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NAT10-mediated ac 4 C-modified ANKZF1 promotes tumor progression and lymphangiogenesis in clear-cell renal cell carcinoma by attenuating YWHAE-driven cytoplasmic retention of YAP1

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Cancer Communications 2024年第3期44卷 361-383页

作者： Daojia Miao jian Shi Qingyang Lv Diaoyi Tan Chuanyi Zhao Zhiyong xiong Xiaoping Zhang Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Institute of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China

Background:Lymphatic metastasis is one of the most common metastatic routes and indicates a poor prognosis in clear-cell renal cell carcinoma(ccRCC).N-acetyltransferase 10(NAT10)is known to catalyze N4-acetylcytidine(ac4C)modification of mRNA and participate in many cellular ***,its role in the lymphangiogenic process of ccRCC has not been *** study aimed to elucidate the role of NAT10 in ccRCC lymphangiogenesis,providing valuable insights into potential therapeutic targets for ***:ac4C modification and NAT10 expression levels in ccRCC were assessed using public databases and clinical *** investigations involved manipulating NAT10 expression in cellular and mouse models to study its role in *** insights were gained through a combination of RNA sequencing,mass spectrometry,co-immunoprecipitation,RNA immuno-precipitation,immunofluorescence,and site-specific mutation ***:We found that ac4C modification and NAT10 expression levels increased in ***10 promoted tumor progression and lymphangiogene-sis of ccRCC by enhancing the nuclear import of Yes1-associated transcriptional regulator(YAP1).Subsequently,we identified ankyrin repeat and zinc fin-ger peptidyl tRNA hydrolase 1(ANKZF1)as the functional target of NAT10,and its upregulation in ccRCC was caused by NAT10-mediated ac4C *** analyses demonstrated that ANKZF1 interacted with tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon(YWHAE)to competitively inhibit cytoplasmic retention of YAP1,leading to transcriptional activation of pro-lymphangiogenic ***:These results suggested a pro-cancer role of NAT10-mediated acetylation in ccRCC and identified the NAT10/ANKZF1/YAP1 axis as an under-reported pathway involving tumor progression and lymphangiogenesis in ccRCC.

关键词： clear-cell renal cell carcinoma N4-acetylcytidine N-acetyltransferase 10 YAP1 nuclear import

Adaptive detection of range-spread targets in homogeneous and partially homogeneous clutter plus subspace interference

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Journal of Systems Engineering and Electronics 2024年第1期35卷 43-54页

作者： jian Tao HE Jia WANG Bencai liu Yu XU Congan XIE Zikeng Research Institute of Information Fusion Naval Aviation UniversityYantai 264001China Air Force Early Warning Academy Wuhan 430019China

Adaptive detection of range-spread targets is considered in the presence of subspace interference plus Gaussian clutter with unknown covariance *** target signal and interference are supposed to lie in two linearly independent subspaces with deterministic but unknown *** on the two-step criteria,two adaptive detectors based on Gradient tests are proposed,in homogeneous and partially homogeneous clutter plus subspace interference,*** of the proposed detectors exhibit theoretically constant false alarm rate property against unknown clutter covariance matrix as well as the power *** results show that,the proposed detectors have better performance than their existing counterparts,especially for mismatches in the signal steering vectors.

关键词： adaptive detection subspace interference constant false alarm rate Gradient test partially homogeneous environment

MIL-100(V) derived porous vanadium oxide/carbon microspheres with oxygen defects and intercalated water molecules as high-performance cathode for aqueous zinc ion battery

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Journal of Energy Chemistry 2024年第3期90卷 578-589,I0013页

作者： Yuexin liu jian Huang Xiaoyu Li Jiajia Li Jinhu Yang Kefeng Cai Shanghai Key Laboratory of Development and Application for Metal-Functional Materials Key Laboratory of Advanced Civil Engineering MaterialsMinistry of EducationSchool of Materials Science&EngineeringTongji UniversityShanghai 201804China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201800China Research Center for Translational Medicine East HospitalTongji University School of MedicineShanghai 200092China

