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High-resolution coupling of stratigraphic'sweet-spot'lithofacies and petrophysical properties:A multiscale study of Ordovician Goldwyer Formation,Western Australia

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Petroleum Science 2023年第3期20卷 1312-1326页

作者： Yu-jie Yuan Reza Rezaee jian-wei gu Song-Tao Wu Emad A.Al-Khdheeawi Jun Wang Bin Pan School of Earth Sciences Yunnan UniversityKunmingYunnan650500China Western Australian School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerthWestern AustraliaAustralia School of Petroleum Engineering China University of Petroleum(East China)QingdaoShandong266580China Research Institute of Petroleum Exploration and Development CNPCBeijing100083China National Energy of Tight Oil and Gas R&D Center Bejing100083China Petroleum Technology Department University of Technology-IraqBaghdad10066Iraq School of Civil and Resource Engineering University of Science and Technology BeijingNo.30Xueyuan RoadBeijing10083China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing400044China

The identification of stratigraphic'sweet-spot'interval is significant in oil and gas formation ***,formation evaluation in macroscopic-scale merely provides low resolution and limited infor-mation,thus may lead to uncertainties in resource *** accurately identify the'sweet-spot'intervals amongst heterogeneous lithofacies,we conducted a very high-resolution and quantitative analysis from in-situ macroscopic scale to laboratory microscopic scale on the Goldwyer formation of Canning Basin,Western *** comprehensive advanced well logging and slim-compact micro imager(SCMI)technologies were synthetically applied in couple with the laboratory nanoscaled *** results unveiled an extraordinarily large lithofacies heterogeneity between different rock intervals,with distinguished features shown in Goldwyer Ⅰ,Ⅱ,and Ⅲ *** most favorable lithofacies is recognized as the laminated argillaceous thermally-matured organic matter(OM)-rich mudstone,which is widely developed in Goldwyer Ⅲ as the major attributor to'sweet-spot'*** Ⅱ is exclusively characterized by thick mudstone intervals(94.4%),interbedded with thin calcareous mudstones(5.5%),corresponding to a depositional environment of low-energy distal section of the outer ramp ***,the most favorable lithofacies in'sweet-spot'intervals develop numerous OM-/mineral nanopores for hydrocarbon ***-rich lithofacies develops abundant inter-particle pores from 2 to 17 nm that mainly contribute to pore volume for free gas storage ***-rich lithofacies with higher maturity have OM-pores with good connectivity,bearing large specific surface area that is beneficial for adsorbed gas capacity.

关键词： Shale Nanopore structure Pore characterization Lithofacies

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AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang Wenying Zheng wei gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

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Clinical study on low-frequency repetitive transcranial magnetic atimulation combined with fasudil in the treatment of acute cerebral infarction

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Journal of Hainan Medical University 2019年第23期25卷 25-29页

作者： Yun-Feng Yang Ju-Hua Liu Bi-Hua Wu jian-wei gu Department of Gerontology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000SichuanChina

Objective:To investigate the effect of low-frequency rTMS combined with fasudil on neurological function in patients with acute cerebral infarction and its ***:120 patients with acute cerebral infarction admitted from January 2016 to January 2019 were randomly divided into four groups:control group(n=30),fasudil group(n=30),rTMS group(n=30),fasudil+rTMS group(n=30).The changes of NIHSS score,ADL score,serum GAP-43,serum RhoA and serum ROCK-Ⅱwere observed and recorded before and after ***:The ADL scores and serum GAP-43 levels of the four groups after treatment were higher than those before treatment(P<0.05);the NIHSS scores,serum RhoA and serum ROCK-Ⅱlevels of the four groups after treatment were lower than those before treatment(P<0.05);After treatment,ADL score and serum GAP-43 level in fasudil+rTMS group were higher than those in other three groups(P<0.05);After treatment,NIHSS score,serum RhoA and serum ROCK-Ⅱlevels in fasudil+rTMS group were lower than those in other three groups(P<0.05).After treatment,NIHSS score was positively correlated with RhoA and ROCK-Ⅱcontent,negatively correlated with GAP-43 content and ADL ***:Low-frequency rTMS combined with fasudil in the treatment of acute cerebral infarction can significantly improve neurological deficits,improve daily living ability,promote axonal remodeling and *** may be one of its mechanisms by increasing the expression of GAP-43 in serum and reducing the expression levels of RhoA and ROCK-Ⅱin *** has high clinical value.

