,when the content of Al powder is seriously insufficient,the heat release of the sample prepared by physical mixing is 1.6 times that of by sol-gel *** the increase of Al powder content,the exothermic properties of Al/CuO NPs prepared by sol-gel method began to increase significantly compared with physical mixing and the difference is 1.5 times when the equivalence ratio increases to *** can be concluded that the reason for this result may be attributed to the different mass transfer modes of components due to the different morphologies of samples.

关键词： Nanothermite Energetic materials Sol-gel Characterization

Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study

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Chinese Journal of Integrative Medicine 2019年第11期25卷 812-819页

作者： wang Xue-qian zhang ying HOU wei wang ying-tian ZHENG Jia-bin li Jie liN li-zhu jiang Yi-lan wang Shen-yu XIE ying zhang Hong-liang SHU Qi-jin li Ping wang wei you jian-liang li Ge liU Jie FAN Hui-ting zhang Mei-ying liN Hong-sheng Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing (100053)China Department of Oncology Wuxi Hospital of Traditional Chinese MedicineWuxiJiangsu Province (214000)China Department of Oncology Dalian Hospital of Traditional Chinese MedicineDalianLiaoning Province (116000)China Department of Oncology The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou (510000)China Department of Oncology Hunan Academy of Traditional Chinese Medicine Affiliated HospitalChangsha (410000)China Department of Integrated TCM & Western Medicine Cancer Hospital of Liaoning ProvinceShenyang (110000)China Department of Traditional Chinese Medicine Cancer Hospital of Shanxi ProvinceTaiyuan (030000)China Department of Oncology The Xinjiang Uygur Autonomous Region Traditional Chinese Medicine HospitalUrumqi (830000)China Department of Oncology Zhejiang Provinee Traditional Chinese Medicine HospitalHangzhou (310000)China Oncology Department of Traditional Chinese Medicine Anhui Provincial HospitalHefei (230000)China Oncology Department of Traditional Chinese Medicine Chongqing Cancer HospitalChongqing (400000)China

Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in *** with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were *** recruited patients were divided into a CM treatment group and a control group according to their *** in the CM treatment group received continuous CM therapy for more than 6 months or until disease *** in the control group received CM therapy for less than 1 ***-up was 8nducted over 3 *** primary outcome was DFS,with recurrence/metastasis rates as a secondary ***:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control *** for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group ***:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and *** treatment is associated with improving survival outcomes of postoperative NSCLC patients in China.

关键词： Chinese medicine non-small cell lung cancer postoperative care cohort study disease-free survival

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng chen Rui Han yan-Ting liu wei Huang Qi wang Xin Xiong ying zhang jian-Guo Zhao Shi-Hua li Xiao-jiang li wei-li yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu yan Xie jian Yu Kun-Ning zhang Zhou-Bo Guo Di wang Zhao-Xian li wei-Qi zhang Yu-ying Tan li zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of liver Cancer Tianjin First Center HospitalTianjin 300192China Department of liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Advanced Space-based Solar Observatory(ASO-S):an overview

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Research in Astronomy and Astrophysics 2019年第11期19卷 3-10页

作者： wei-Qun Gan cheng Zhu Yuan-Yong Deng Hui li yang Su hai-ying zhang Bo chen Zhe zhang jian Wu Lei Deng Yu Huang jian-Feng yang Ji-Jun Cui Jin Chang Chi wang Ji Wu Zeng-Shan Yin Wen chen cheng Fang Yi-Hua yan Jun lin wei-Ming Xiong Bin chen hai-Chao Bao Cai-Xia Cao yan-Ping Bai Tao wang Bing-Long chen Xin-Yu li Ye zhang li Feng jiang-Tao Su ying li wei chen you-Ping li ying-Na Su hai-yan Wu Mei Gu Lei Huang Xue-Jun Tang Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of SciencesNanjing 210034China Innovation Academy for Microsatellites Chinese Academy of SciencesShanghai 201203China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Nanjing Institute of Astronomical Optics&Technology National Astronomical ObservatoriesChinese Academy of SciencesNanjing 210042China Changchun Institute of Optics Fine Mechanics and PhysicsChangchun 130033China Xi’an Institute of Optics and Precision Mechanics Chinese Academy of SciencesXi’an 710119China National Space Science Center Chinese Academy of SciencesBeijing 100190China School of Astronomy and Space Science Nanjing UniversityNanjing 210023China Yunnan Observatories Chinese Academy of SciencesKunming 650011China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 101408China Beijing Special Engineering and Design Institute Beijing 100028China Beijing Institute of Tracking and Telecommunications Technology Beijing 100094China Shanghai Academy of Spaceflight Technology Shanghai 201109China

