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Comparison of the Reference Intervals Used for the Evaluation of Maternal Thyroid Function During Pregnancy Using Sequential and Nonsequential Methods

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Chinese Medical Journal 2016年第7期129卷 785-791页

作者： jian-xia fan Shuai Yang Wei Qian Feng-Tao Shi He-Feng Huang Department of Obstetrics and Gynecology International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China Institute of Embryo-Fetal Original Adult Disease Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Background： Maternal thyroid dysfunction is common during pregnancy, and physiological changes during pregnancy can lead to the overdiagnosis of hyperthyroidism and misdiagnosis of hypothyroidism with nongestation-specific reference intervals. Our aim was to compare sequential with nonsequential methods for the evaluation of thyroid function in pregnant women. Methods： We tested pregnant women who underwent their trimester prenatal screening at our hospital from February 2011 to September 2012 for serum thyroid stimulating hormone （TSH） and free thyroxine （FT4） using the Abbott and Roche kits. There were 447 and 200 patients enrolled in the nonsequential and sequential groups, respectively. The central 95% range between the 2.5th and the 97.5th percentiles was used as the reference interval for the thyroid function parameter. Results： The nonsequential group exhibited a significantly larger degree of dispersion in the TSH reference interval during the 2nd and 3rd trimesters as measured using both the Abbott and Roche kits （all P 〈 0.05）. The TSH reference intervals were significantly larger in the nonsequential group than in the sequential group during the 3rd trimester as measured with both the Abbott （4.95 vs. 3.77 mU/L, P 〈 0.001） and Roche kits （6.62 vs. 5.01 mU/L, P〈 0.004）. The nonsequential group had a significantly larger FT4 reference interval as measured with the Abbott kit during all trimesters （ 12.64 vs. 5.82 pmol/L; 7,96 vs. 4.77 pmol/L; 8.10 vs. 4.77 pmol/L, respectively, all P 〈 0.05）, whereas a significantly larger FT4 reference interval was only observed during the 2nd trimester with the Roche kit （7.76 vs. 5.52 pmol/L, P = 0.002）. Conclusions： It was more reasonable to establish reference intervals for the evaluation of maternal thyroid function using the sequential method during each trimester of pregnancy. Moreover, the exclusion of pregnancy-related complications should be considered in the inclusion criteria for thyroid function tests.

关键词： Nonsequential Pregnancy Trimester Reference Interval Sequential Thyroid Function Tests

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Thyroid function reference ranges during pregnancy in a large Chinese population and comparison with current guidelines

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Chinese Medical Journal 2019年第5期132卷 505-511页

作者： Xi Yang Yu Meng Yong Zhang Chen Zhang Fei Guo Shuai Yang Rong Ding jian-xia fan Department of Gynecology and Obstetrics International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China

Background: A correct thyroid function reference range is important for the accurate diagnosis of thyroid disease during pregnancy. However, there is no consensus on whether thyroid function reference ranges in Chinese population should follow the America Thyroid Association (ATA) guidelines. This study aimed to establish a thyroid function reference range more suited to the Chinese population by evaluating the current thyroid function reference range in pregnant Chinese women and comparing it to the ATA guidelines. Methods: A total of 52,027 pregnant women were enrolled from January 2013 to December 2016. Thyroid stimulating hormone (TSH), free thyroxine (FT4), and thyroid peroxidase antibody (TPOAb) levels were tested during the first and third trimesters of pregnancy. Reference ranges of TSH and FT4 were established from the 2.5th and 97.5th percentiles of the TPOAb-negative population of women. The Mann-Whitney U test was used to compare thyroid hormones between the TPOAb-positive and TPOAbnegative groups. Results: We obtained that the TSH reference ranges were 0.03 to 3.52 mU/L and 0.39 to 3.67 mU/L, and the FT4 reference ranges were 11.7 to 19.7 pmol/L and 9.1 to 14.4pmol/L, in the firstand third trimester, respectively. If we used the 2011 ATA criteria about 7.0% and 4.0% pregnant women would be over diagnosed in first and third trimester, respectively, compared with local population thyroid hormone reference. When we compared our local criteria with the new 2017 ATA criteria, about 1.2% and 0.8% pregnant women would have a missed diagnosis in first and third trimester, respectively. Conclusions: Based on our data, which is in line with the current ATA guidelines, a population-based thyroid function reference range would be the first choice for diagnosis of thyroid disease during pregnancy in China. In case such population-based thyroid function reference ranges are unavailable in the east of China, our reference ranges can be adopted, if the same assay is us

关键词： Thyroid hormones Reference values Pregnant women Guideline

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Intravaginal Misoprostol for Cervical Ripening and Labor Induction in Nulliparous Women： A Double-blinded, Prospective Randomized Controlled Study

