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pH-Switched fluorescent pseudorotaxane assembly of cucurbit[7]uril with bispyridinium ethylene derivatives

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Chinese Chemical Letters 2018年第1期29卷 95-98页

作者： Wei Wu Sen Song Xiaowei Cui Tao sun jian-xin zhang xin-Long Ni Key Laboratory of Mocrocyclic and Supromolecular Chemistry of Guizhou Province Guizhou University Guiyang 550025 China Key Laboratory of Guizhou High Performance Computational Chemistry Guizhou University Guiyang 550025 China Key Laboratory of Chemistry for Natural Products of Guizhou Province Guiyang 550002 China

The host-guest properties of cucurbit[7]uril （0_[7]） and bispyridinium ethylene derivatives have been studied by 1H NMR spectroscopy, UV-vis absorption spectra, and fluorescence emission analysis. The proton shifts associated with the guest encapsulated by the host suggested that the Q[7]-based [2] pseudorotaxane behaves like a fast molecular shuttle along the bispyridinium ethylene axle of the guest upon protonation and deprotonation of the terminal carboxylates. In particular, the distinct fluorescent response signals indicated that the bispyridinium component for the pseudorotaxane system, but also ~uest comDlexation. ethylene moiety not only behaves as the axle acts as an optical reporting unit during the host-

关键词： Cucurbit[7lurilPseudorotaxaneHost-guest interactionFluorescence signalBispyridinium ethylene

Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第11期11卷 828-835页

作者： Sheng-chun DANG De-li jianG Min CHEN Di LI jian-xin zhang Department of General Surgery the Affiliated Hospital of Jiangsu University Zhenjiang 212001 China School of Chemistry and Chemical Engineering Jiangsu University Zhenj iang 212013 China

Objectives： Severe acute pancreatitis （SAP） can lead to acute lung injury （ALl）. The purpose of this paper is to investigate the protective effect of clodronate-containing liposomes on ALl in rats with SAP. Methods： The thin film method was used to prepare liposomes. Sprague-Dawley rats were randomly divided into three groups. After the SAP model was established by injecting 5% （w/v） sodium taurocholate （2 ml/kg body weight） into the subcapsular space of the pancreata, normal saline was administered to the control （C） group, phosphate buffer solution （PBS）-containing liposome to the P group, and clodronate-containing liposome to the T group through tail veins. Blood samples were obtained from the superior mesenteric vein at 2 and 6 h to measure the levels of amylase, interleukin-6 （IL-6）, and tumor necrosis factor-a （TNF-α）. Morphological changes in the pancreata and lung were observed using hematoxylin and eosin （H＆E） staining, while cell apoptosis was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL）. In addition, the macrophage marker cluster of differentiation 68 （CD68） in lung tissue was detected with immunohistochemistry. Results： Blood levels of amylase, IL-6, and TNF-α were significantly increased in the P group compared to those in the T group （P〈0.05）. In the T group, large numbers of TUNEL-positive cells were observed, but no or few in the C and P groups. Gross inspection and H＆E staining of pancreata and lung showed dramatic tissue damage, including inflammation and necrosis in the P group. Less remarkable changes were noted in the T group, and the C group exhibited normal histology. The histological scores according to Kaiser＇s criteria were consistent with H＆E findings. The number of CD68-positive macrophages decreased in the T group. Conclusions CIodronate-containing liposomes have a protective effect against ALl in rats with SAP. Blockade of macrophages may represent a novel therapeutic strategy in SAP.

关键词： Pancreatitis Clodronate disodium Macrophage Lung injury

A novel synthesis route to furo[3,2-a]carbazole

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Chinese Chemical Letters 2015年第3期26卷 282-284页

作者： Mei Xu Tian-Yun Fan jian-xin zhang Xiao-jiang Hao Sheng Liu The Key Laboratory of Chemistry for Natural Products of Guizhou Province Chinese Academy of Sciences Guizhou University

In this paper, we report a novel approach to the heteroaryl-condensed nuclei of natural furo[3,2- a]carbazole alkaloids. Our synthetic studies use N-phthaloyl tryptophan methyl ester as starting material and zinc ion mediated transamination reaction as the key step. This work also implicated a novel strategy to assemble other [a]-fused carbazoles.

关键词： Synthesis Furo[3 2-a]carbazole Transamination

Hydrothermal Synthesis,Crystal Structure and Fluorescent Property of a Novel Mo(V) Phosphate [Zn(Mo^v_6P_4O_(31)H_(10))_2(C_4H_(14)N_3)_2]·2C_4H_(13)N_3·8H_2O

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1071-1077页

作者： WEI Chun-Xia CHEN jian-xin zhang Zhi-Chun LANTing-Yan HUANG Yuan-Biao LI Zhong-Shui zhang Wen-Jie College of Chemistry and Materials Science Fujian Normal University Fuzhou 350007 China