The development of aqueous zinc ion battery cathode materials with high capacity and high magnification is still a ***,porous vanadium oxide/carbon(p-VO_(x)@C,mainly VO_(2) with a small amount of V_(2)O_(3)) core/shell microspheres with oxygen vacancies are facilely fabricated by using a vanadium-based metal-organic framework(MIL-100(V)) as a sacrificial *** unique structure can improve the conductivity of the VO_(x),accelerate electrolyte diffusion,and suppress structural collapse during ***,H_(2)O molecules are introduced into the interlayer of VO_(x) through a highly efficient in-situ electrochemical activation process,facilitating the intercalation and diffusion of zinc *** the activation,an optimal sample exhibits a high specific capacity of 464.3 mA h g^(-1) at0.2 A g^(-1) and 395.2 mA h g^(-1) at 10 A g^(-1),indicating excellent rate ***,the optimal sample maintains a capacity retention of about 89.3% after 2500 cycles at 10 A g^(-1).Density functional theory calculation demonstrates that the presence of oxygen vacancies and intercalated water molecules can significantly reduce the diffusion barrier for zinc *** addition,it is proved that the storage of zinc ions in the cathode is achieved by reversible intercalation/extraction during the charge and discharge process through various ex-situ analysis *** work demonstrates that the p-VO_(x)@C has great potential for applications in aqueous ZIBs after electrochemical activation.

关键词： Metal-organic frameworks Vanadium oxide Carbon Zn-ion batteries Electrochemical activation

基于车辆运动模型辅助的智能手机平台车载组合导航算法

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中国惯性技术学报 2017年第2期25卷 203-208页

作者：许建新熊智刘建业黄欣张苗南京航空航天大学导航研究中心南京211106

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台... 详细信息

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台中所采用的消费级MEMS惯性传感器模块其精度很低,通常难以满足车载DR导航算法的性能需求;同时在车辆行驶过程中,不可避免会经过高架、隧道等路径,也会导致GPS信号受到遮挡和屏蔽从而无法定位。针对以上问题,设计了适用于智能手机平台的基于车辆运动模型辅助的车载DR/GPS组合导航方案,推导建立了基于车辆侧向速度约束的组合导航算法模型,并以智能手机作为验证平台,测试验证了所设计的算法在无GPS环境下,采用智能手机平台中的消费级MEMS惯性测量组件,仍然可以在短时间内维持较高的导航定位性能。

关键词：车载导航车辆运动模型组合导航卡尔曼滤波

Establishing and clinically validating a machine learning model for predicting unplanned reoperation risk in colorectal cancer

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World Journal of Gastroenterology 2024年第23期30卷 2991-3004页

作者： Li-Qun Cai Da-Qing Yang Rong-jian Wang He Huang Yi-xiong Shi Department of Colorectal and Anal Surgery Whenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina Department of Colorectal and Anorectal Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Colorectal cancer significantly impacts global health,with unplanned reoperations post-surgery being key determinants of patient *** predictive models for these reoperations lack precision in integrating complex clinical *** To develop and validate a machine learning model for predicting unplanned reoperation risk in colorectal cancer *** Data of patients treated for colorectal cancer(n=2044)at the First Affiliated Hospital of Wenzhou Medical University and Wenzhou Central Hospital from March 2020 to March 2022 were retrospectively *** were divided into an experimental group(n=60)and a control group(n=1984)according to unplanned reoperation *** were also divided into a training group and a validation group(7:3 ratio).We used three different machine learning methods to screen characteristic variables.A nomogram was created based on multifactor logistic regression,and the model performance was assessed using receiver operating characteristic curve,calibration curve,Hosmer-Lemeshow test,and decision curve *** risk scores of the two groups were calculated and compared to validate the *** More patients in the experimental group were≥60 years old,male,and had a history of hypertension,laparotomy,and hypoproteinemia,compared to the control *** logistic regression analysis confirmed the following as independent risk factors for unplanned reoperation(P<0.05):Prognostic Nutritional Index value,history of laparotomy,hypertension,or stroke,hypoproteinemia,age,tumor-node-metastasis staging,surgical time,gender,and American Society of Anesthesiologists *** operating characteristic curve analysis showed that the model had good discrimination and clinical *** This study used a machine learning approach to build a model that accurately predicts the risk of postoperative unplanned reoperation in patients with colorectal cancer,which can improve tr

关键词： Colorectal cancer Postoperative unplanned reoperation Unplanned reoperation Clinical validation Nomogram Machine learning models

A review of inorganic particles synthesized through electrical discharge in different dielectric media: from devices, structures and components to applications

