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Association of TCR-signaling pathway with the development of lacrimal gland benign lymphoepithelial lesions

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 685-689页

作者： jian-Min Ma Yi-xin cui xin Ge Jing Li Jin-Ru Li Xiao-Na Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical University Beijing Ophthalmology &Vision Science Key Lab

·AIM: To identify the association of the T cell receptor(TCR) signaling with the development of benign lymphoepithelial lesions(BLEL) of the lacrimal gland.· METHODS: We collected affected lacrimal gland tissues from 9 patients who underwent dacryoadenectomy in the Capital Medical University Beijing Tongren Hospital Eye Center between August2010 and March 2013 and were confirmed to have lacrimal gland BLEL by histopathological analysis. Tumor tissues from 9 patients with orbital cavernous hemangioma were also collected and used as *** genome gene expression microarray was used to compare gene expression profiles of affected lacrimal gland tissues from patients with lacrimal gland BLEL to those from of orbital cavernous *** expression of TCR pathway genes between these tissues was confirmed by polymerase chain reaction(PCR) and immunohistochemistry.·RESULTS: Microarray analysis showed that in lacrimal glands with BLEL, 32 signaling pathways were enriched in the upregulated genes, while 25 signaling pathways were enriched in the downregulated genes. In-depth analysis of the microarray data showed that the expression of 27 genes of the TCR signaling pathway increased significantly. To verify the differential expression of three of these genes, CD3, CD4, and interleukin(IL)-10, reverse transcription-PCR(RT-PCR)and immunohistochemistry assays were performed. RT-PCR analysis showed that CD3 and CD4 were expressed in the lacrimal glands with BLEL, but IL-10 was not expressed. Immunohistochemistry confirmed that CD3 and CD4 proteins were also present, but IL-10 protein was not. CD3, CD4, or IL-10 expression was not found in the orbital cavernous hemangiomas with either RT-PCR or immunohistochemistry.· CONCLUSION: TCR signaling pathway might be involved in the pathogenesis of lacrimal gland BLEL.

关键词： lacrimal gland benign lymphoepithelial lesion whole genome gene expression microarray T cell receptor-signaling pathway

Performance of a plastic scintillation fiber dosimeter based on different photoelectric devices

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Nuclear Science and Techniques 2021年第11期32卷 25-31页

作者： Yue Yang cui-Ping Yang Jie xin Hai-Feng Chen Zhong-Xu xing Wei-Wei Qu Liang Hu xin-jian Chen Ren-Sheng Wang State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China Renji Hospital Affiliated with the Shanghai Jiao Tong University School of MedicineShanghai 200127China Shanghai Ninth People’s Hospital Affiliated with the Shanghai Jiao Tong University School of MedicineShanghai 200127China Collaborative Innovation Center of Radiological Medicine of jiangsu Higher Education Institutions Suzhou 215123China

The photoelectric device of a scintillation dosimeter converts photons produced by radiation into an electrical *** features directly determine the overall performance of the *** a plastic scintillation fiber dosimeter(PSFD)with a current readout mode,systematic studies of the stability and light-dose response were performed for the photomultiplier tube(PMT),silicon photomultiplier(SiPM),avalanche photodiode(APD),and photodiode(PD).The temperature stability,long-term stability,repeatability,signal-to-noise ratio(SNR),and current dose response of the PSFD with the abovementioned photoelectric devices were studied using a pulsed LED light source and the Small Animal Radiation Therapy *** exponential relationship between the dark/ne current and temperature was obtained for all the devices.I is shown that the APD is the most sensitive device to temperature,with a current dependence on temperature reaching 6.5%C^(-1)at room temperature,whereas for the other devices this dependence is always<0:6%C^(-1).In terms of long-term stability,the net current of PD can change by up to 4%when working continuously for 8 h and 2%when working intermittently for 32 h,whereas for the other devices,the changes are all<1%.For the dose response,the PMT and SiPM exhibit excellent linear responses and SNRs within the range of 0.1-60 Gy/min For the PSFD with a current readout mode,the performance of the PMT and SiPM is concluded to be better than that of the other devices in the *** particular,the SiPM,which has a compact size,low bias voltage,and antimagnetic interference,has great advantages for further applications.