关键词： Low-frequency rTMS Fasudil cerebral infarction GAP-43 RhoA ROCK-Ⅱ

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Resistance of Cement-based Grouting Materials with Nano- SiO_(2) Emulsion to Chloride Ion Penetration

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 114-119页

作者： LI Shuiping CHENG jian wei Chao YUAN Bin YU Chengxiao College of Architectural Science and Engineering Yangzhou UniversityYangzhou 225127China

The chloride penetration resistance of cement-based grout materials was improved by nano-silica *** of mixtures containing different nano-silica particles or emulsions were exposed in sodium chloride solutions of specific concentrations with different test *** properties of the mixes were assessed in terms of weight loss and compressive strength.X-ray diffraction(XRD)and scanning electron microscopy(SEM)of mixes were performed to analysis the phase evolution and *** results demonstrated that the introduction of nano-SiO_(2) emulsion significantly decreased the compressive strength loss and calcium hydroxide(CH)crystal content of hydration production,and then enhanced the resistance of cement-based grouting materials to chloride ion *** improvement derives from the filling and pozzolanic effects of nano-SiO_(2) particles,which were incorporated via an emulsion and attributed to a well dispersion in grouting matrix.

关键词： grouting materials nano-SiO_(2)emulsion chloride ion penetration,weight loss strength loss

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GPS: graph contrastive learning via multi-scale augmented views from adversarial pooling

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Science China(Information Sciences) 2025年第1期68卷 145-158页

作者： wei JU Yiyang gu Zhengyang MAO Ziyue QIAO Yifang QIN Xiao LUO Hui XIONG Ming ZHANG School of Computer Science National Key Laboratory for Multimedia Information ProcessingPeking University Artificial Intelligence Thrust The Hong Kong University of Science and Technology Department of Computer Science University of California

Self-supervised graph representation learning has recently shown considerable promise in a range of fields, including bioinformatics and social networks. A large number of graph contrastive learning approaches have shown promising performance for representation learning on graphs, which train models by maximizing agreement between original graphs and their augmented views(i.e., positive views). Unfortunately, these methods usually involve pre-defined augmentation strategies based on the knowledge of human experts. Moreover, these strategies may fail to generate challenging positive views to provide sufficient supervision signals. In this paper, we present a novel approach named graph pooling contrast(GPS) to address these *** by the fact that graph pooling can adaptively coarsen the graph with the removal of redundancy, we rethink graph pooling and leverage it to automatically generate multi-scale positive views with varying emphasis on providing challenging positives and preserving semantics, i.e., strongly-augmented view and weakly-augmented view. Then, we incorporate both views into a joint contrastive learning framework with similarity learning and consistency learning, where our pooling module is adversarially trained with respect to the encoder for adversarial robustness. Experiments on twelve datasets on both graph classification and transfer learning tasks verify the superiority of the proposed method over its counterparts.

关键词： graph representation learning graph neural networks graph contrastive learning graph augmentations graph pooling

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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： wei ZHANG weiCHENG WANG RUI WANG XIAO HAN LIJUN ZHU WENJIE guO YANHONG gu Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu Hong-wei Li jian-Hong Shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Speed-regulating Simulation of Electronic Governor of Marine Main Diesel Engine

Speed-regulating Simulation of Electronic Governor of Marine...

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作者： CHU jian-xin, gu wei, ZHENG Shi-jun (Marine SimulationCenter, Shanghai Maritime University,Shanghai,200135, China)

＜正＞This paper takes SPC-33 electronic governor as a research object, deduces its mathematics model and puts forward its simulative calculation block diagram. A visualized simulation software of electronic governor ... 详细信息

关键词： electronic governor speed regulation simulation

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li wei Zhang jian Wu Hui Hong wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun gu wei Ma Yuying guan Mengyuan guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

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