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Frontiers of Materials Science 2024年第2期18卷 1-35页

作者： Yifan liu Guilu Qin Liangjun Yin Xian jian Xianglong Li School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313001China School of Mechanical Engineering Sichuan UniversityChengdu 610065China

Size effects and compositions constitute new properties for inorganic particles in different application *** physical method has recently attracted more attention in the preparation of inorganic ***,a low-cost,eco-friendly,simple-operating,and time-saving technique,named electrical discharge,is reviewed in relation to developments from the nature of this technique in different dielectric media to the practical experience in controlling the main processing parameters,apparatuses,types of discharge,from the various structures and components to the wide *** development of the electrical discharge technique will play an important role in improving the technology to prepare superfine inorganic particles with high ***,electrical discharge contributes to easily mixing solid materials from the atomic scale to several micrometers with different ***,metal oxides or doping materials are accessible as the dielectric medium is *** some excellent advantages,new inorganic particles exploited through the electrical discharge method will promise to be the most rewarding in some potential applications.

关键词： electrical discharge gas/liquid-phase dielectric medium inorganic particle sizeandcomposition application

Automatic modulation recognition of radiation source signals based on two-dimensional data matrix and improved residual neural network

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Defence Technology（防务技术） 2024年第3期33卷 364-373页

作者： Guanghua Yi Xinhong Hao Xiaopeng Yan jian Dai Yangtian liu Yanwen Han Science and Technology on Electromechanical Dynamic Control Laboratory School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China BIT Tangshan Research Institute Beijing 100081China

Automatic modulation recognition(AMR)of radiation source signals is a research focus in the field of cognitive ***,the AMR of radiation source signals at low SNRs still faces a great ***,the AMR method of radiation source signals based on two-dimensional data matrix and improved residual neural network is proposed in this ***,the time series of the radiation source signals are reconstructed into two-dimensional data matrix,which greatly simplifies the signal preprocessing ***,the depthwise convolution and large-size convolutional kernels based residual neural network(DLRNet)is proposed to improve the feature extraction capability of the AMR ***,the model performs feature extraction and classification on the two-dimensional data matrix to obtain the recognition vector that represents the signal modulation *** analysis and simulation results show that the AMR method based on two-dimensional data matrix and improved residual network can significantly improve the accuracy of the AMR *** recognition accuracy of the proposed method maintains a high level greater than 90% even at -14 dB SNR.

关键词： Automatic modulation recognition Radiation source signals Two-dimensional data matrix Residual neural network Depthwise convolution

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-Sheng Chen Rui Han Yan-Ting liu Wei Huang Qi Wang Xin xiong Ying Zhang jian-Guo Zhao Shi-Hua Li Xiao-jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Tortuosity regulation of two-dimensional nanofluidic films for water evaporation-induced electricity generation

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Nano Research 2024年第7期17卷 6192-6202页

作者： Zhihang liu Chao liu Anqi Ni Kunpeng Mao Long Chen Liang Xue Jingwen Sun Xin Wang Pan xiong Junwu Zhu Key Laboratory for Soft Chemistry and Functional Materials of Ministry Education School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing 210094China

Water evaporation-induced electricity generation is a promising technology for renewable energy ***,the output power of some reported two-dimensional(2D)nanofluidic films is still restricted by the relatively weak water–solid interactions within the tortuous *** further enhance the comprehension and utilization of water–solid interactions,it is of utmost importance to conduct an in-depth investigation and propose a regulatory concept encompassing ion ***,we propose tortuosity regulation of 2D nanofluidic titanium oxide(Ti_(0.87)O_(2))films to optimize the ion transport within the interlayer nanochannel for enhanced efficiency in water evaporation-induced electricity generation for the first *** significance of tortuosity in ion transport is elucidated by designing three 2D nanofluidic films with different *** analysis and in situ Raman measurement demonstrate that low tortuosity can facilitate the formation of efficient pathways for hydrated proton transport and promote water–solid ***,devices fabricated with the optimized 2D nanofluidic films exhibited a significantly enhanced output power density of approximately 204.01μW·cm^(−2),far exceeding those prepared by the high-tortuosity 2D nanofluidic *** work highlights the significance of the construction of low tortuosity channels for 2D nanofluidic films with excellent performance.

关键词： water evaporation-induced electricity generation tortuosity ion transport two-dimensional nanofluidic films