关键词： Photoelectric device Plastic scintillation fiber dosimeter(PSFD) Current readout Dose response

Variation of Ti Valence with Lithium Content in Lithiated/Delithiated Li_(4)Ti_(5)O_(12) Studied by X-Ray Absorption near the Edge Structure

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Chinese Physics Letters 2013年第3期30卷 108-111页

作者： YU Peng-Fei cui Zhong-Hui MENG jian-Wei GUO Xiang-xin State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050 State Key Laboratory of ASIC and System Department of MicroelectronicsFudan UniversityShanghai 200433

Synchrotron-based x-ray absorption near-edge structure(XANES)spectroscopy is applied to investigate the variation of Ti valence in the discharge and charge processes of Li_(4)Ti_(5)O_(12).Through analysis of the XANES data,the average valence of Ti can be calculated,which allows quantitative determination of the ratios of Ti^(3+)/Ti^(4+) as a function of Li content in the *** is found that the ratios in the composites of Li_(4)Ti_(5)O_(12)/acetylene black(AB)-carbon are larger than those in Li_(4)Ti_(5)O_(12)/Ag/AB-carbon after the discharge to 1.1 V,indicating a larger amount of Li inserted into the former than that into the *** finding provides a good explanation for the fact that the Li_(4)Ti_(5)O_(12)/AB-carbon samples exhibit larger storage capacities than the Li_(4)Ti_(5)O_(12)/Ag/AB-carbon ones prepared in this work,concerning the larger Ti^(3+)/Ti^(4+) ratio and the larger amount of Li^(+) inserted in the electrode for satisfying the charge neutralization requirement.

关键词： Li_(4)Ti_(5)O_(12) composites XANES

Variance Variation Criterion and Consistency in Estimating the Number of Significant Signals of High-dimensional PCA

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 513-531页

作者： Guan-peng WANG Heng-jian cui School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

In this paper,we propose a criterion based on the variance variation of the sample eigenvalues to correctly estimate the number of significant components in high-dimensional principal component analysis(PCA),and it corresponds to the number of significant eigenvalues of the covariance matrix for p-dimensional *** the random matrix theory,we derive that the consistent properties of the proposed criterion for the situations that the significant eigenvalues tend to infinity,as well as that the bounded significant population *** simulation shows that the probability of estimator is correct by our variance variation criterion converges to 1 is faster than that by criterion of Passemier and Yao[Estimation of the number of spikes,possibly equal,in the high-dimensional *** Anal.,(2014)](PYC),AIC and BIC under the finite fourth moment condition as the dominant population eigenvalues tend to ***,in the case of the maximum eigenvalue bounded,once the gap condition is satisfied,the rate of convergence to 1 is faster than that of PYC and AIC,especially the effect is better than AIC when the sample size is *** is worth noting that the variance variation criterion significantly improves the accuracy of model selection compared with PYC and AIC when the random variable is a heavy-tailed distribution or finite fourth moment not exists.

关键词： consistency variance variation criterion significant eigenvalues high dimension spiked model

Local Dependence Test Between Random Vectors Based on the Robust Conditional Spearman's ρ and Kendall's τ

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Acta Mathematicae Applicatae Sinica 2023年第3期39卷 491-510页

作者： Ling-yue ZHANG Heng-jian cui School of Mathematical Sciences Capital Normal UniversityBeijing 100048China

This paper introduces two local conditional dependence matrices based on Spearman'sρand Kendall'sτgiven the condition that the underlying random variables belong to the intervals determined by their *** robustness is studied by means of the influence functions of conditional Spearman'sρand Kendall'sτ.Using the two matrices,we construct the corresponding test statistics of local conditional dependence and derive their limit behavior including consistency,null and alternative asymptotic *** studies illustrate a superior power performance of the proposed Kendall-based *** data analysis with proposed methods provides a precise description and explanation of some financial phenomena in terms of mathematical statistics.

关键词： local dependence influence function rank correlation U-statistic

Nil-Clean Rings with Involution

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Algebra Colloquium 2021年第3期28卷 367-378页

作者： jian cui Guoli Xia Yiqiang Zhou Department of Mathematics Anhui Normal UniversityWuhuAnhui 241002China Department of Mathematics and Statistics Memorial University of Newfoundland St.John’sNL A1C 5S7Canada

A*-ring R is called a nil *-clean ring if every element of R is a sum of a projection and a ****-clean rings are the version of nil-clean rings introduced by *** paper is about the nil*-clean property of rings with emphasis on matrix *** show that a*-ring R is nil*-clean if and only if J(R)is nil and R/J(R)is nil*-*** a 2-primal*-ring R,with the induced involution given by(aij)*=(a*ij)^(T),the nil*-clean property of Mn(R)is completely reduced to that of Mn(Zn).Consequently,Mn(R)is not a nil*-clean ring for n=3,4,and M2(R)is a nil*-clean ring if and only if J(R)is nil,R/J(R)is a Boolean ring and a*-a∈J(R)for all a∈R.