A new molybdenum phosphate [Zn（Mo^v6P4O31H10）2（C4H144N3）2].2C4H13N3.8H2O 1 （C4H13N3 = diethylenetriamine） has been synthesized under hydrothermal condition. Single-crystal X-ray diffraction reveals that compound 1 crystallizes in the monoclinic, space group P21/n, a = 13.1679（3）, b = 22.1240（6）, c = 13.6146（3） A, β= 103.4847（7）°, V = 3856.95（16） A^3, C16H90N12O70P8ZnMo12, Mr = 3035.41, Z = 2, Dc = 2.614 g/cm^3, μ = 2.483 mm^-1, F（000） = 2968, S = 1.014, the final R = 0.0196 and wR = 0.0506 for 7486 observed reflections （1 〉 2σ（I））. Compound 1 consists of two identical rings of six edge-sharing MoOt, octahedra interconnected by one ZnO6 octahedron, whereas the PO4 tetrahedra which share their apices with the MoO6, octahedra are only located on one side of each Mo6, ring. The 2-charge of polyanion [Zn（Mo^v6P4O31H10）2]^2- unit is compensated in the crystal by two mono-protonated diethylenetriamines （C4H14N3）^＋. By hydrogen bonding interactions the polyanion of compound 1 is interconnected to form pseudo threedimensional molybdophosphate. Other characterizations by elemental analyses, IR spectrum and fluorescent spectrum are also described.

关键词： molybdenum(V) phosphate hydrothermal synthesis crystal structure fluorescent property

Curcumin Synergizes with Cisplatin to Inhibit Colon Cancer through Targeting the MicroRNA-137-Glutaminase Axis

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Current Medical Science 2022年第1期42卷 108-117页

作者： Wen-hui FAN Feng-chun WANG Zhi JIN Lin ZHU jian-xin zhang Department of Traditional Chinese Medicine the Second Hospital of Shandong UniversityJinan 250014China Department of Vascular Surgery the Second Hospital of Shandong UniversityJinan 250014China

Objective:Colorectal cancer(CRC)is one of the most lethal and prevalent malignancies ***,surgery,radiotherapy and chemotherapy are clinically applied as common approaches for CRC *** is one of the most frequently used chemotherapy drugs for diverse *** chemotherapeutic strategies have improved the prognosis and survival of cancer patients,development of cisplatin resistance has led to cancer ***,isolated from turmeric,has been used as an effective anti-cancer ***,the molecular mechanisms for curcumin-mediated cisplatin sensitivity of CRC have not been elucidated.

关键词： glutamine metabolism microRNA-137 curcumin cisplatin resistant glutamina

Bright-Dark Mode Coupling Model of Plasmons

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Chinese Physics Letters 2020年第3期37卷 50-54页

作者： Jing zhang Yong-Gang Xu jian-xin zhang Lu-Lu Guan Yong-Fang Li School of Physics and Information Technology Shaanxi Normal UniversityXi'an 710119 School of Electronic Engineering Xi'an Shiyou UniversityXi'an 710065 School of Science Xi'an University of Posts and TelecommunicationsXi'an 710121

We propose a coupling model to describe the interaction between the bright and dark modes of the plasmons of a dimer composed of two orthogonal gold nano-rods(GNRs),referred to as the BDMC *** model shows that the eigen-frequencies of the coupled plasmons are governed by Coulomb potential and electrostatic *** the BDMC model,the behaviors of the coupling coefficient and the frequency offset,which is a new parameter introduced here,are ***,the asymmetric behavior of two eigen-frequencies related to gap of two GNRs is *** the harmonic oscillator model and the coupled parameters obtained by the BDMC model,the bright mode absorption spectra of the dimer are calculated and the results agree with the numerical simulation.

关键词： potential. coupling dimer

IRF5 regulates lung macrophages M2 polarization during severe acute pancreatitis in vitro

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World Journal of Gastroenterology 2016年第42期22卷 9368-9377页

作者： Kang Sun Song-Bing He jian-Guo Qu Sheng-Chun Dang Ji-Xiang Chen Ai-Hua Gong Rong Xie jian-xin zhang Department of General Surgery The Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China Department of General Surgery The First Affiliated Hospital of Soochow University Zhenjiang 215006 Jiangsu Province China Medical School of jiangsu University Zhenjiang 212013 Jiangsu Province China

