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Duodenum has the greatest potential to absorb soluble non-ammonia nitrogen in the nonmesenteric gastrointestinal tissues of dairy cows

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第6期16卷 503-510页

作者： Ying-ming XIE Qing-biao XU Yue-ming WU xin-bei HUANG jian-xin liu Institute of Dairy Science Mo E Key Laboratory of Molecular Animal NutritionCollege of Animal SciencesZhejiang University

In cattle, dietary protein is gradually degraded into peptide-bound amino acids（PBAAs）, free amino acids（FAAs）, and ultimately into ammonia by the rumen microbes. Both PBAA and FAA are milk protein precursors, and the rumen and small intestines are the main sites where such precursors are produced and absorbed. This work was designed to investigate the expression of the peptide transporter Pep T1 and the AA transporters ASCT2, y＋LAT1, and ATB0,＋, and the concentrations of PBAA, FAA, and soluble protein in the rumen, omasum, and duodenum of dairy cows. Tissues and digesta were collected from six healthy Chinese Holstein dairy cows immediately after the animals were slaughtered. The expression of transporters was analyzed by real-time quantitative polymerase chain reaction（PCR）. The FAA concentration was assessed using an amino acid（AA） analyzer, PBAA concentration by quantification of AA before and after acid-hydrolysis by 6 mol/L HCl, and soluble protein concentration by quantification of the bicinchoninic acid content. The results showed that the relative abundance of m RNA of the transporters and the soluble non-ammonia nitrogen（SNAN） concentration of each fraction were greater in the duodenum than in the rumen or omasum. These results indicate that the duodenum is the predominant location within the nonmesenteric digestive tract for producing milk protein precursors. In addition, PBAA was the largest component of SNAN in the digesta from the rumen, omasum, and duodenum. In conclusion, the duodenum has the greatest concentrations of SNAN and PBAA, and the greatest potential for absorption of SNAN in the form of PBAA in the nonmesenteric gastrointestinal tissues of dairy cows.

关键词： Soluble non-ammonia nitrogen Nonmesenteric gastrointestine Transporters Dairy cows

Rumen fermentation and acetogen population changes in response to an exogenous acetogen TWA4 strain and Saccharomyces cerevisiae fermentation product

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第8期16卷 709-719页

作者： Chun-lei YANG Le-luo GUAN jian-xin liu Jia-kun WANG Institute of Dairy Science Mo E Key Laboratory of Molecular Animal Nutrition College of Animal SciencesZhejiang University Department of Agricultural Food & Nutritional Science Faculty of Agricultural Life & Environmental SciencesUniversity of Alberta

The presence of yeast cells could stimulate hydrogen utilization of acetogens and enhance acetogenesis. To understand the roles of acetogens in rumen fermentation, an in vitro rumen fermentation experiment was conducted with addition of acetogen strain （TWA4） and/or Saccharomyces cerevisiae fermentation product （XP）. A 2×2 factorial design with two levels of TWA4 （0 or 2×10^7 cells/ml） and XP （0 or 2 g/L） was performed. Volatile fatty acids （VFAs） were increased （P〈0.05） in XP and TWA4XP, while methane was increased only in TWA4XP （P〈0.05）. The increase rate of microorganisms with formyltetrahydrofolate synthetase, especially acetogens, was higher than that of methanogens under all treatments. Lachnospiraceae was predominant in all acetogen communities, but without close acetyI-CoA synthase （ACS） amino acid sequences from cultured isolates. Low-Acetitomaculum ruminis-like ACS was predominant in all acetogen communities, while four unique phylotypes in XP treatment were all amino acid identified Iow-Eubacterium limosum-like acetogens. It differs to XP treatment that more Iow-A. ruminis-like and less Iow- E. limosum-like sequences were identified in ＂I＇WA4 and TWA4XP treatments. Enhancing acetogenesis by supple- mentation with an acetogen strain and/or yeast cells may be an approach to mitigate methane, by targeting proper acetogens such as uncultured Iow-E. limosum-like acetogens.