关键词： idempotent nilpotent projection nil-clean ring *-ring nil*-clean ring matrix ring

Efficient Distributed Estimation of High-dimensional Sparse Precision Matrix for Transelliptical Graphical Models

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Acta Mathematica Sinica,English Series 2021年第5期37卷 689-706页

作者： Guan Peng WANG Heng jian cui School of Mathematical Sciences Capital Normal UniversityBeijing 100048P.R.China

In this paper,distributed estimation of high-dimensional sparse precision matrix is proposed based on the debiased D-trace loss penalized lasso and the hard threshold method when samples are distributed into different machines for transelliptical graphical *** a certain level of sparseness,this method not only achieves the correct selection of non-zero elements of sparse precision matrix,but the error rate can be comparable to the estimator in a non-distributed *** numerical results further prove that the proposed distributed method is more effective than the usual average method.

关键词： Distributed estimator sparse precision matrix high-dimensional hard threshold efficient communication

The First Observation on Plant Cell Fossils in China

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Acta Geologica Sinica(English Edition) 2007年第1期81卷 16-22页

作者： WANG xin cui Jinzhong State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences Nanfing Jiangsu 210008 Institute of Botany Chinese Academy of Sciences Beijing 100093

For a long time, paleontologists have been focusing on hard parts of organisms during different geological periods while soft parts are rarely reported. Well-preserved plant cells, if found in fossils, are treated only as a rarity. Recent prowess in research on fossil cytoplasm indicates that plant cytoplasm not only has excellent ultrastructures preserved but also may be a quite commonly seen fossil in strata. However, up to now there is no report of plant cell fossils in China yet. Here plant cell fossils are reported from Huolinhe Coal Mine （the early Cretaceous）, Inner Mongolia, China. The presence of plant cytoplasm fossils in two cones on the same specimen not only provides further support for the recently proposed hypothesis on plant cytoplasm fossilization but also marks the first record of plant cytoplasm fossils in China, which suggests a great research potential in this new area.

关键词： fossil cells plant China Cretaceous

“Zero ischemia”laparoscopic partial nephrectomy by high-power GreenLight laser enucleation for renal carcinoma:A single-center experience

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World Journal of Clinical Cases 2022年第17期10卷 5646-5654页

作者： Xiang-Min Zhang Ji-Dong Xu jian-Min Lv Xiu-Wu Pan jian-Wei Cao jian Chu xin-Gang cui Department of Urology Xinhua HospitalShanghai Jiaotong UniversitySchool of MedicineShanghai 200092China Department of Urology Shanghai Baoshan Luodian HospitalShanghai 201908China Department of Urology Gongli Hospital of The Second Military Medical UniversityShanghai 200135China Department of Urology Shanghai The Seventh People's HospitalShanghai 200137China

BACKGROUND Laparoscopic partial nephrectomy has been widely used in renal cell carcinoma *** efficacy of GreenLight laser on Laparoscopic partial nephrectomy is still *** To present the first series of laparoscopic partial nephrectomy(LPN)by GreenLight laser enucleation without renal artery *** to the excellent coagulation and hemostatic properties of the laser,laser-assisted LPN(LLPN)makes it possible to perform a“zero ischemia”*** Fifteen patients with T1a exogenous renal tumors who received high-power GreenLight laser non-ischemic LPN in our hospital were retrospectively *** clinical information,surgical and post-operative data,complications,pathological and functional outcomes were *** Surgery was successfully completed in all patients,and no open or radical nephrectomy was *** renal artery was not clamped,leading to no ischemic *** blood transfusions were required,the average hemoglobin level ranged from 96.0 to 132.0 g/L and no postoperative complications *** mean operation time was 104.3±8.2 *** postoperative removal of negative pressure drainage time ranged from 5.0 to 7.0 d,and the mean postoperative hospital stay was 6.5±0.7 *** serious complications *** pathological results showed clear cell carcinoma in 12 patients,papillary renal cell carcinoma in 2 patients,and hamartoma in 1 *** mean creatinine level was 75.0±0.8μmol/L(range 61.0-90.4μmol/L)at 1 mo after surgery,and there were no statistically significant differences compared with pre-operation(P>0.05).The glomerular filtration rate ranged from 45.1 to 60.8 mL/min,with an average of 54.0±5.0 mL/min,and these levels were not significantly different from those before surgery(P>0.05).CONCLUSION GreenLight laser has extraordinary cutting and sealing advantages when used for small renal tumors(exogenous tumors of stage T1a)during ***,use of this technique can lead to the generation

关键词： GreenLight laser Zero ischemia Partial nephrectomy Laparoscopy Renal tumor