The Advanced Space-based Solar Observatory(ASO-S)is a mission proposed for the 25 th solar maximum by the Chinese solar *** scientific objectives are to study the relationships between the solar magnetic field,solar flares and coronal mass ejections(CMEs).Three payloads are deployed:the Full-disk vector Magneto Graph(FMG),the Lyman-αSolar Telescope(LST)and the Hard X-ray Imager(HXI).ASO-S will perform the first simultaneous observations of the photospheric vector magnetic field,non-thermal imaging of solar flares,and the initiation and early propagation of CMEs on a single ***-S is scheduled to be launched into a 720 km Sun-synchronous orbit in *** paper presents an overview of the mission till the end of Phase-B and the beginning of Phase-C.

关键词： space vehicles instruments-Sun magnetic fields-Sun flares-Sun CMEs-Sun UV radiation-Sun X-ray,gamma-rays

Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5325-5337页

作者： ying Fang Mu-chen zhang yang He chen li hai Fang Peng-Peng Xu Shu cheng yan Zhao yan Feng Qian liu li wang wei-li Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Network and Information Center Shanghai Jiao Tong UniversityShanghaiChina State Key Laboratory of Microbial Metabolism School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghaiChina

TP53 mutation(TP53^(mut))occurs in 10–20%of diffuse large B-cell lymphoma(DLBCL)cases and serves as an unfavorable biomarker of DLBCL *** confers resistance to immunochemotherapy,high-dose chemotherapy,autologous stem cell transplantation,and anti-CD19 chimeric antigen receptor T-cell *** targeting of TP53^(mut) remains a significant challenge in DLBCL *** we assessed TP53^(mut) in 667 patients with newly diagnosed DLBCL,including 576 patients treated with immunochemotherapy rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)and 91 patients with decitabine plus R-CHOP(DR-CHOP,NCT02951728 and NCT04025593).TP53^(mut) independently predicted an inferior prognosis in R-CHOP-treated DLBCL,although this could be mitigated by DR-CHOP *** TP53^(mut) patients,multiple viral regulation pathways were repressed,resulting in the inhibition of immune modulation,as revealed by gene set enrichment ***53^(mut) DLBCL exhibited increased methyltransferase SUV39H1 expression and H3K9 trimethylation(H3K9me3),contributing to repression of endogenous retroviruses(ERVs)and immunosuppressive tumor *** TP53^(mut) DLBCL cell lines,decitabine down-regulated SUV39H1,inhibited H3K9me3 occupancy on ERVs,and triggered ERV expression,thereby unleashing interferons program and CD4^(+)T/CD8^(+)T cell *** silencing of SUV39H1 significantly abrogated decitabine-induced H3K9me3 inhibition and ERV *** TP53^(mut) patient-derived xenograft models and TP53^(mut) patients,the anti-tumor effect was improved upon the use of combined treatment of decitabine and doxorubicin via SUV39H1-H3K9me3-ERVs ***,our findings highlight an ERV regulatory circuitry in TP53^(mut) DLBCL and the crucial roles ERVs for epigenetically reprogramming tumor microenvironment for treating TP53^(mut)-driven cancers.

关键词： TP53 endogenous chemotherapy