关键词： Acetogen Saccharomyces cerevisiae fermentation product Rumen fermentation Methanogen

Sources of rare earth elements REE+Y(REY)in Bayili Coal Mine from Wensu County of xinjiang,China

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Transactions of Nonferrous Metals Society of China 2021年第10期31卷 3105-3115页

作者： jian-qiang XUE jian-xin liu De-zhi HUANG Wei-jian ZHOU Chun-ming liu Yu-sen CAO Chuang-hua CAO School of Geosciences and Info-physics Central South UniversityChangsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationCentral South UniversityChangsha 410083China Hunan Institute of Geology Survey Changsha 410011China

By analyses on the trace elements of coals,host-rocks and wall-rocks,this study aims to trace the sources and evaluate the utilization prospects of REE+Y(REY)in coals from Bayili Coal Mine(Wensu,xinjiang,China).The distribution patterns of REY in the coals are divided into two groups,flat-type and heavy REE-enrichment type(H-type).The REY of the former was mainly from the gneisses of the basement of the coal-bearing basin,and that of the later was partly from hydrothermal *** host-rocks show two types of REY patterns,middle REE-enrichment type(M-type)and H-type,which are due to the injection of REY from acid terrestrial water and hydrothermal solution,*** all the coal samples are plotted into the promising area on the diagram of percentage of critical elements(REY_(def,rel))vs ratio of sum of critical elements to the sum of excessive elements(C_(outl))and half of the coal samples have high contents of Ga closing to the cut-off grade of Ga deposit as by-product,which indicate that the REY and Ga in Bayili Coal Mine are of utilization prospects as by-product.

关键词： source rare earth elements distribution pattern coal Wensu County(xinjiang)

The Numbers of Configurations, Chiral and Achiral Configurations of Saturated Polybasic Alcohols Containing an Adamantane Skeleton

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Chemical Research in Chinese Universities 1992年第4期8卷 405-409页

作者： WANG jian-ji, liu xin-hua and WANG Xi-gui (Department of Chemistry, Inner Mengoulia Normal University, Huhehaote, 010022)

By using Polya' s theorem, the generating functions of configurations, chiral and achi-ral configurations of saturated polybasic alcohols containing an adamantane skeleton were obtained. Tn order to calculate the generating functions of compounds which are substituted with a limited condition, an exclusive method is used and cycle index is modified.

关键词： Enumeration Adamantane skeleton Alcohol

基于车辆运动模型辅助的智能手机平台车载组合导航算法

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中国惯性技术学报 2017年第2期25卷 203-208页

作者：许建新熊智刘建业黄欣张苗南京航空航天大学导航研究中心南京211106

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台... 详细信息

随着智能手机硬件性能的提升以及MEMS传感器技术的发展和应用普及,现有中高端智能手机平台中大多安装有消费级的微惯性测量单元和GPS接收机模块,将这两者相互结合,利用一定的信息融合方法,即可实现连续的车载导航定位。在智能手机平台中所采用的消费级MEMS惯性传感器模块其精度很低,通常难以满足车载DR导航算法的性能需求;同时在车辆行驶过程中,不可避免会经过高架、隧道等路径,也会导致GPS信号受到遮挡和屏蔽从而无法定位。针对以上问题,设计了适用于智能手机平台的基于车辆运动模型辅助的车载DR/GPS组合导航方案,推导建立了基于车辆侧向速度约束的组合导航算法模型,并以智能手机作为验证平台,测试验证了所设计的算法在无GPS环境下,采用智能手机平台中的消费级MEMS惯性测量组件,仍然可以在短时间内维持较高的导航定位性能。

关键词：车载导航车辆运动模型组合导航卡尔曼滤波

Dynamic imaging of metallic contamination plume based on self-potential data

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Transactions of Nonferrous Metals Society of China 2017年第8期27卷 1822-1830页