AIM To investigate the role of interferon regulatory factor 5(IRF5) in reversing polarization of lung macrophages during severe acute pancreatitis(SAP) in *** A mouse SAP model was established by intraperitoneal(ip) injections of 20 μg/kg body weight caerulein. Pathological changes in the lung were observed by hematoxylin and eosin staining. Lung macrophages were isolated from bronchoalveolar lavage fluid. The quantity and purity of lung macrophages were detectedby fluorescence-activated cell sorting and evaluated by real-time polymerase chain reaction(RT-PCR). They were treated with IL-4/IRF5 specific siR NA(IRF5 siR NA) to reverse their polarization and were evaluated by detecting markers expression of M1/M2 using *** SAP associated acute lung injury(ALI) was induced successfully by ip injections of caerulein, which was confirmed by histopathology. Lung macrophages expressed high levels of IRF5 as M1 phenotype during the early acute pancreatitis stages. Reduction of IRF5 expression by IRF5 siR NA reversed the action of macrophages from M1 to M2 phenotype in vitro. The expressions of M1 markers, including IRF5(S + IRF5 siR NA vs S + PBS, 0.013 ± 0.01 vs 0.054 ± 0.047, P < 0.01), TNF-α(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.019 ± 0.018, P < 0.001), iN OS(S + IRF5 siR NA vs S + PBS, 0.0003 ± 0.0002 vs 0.026 ± 0.018, P < 0.001) and IL-12(S + IRF5 si RNA vs S + PBS, 0.000005 ± 0.00004 vs 0.024 ± 0.016, P < 0.001), were decreased. In contrast, the expressions of M2 markers, including IL-10(S + IRF5 siR NA vs S + PBS, 0.060 ± 0.055 vs 0.0230 ± 0.018, P < 0.01) and Arg-1(S + IRF5 siR NA vs S + PBS, 0.910 ± 0.788 vs 0.0036 ± 0.0025, P < 0.001), were increased. IRF5 si RNA could reverse the lung macrophage polarization more effectively than *** Treatment with IRF5 siR NA can reverse the pancreatitisinduced activation of lung macrophages from M1 phenotype to M2 phenotype in SAP associated with ALI.

关键词： Interferon regulatory factor 5 Macrophage polarization Severe acute pancreatitis SiR NA

An updated classification for the hyper-diverse genus Corydalis(Papaveraceae: Fumarioideae)based on phylogenomic and morphological evidence

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Journal of Integrative Plant Biology 2023年第9期65卷 2138-2156页

作者： Jun‐Tong Chen Magnus Lidén Xian‐Han Huang Liang zhang xin‐jian zhang Tian‐Hui Kuang Jacob BLandis Dong Wang Tao Deng Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Evolutionary Biology Centre Systematic BiologyUppsala UniversityUppsala 75236Sweden School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA School of Life Sciences Central China Normal UniversityWuhan 430079China

The genus Corydalis, with ca. 530 species, has long been considered taxonomically challenging because of its great variability. Previous molecular analyses,based on a few molecular markers and incomplete taxonomic sampling, were clearly inadequate to delimit sections and subgenera. We have performed phylogenetic analyses of Corydalis and related taxa,using 65 shared protein-coding plastid genes from313 accessions(including 280 samples of ca. 226species of Corydalis) and 152 universal low-copy nuclear genes from 296 accessions(including 271samples of Corydalis) covering all 42 previously recognized sections and five independent “series”.Phylogenetic trees were inferred using Bayesian Inference and Maximum Likelihood. Eight selected morphological characters were estimated using ancestral state reconstructions. Results include:(i) of the three subgenera of Corydalis, two are fully supported by both the plastid and nuclear data;the third,subg. Cremnocapnos, is weakly supported by plastid DNA only, whereas in the nuclear data the two included sections form successive outgroups to the rest of the genus;(ii) among all 42 sections and five“series”, 25 sections and one “series” are resolved as monophyletic in both data sets;(iii) the common ancestor of Corydalis is likely to be a perennial plant with a taproot, yellow flowers with a short saccate spur, linear fruits with recurved fruiting pedicels, and seeds with elaiosomes;(iv) we provide a new classification of Corydalis with four subgenera(of which subg. Bipapillatae is here newly described), 39 sections, 16 of which are consistent with the previous classification, 16 sections have been recircumscribed, one section has been reinstated and six new sections are established. Characters associated with lifespan, underground structures, floral spur, fruit and elaiosomes are important for the recognition of subgenera and sections. These new phylogenetic analyses combined with ancestral character reconstructions uncovered previo

关键词： character evolution Corydalis genome skimming Papaveraceae phylogeny

Transesterified Chinese Spicehush (Lindera communis) seed oil as a biodiesel fuel

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Forestry Studies in China 2007年第2期9卷 132-136页

作者： Wang Wei-gang Ma Lei jiang jian-xin jiang Li zhang Zhi-xiang College of Materials Science and Technology Beijing Forestry University Beijing 100083 P. R. China

Studies were carried out on the transesterification of the Chinese Spicehush （Lindera communis） seed （LCS） oil with methanol for the production of biodiesel. The methyl esters of LCS oil were compared with soybean esters to determine biodiesel fuel performance and properties. The fatty acids content in the seed kernel oil （LKO） and coat oil （LCO） were quantified by gas chromatography and mass spectrometry method （C-C-MS）. LKO contains 95.1% saturated acids （capric, lauric, myristic and palmitic） and 2.3% unsaturated acids （oleic）. LCO contains 24.6% saturated acids （palmitic and stearic） and 73.6% unsaturated acids （oleic, linoleic and palmitoleic）. The kinematic viscosity, cold filter plugging point, cloud point, flash point and cetane index were determined. The methyl esters of LKO had a higher kinematic viscosity and a lower cold filter plugging point value, so it has better performance in cold weather. The biodiesel of LCS oil has fuel properties within the limits prescribed by American （ASTM D 6751-02） standards, except for a slightly lower flash point of LKO biodiesel than that prescribed by these standards （130℃）. Thus, LKO and LCO biodiesel have great potential to be used on a large scale as fuel for diesel engines.

关键词： biodiesel Lindera communis oil transesterification property