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Chinese Medical Journal 2015年第20期128卷 2736-2742页

作者： Yu Zhang Hao-Ping Zhu jian-xia fan Hong Yu Li-Zhou Sun Lian Chen Qing Chang Nai-Qing Zhao Wen Di Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Clinical Trial and Training Center Shanghai Institute of Planned Parenthood Research Shanghai 200032 China Department of Obstetrics International Peace Maternity and Children's Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China Department of Obstetrics and Gynecology Zhongda Hospital Medical School Southeast University Nanjing Jiangsu 210009 China Department of Obstetrics and Gynecology First Hospital of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Obstetrics and Gynecology Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital Chengdu Sichuan 610072 China Department of Obstetrics and Gynecology First Hospital Affiliated to The Third Medical University of Chinese PLA Chongqing 400038 China Department of Biostatistics and Social Medicine School of Public Health Fudan University Shanghai 200032 China

Background： In China, no multicenter double-blinded prospective randomized controlled study on labor induction has been conducted till now. This study is to evaluate the efficacy and safety ofintravaginal accurate 25-μg misoprostol tablets for cervical ripening and labor induction in term pregnancy in nulliparous women. Methods： This was a double-blinded, prospective randomized controlled study including nulliparous women from 6 university hospitals across China. Subjects were randomized into misoprostol or placebo group with the sample size ratio set to 7：2. lntravaginal 25-μg misoprostol or placebo was applied at an interval of 4 h （repeated tip to 3 times） for labor induction. Primary outcome measures were the incidence of cumulative Bishop score increases ≥3 within 1211 or vaginal delivery within 24 h. Safety assessments included the incidences of maternal morbidity and adverse fetal/neonatal outcomes. Results： A total of 173 women for misoprostol group and 49 women for placebo were analyzed. The incidence of cumulative Bishop score increases ≥3 within 12 h or vaginal delivery within 24 h was higher in the misoprostol group than in the placebo （64.2% vs. 22.5%, relative risk [RR]： 2.9, 95% confidence interval [C/]： 1.4-6.0）. The incidence of onset of labor within 24 h was significantly higher in the misoprostol group than in the placebo group （48.0% vs. 18.4%, RR： 2.6, 95% CI： 1.2-5.7）; and the induction-onset of labor interval was significantly shorter in the misoprostol group （P = 0.0003）. However, there were no significant differences in the median process time of vaginal labor （6.4 vs. 6.8 h; P = 0.695）, incidence （39.3% vs. 49.0%, RR： 0.8, 95% CI： 0.4-1.5） and indications （P = 0.683） of cesarean section deliveries, and frequencies of maternal, fetal/neonatal adverse events between the groups. Conclusion： Intravaginal misoprostol 25 μg every 4 h is efficacious and safe in labor induction and cervical ripening.

关键词： Cervical Ripening: lntravaginal: Labor Induction: Misoprostol Placebo

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Altered Matrix Metalloproteinases Expression in Placenta from Patients with Gestational Diabetes Mellitus

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Chinese Medical Journal 2018年第10期131卷 1255-1258页

作者： Rong Ding Xi-Mei Liu Yu-Qian xiang Yong Zhang Jun-Yu Zhang Fei Guo Zhi-Wei Liu jian-xia fan Department of Obstetrics and Gynecology International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China Institute of Embryo-Fetal Original Adult Disease Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

To the Editor：Gestational diabetes mellitus （GDM） is defined as glucose intolerance with the onset of pregnancy and is related to increased maternal and fetal *** of GDM varies in different countries and the prevalence ranges between 4% and 17%. GDM is one of the most common medical complications of pregnancy,negatively affecting fetal development and metabolic *** untreated,GDM can cause fetal malformation,macrosomia,fetal growth retardation,and even intrauterine fetal *** studies have shown correlations between GDM and postpartum insulin resistance,pregnancy-induced hypertension,and *** has also been shown to be associated with placental abnormalities including altered placental function,oxidative stress,and vascular dysfunction.

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Association of stent thrombectomy and conventional treatment with neuroprotection, complications, anxiety, and depression in acute ischemic stroke patients

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World Journal of Psychiatry 2025年第1期15卷 72-82页

作者： Kai-Jie Yang Jia-jian Huang Cai-xia Xuan Department of Neurology Qinzhou Second People's HospitalQinzhou 535000Guangxi Zhuang Autonomous RegionChina