作者： Yi-an CUI Xiao-xiong ZHU Wen-sheng WEI jian-xin liu Tie-gang TONG School of Geosciences and Info-Physics Central South University Changsha 410083 China Hunan Key Laboratory of Non-ferrous Resources and Geological Hazard Detection Central South University Changsha 410083 China Key Laboratory of Metallogenic Prediction of Nonferrous Metals Ministry of EducationCentral South University Changsha 410083 China

A dynamic imaging method for monitoring self-potential data was *** on the Darcy’s law and Archie’sformulas,a dynamic model was built as a state model to simulate the transportation of metallic ions in porous medium,and theNernst equation was used to calculate the redox potential of metallic ions for observation ***,the state model andobservation model form an extended Kalman filter cycle to perform dynamic *** noise added synthetic data imaging testshows that the extended Kalman filter can effectively fuse the model evolution and observed self-potential *** further sandboxmonitoring experiment also demonstrates that the self-potential can be used to monitor the activities of metallic ions and exactlyretrieve the dynamic process of metallic contamination.

关键词： dynamic imaging self-potential metallic contamination extended Kalman filter

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang xin liu jian Zhang Ya Gao Shuyue Li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Deep metallogenic mechanism in southeastern China based on receiver function data

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Transactions of Nonferrous Metals Society of China 2022年第1期32卷 273-284页

作者： jian-xin liu Syed muzyan SHAHZAD Ya SUN Asim SHAHZAD Chuan LI Meryem FANIDI Ishfaque MUHAMMAD School of Geosciences and Info-physic Central South UniversityChangsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationCentral South UniversityChangsha 410083China Hunan Provincial Key Laboratory of Nonferrous Resources and Geological Hazard Detection Central South UniversityChangsha 410083China College of Earth Sciences Guilin University of TechnologyGuilin 541006China

Crustal deformation and deep metallogenic mechanisms in southeastern(SE)China are still *** this study,we applied the receiver function method to measure crustal thickness and Poisson’s ratio for crustal rock using teleseismic data recorded at 207 seismic stations from China Earthquake Administration *** results showed that crustal thickness varied from~27 km in the eastern part to~43 km in the western part of the study area,with an average crustal thickness of 31 *** crust is thick in the west and thin in the *** observed Poisson’s ratio for crustal rock was relatively high in the southern Cathaysia Block(CB),with an average of 0.295,while in the Qinling—Dabie terrane,it was relatively low,with an average of *** the middle of the Yangtze craton and central east of the CB,Poisson’s ratio for crustal rock varied from 0.257 to *** comparing Poisson’s ratio of the intrusive deposits with that of igneous rocks in volcanic complexes,we deduced that the metallic mineral system might be associated with orogenic and hydrothermal *** results indicated that multistage magma and mineralization in the study area might be attributed to the tectonic-magma-thermal *** high Poisson’s ratio for crustal rock in the southeastern margin of the CB and northeastern Upper Yangtze Craton might be related to Mesozoic lower crustal mafic partial melt,which provides an important environment for various magmatic intrusions and metallogenies.

关键词： deep metallogenic mechanism Poisson’s ratio southeastern China crustal thickness

Mass Spectrometric Study of Acetylated Glycopyranosyl Azides

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Chemical Research in Chinese Universities 1993年第2期9卷 171-174页

作者： YU jian-xin liu Yu-ting (Department of Chemistry, xinjiang University, Wulumuqi, 830046)liu Li (xinjiang Institute of Chemistry, Academia Sinica, Wulumuqi, 830011) To whom correspondence should be addressed.

Introduction Glycosyl azides are useful, versatile intermediates for the synthesis of N-glyeosyl derivatives and other biologically important non-carbohydrate derivatives since the azido group can be introduced readily into aliphatic, aromatic and heterocyclic systems, and can be transformed into other functional groups and utilized for the synthesis of hetero-

关键词： Mass spectra Acetylated glycopyranosyl azides Reduction Glycosyl amine