BACKGROUND Acute ischemic stroke(AIS)is an abrupt blood flow cessation to a specific brain region within a vascular zone,causing a subsequent decline in neurological *** thrombectomy is a recently established technique for treating *** provides the benefits of being a relatively simple and safe procedure,capable of partially enhancing a patient’s ***,some patients may experience endothelial damage and recurrent thrombosis,with clinical outcomes that are not always ***,the efficacy of this method remains *** To survey the association of stent thrombectomy vs standard treatment with neurological function protection,complications,and short-term prognosis in patients diagnosed with *** This study assigned 90 patients with AIS to the observation and control groups(n=45 patients)from December 2020 to December *** thrombectomy was conducted in the observation group,whereas routine treatment was provided to the control *** study assessed the therapeutic outcomes of two groups,including a comparison of their neurological function,living ability,anxiety and depression status,plaque area,serum inflammatory factors,serum Smur100βprotein,neuron-specific enolase(NSE),homocysteine(Hcy),and vascular endo-thelial ***,the incidence of complications was calculated and analyzed for each *** The total effective rate of treatment was 77.78%and 95.56%in the control and observation groups,*** 8 weeks of treatment,the scores on the National Institutes of Health Stroke Scale,Hamilton Anxiety Scale,and Hamilton Depression Scale decreased remarkably;the Barthel index increased remarkably,with better improvement effects of the scores in the observation group(P<0.05);total cholesterol,triglyceride,C-reactive protein,and plaque area lessened remarkably,with fewer patients in the observation group(P<0.05);S-100βprotein,NSE,and Hcy levels lessened remarkably,with fewer patients in

关键词： Stent thrombectomy Acute ischemic stroke Neurological function Complications Short-term prognosis

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei xia Jinxin Lu Jiale Liu Lei Bai xiang Li Zhengquan Yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He Jing Jin Hong-Lian Wang Yun-Feng Wang fan Yang jian-Qin Liu Jie Chen Zhi Li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

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Simulation of 3D parachute fluid–structure interaction based on nonlinear finite element method and preconditioning finite volume method

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Chinese Journal of Aeronautics 2014年第6期27卷 1373-1383页

作者： fan Yuxin xia jian College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics

A fluid–structure interaction method combining a nonlinear finite element algorithm with a preconditioning finite volume method is proposed in this paper to simulate parachute transient dynamics. This method uses a three-dimensional membrane–cable fabric model to represent a parachute system at a highly folded configuration. The large shape change during parachute inflation is computed by the nonlinear Newton–Raphson iteration and the linear system equation is solved by the generalized minimal residual（GMRES） method. A membrane wrinkling algorithm is also utilized to evaluate the special uniaxial tension state of membrane elements on the parachute canopy. In order to avoid large time expenses during structural nonlinear iteration, the implicit Hilber–Hughes–Taylor（HHT） time integration method is employed. For the fluid dynamic simulations, the Roe and HLLC（Harten–Lax–van Leer contact） scheme has been modified and extended to compute flow problems at all speeds. The lower–upper symmetric Gauss–Seidel（LUSGS） approximate factorization is applied to accelerate the numerical convergence speed. Finally,the test model of a highly folded C-9 parachute is simulated at a prescribed speed and the results show similar characteristics compared with experimental results and previous literature.

关键词： Flow fields analysis Fluid–structure interaction Nonlinear structural dynam-ics Numerical analysis Parachute inflation

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单侧后牙正锁[牙合]患者下颌侧方运动时的髁突轨迹特征

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上海口腔医学 2008年第4期17卷 356-359页

作者：陈军邓锋李建霞范小平重庆医科大学附属口腔医院正畸科重庆400015

目的:探讨单侧后牙正锁(牙合)患者在下颌侧方运动过程中髁突的运动轨迹特征及其与正常(牙合)者之间的差异。方法:选取单侧后牙正锁(牙合)患者26例为实验组,个别正常(牙合)26例为对照组,应用髁突运动轴图描记仪(computer aided diagnosis... 详细信息

目的:探讨单侧后牙正锁(牙合)患者在下颌侧方运动过程中髁突的运动轨迹特征及其与正常(牙合)者之间的差异。方法:选取单侧后牙正锁(牙合)患者26例为实验组,个别正常(牙合)26例为对照组,应用髁突运动轴图描记仪(computer aided diagnosis axiograph,CADIAX)记录下颌侧方运动时髁突的运动轨迹。实验数据采用SPSS10.0软件包分析,选用成组t检验、配对t检验或秩和检验比较组间差异有无统计学意义。结果:实验组下颌侧方运动过程中髁突轨迹不流畅变异大,两侧运动轨迹不对称。非锁(牙合)侧髁突的矢状位移、垂直位移以及空间最大位移大于锁(牙合)侧和对照组,水平位移小于后者,差异有统计学意义(P<0.05);非锁(牙合)侧髁突的矢状倾斜度大于锁(牙合)侧和对照组,水平倾斜度小于后者,差异有统计学意义(P<0.05)。结论:单侧后牙正锁(牙合)患者下颌侧方运动过程中两侧髁突运动轨迹不对称。

关键词：髁突运动轨迹正常[牙合] 正锁[牙合] 描记仪

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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